Patents Represented by Attorney Robert L. Stone
  • Patent number: 5208009
    Abstract: An anticalculus oral composition, which is preferably a toothpaste or a mouthrinse, includes an effective anticalculus azacycloalkane-2,2-diphosphonic acid or a salt thereof, preferably azacycloheptane-2,2-diphosphonic acid, and a water-soluble or water swellable polymer having a molecular weight of about 1,000-2,000,000, such as a linear copolymer of maleic anhydride and vinyl methyl ether or a polyvinyl phosphonate. The polymer surprisingly increases the anticalculus effectiveness of the azacycloalkane-2,2-diphosphonic acid or salt thereof in such compositions, even at comparatively low concentrations of both such materials. Also within the invention is a process for applying such compositions to the teeth, and it has been shown by both in vitro and in vivo testing that significant repeatable improvements in anticalculus effects are obtained by such processes, compared to control processes in which either of the active components mentioned is employed alone in the described oral compositions.
    Type: Grant
    Filed: November 25, 1991
    Date of Patent: May 4, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, John J. Afflito, Marilou T. Joziak
  • Patent number: 5202112
    Abstract: A toothpaste or dental gel composition containing an amount of a synthetic linearly viscoelastic cross-linked polymeric thickening agent, especially a cross-linked methyl vinyl ether/maleic anhydride copolymer, effective to render the composition linearly viscoelastic, and a method of promoting oral hygiene by applying an effective amount of the composition to dental surface.
    Type: Grant
    Filed: August 1, 1991
    Date of Patent: April 13, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Michael Prencipe, Gary A. Durga
  • Patent number: 5192530
    Abstract: An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan), and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, wherein said antiplaque agent is substantially completely dissolved in saliva present during tooth and gum cleaning in a solubilizing agent therefor. The solubilizing agent may be a humectant polyol such as propylene glycol, dipropylene glycol and hexylene glycol; a cellosolve such as methyl cellosolve and ethyl cellosolve; a vegetable oil or wax containing at least about 12 carbon atoms in a straight chain such as olive oil, castor oil and petrolatum; or an ester such as ethyl acetate, amyl acetate, glyceryl tristearate and benzyl benzoate.
    Type: Grant
    Filed: September 6, 1991
    Date of Patent: March 9, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
  • Patent number: 5192531
    Abstract: An oral composition dentifrice containing an orally acceptable vehicle, about 30-75% by weight of a dentally acceptable water-insoluble polishing agent, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan) an antibacterial enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces, and a surface active agent and/or a flavoring oil.
    Type: Grant
    Filed: September 9, 1991
    Date of Patent: March 9, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer, Michael Prencipe
  • Patent number: 5188821
    Abstract: An oral composition mouthwash or liquid dentifrice containing an aqueous vehicle acceptable vehicle, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxy-diphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: February 23, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
  • Patent number: 5180578
    Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Triclosan). Antiplaque effectiveness is optimized by the presence of an antibacterial-enhancing agent which enhances delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
    Type: Grant
    Filed: February 19, 1991
    Date of Patent: January 19, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
  • Patent number: 5178851
    Abstract: An oral composition dentifrice comprising an orally acceptable vehicle, about 5-30% by weight of a siliceous polishing agent, about 0.25-0.35% by weight of a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2'-hydroxydiphenyl ether (triclosan) and an antibacterial-enhancing agent which enhances the delivery of said antibacterial agent to, and retention thereof on, oral surfaces.
    Type: Grant
    Filed: February 14, 1991
    Date of Patent: January 12, 1993
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Nuran Nabi, John Afflitto, Orum Stringer
  • Patent number: 5167951
    Abstract: An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque activity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition, but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula.
    Type: Grant
    Filed: April 6, 1990
    Date of Patent: December 1, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Richard S. Robinson, Jeffrey Miller, Chimpiramma Potini, Michael A. Collins, Theresa G. Shackil
  • Patent number: 5156835
    Abstract: An oral composition such as a dentifrice or mouthwash, containing an aqueous phase of water and as solubilizing agent propylene glycol, dipropylene glycol, methyl cellosolve, ethyl cellosolve, olive oil, castor oil, amyl acetate, ethyl acetate, glyceryl tristearate or benzyl benzoate mixed with at least one of glycerine and sorbitol, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (triclosan) or hexyl resorcinol and a synthetic anionic linear polymeric polycarboxylate having a molecular weight of about 1,000 to about 1,000,000.
    Type: Grant
    Filed: August 9, 1991
    Date of Patent: October 20, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Nuran Nabi, Abdul Gaffar
  • Patent number: 5139769
    Abstract: An oral composition such as a toothpaste (including gel or cream), mouthwash, lozenge, chewing gum or tooth powder containing a calculus-inhibiting amount of a linear molecularly dehydrated polyphosphate salt and, to inhibit enzymatic hydrolysis of said polyphosphate salt in saliva, a combination of a fluoride ion-providing source and a synthetic linear polymeric polycarboxylate.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: August 18, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Thomas G. Polefka
  • Patent number: 5135738
    Abstract: An oral composition, such as a paste or gel dentifrice or a liquid mouthwash, containing a substantially water insoluble non-cationic antibacterial agent, such as triclosan, which, when used to clean the teeth or rinse the mouth, acts to decrease plaque on the teeth, is packaged in a dispensing container or bottle which includes a solid polymeric material, such as polyfluoroethylene, which is compatible with the antibacterial agent so that excessive loss of anti-plaque acitivity of such agent on storage is avoided. Alternatively, various other polymers may be employed as container parts, which normally would cause excessive losses of anti-plaque action of the antibacterial agent in the composition but such action is countered by the presence of a stabilizer, such as a terpene, e.g., limonene, in the oral composition formula. Also described is a method for inhibiting development of plaque on teeth.
