Patents Represented by Attorney, Agent or Law Firm Robert L Buchanan
  • Patent number: 6277397
    Abstract: The present invention relates to a collagen material comprising a laminate in which a collagen ultra-fine fibrous non-woven fabric-like multi-layer structure is sandwiched between non-fibrous collagen layers, a thread-like material containing said collagen material, their production processes, and a medical material containing said collagen material, and particularly a medical alternative membrane comprised of said medical material.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: August 21, 2001
    Assignees: Tapic International Co., Ltd.
    Inventor: Yasuhiko Shimizu
  • Patent number: 6258561
    Abstract: The method of the present invention is suitable for the commercial high-level production of a protein or peptide which can be used as a prophylactic and therapeutic drug for various diseases such as senile dementia, cerebrovascular dementia (dementia arising from cerebrovascular disorders), dementia associated with genealogical retroplastic diseases (e.g. Alzheimer's disease, Parkinson's disease, Pick's disease, Huntington's disease, etc.), dementia associated with infectious diseases (e.g. Creutzfeldt-Jakob's and other virus diseases), dementia associated with endocrine or metabolic disease or toxicosis (e.g. hypothyroidism, vitamin B12 deficiency, alcoholism, intoxication by drugs, metals, and organic compounds), dementia associated with tumorigenic diseases (e.g. brain tumor), dementia associated with traumatic diseases (e.g.
    Type: Grant
    Filed: October 20, 1999
    Date of Patent: July 10, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Suenaga Masato, Moriya Takeo, Tanaka Yoko, Nishimura Osamu
  • Patent number: 6248078
    Abstract: The present invention features test systems and methods for detecting a hepatic disorder in a mammal and especially a primate. Preferred use of the invention involves staging the hepatic disorder in a human patient.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: June 19, 2001
    Assignee: Johns Hopkins University
    Inventors: Terence H. Risby, Shelley Sehnert, Long Jiang, James F. Burdick
  • Patent number: 6241774
    Abstract: Disclosed is an artificial esophagus suitable for human use that includes a fine fibrous collagen layer and a tubular outer surface. The invention generally provides a degradable artificial structure that helps maintain an existing esophagus or form a new esophagus. The invention has many important uses including improving esophageal reconstruction techniques.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: June 5, 2001
    Assignees: Tapic International Co., Ltd.
    Inventor: Yasuhiko Shimizu
  • Patent number: 6235878
    Abstract: This invention is directed toward novel human and murine Fas ligand-like proteins having an apoptosis-inducing activity. Cloned cDNAs encoding human, mouse, and rat Fas ligand-like proteins were obtained from human liver, mouse embryo, and rat liver cDNA libraries. The cDNAs were expressed in a recombinant yeast (e.g., Pichia) expression system. The expressed proteins should prove useful in a number of biochemical and immunological applications.
    Type: Grant
    Filed: September 4, 1997
    Date of Patent: May 22, 2001
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Kazunori Nishi, Yukiko Hikichi, Yasushi Shintani
  • Patent number: 6232445
    Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II &bgr;2 chain modification, e.g., deletion of essentially the entire class II &bgr;2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.
    Type: Grant
    Filed: October 29, 1997
    Date of Patent: May 15, 2001
    Assignee: Sunol Molecular Corporation
    Inventors: Peter R. Rhode, Jorge Acevedo, Martin Burkhardt, Jin-an Jiao, Hing C. Wong
  • Patent number: 6228889
    Abstract: The present invention includes methods for treatment and prophylaxis of diseases, post-surgical disorders and bacterial infections associated with lactosylceramide. The methods generally provide for administration for a mammal, particularly a human, of a therapeutically effective amount of a compound that inhibits UDPGal:GlcCer&bgr;1−>4 galactosylceramide (GalT-2). In vitro and in vivo assays for detecting compounds with therapeutic capacity to modulate GalT-2 are also provided.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: May 8, 2001
    Assignee: Johns Hopkins University
    Inventor: Subroto Chatterjee
  • Patent number: 6221355
    Abstract: The present invention provides an anti-pathogen system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically activated by a pathogen infection. The anti-pathogen system effectively kills or injures cells infected by one or a combination of different pathogens. Further provided are protein transduction domains that provide enhanced transduction efficiency.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: April 24, 2001
    Assignee: Washington University
    Inventor: Steven F. Dowdy
  • Patent number: 6210908
    Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.
    Type: Grant
    Filed: September 2, 1999
    Date of Patent: April 3, 2001
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael E. Annunziato, Paul S. Palumbo
  • Patent number: 6156514
    Abstract: Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: December 5, 2000
    Assignee: Sunol Molecular Corporation
    Inventors: Jorge L. Acevedo, Peter R. Rhode
  • Patent number: 6127524
    Abstract: The present invention features novel binding molecules and methods of improving the specific binding affinity of binding molecules, which methods do not use X-ray crystallography. For example, in one aspect, the invention features methods of making antibodies with improved specific binding affinity for a polypeptide produced during prothrombin activation. The present invention is useful for a variety of applications including, e.g., producing binding molecules with improved binding affinity; and screening for binding molecules which are in low abundance.
    Type: Grant
    Filed: October 18, 1996
    Date of Patent: October 3, 2000
    Assignee: Dade Behring Inc.
