Patents Represented by Attorney, Agent or Law Firm Robert L Buchanan
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Patent number: 6277397Abstract: The present invention relates to a collagen material comprising a laminate in which a collagen ultra-fine fibrous non-woven fabric-like multi-layer structure is sandwiched between non-fibrous collagen layers, a thread-like material containing said collagen material, their production processes, and a medical material containing said collagen material, and particularly a medical alternative membrane comprised of said medical material.Type: GrantFiled: May 20, 1999Date of Patent: August 21, 2001Assignees: Tapic International Co., Ltd.Inventor: Yasuhiko Shimizu
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Patent number: 6258561Abstract: The method of the present invention is suitable for the commercial high-level production of a protein or peptide which can be used as a prophylactic and therapeutic drug for various diseases such as senile dementia, cerebrovascular dementia (dementia arising from cerebrovascular disorders), dementia associated with genealogical retroplastic diseases (e.g. Alzheimer's disease, Parkinson's disease, Pick's disease, Huntington's disease, etc.), dementia associated with infectious diseases (e.g. Creutzfeldt-Jakob's and other virus diseases), dementia associated with endocrine or metabolic disease or toxicosis (e.g. hypothyroidism, vitamin B12 deficiency, alcoholism, intoxication by drugs, metals, and organic compounds), dementia associated with tumorigenic diseases (e.g. brain tumor), dementia associated with traumatic diseases (e.g.Type: GrantFiled: October 20, 1999Date of Patent: July 10, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Suenaga Masato, Moriya Takeo, Tanaka Yoko, Nishimura Osamu
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Patent number: 6248078Abstract: The present invention features test systems and methods for detecting a hepatic disorder in a mammal and especially a primate. Preferred use of the invention involves staging the hepatic disorder in a human patient.Type: GrantFiled: August 27, 1999Date of Patent: June 19, 2001Assignee: Johns Hopkins UniversityInventors: Terence H. Risby, Shelley Sehnert, Long Jiang, James F. Burdick
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Patent number: 6241774Abstract: Disclosed is an artificial esophagus suitable for human use that includes a fine fibrous collagen layer and a tubular outer surface. The invention generally provides a degradable artificial structure that helps maintain an existing esophagus or form a new esophagus. The invention has many important uses including improving esophageal reconstruction techniques.Type: GrantFiled: May 20, 1999Date of Patent: June 5, 2001Assignees: Tapic International Co., Ltd.Inventor: Yasuhiko Shimizu
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Patent number: 6235878Abstract: This invention is directed toward novel human and murine Fas ligand-like proteins having an apoptosis-inducing activity. Cloned cDNAs encoding human, mouse, and rat Fas ligand-like proteins were obtained from human liver, mouse embryo, and rat liver cDNA libraries. The cDNAs were expressed in a recombinant yeast (e.g., Pichia) expression system. The expressed proteins should prove useful in a number of biochemical and immunological applications.Type: GrantFiled: September 4, 1997Date of Patent: May 22, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Kazunori Nishi, Yukiko Hikichi, Yasushi Shintani
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Patent number: 6232445Abstract: The present invention relates to novel complexes of major histocompability complex (MHC) molecules and uses of such complexes. In one aspect, the invention relates to single chain MHC class II complexes that include a class II &bgr;2 chain modification, e.g., deletion of essentially the entire class II &bgr;2 chain. In another aspect, the invention features single chain MHC class II which comprise an immunoglobin constant chain or fragment. Further provided are polyspecific MHC complexes comprising at least one single chain MHC class II molecule. MHC complexes of the invention are useful for a variety of applications including: 1) in vitro screens for identification and isolation of peptides that modulate activity of selected T cells, including peptides that are T cell receptor antagonists and partial agonists, and 2) methods for suppressing or inducing an immune response in a mammal.Type: GrantFiled: October 29, 1997Date of Patent: May 15, 2001Assignee: Sunol Molecular CorporationInventors: Peter R. Rhode, Jorge Acevedo, Martin Burkhardt, Jin-an Jiao, Hing C. Wong
