Patents Represented by Attorney, Agent or Law Firm Richard F. Trecartin, Esq.
  • Patent number: 6423333
    Abstract: Proteinaceous polymers having repetitive units from naturally occurring structural proteins are employed as backbones for functionalities for crosslinking to provide strongly adherent tissue adhesive compositions for bonding together separated tissue, and for sealing or filling tissue defects by injecting the compositions into the defects. Particularly, block copolymers having repeating units of elastin and fibroin are employed having lysine substitutions in spaced apart units, where the amino group can be crosslinked using difunctional crosslinking agents such as glutaraldehyde, activated diolefins, diisocyanates, acid anhydrides or diamines. The protein polymer contains at least 40 weight percent of repetitive units of 3 to 30 amino acids, preferably 3 to 15 amino acids, of at least one naturally occurring structural protein and at least two amino acids containing a functional group capable of reacting with the crosslinking agent.
    Type: Grant
    Filed: November 29, 1999
    Date of Patent: July 23, 2002
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Erwin R. Stedronsky, Joseph Cappello
  • Patent number: 6420523
    Abstract: The present invention provides compositions of matter comprising a polypeptide expressed from insect cells harboring a baculovirus vector the encodes the polypeptide, wherein the polypeptide comprises amino acid sequences derived from the p42 fragment of the Plasmodium falciparum gp 195 protein or derivatives thereof. Such compositions of matter find use for example for inducing the production of anti-p42 antibodies both in vivo and in vitro.
    Type: Grant
    Filed: February 14, 1994
    Date of Patent: July 16, 2002
    Assignee: University of Hawaii
    Inventors: Sandra Chang, George S. N. Hui, Philip J. Barr, Helen Gibson
  • Patent number: 6380154
    Abstract: Method and compositions are provided which are useful for delivering a biologically active substance to a localized site in vivo and for altering the physical dimensions of a body tissue. These method and compositions employ protein polymers having varying ratios of elastin-like collagen-like, keratin-like repeating units and repeating units which promote protein crystallization such as silk-like repeating units. By varying the length of segments of the repeating units and/or the concentration of the protein polymers in the composition, the rate of delivery of a biologically active substance to a localized site can be greatly varied. Moreover, because the compositions are capable of acquiring a non-liquid form under normal physiological conditions, they find use as biocompatible tissue augmentation products.
    Type: Grant
    Filed: February 24, 1997
    Date of Patent: April 30, 2002
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Joseph Cappello, Erwin R. Stedronsky
  • Patent number: 6369252
    Abstract: Described herein are novel structured lipids as well as novel mixtures comprising structured lipids. Also described herein are enzymatic methods of forming these structured lipids and mixtures comprising structured lipids. Also described herein are methods of modulating total cholesterol levels, low-density lipoprotein cholesterol, triacylglycerol levels, and/or the ratio of T-helper cells to T-cytotoxic cells in an individual comprising administrating a structured lipid mixture as provided herein. It is further an object to provide a method of modulating weight in an individual comprising administrating a structured lipid mixture as provided herein.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: April 9, 2002
    Assignee: The University of Georgia Research Foundation, Inc.
    Inventor: Casimir C. Akoh
  • Patent number: 6355776
    Abstract: Novel polypeptides comprising repetitive units of amino acids, as well as synthetic genes encoding the subject polypeptides are provided. The subject polypeptides are characterized by comprising repetitive units of amino acids, where the repetitive units are present in naturally occurring proteins, particularly naturally occurring structural proteins. The subject polypeptides find use in a variety of applications, such as structural components of prosthetic devices, synthetic fibers, and the like.
    Type: Grant
    Filed: November 22, 1999
    Date of Patent: March 12, 2002
    Assignee: Protein Polymer Technologies, Inc.