    Type: Grant
    Filed: October 26, 1989
    Date of Patent: August 4, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, Richard S. Robinson, Jeffrey Miller, Chimpiramma Potini, Michael A. Collins, Theresa G. Shackil
  • Patent number: 5116602
    Abstract: An antiplaque oral composition containing a low concentration of a sesquiterpene alcohol flavor compound to inhibit the formation of dental plaque in the presence of an additive selected from the group consisting of benzoic acid, a preservative, and a polycarboxylate and mixtures thereof, in an oral vehicle having a low pH of about 3-5.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: May 26, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Richard S. Robinson, Arthur B. Buzin, Ruby E. Kirkup
  • Patent number: 5096699
    Abstract: An anticalculus oral composition, which is preferably a toothpaste or a mouthrinse, includes an effective anticalculus azacycloalkane-2,2-diphosphonic acid or a salt thereof, preferably azacycloheptane-2,2-diphosphonic acid, and a polymeric polycarboxylate, which is preferably a linear copolymer of maleic anhydride and vinyl methyl ether of a molecular weight in the range of about 5,000-2,000,000, preferably about 30,000-1,500,000. The copolymer surprisingly increases the anticalculus effectiveness of the azacycloalkane-2,2-diphosphonic acid or salt thereof in such compositions, even at comparatively low concentrations of both such materials.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: March 17, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, John J. Afflitto, Marilou T. Joziak
  • Patent number: 5094844
    Abstract: An oral composition such as a toothpaste (including gel or cream), mouthwash, lozenge, chewing gum or tooth powder containing a calculus-inhibiting amount of a linear molecularly dehydrated polyphosphate salt and, as inhibitor of enzymatic hydrolysis of said polyphosphate salt in saliva, a synthetic polymeric vinyl phosphate. A fluoride-ion providing source may also be present to further inhibit the enzymatic hydrolysis of said polyphosphate salt.
    Type: Grant
    Filed: December 20, 1990
    Date of Patent: March 10, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, John Afflitto, Sahar F. Smith
  • Patent number: 5089255
    Abstract: A method is disclosed for remineralizing demineralized portions of teeth by treatment with a non-astringent composition containing about 10-20% xylitol, and at least one fluoride ion-providing compound in a total amount sufficient to provide about 150 ppm to about 1800 ppm of fluoride ions, with sodium fluoride providing a predominant proportion of such fluoride ions.
    Type: Grant
    Filed: January 25, 1991
    Date of Patent: February 18, 1992
    Assignee: Colgate-Palmolive Company
    Inventors: Abdul Gaffar, James Mellberg, John Blake-Haskins
  • Patent number: 5043154
    Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (Triclosan).
    Type: Grant
    Filed: May 1, 1989
    Date of Patent: August 27, 1991
    Assignee: Colgate-Palmolive Co.
    Inventors: Abdul Gaffar, Nuran Nabi, Brian S. Jannone
  • Patent number: 5041279
    Abstract: Dental cream in contact with a polyolefin resin surface of a package such as a laminate tube, a mechanical dispenser or a flexible sachet. The dental cream contains at least a major amount of dentally acceptable water-insoluble polishing material, alpha-alumina trihydrate, a liquid aqueous humectant vehicle wherein glycerine and sorbitol are humectants, a gelling agent and benzoic acid to reduce pH and prevent syneresis due to contact between the dental cream and the polyolefin resin.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: August 20, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: Marie Brett, Harry Hayes
  • Patent number: 5037637
    Abstract: An oral composition such as a dentifrice, mouthwash, lozenge or chewing gum containing a polyphosphate anticalculus agent, such as tetraalkali metal pyrophosphate and antibacterial antiplaque agent compatible therewith. The antiplaque agent is a substantially water-insoluble noncationic antibacterial agent such as 2,4,4'-tricholoro-2.sup.1 -hydroxydiphenyl ether (Triclosan).
    Type: Grant
    Filed: December 8, 1989
    Date of Patent: August 6, 1991
    Assignee: Colgate-Palmolive Company
    Inventors: Abaul Gaffar, Nuran Nabi, Brian S. Jannone
  • Patent number: 5037635
    Abstract: An oral composition such as a dentifrice or mouthwash, containing an aqueous phase of water and as solubilizing agent propylene glycol, dipropylene glycol, methyl cellosolve, ethyl cellosolve, olive oil, castor oil, amyl acetate, ethyl acetate, glyceryl tristrearate or benzyl benzoate mixed with at least one glycerine and sorbitol, a substantially water-insoluble noncationic antibacterial antiplaque agent, such as 2,4,4'-trichloro-2.sup.1 -hydroxydiphenyl ether (triclosan), and a synthetic anionic linear polymeric polycarboxylate having a molecular weight of about 1,000 to about 1,000,000.
    Type: Grant
    Filed: November 13, 1989
    Date of Patent: August 6, 1991
    Assignee: Colate-Palmolive Company
    Inventors: Nuran Nabi, Abdul Gaffar
  • Patent number: 5033488
    Abstract: Porous, high strength (that is, "Expanded") polytetrafluoroethylene (PTFE) dental floss is coated with microcrystalline wax. If desired, the floss may also incorporate one or more actives tartar control anti-caries antiplaque and/or antibacterial actives and/or dentally acceptable agents such as polishing and abrasive agents, coolants, flavorants and/or coagulants.
    Type: Grant
    Filed: December 2, 1988
    Date of Patent: July 23, 1991
    Assignee: Colgate-Palmolive Co.
    Inventors: John P. Curtis, Jan-Joost Pabst, James H. Kemp