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Patent number: 6228889Abstract: The present invention includes methods for treatment and prophylaxis of diseases, post-surgical disorders and bacterial infections associated with lactosylceramide. The methods generally provide for administration for a mammal, particularly a human, of a therapeutically effective amount of a compound that inhibits UDPGal:GlcCer&bgr;1−>4 galactosylceramide (GalT-2). In vitro and in vivo assays for detecting compounds with therapeutic capacity to modulate GalT-2 are also provided.Type: GrantFiled: June 25, 1999Date of Patent: May 8, 2001Assignee: Johns Hopkins UniversityInventor: Subroto Chatterjee
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Patent number: 6221355Abstract: The present invention provides an anti-pathogen system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically activated by a pathogen infection. The anti-pathogen system effectively kills or injures cells infected by one or a combination of different pathogens. Further provided are protein transduction domains that provide enhanced transduction efficiency.Type: GrantFiled: December 10, 1998Date of Patent: April 24, 2001Assignee: Washington UniversityInventor: Steven F. Dowdy
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Patent number: 6210908Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.Type: GrantFiled: September 2, 1999Date of Patent: April 3, 2001Assignee: Dade Behring Marburg GmbHInventors: Michael E. Annunziato, Paul S. Palumbo
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Patent number: 6156514Abstract: Disclosed are methods for producing recombinant cells and especially recombinant mammalian cell lines with enhanced expression of an amino acid sequence. Also disclosed are recombinant mammalian cell lines producing high levels of the amino acid sequence. The methods and recombinant cell lines of the invention have a number of useful applications including use in the efficient and large-scale production of recombinant proteins and polypeptides.Type: GrantFiled: December 3, 1998Date of Patent: December 5, 2000Assignee: Sunol Molecular CorporationInventors: Jorge L. Acevedo, Peter R. Rhode
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Patent number: 6127524Abstract: The present invention features novel binding molecules and methods of improving the specific binding affinity of binding molecules, which methods do not use X-ray crystallography. For example, in one aspect, the invention features methods of making antibodies with improved specific binding affinity for a polypeptide produced during prothrombin activation. The present invention is useful for a variety of applications including, e.g., producing binding molecules with improved binding affinity; and screening for binding molecules which are in low abundance.Type: GrantFiled: October 18, 1996Date of Patent: October 3, 2000Assignee: Dade Behring Inc.Inventors: Clayton L. Casipit, Hing C. Wong, Bee Y. Huang
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Patent number: 6103882Abstract: The method of the present invention is suitable for the commercial high-level production of a protein or peptide which can be used as a prophylactic and therapeutic drug for various diseases such as senile dementia, cerebrovascular dementia (dementia arising from cerebrovascular disorders), dementia associated with genealogical retroplastic diseases (e.g. Alzheimer's disease, Parkinson's disease, Pick's disease, Huntington's disease, etc.), dementia associated with infectious diseases (e.g. Creutzfeldt-Jakob's and other virus diseases), dementia associated with endocrine or metabolic disease or toxicosis (e.g. hypothyroidism, vitamin B12 deficiency, alcoholism, intoxication by drugs, metals, and organic compounds), dementia associated with tumorigenic diseases (e.g. brain tumor), dementia associated with traumatic diseases (e.g. chronic subarachnoidal hemorrhage), and other types of dementia, depression, hyperactive child syndrome (microencephalopathy), and disturbance of consciousness.Type: GrantFiled: June 26, 1998Date of Patent: August 15, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Suenaga Masato, Moriya Takeo, Tanaka Yoko, Nishimura Osamu
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Patent number: 6060260Abstract: The present invention relates to methods for substantially reducing adsorption of at least one positively charged molecule to a negatively charged surface upon contact therebetween, the method comprising combining the positively charged molecule with at least one blocking agent in an amount sufficient to substantially reduce the adsorption of the positively charged molecule to the negatively charged surface.Type: GrantFiled: February 27, 1998Date of Patent: May 9, 2000Assignee: Dade Behring Inc.Inventors: Joseph W. Amshey, Jr., Rosy Sheng Donn