    Inventors: Clayton L. Casipit, Hing C. Wong, Bee Y. Huang
  • Patent number: 6103882
    Abstract: The method of the present invention is suitable for the commercial high-level production of a protein or peptide which can be used as a prophylactic and therapeutic drug for various diseases such as senile dementia, cerebrovascular dementia (dementia arising from cerebrovascular disorders), dementia associated with genealogical retroplastic diseases (e.g. Alzheimer's disease, Parkinson's disease, Pick's disease, Huntington's disease, etc.), dementia associated with infectious diseases (e.g. Creutzfeldt-Jakob's and other virus diseases), dementia associated with endocrine or metabolic disease or toxicosis (e.g. hypothyroidism, vitamin B12 deficiency, alcoholism, intoxication by drugs, metals, and organic compounds), dementia associated with tumorigenic diseases (e.g. brain tumor), dementia associated with traumatic diseases (e.g. chronic subarachnoidal hemorrhage), and other types of dementia, depression, hyperactive child syndrome (microencephalopathy), and disturbance of consciousness.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: August 15, 2000
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Suenaga Masato, Moriya Takeo, Tanaka Yoko, Nishimura Osamu
  • Patent number: 6060260
    Abstract: The present invention relates to methods for substantially reducing adsorption of at least one positively charged molecule to a negatively charged surface upon contact therebetween, the method comprising combining the positively charged molecule with at least one blocking agent in an amount sufficient to substantially reduce the adsorption of the positively charged molecule to the negatively charged surface.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: May 9, 2000
    Assignee: Dade Behring Inc.
    Inventors: Joseph W. Amshey, Jr., Rosy Sheng Donn
  • Patent number: 5977299
    Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.
    Type: Grant
    Filed: April 7, 1997
    Date of Patent: November 2, 1999
    Assignee: Dade Behring Marburg GmbH
    Inventors: Michael E. Annunziato, Paul S. Palumbo
  • Patent number: 5888760
    Abstract: The present invention relates to a universal test systems and methods of use thereof for identifying a microorganism among at least two groups of widely divergent microorganisms. The universal test system comprises a predetermined combination of non-redundant biochemical tests comprising a substrate for at least one enzyme wherein the substrate, if acted on by the enzyme results in formation of a detectable product. Detectable products from the combination of biochemical tests are then used to identify the microorganism.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: March 30, 1999
    Assignee: Dade MicroScan Inc.
    Inventors: James H. Godsey, Daniel M. Nothaft
  • Patent number: 5882495
    Abstract: The present invention provides electrophoresis systems and methods for forming at least one gel therein and for conducting electrophoresis on the gel without removing the gel from the electrophoresis system. The systems of the present invention include an electrophoresis platform which is a surface onto which one or more electrophoresis gels can be cast, and at least one gel casting/electrophoresis member for use in casting at least one gel on the electrophoresis platform and conducting electrophoresis on the gel. The present invention also includes optional members specific to other stages of the electrophoresis process, including a gel staining member and a gel drying member.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: March 16, 1999
    Assignee: Proteome, Inc.
    Inventor: James I. Garrels
  • Patent number: 5856114
    Abstract: The present invention is directed to immunochemical detection procedures, e.g., using both Western blotting and direct immunoassays, for fragments of Factor Va, which can thus be used; (a) in a predictive manner to evaluate the existence and/or extent of a thrombotic complication; (b) to monitor the efficacy of prophylaxis for a thrombotic condition; and (c) as a means to evaluate potential risk of hemorrhage during thrombolytic therapy.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: January 5, 1999
    Assignee: The University of Vermont
    Inventors: Kenneth G. Mann, Michael Kalafatis
  • Patent number: 5759735
    Abstract: A method for preparing an electrophotographic printing-use developer by mixing components of toner material, fusing and kneading the toner material, and then crushing and classifying the toner material, includes the step of arranging carbon black which is one of the components of the toner material to contain water before the mixing step. This arrangement permits even dispersion of water in the mixture of the components, prevents the flowability of the mixture from being lowered, and achieves stable kneading. Therefore, improved dispersion of the components is achieved. Since water adsorption is stable, water-treated carbon showing reduced water segregation is obtained. Consequently, high quality less foggy images with high resolution are obtained.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: June 2, 1998
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Tadashi Nakamura, Kanshiro Okamoto, Hirofumi Sakita, Toshihiko Murakami, Yoshiaki Akazawa
  • Patent number: 5645427
    Abstract: Disclosed is a tool with cutting surfaces on the sides, end and tip that is inserted into a handpiece or milling machine. It is used according to a specific technique disclosed herein to mill precision surfaces in dental prostheses that are retained by screws to dental implants, abutments or replicas. The invention mills all types of dental implant prostheses that use a screw for retention. The milling tool of this invention allows the screw to pass through the screw access opening in the prosthesis and fit flush against the screw seat in the prosthesis, leaving space between the axial surfaces of the head of the screw and the screw access channel of the restoration. It also mills the small opening through the prosthesis through which the shank of the screw passes, so there is no contact between the prosthesis and the shank of the screw.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: July 8, 1997
    Assignee: North Shore Dental Porcelains Laboratories, Inc.
    Inventors: Thomas S. Peterson, Dirk Schwichtenberg