Patents Represented by Attorney Roman Saliwanchik

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  • N-Oxide of the O-.beta.-D glucuronides of anticholinergic compounds, and process for preparing the same
    Patent number: 4476300
    Abstract: The subject invention concerns a novel process for preparing novel N-oxide compounds of O-.beta.-D-glucuronides of an anticholinergic compound containing a tertiary nitrogen. Examples of suitable glucuronide starting materials are O-.beta.-D-glucuronides of tropicamide, scopolamine, atropine, hyoscyamine, and the like. The novel process gives high yields of the desired N-oxides which are useful as UV filters.
    Type: Grant
    Filed: August 4, 1983
    Date of Patent: October 9, 1984
    Assignee: Repligen Corporation
    Inventors: Walter C. Herlihy, David M. Epstein
  • Antibiotic producing streptomyces
    Patent number: 4473649
    Abstract: Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: September 2, 1982
    Date of Patent: September 25, 1984
    Assignee: The Upjohn Company
    Inventors: Lester A. Dolak, Fritz Reusser, Thomas M. Castle, Betty R. Hannon, Alice L. Laborde, Charles K. Marschke
  • Glucuronides of ester-containing anti-cholinergics
    Patent number: 4471111
    Abstract: An in vitro enzymatic process which efficiently converts ester-containing anticholinergics having a primary alcohol to their corresponding novel O-glucuronic acid derivatives. These novel glucuronides are useful as antiperspirants.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: September 11, 1984
    Assignee: Repligen Corporation
    Inventor: Walter C. Herlihy
  • Process of producing lincomycin nucleotides
    Patent number: 4464466
    Abstract: Novel and useful ribonucleotides of analogs of the well known antibiotics lincomycin and clindamycin. These ribonucleotides are unexpectedly highly active against Streptococcus hemolyticus and Staphylococcus aureus in vivo.
    Type: Grant
    Filed: February 18, 1983
    Date of Patent: August 7, 1984
    Assignee: The Upjohn Company
    Inventors: Alexander D. Argoudelis, David W. Stroman
  • Biologically pure culture of Streptomyces microspinus NRRL 12524 capable of producing antibiotic U-64,815
    Patent number: 4454228
    Abstract: Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus, antibiotic U-64,815 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: June 12, 1984
    Assignee: The Upjohn Company
    Inventors: Howard A. Whaley, William C. Snyder, John C. Greenfield, John H. Coats
  • Nargenicin derivatives
    Patent number: 4448970
    Abstract: Novel antibacterially-active analogs of the antibiotics nodusmicin and nargenicin A.sub.1. These compounds are prepared by selectively blocking active hydroxyl groups at the 9, 11 and 18 positions of nodusmicin, and the 11 and 18 positions of nargenicin A.sub.1. Antibacterially-active compounds can be used in various environments to control or eradicate susceptible bacteria. The techniques for such use are well known in the art.
    Type: Grant
    Filed: May 4, 1981
    Date of Patent: May 15, 1984
    Assignee: The Upjohn Company
    Inventor: Barney J. Magerlein
  • Process for preparing bovine growth hormone
    Patent number: 4443539
    Abstract: A process for expression of the gene for bovine growth hormone in the yeast Saccharomyces cerevisiae. Bovine growth hormone can be used to increase milk production in cows.