    Inventors: Franco A. Ferrari, Charles Richardson, James Chambers, Stuart Causey, Thomas J. Pollock, Joseph Cappello, John W. Crissman
  • Patent number: 6290839
    Abstract: The invention relates to compositions and methods useful in the electrophoretic transport of target analytes to a detection electrode comprising a self-assembled monolayer (SAM). Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: September 18, 2001
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Gary Blackburn, Stephen D. O'Connor
  • Patent number: 6280711
    Abstract: The disclosure provides sunscreen compositions comprising a carrier for topical administration and photoresponsive first sunscreen agents which are capable of undergoing intramolecular photorearrangements to form second sunscreen agents. The second sunscreen agents absorb more ultraviolet radiation than the first sunscreen agents. The sunscreen composition may comprise the prephotorearrangement first sunscreen agent, the photorearranged second sunscreen agent, a combination of the first and second sunscreen agents, or any of the above in combination with a known sunscreen agent.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: August 28, 2001
    Assignee: California Institute of Technology
    Inventors: Ronald S. Rock, Michael H. B. Stowell
  • Patent number: 6269312
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: July 31, 1998
    Date of Patent: July 31, 2001
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street, Yaoying Su
  • Patent number: 6268150
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: July 31, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Patent number: 6264825
    Abstract: The invention relates to compositions and methods useful in the acceleration of binding of target analytes to capture ligands on surfaces. Detection proceeds through the use of an electron transfer moiety (ETM) that is associated with the target analyte, either directly or indirectly, to allow electronic detection of the ETM.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: July 24, 2001
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Gary Blackburn, Stephen E. Creager, Scott Fraser, Bruce D. Irvine, Thomas J. Meade, Stephen D. O'Connor, Robert H. Terbrueggen, Jost G. Vielmetter, Thomas W. Welch
  • Patent number: 6258872
    Abstract: The present invention concerns novel methods for enhancing the mechanical performance of tissue adhesives and sealants which comprises employing a primer molecule in association with a tissue adhesive or sealant, wherein the primer molecule serves to enhance the strength of the interface between the tissue and the adhesive matrix. The primer molecules described herein function to interact with a protein present in the tissue, thereby altering its characteristics to make it more amenable to bonding with the adhesive matrix. Primer molecules may be applied to the tissue independently from the tissue adhesive or sealant or may be mixed with the tissue adhesive or sealant prior to application to the tissue.
    Type: Grant
    Filed: June 22, 1998
    Date of Patent: July 10, 2001
    Assignee: Protein Polymer Technologies, Inc.
    Inventor: Erwin R. Stedronsky
  • Patent number: 6255113
    Abstract: The invention relates to methods for targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a eukaryotic cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence, typically by targeted homologous recombination. In certain embodiments, the invention relates to methods for targeting an exogenous polynucleotide having a linked chemical substituent to a predetermined endogenous DNA sequence in a metabolically active eukaryotic cell, generating a DNA sequence-specific targeting of one or more chemical substituents in an intact nucleus of a metabolically active eukaryotic cell, generally for purposes of altering a predetermined endogenous DNA sequence in the cell.
    Type: Grant
    Filed: February 8, 1995
    Date of Patent: July 3, 2001
    Assignee: SRI International
    Inventors: David A. Zarling, Elissa P. Sena
  • Patent number: 6248229
    Abstract: The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, &lgr;, of an electron transfer process.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: June 19, 2001
    Assignee: Clinical Micro Sensors, Inc.
    Inventor: Thomas J. Meade
  • Patent number: 6221583
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: July 24, 1997
    Date of Patent: April 24, 2001
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade
  • Patent number: 6200761
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: December 6, 1999
    Date of Patent: March 13, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Patent number: 6197515
    Abstract: An article suitable for use as a biosensor includes a molecule of a formula X—R—Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: March 6, 2001
    Assignee: Harvard University
    Inventors: Cynthia C. Bamdad, George B. Sigal, Jack L. Strominger, George M. Whitesides
  • Patent number: 6188965
    Abstract: The present invention relates to apparatus and methods for quantitative protein design and optimization.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: February 13, 2001
    Assignee: California Institute of Technology
    Inventors: Stephen L. Mayo, Bassil I. Dahiyat, D. Benjamin Gordon, Arthur Street
  • Patent number: 6180352
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: January 30, 2001
    Assignee: California Insitute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Patent number: 6177250
    Abstract: The present invention provides for the selective covalent modification of nucleic acids with redox active moieties such as transition metal complexes. Electron donor and electron acceptor moieties are covalently bound to the ribose-phosphate backbone of a nucleic acid at predetermined positions. The resulting complexes represent a series of new derivatives that are bimolecular templates capable of transferring electrons over very large distances at extremely fast rates. These complexes possess unique structural features which enable the use of an entirely new class of bioconductors and photoactive probes.
    Type: Grant
    Filed: May 7, 1999
    Date of Patent: January 23, 2001
    Assignee: California Institute of Technology
    Inventors: Thomas J. Meade, Jon Faiz Kayyem, Scott E. Fraser
  • Patent number: 6090933
    Abstract: The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: July 18, 2000
    Assignee: Clinical Micro Sensors, Inc.
    Inventors: Jon Faiz Kayyem, Stephen D. O'Connor, Michael Gozin, Changjun Yu, Thomas J. Meade