Patents Represented by Attorney, Agent or Law Firm Reising, Ethington, Barnes, Kissellle, Learman & McCulloch, P.C.
  • Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
    Patent number: 6455534
    Abstract: Described are compounds and a method of inhibiting epidermal growth factor receptor tyrosine kinase by treating, with an effective inhibiting amount, a mammal, in need thereof, a compound of Formula II: where: one of A or E is nitrogen, with remaining atoms carbon; X=O, S, NH or NR7, such that R7=lower alkyl (1-4 carbon atoms), OH, NH2, lower alkoxy (1-4 carbon atoms) or lower monoalkylamino (1-4 carbon atoms). Other terms are described in the specification.
    Type: Grant
    Filed: April 2, 2001
    Date of Patent: September 24, 2002
    Assignee: Warner-Lambert Company
    Inventors: Alexander James Bridges, William Alexander Denny, David Fry, Alan Kraker, Robert Frederick Meyer, Gordon William Rewcastle, Andrew Mark Thompson