Abstract: Cultivation of a strain of the microorganism Micromonospora sp. A.T.C.C. No. 53481, yields the novel antibiotic substance glyphomicin, which is a mixture of glyphomicin A and glyphomicin B.

Abstract: A polymeric, surgical clip having first and second curved leg members joined at their proximal end by a reduced thickness hinge portion and movable from an open position to a closed position for clamping a vessel between curved opposing inner surfaces which are substantially parallel when the clip is closed. The first leg member has a concave inner surface and a hook portion at its distal end curved toward the second leg member. A ligating clip applying instrument for applying the clip has a pair of handles pivoted about a hinge point and extends beyond the hinge point to form a pair of clip closing jaws equipped with means for engaging bosses located on the sides of the first and second leg members.

Abstract: A three part ostomy coupling has a first part having a flange, a central chute and an array of space projections. A second part has a peripheral seal for engaging and surrounding the outer wall of the chute an outwardly projecting rim which can be snap fitted on the space projection. A third part is rotatable to effect a positive lock between the rim the projections, for example by deforming the projections inwardly.

Abstract: The guidewire gripping device is usable in connection with guidewires of the type used in medical application, i.e., for guiding catheters. The guidewire gripping device is constructed from a spring loaded, slitted cylindrical body.

Abstract: A biological test pack adapted for use in testing the efficacy of an ethylene oxide sterilization process is described. The test pack is a clear plastic tray containing an sterilization sensitive ink which has been imprinted on a card which faces out of the bottom of the plastic tray. In addition, the tray contains a plastic syringe which holds a biological indicator. On top of the plastic syringe, absorbent paper is placed. The entire pack has a Tyvek sheet which seals it until it is used. The plastic tray is molded into a shape for holding the various items in particularly desirable locations. Accordingly, a disposable test pack which is uniformly manufactured and which should yield consistent results, is described. It can be used either as a general purpose routine test pack or as a validation challenge test pack.

Abstract: An ostomy device for releasably connecting an ostomy bag to an adhesive backed label including a mounting member for connecting one of two coupling parts to the label. The mounting member comprises an expandable portion for facilitating displacement of the connected coupling part between a normal position and an expanded position. The expanded portion comprises a pair of accordion-like folds including an inner fold and a smaller outer fold. The connected coupling part comprises a rib portion having a deflectible sealing strip extending therefrom. The rib portion is connected to the mounting member adjacent the outer folds such that the sealing strip is positioned intermediate the inner and outer folds when the coupling part is in the normal position. The inner fold guides discharge from the stoma into the bag and away from the interengaged coupling parts. In an alternate embodiment, the mounting member is affixed to the label.

Abstract: An incontinence device for females is intended for long term wear. It includes a tubular sheath integral with a funnel and a urine-conducting pipe. The sheath is secured to a pad of adhesive material having a central hole leading into the interior of the sheath. The pad is dimensioned so that it can be stuck to the skin of the wearer in the region immediately surrounding the urethral orifice (meatus).

Abstract: The bayonet coupling uses a body side flange and a bag side flange. The body side flange has L-shaped openings engaged to engage with pins on the body side flange. The body side flange includes an annular detent which includes an O-ring for sealing purposes.

Abstract: The present invention is an improved coupling for as ostomy bag system. In the improved coupling, an integral O-ring is included to improve the retention of the coupling as well as its seal by extending through the annular ring.

Abstract: The present catheter employee a series of axial slits adjacent to its tip. The slits act to increase the flexibility of the catheter adjacent the tip thereby providing pressure relief in the event of blockage of the lumen at the tip. In addition, by forming the slits as slots, i.e. by removing material from the slits, it is possible to provide a catheter having flow through the sides adjacent to the tip for any desired purpose.

Abstract: A dispensing device for a radionuclide generator includes an eluant container, a receptacle for receiving the container, the receptacle being in sliding engagement with a support, a hollow needle which pierces the elastic stopper of the container so that the tip of the needle penetrates into the container, and a fixing device for holding the needle at a distance from its tip. The volume dispensed from the container is controlled by shifting the receptacle up or down within the support along the longitudinal axis of the needle.

