Patents Represented by Attorney, Agent or Law Firm R. Scott Meece
  • Patent number: 6451871
    Abstract: Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: September 17, 2002
    Assignee: Novartis AG
    Inventors: Lynn Cook Winterton, Juergen Vogt, John Martin Lally, Friedrich Stockinger
  • Patent number: 6448563
    Abstract: The invention relates to an apparatus for the photo-initiated chemical cross-linking of material (28). To form one or more mouldings the material is enclosed in an optically transparent mould (26). The apparatus has at least one light source (12), for example a pulsed UV light source by which the material (28) can be acted upon by a light that triggers the cross-linking. The region to be cross-linked in the mould (26) is determined at least partially by beam-delimiting elements (20, 22) between the light source (12) and the mould (26). That can be achieved by arranging between the light source (12) and the mould (26) a mask (20) having transparent and non-transparent surface portions. The mask (20) is then projected onto the material (28) that is enclosed in the mould (26) by projection optics (24). The projection of the mask (20) onto the material is effected in a telecentric beam path.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: September 10, 2002
    Assignee: Novartis AG
    Inventors: Roland Hauck, Stefan Bickert
  • Patent number: 6447920
    Abstract: The invention relates to novel composite materials comprising (a) an inorganic or organic bulk material having covalently bound to its surface initiator moieties for radical polymerization; and (b) a hydrophilic surface coating obtainable by applying one or more different ethylenically unsaturated hydrophilic macromonomers of formula (1) as outlined in the claims to the bulk material surface provided with the initiator radicals and polymerizing said macromonomers. The composite materials of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus useful for the manufacture of biomedical articles such as ophthalmic devices.
    Type: Grant
    Filed: October 27, 2000
    Date of Patent: September 10, 2002
    Assignee: Novartis AG
    Inventors: Peter Chabrecek, Jens Höpken, Dieter Lohmann
  • Patent number: 6444776
    Abstract: The present invention relates to novel crosslinkable amphiphilic block copolymers of formula wherein the variables are as defined in the claims, a process for their preparation and their use for the manufacture of mouldings. The block copolymers of the invention are especially useful for the manufacture of ophthalmic mouldings such as in particular contact lenses.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: September 3, 2002
    Assignee: Novartis AG
    Inventors: Troy Vernon Holland, Thomas Hirt, Jacalyn Mary Schremmer, Richard Carlton Baron, Wilson Leonard Terry, Jr., Aaldert Rens Molenberg
  • Patent number: 6440411
    Abstract: The present invention is directed to an ophthalmic product comprising, as a colouring agent, the extract of an alga. A preferred class of alga the extract of which is useful in the present invention is blue alga (Spirulina type), more preferred it is Japanese blue alga (Spirulina platensis). The ophthalmic product is preferably a contact lens care product.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: August 27, 2002
    Assignee: Novartis, AG
    Inventors: Anton Scherer, Peter Schwind
  • Patent number: 6436481
    Abstract: The present invention describes coated articles and methods for preparing such articles, wherein the primary coating comprises a plasma-induced polymer carrying reactive groups. The invention further relates to the reaction of said primary coatings carrying reactive groups with monomeric, oligomeric or macromolecular compounds of synthetic, semisynthetic or biological origin to provide hybrid-type coated articles (secondary coatings).
    Type: Grant
    Filed: June 22, 1999
    Date of Patent: August 20, 2002
    Assignee: Novartis AG
    Inventors: Peter Chabrecek, Dieter Lohmann
  • Patent number: 6413334
    Abstract: In a method for the thermal bonding of a base part (3) of a packaging with a cover film (F), especially for the welding or sealing of a base part of a packaging for contact lenses with a cover film, the contact surface of the base part (3) facing the cover film (F) and the corresponding contact surface of the cover film (F) facing the base part are mechanically pressed against one another along a join. While the mechanical pressure is being generated along the join, heat is simultaneously caused to act on the join, so that the contact surfaces of base part (3) and cover film (F) are thermally bonded to one another along the join. For the purpose of generating the mechanical pressure and causing heat to act on the join there is used a contact plate (70) of low heat capacity which, during the thermal bonding, is pressed against the surface of the cover film (F) remote from the contact surface.
