Abstract: This invention relates to novel isoxazolo-pyrido-benzoxazine and isothiazolo-pyrido-benzoxazine derivatives having antibacterial properties.

Abstract: An optical module couples a fiberoptic catheter to a catheter oximeter processing apparatus. The module includes a plurality of LED's for coupling the electrical control signals from the processor and converting them to light signals to transmit to the catheter. The module also includes the means to convert the received reflected light signals from the catheter to electrical signals to be transmitted to the processor. The module further includes a memory to store calibration signals and other data so that the module and catheter can be disconnected from the processor and used with a different processor without necessitating a recalibration.

Abstract: A calibrating device for an optical catheter is provided in order to calibrate the catheter for use in a catheter oximeter system. The calibrating device includes a tube having a reference block therein which is spring-loaded into compliant engagement with the distal end of the catheter carrying the fiberoptic light transmitting and receiving guides. A releasable strap tightly secures the catheter to the calibrating device. The packaged catheter is therefore ready for calibration by simply removing the proximal end thereof from a sealed package while the calibrating device and major length of the catheter remain in their sealed and sterilized condition and connecting it to a processor for performing the calibration operation.

Abstract: A surgical instrument includes a handle and a disposable assembly which can be readily replaced after each operation or as necessary. The disposable assembly includes both an electrically heated scalpel blade and an electrosurgical active electrode which are mounted in a spaced parallel arrangement so that they can be used alternately by rotating the instrument by 180 degrees. The mounted ends of both the blade and the electrode are adapted to be received by separate terminals in the instrument handle so that the appropriate external power sources can be selectively connected thereto.

Abstract: A fluid infusion pump driver device for pumping fluid from the chamber of a disposable cassette. The pump driver includes a reciprocatable plunger which is driven by a stepping motor. The motor and plunger are coupled through a universal joint which provides a threaded connection translating the incremental angular movements of the motor into incremental linear movements of the plunger, and the plunger is coupled directly to the frame through a flexible leaf spring to prevent wear in the threaded connection from generating undue noise or creating accuracy problems.

Abstract: Compounds of the formula ##STR1## where R.sub.1 is a trinuclear aromatic or biaryl group; R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl or cycloalkyl; n is 0 or 1; and M is a pharmaceutically acceptable cation, are potent inhibitors of the enzymes 5-, 12-, and 15-lipoxygenase.

Abstract: The cutting instrument of this invention is made by threading a heater assembly through a hollow cutting instrument body. A blade having a shank and a blade body including a cutting edge is secured within the hollow cutting instrument body at its shank portion such that the blade body extends from the hollow cutting instrument body. The heating assembly is secured to the blade body and to the cutting instrument body. The blade body is coated with a non-stick means.

Abstract: A catheter oximeter includes a fiber optic catheter for supplying radiation to blood under test at a plurality of wavelengths and detecting the intensities of the radiation back-scattered from the blood at each of the wavelengths. The oxygen saturation level of the blood is then computed by deriving it with a formula which uses the ratio of one pair of intensity signals when the oxygen saturation level is relatively low and with a formula which uses the ratio of another pair of intensity signals when the oxygen saturation level relatively is high.

Abstract: A stoppered vial containing a medicament to be mixed with a diluent is enclosed within a flexible I.V. fluid container. Mixing of the medicament in the stoppered vial with a diluent also contained within the flexible I.V. fluid container is accomplished by first, unstoppering the vial by manipulation of the flexible sides of the container; then second, causing the fluid to intermix with the medicament in the vial by compressing that portion of the flexible container holding the diluent.

Abstract: Compounds of the formula ##STR1## where X is selected from hydrogen, C.sub.1 to C.sub.22 alkyl or alkenyl, or an electron withdrawing group;n=0 or 1 and m=0, 1, 2 or 3; but n and m are not O simultaneously;R.sub.1 and R.sub.2 independently are hydrogen, C.sub.1 to C.sub.6 alkyl, an electron withdrawing group, or R.sub.4 ;R.sub.3 is H, C.sub.1 to C.sub.6 alkyl or cycloalkyl, or R.sub.4 ; andR.sub.4 independently at each occurrence, has the formula ##STR2## where Y is hydrogen or an electron withdrawing group; and wherein M is a pharmaceutically acceptable cation, are potent inhibitors of lipoxygenase enzymes.

Abstract: A container mixing system wherein a medicament is placed in a container mounted externally of a container with a diluent. Mixing of the medicament in one container with the diluent in the other is accomplished by attaching an additive assembly with a piercing element to an additive port of the diluent container to pierce a diaphragm in the additive port and a diaphragm or stopper in the additive container. In one embodiment, the additive assembly includes a bellows portion which will permit movement of the piercing element through the additive assembly stopper and the port diaphragm while maintaining a sterile medicament in a glass vial.

Abstract: Quino-benoxazine compounds having the formula: ##STR1## wherein R.sub.2 is one or more substituents, R.sub.1 is a hydrogen or a carboxy-protecting group and Z is an amine group or an aliphatic heterocyclic group. The compounds have antibacterial activity.

Abstract: A container mixing system wherein a medicament is placed in a container mounted externally of a container with a diluent. Mixing of the medicament in one container with the diluent in the other is accomplished by moving a piston member with a piercing element in the direction of the diluent container to pierce a diaphragm or stopper in the medicament container. In one embodiment, the medicament container is sealed by means of a flange to the diluent container wall and the piercing element will pierce a diaphragm and the container wall with the piercing member also serving as an injection site.