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Patent number: 5977299Abstract: Novel activated peptides and conjugates thereof, useful in diagnostic assays and therapeutics, and processes for the preparation thereof are disclosed.Type: GrantFiled: April 7, 1997Date of Patent: November 2, 1999Assignee: Dade Behring Marburg GmbHInventors: Michael E. Annunziato, Paul S. Palumbo
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Patent number: 5888760Abstract: The present invention relates to a universal test systems and methods of use thereof for identifying a microorganism among at least two groups of widely divergent microorganisms. The universal test system comprises a predetermined combination of non-redundant biochemical tests comprising a substrate for at least one enzyme wherein the substrate, if acted on by the enzyme results in formation of a detectable product. Detectable products from the combination of biochemical tests are then used to identify the microorganism.Type: GrantFiled: April 10, 1997Date of Patent: March 30, 1999Assignee: Dade MicroScan Inc.Inventors: James H. Godsey, Daniel M. Nothaft
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Patent number: 5882495Abstract: The present invention provides electrophoresis systems and methods for forming at least one gel therein and for conducting electrophoresis on the gel without removing the gel from the electrophoresis system. The systems of the present invention include an electrophoresis platform which is a surface onto which one or more electrophoresis gels can be cast, and at least one gel casting/electrophoresis member for use in casting at least one gel on the electrophoresis platform and conducting electrophoresis on the gel. The present invention also includes optional members specific to other stages of the electrophoresis process, including a gel staining member and a gel drying member.Type: GrantFiled: November 12, 1996Date of Patent: March 16, 1999Assignee: Proteome, Inc.Inventor: James I. Garrels
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Patent number: 5856114Abstract: The present invention is directed to immunochemical detection procedures, e.g., using both Western blotting and direct immunoassays, for fragments of Factor Va, which can thus be used; (a) in a predictive manner to evaluate the existence and/or extent of a thrombotic complication; (b) to monitor the efficacy of prophylaxis for a thrombotic condition; and (c) as a means to evaluate potential risk of hemorrhage during thrombolytic therapy.Type: GrantFiled: February 26, 1996Date of Patent: January 5, 1999Assignee: The University of VermontInventors: Kenneth G. Mann, Michael Kalafatis
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Patent number: 5759735Abstract: A method for preparing an electrophotographic printing-use developer by mixing components of toner material, fusing and kneading the toner material, and then crushing and classifying the toner material, includes the step of arranging carbon black which is one of the components of the toner material to contain water before the mixing step. This arrangement permits even dispersion of water in the mixture of the components, prevents the flowability of the mixture from being lowered, and achieves stable kneading. Therefore, improved dispersion of the components is achieved. Since water adsorption is stable, water-treated carbon showing reduced water segregation is obtained. Consequently, high quality less foggy images with high resolution are obtained.Type: GrantFiled: January 29, 1997Date of Patent: June 2, 1998Assignee: Sharp Kabushiki KaishaInventors: Tadashi Nakamura, Kanshiro Okamoto, Hirofumi Sakita, Toshihiko Murakami, Yoshiaki Akazawa
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Patent number: 5645427Abstract: Disclosed is a tool with cutting surfaces on the sides, end and tip that is inserted into a handpiece or milling machine. It is used according to a specific technique disclosed herein to mill precision surfaces in dental prostheses that are retained by screws to dental implants, abutments or replicas. The invention mills all types of dental implant prostheses that use a screw for retention. The milling tool of this invention allows the screw to pass through the screw access opening in the prosthesis and fit flush against the screw seat in the prosthesis, leaving space between the axial surfaces of the head of the screw and the screw access channel of the restoration. It also mills the small opening through the prosthesis through which the shank of the screw passes, so there is no contact between the prosthesis and the shank of the screw.Type: GrantFiled: March 2, 1995Date of Patent: July 8, 1997Assignee: North Shore Dental Porcelains Laboratories, Inc.Inventors: Thomas S. Peterson, Dirk Schwichtenberg