    Type: Grant
    Filed: July 27, 1999
    Date of Patent: July 2, 2002
    Assignee: Novartis AG
    Inventors: Peter Rittner, Peter Zang, Dieter Koch, Bernd Bochmann, Kurt Heinzelmann, Karl Kappler, Heiner Hornberger, Heinz Schlumpberger
  • Patent number: 6407145
    Abstract: The invention relates to a novel process for the manufacture of mouldings, especially contact lenses, in which a soluble prepolymer comprising crosslinkable groups is crosslinked in solution, and also to mouldings, especially contact lenses, obtainable in accordance with that process. The present invention relates also to novel prepolymers that can be used in the process according to the invention, especially derivatives of a polyvinyl alcohol having a molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprise from approximately 0.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: June 18, 2002
    Assignee: Novartis AG
    Inventor: Beat Müller
  • Patent number: 6342570
    Abstract: The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: January 29, 2002
    Assignee: Novartis AG
    Inventors: Harald Bothe, Achim Müller, Bernhard Seiferling, Sharla Borghorst, John Golby, Peter Hagmann, Peter Herbrechtsmeier, Otto Kretzschmar
  • Patent number: 6314199
    Abstract: A process and an apparatus for the examination, especially the quality control, of optical components, in which an image of the particular component to be examined is produced and flaws in the imaged article are detected by image analysis, as well as the integration of that examining process into the manufacture of the component. The optical components may be optical components for the eye, such as spectacle lenses, contact lenses, intraocular lenses and the like.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: November 6, 2001
    Assignee: Novartis AG
    Inventors: Peter Höfer, Peter Hagmann, Roland Hauck, Wolfgang Geissler, Hubert Lutz
  • Patent number: 6311967
    Abstract: The invention relates to a process for the production of a clamping means for clamping a component (20) in a holder (16), especially for the production of moulding tools for the manufacture of precision articles. Spring-action clamping elements (72), for example tightening discs or clamping sleeves (72), are inserted into a recess of the holder (16) and final working thereof takes place in a position that corresponds to the subsequent position when the component (20) to be clamped is clamped. With this process, very good centricity and coaxiality of the clamped components (20) is achieved, whereby the manufacturing tolerances to be maintained for the individual components are not critical.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: November 6, 2001
    Assignee: Novartis AG
    Inventor: Stefan Bickert
  • Patent number: 6303687
    Abstract: The invention relates to a process for the production of moldings, in particular contact lenses, in which a water-soluble crosslinkable polymer is crosslinked in solution, and to moldings, in particular contact lenses, obtainable by this process.
    Type: Grant
    Filed: June 16, 1999
    Date of Patent: October 16, 2001
    Assignee: Novartis AG
    Inventor: Beat Müller
  • Patent number: 6271332
    Abstract: The present invention describes a polymer and a precursor thereof; a prepolymer made essentially from a macromer that is cross-linked, for example, via its free hydroxy groups with a polyisocyanate, the macromer being made essentially from a polysiloxane and a polyol component; processes for the production of such prepolymers and polymers; the use of such polymers, for example, as artificial corneas, as molded articles, especially as contact lens material; also the use of a prepolymer or polymer for coating surfaces, especially functionalized polymer surfaces.
