Patents Represented by Attorney, Agent or Law Firm Richard J. Mazza
  • Patent number: 4616010
    Abstract: Compounds which are imidazodiazepine derivatives of the formula ##STR1## wherein A together with the carbon atoms denoted by .alpha. and .beta. signifies the group ##STR2## one of R.sup.1 and R.sup.2 signifies hydrogen and the other signifies hydrogen, halogen or trifluoromethyl, R.sup.3 and R.sup.4 each signify hydrogen or halogen and n signifies the number 2 or 3, the compounds having the (S)- or (R,S)-configuration with reference to the carbon atom denoted by .gamma., and their pharmaceutically acceptable acid addition salts have been discovered which possess anxiolytic, anticonvulsant, muscle relaxant and sedative-hypnotic properties. They can be prepared into compositions, including pharmaceutically acceptable ones, using suitable inert carriers.
    Type: Grant
    Filed: February 20, 1986
    Date of Patent: October 7, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Walter Hunkeler, Emilio Kyburz
  • Patent number: 4601984
    Abstract: There are provided antibiotics X-14873 A, G and H of the formulas ##STR1## wherein for X-14873A, R.sub.1 is CO.sub.2 H and R.sub.2 is ##STR2## for X-14873G, R.sub.1 is hydrogen and R.sub.2 is ##STR3## and for X-14873H, R.sub.1 is hydrogen and R.sub.2 is ##STR4## The compounds exhibit antibiotic activity. Also disclosed is a process to produce the above compounds.
    Type: Grant
    Filed: June 30, 1983
    Date of Patent: July 22, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chao-Min Liu, Homer D. Tresner, John Westley
  • Patent number: 4593093
    Abstract: There are presented compounds of the formula ##STR1## wherein R.sup.1 is one of the 3-substituents usable in cephalosporin chemistry, R.sup.2 is hydrogen, lower alkyl or COOR.sup.3 -lower alkyl, wherein R.sup.3 is hydrogen, a cation of a base or a readily hydrolyzable ester group, and X is sulphur, oxygen or one of the groups --SO-- and --SO.sub.2 --,and the readily hydrolyzable esters, readily hydrolyzable ethers and salts of these compounds and hydrates of the compounds of formula I or of their esters, ethers and salts, also presented are methods for the manufacture of these compounds as well as compounds used in their manufacture.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: June 3, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roland Reiner, Urs Weiss
  • Patent number: 4591636
    Abstract: The invention relates to compounds of the formula ##STR1## wherein R is lower alkyl or a carboxy group or a group of the formula--(CH.sub.2).sub.n --OY ain which n stands for 1 or 2 and Y is hydrogen or alkyl and R.sup.Y and R.sup.z each are hydrogen or one of R.sup.Y and R.sup.z is hydrogen and the other is hydroxy,and pharmaceutically acceptable acid addition salts thereof.These compounds and salts possess antibiotic and antitumor activity and can be used as medicaments in the form of pharmaceutical preparations.
    Type: Grant
    Filed: December 17, 1984
    Date of Patent: May 27, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael J. Broadhurst, Cedric H. Hassall, Gareth J. Thomas
  • Patent number: 4591559
    Abstract: The present invention relates to a novel polyether ionophore antibiotic of the formula ##STR1## and its pharmaceutically acceptable salts. The compound of formula I and its salts exhibit activity as an antibacterial agent and as an anticoccidial agent.
    Type: Grant
    Filed: January 22, 1985
    Date of Patent: May 27, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chao-Min Liu, John Westley
  • Patent number: 4582853
    Abstract: The present invention relates to a novel polyether ionophore antibiotic of the formula ##STR1## and its pharmaceutically acceptable salts. The compound of formula I and its salts exhibit activity as an antibacterial agent and as an anticoccidial agent.
    Type: Grant
    Filed: January 22, 1985
    Date of Patent: April 15, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Chao-Min Liu, John Westley
  • Patent number: 4247305
    Abstract: Composite compacts comprising a cluster of abrasive particles selected from among diamond, cubic boron nitride and wurtzite boron nitride on a support medium, are securely bonded to metal tool parts by a process comprising providing a bond initiator between, and in contact with, a surface of the composite compact and a surface of the tool part, passing a short duration, high electrical current pulse through the contacting surfaces sufficient to cause melting of the bond initiator without raising the temperature of the abrasive particles to their decomposition temperature, forcing the composite compact and tool part together under an applied magnetic force pulse while the bond initiator is molten, and recovering the article.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: January 27, 1981
    Assignee: General Electric Company
    Inventors: William H. Daniels, Mahlon D. Dennis, Earl Feingold
  • Patent number: 4066627
    Abstract: Poly(alkylene terephthalates) are prepared by an improved process which provides high molecular weight, in a shortened reaction time, without excessive loss of the diol reactant to side reactions. In the process an excess of the diol reactant is heated with a mixture of the corresponding dialkyl terephthalate and from 5 to 95 mole % of terephthalic acid, based on the mixture.
    Type: Grant
    Filed: July 22, 1976
    Date of Patent: January 3, 1978
    Assignee: General Electric Company
    Inventors: Willem F. H. Borman, Eugene P. Reilly