Abstract: Substituted methoxy benzylidene indenyl compounds are useful in the treatment of precancerous lesions and neoplasms.

Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to substituted quinazoline compounds.

Abstract: Substituted indene derivatives are useful for treating patients having precancerous lesions and for inhibiting the growth of neoplastic cells.

Abstract: Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of sarcoidosis.

Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.

Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to substituted thienopyrimidine compounds.

Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to substituted N-cycloalkylmethyl-1H-pyrazolo?3,4-b!quinolin-4-amines.

Abstract: 1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives for inhibiting neoplastic conditions.

Abstract: Substituted indenyl sulfonyl acetic acids, esters and alcohols are useful in the treatment of psoriasis.

Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to substituted N-arylmethyl and heterocyclmethyl-1H-pyrazolo?3,4-B!quinolin-4-amines.

Abstract: The present invention is directed to a fluorescence polarization immunoassay for determining the phenylacetylglutamine (PAG) content in body fluids, to the various components needed for preparing and carrying out such an assay, and to the methods of making these components. Specifically, tracers, immunogens and antibodies are disclosed, as well as methods for preparing them. The assay is conducted by measuring the degree of polarization of plane polarized light that has been passed through a solution continuing sample, antiserum and tracer.

Abstract: A method for performing a diagnostic immunoassay by solid phase separation for digoxin. To a reaction mixture of a test sample and labeled anti-digoxin antibody, which forms a complex of any digoxin present in the test sample, is added a solid phase material having an immobilized ouabain triacetate derivative compound capable of binding any excess labeled antibody. The solid phase material is chosen to rapidly settle whereby a solid and liquid phase is formed. The liquid phase can then be extracted to measure the amount of digoxin-labeled antibody present therein. Ouabain triacetate derivative compounds possess sufficient affinity for anti-digoxin antibodies, and are therefore useful in a solid phase separation based digoxin immunoassay for settling out such antibodies without contributing to undesired background interference.

Abstract: Novel polyamino acid based coupling agents are disclosed. These reagents are useful for conjugating proteins (e.g. antibodies to enzymes) for use in diagnostic assays.

Abstract: Improvements in apparatus for performing an assay to determine the presence or amount of a substance in a test sample, which apparatus comprises means for dispensing one or more reagents from containment means therefor into a reaction vessel and means for dispensing the sample from a sample container into said vessel for reaction with the reagents during performance of the assay, are disclosed. The improvements reside in the apparatus further comprising containment means for the reagents integral and in combination with the sample container and the reaction vessel.

Abstract: The present invention provides novel fluorescein derivative compounds having fluorescence spectrum and quantum yield characteristics similar to those of fluorescein. The compounds are readily synthesized and purified and are readily soluble in water at self-quenching concentrations. Significantly, due to the presence of polar polyhydroxy group substituents and the absence of metal-chelating groups, these fluorescein derivatives are susceptible to minimal leakage across liposome membranes and have fluorescence characteristics minimally sensitive to the presence of metal ions. Compounds of the invention are thus exceptionally suitable for use in the development of highly storage stable liposome preparations to be employed in immunolytic assays involving human body fluid samples.

Abstract: This disclosure relates to a fluorescence polarization immunoassay method for determining C-reactive protein in liquids, especially in biological fluids such as serum, plasma, spinal fluid, amnionic fluid and urine. This disclosure also relates to novel reagents useful in such fluorescence polarization immunoassays.

Abstract: Compounds of the formula: ##STR1## where R.sub.1 is amino or methyl; R.sub.2 is C.sub.1 -C.sub.2 alkyl; R.sub.3 is one or more substituents selected from hydrogen, halogen or trihalomethyl; R.sub.4 is one or more substituents selected from hydrogen, halogen, trihalomethyl, C.sub.1 to C.sub.4 alkoxy or C.sub.1 to C.sub.4 alkyl; and M is hydrogen, a pharmaceutically acceptable cation, aroyl, or C.sub.1 to C.sub.6 alkoyl are inhibitors of 5- and/or 12-lipoxygenase enzymes.

Abstract: The present invention provides novel methods for generating aqueous liquid encapsulating multi-lamellar lipid vesicles (liposomes) wherein one or more lipids, or lipid conjugates, and an aqueous liquid to be encapsulated, are agitated in a vessel in the presence of spherical contact masses having a mean diameter of less than 3,000 microns, the preferred size range being 50-100 microns in diameter, and resulting in a substantially homogeneous population of vesicles having diameters in the range of about 150 to about 3,000 nanometers. The methods allow for the use of small quantities of marker and lipid, leave no residual solvents, allow for contact only with glass surfaces, and involve no transfer of liposome preparations from lipid film drying vessels to sizing apparatus.