    Type: Grant
    Filed: April 20, 1999
    Date of Patent: August 7, 2001
    Assignee: Novartis AG
    Inventors: Dieter Lohmann, Jens Höpken, Angelika Domschke
  • Patent number: 6265509
    Abstract: The invention relates to a novel process for the production of mouldings, in particular contact lenses, in which a soluble prepolymer comprising units containing a crosslinkable group and at least one unit containing a modifier is crosslinked in solution, and to mouldings, in particular contact lenses, obtainable by this process. The present invention likewise relates to novel prepolymers which can be employed in the novel process, in particular derivatives of a polyvinyl alcohol having a molecular weight of at least about 2000 which comprises from about 0.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: July 24, 2001
    Assignee: Novartis AG
    Inventor: Beat Müller
  • Patent number: 6259518
    Abstract: The invention provides an inspection cell for inspecting an ophthalmic lens. The inspection cell is a solid block that has a bottom planar surface, a top surface, and an indentation in the top surface. The indentation is adapted to receive an ophthalmic lens, which is to be inspected. The invention additionally provides an inspection unit for an ophthalmic lens, which holds one or more of the inspection cells.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: July 10, 2001
    Assignee: Novartis AG
    Inventors: Todd Aldridge Russell, Shiao-Tsing David Chiang
  • Patent number: 6255360
    Abstract: The present invention relates to a process for the manufacture of porous polymers, wherein a polymerizable component comprising at least one free radically polymerizable unsaturated monomer of formula Q—X—A  (1), wherein the variables are defined as described in the claims, is polymerized in the presence of a specific solvent mixture, and the resulting porous polymer, after removal of the solvent, is subjected to an aftertreatment in an acidic or basic medium. The polymers obtainable according to the invention are useful, for example, as substrates for the attachment and growth of mammalian cells and tissue and in particular as materials for the manufacture of biomedical devices and prostheses, including implanted devices.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: July 3, 2001
    Assignee: Novartis AG
    Inventors: Angelika Maria Domschke, Vimala Mary Francis
  • Patent number: 6221303
    Abstract: The invention relates to ophthalmic mouldings, especially contact lenses, obtainable by cross-linking a prepolymer that corresponds essentially to formula (1) wherein the variables are as defined in the claims, in the absence or presence of an additional vinyl comonomer.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: April 24, 2001
    Assignee: Novartis AG
    Inventor: Bettina Steinmann
  • Patent number: 6217171
    Abstract: The invention provides a molded ophthalmic lens having at least first and second optical components, wherein the first optical component is cast molded to encapsulate the second optical component such that the first optical component provides an optical function and the second optical component provides an additional optical function. The invention additionally provides a process for producing a molded composite ophthalmic lens.
    Type: Grant
    Filed: May 26, 1998
    Date of Patent: April 17, 2001
    Assignee: Novartis AG
    Inventors: Richard Dale Auten, John Lally, Xiao-Xiao Zhang
  • Patent number: 6210639
    Abstract: Compositions and methods of disinfecting and cleaning medical articles are disclosed. Disinfecting contact lenses by generating of peracetic acid in situ, while simultaneously cleaning with a proteolytic enzyme, is a preferred embodiment. Tablets for simple consumer use including disinfecting and cleaning means, and delayed release neutralizing means, are also disclosed.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: April 3, 2001
    Assignee: Novartis AG
    Inventors: Elizabeth Gayle Vlass, Christopher Roy Boam, Ian Michael Riorden George, Stephen Dennis Cooper
  • Patent number: 6204306
    Abstract: The present invention relates to &agr;-aminoacetophenones functionalized with organic diisocyanates, which can be used as reactive photoinitiators; to oligomers and polymers to which such functionalized &agr;-aminoacetophenones are bonded; to &agr;-aminoacetophenones having unsaturated polymerizable side-chain; to dimeric and trimeric photoinitiators; to the use of such photoinitiators; to materials coated with such photoinitiators; and to the use of the functionalized &agr;-aminoacetophenones for modifying surfaces.
    Type: Grant
    Filed: August 11, 1997
    Date of Patent: March 20, 2001
    Assignee: Novartis AG
    Inventors: Peter Chabrecek, Kurt Dietliker, Dieter Lohmann