Abstract: An improved multi-lumen catheter having lumens which do not extend in a straight line down the length of the catheter is disclosed. The twisting of the catheter provides that side holes which extend into the lumens of the catheter are not aligned in a straight line. Accordingly, when the catheter is inserted into a patient's vessel, the side holes cannot be aligned in a manner which causes all of the side holes of a particular lumen to be occluded by the wall of the patient's vessel.A catheter of the type disclosed can be manufactured by an extrusion process in which the catheter is twisted during the extrusion, or by heating a non-twisted catheter and then twisting it in order to impart an appropriate twist therein.

Abstract: The ostomy appliance has two interengaging coupling elements. One of the elements is an annular plate which includes an engaging member formed by two ribs which diverge from each other to define a V-formation. One of the ribs has a stepped formation on its distal region. The other coupling element has an annular channel having cooperating formation adapted to engage the stepped formation, thereby connecting the coupling elements.

Abstract: The catheter protective shield is used to protect a flow directed catheter of the type used in the measurement of central venous pressure and pulmonary wedge pressure. The cathetershield assembly includes front and rear hubs sized to permit movement of the catheter therethrough and an external support tube for interconnecting the front and rear hubs. A flexible protective sleeve interconnects the two hubs. The protective sleeve is substantially longer than the external support tube and is collapsible to permit interconnection of the hubs by the external support tube and may be extended to shield a substantial length of catheter.

Abstract: A pre-filled syringe is provided with a retractile needle. The needle end of a syringe is enclosed in a sterile chamber within a casing sealed by a cap with a break-off tip. The barrel of the syringe is movable within the casing from a remote pre-injection position to a forward injection position and back again. When the barrel is moved forward a first end of the needle passes through the opening of the cap and then the opposite end comes in contact with the injectant. When the barrel is withdrawn to a pre-injection position, the needle is retracted within the casing and is prevented from re-entering the opening in the cap.

Abstract: An ostomy bag has a filter attached to it by a series of plural sequentially peelable adhesive annuli.

Abstract: A one-piece urostomy appliance has a drainage bag secured to an apertured flange which is in turn secured to an apertured adhesive pad. The body side of the apertured flange has a flexible skirt encircling the stoma aperture and located adjacent the radially inner boundary of the adhesive pad. The skirt is constructed and located to impede leakage of urine towards the adhesive pad.

Abstract: An improved ostomy appliance has two interengageable coupling elements, one of which (herein called the body side coupling element) is secured to a medical grade adhesive pad and the other side of which is secured to an ostomy bag. A flexible chute ring is interposed between the body side coupling element and the adhesive pad. The flexible chute ring is attached to a polymeric film surface of the pad at a first annular region and to the body side coupling element at a second annular region. The first annular region is located radially inwardly of the coupling element.

Abstract: A portable recorder has a pinch roller moved to engage a capstan, a recording head brought into a recording position and a motor to power the recorder switched on through the sliding movement of a slide assembly in engagement with the case of the recorder near a hinge between bottom and top portions of the case. The capstan is rotated about an axis substantially perpendicular to the plane of the case by a pulley arrangement driven by the motor with an axis substantially within a plane parallel to the case. The recording head is mounted to the slide assembly which includes a roller attached to the back thereof for rotating engagement with the case when it is opened and closed. Rotating movement of the roller causes the slide assembly to move back and forth within the case as the top of the case is opened and closed causing the recording head to move near or away from the tape. A spring mounted to the case and the slide assembly biases the slide assembly to a remote position when the case is opened.

Abstract: An ostomy appliance comprises a body-attachable pad of skin-compatible adhesive material having a stomal orifice, and means whereby a plurality of ostomy bags can be attached in sequence to the pad by exposing a fresh region of adhesive each time it is desired to attach a clean ostomy bag.