    Type: Grant
    Filed: June 8, 1981
    Date of Patent: April 17, 1984
    Assignee: The Upjohn Company
    Inventors: Thomas H. Fraser, Barbara J. Bruce
  • (+),(-)-Tropicamide O-.beta.-B-glucuronic acid, its diastereomers, and salts thereof
    Patent number: 4443608
    Abstract: An in vitro enzymatic process which efficiently converts (+,-)-tropicamide to essentially pure (+), (-)-tropicamide O-.beta.-D-glucuronide. This product is then separated, advantageously, into the novel compounds (+)-tropicamide O-.beta.-D-glucuronide and (-)-tropicamide O-.beta.-D-glucuronide. The products disclosed herein absorb ultraviolet light, and, thus, can be incorporated into suitable plastic films which are then useful for screening out harmful ultraviolet radiation for the protection of packaged goods. Also the products can be used to protect the skin against burning by sunlight.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: April 17, 1984
    Assignee: Repligen Corporation
    Inventors: Walter C. Herlihy, Thomas H. Fraser
  • 24-Nor-1,4-choladiene-3,22-dione
    Patent number: 4431591
    Abstract: The subject invention concerns a novel fermentation process for making the useful steroid intermediate 24-nor-1,4-choladiene-3,22-dione (I). Compound (I) can be converted to valuable corticoids by known methods.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: February 14, 1984
    Inventors: John C. Knight, Merle G. Wovcha
  • 6-Methoxy indoline acetate and its 5-nitro and 5-amino derivatives
    Patent number: 4431820
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.Claimed compounds include those of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as defined hereinafter.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: February 14, 1984
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Process for preparing lincomycin and clindamycin ribonucleotides
    Patent number: 4430495
    Abstract: Novel and useful ribonucleotides of analogs of the well known antibiotics lincomycin and clindamycin. These ribonucleotides are unexpectedly highly active against Streptococcus hemolyticus and Staphylococcus aureus in vivo. These ribonucleotides are prepared by using resting cell or cell-free extracts of Streptomyces rochei, NRRL 3533, or cell-free extracts of Streptomyces coelicolor, NRRL 3532.
    Type: Grant
    Filed: September 17, 1982
    Date of Patent: February 7, 1984
    Assignee: The Upjohn Company
    Inventors: Tom E. Patt, Alexander D. Argoudelis, Vincent P. Marshall
  • Composition of matter and process
    Patent number: 4430428
    Abstract: A process for expression of a gene, foreign to the host organism, coding for a protein in a suitable vehicle which comprises taking said gene and fusing it in the correct orientation relative to a transcriptional initiation region present in said vehicle, and inserting said vehicle into a eukaryotic host. Via the subject process, the gene for chicken ovalbumin is expressed in the yeast Saccharomyces cerevisiae. Chicken ovalbumin can be used in the food, i.e., baking, industry and also as a protein supplement for animals.
    Type: Grant
    Filed: December 7, 1981
    Date of Patent: February 7, 1984
    Assignee: The Upjohn Company
    Inventors: Thomas H. Fraser, Barbara J. Bruce
  • Process of producing 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid
    Patent number: 4429041
    Abstract: The subject invention concerns a novel one-stage fermentation process for making the useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxylic acid (I). This process is significantly superior to the best prior art process known for making (I).
    Type: Grant
    Filed: May 11, 1981
    Date of Patent: January 31, 1984
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, John C. Knight, Alfred B. Garcia
  • Composition of matter and process
    Patent number: 4427776
    Abstract: Novel antibiotic U-64,815 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces microspinus, NRRL 12524. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus. It is also active against Haemophilus influenzae. Thus, antibiotic U-64,815 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: January 24, 1984
    Assignee: The Upjohn Company
    Inventors: Howard A. Whaley, William C. Snyder, John C. Greenfield, John H. Coats
  • Composition of matter and process
    Patent number: 4425429
    Abstract: The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids.
    Type: Grant
    Filed: July 24, 1981
    Date of Patent: January 10, 1984
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha
  • 1,2,8,8a-Cyclopropa?c!benzo?1,2,-b:-4,3-b'!dipyrrol-4(5H)-ones
    Patent number: 4424365
    Abstract: Novel antibacterially active compound, 1,2,8,8a-cyclopropa?c!benzo?1,2-b:-4,3-b'!dipyrrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: January 3, 1984
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Composition of matter and process
    Patent number: 4423229
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[ c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Composition of matter and process
    Patent number: 4423146
    Abstract: The subject invention concerns a novel fermentation process for making the useful steroid intermediate 24-nor-1,4-choladiene-3,22-dione (I). Compound (I) can be converted to valuable corticoids by known methods.
    Type: Grant
    Filed: August 10, 1981
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha
  • Preparation of an intermediate for N-(methylsulfonyl)-1,2,8,8a-cyclopropa[c][1,2-b:-4,3-b']dipyrol-4(5H)-on e
    Patent number: 4423230
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.Included is a process for the preparation of an intermediate compound of the formula ##STR1## wherein R.sub.2, R.sub.3 and R.sub.4 are as defined hereinafter.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Process for preparing N-(methyl-sulfonyl)-1,2,8,8a-cyclopropa[c]benzo[1,2-b:4,3-b']dipyrrol-4( 5H)-one
    Patent number: 4423228
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: December 27, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga