Patents Represented by Attorney Roman Saliwanchik

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  • Cell growth inhibitory substances
    Patent number: 4414205
    Abstract: Potent cell growth inhibitory substances have been obtained from the Indian Ocean sea hare Dolabella. These substances have been given the names dolastatin 1, dolastatin 2, and dolastatin 3. These compounds are characterized by physical and chemical parameters. Their utility as antiviral agents is supported by the disclosure of various preparations for such use.
    Type: Grant
    Filed: August 28, 1981
    Date of Patent: November 8, 1983
    Assignee: University Patents, Inc.
    Inventor: George R. Pettit
  • Antibiotic CC-1065 indoline intermediates
    Patent number: 4413132
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: November 1, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Composition of matter and process
    Patent number: 4405525
    Abstract: The subject invention concerns a novel fermentation process for making the novel useful steroid intermediate 9-hydroxy-3-oxo-4,17(20)-pregnadiene-20-carboxyaldehyde (I). This compound can be used as in the synthesis of valuable corticoids.
    Type: Grant
    Filed: August 31, 1982
    Date of Patent: September 20, 1983
    Assignee: The Upjohn Company
    Inventors: John C. Knight, Merle G. Wovcha
  • Composition of matter and process
    Patent number: 4404190
    Abstract: Novel antibiotic U-64,864 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces braegensis Dietz sp.n., NRRL 12567. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae. Thus, antibiotic U-64,864 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: January 22, 1982
    Date of Patent: September 13, 1983
    Assignee: The Upjohn Company
    Inventors: Lester A. Dolak, Fritz Reusser, Thomas M. Castle, Betty R. Hannon, Alice L. Laborde, Charles K. Marschke
  • Process for stabilizing plasmids by deletion of DNA
    Patent number: 4401761
    Abstract: Novel chemical compounds, recombinant plasmids pUC1026 and pUC1027, which are obtained by covalent linkage of the E. coli plasmid pBR322 to the Streptomyces espinosus plasmid pUC6. These plasmids are produced by a novel process which can be used to stabilize unstable potential plasmid vectors. These plasmids are useful as cloning vehicles in recombinant DNA work. For example, using DNA methodology, a desired gene, for example, the insulin gene, can be inserted into the plasmids and the resulting plasmids can then be transformed into a suitable host microbe which, upon culturing, produces the desired insulin. The stabilization process disclosed herein can be used to make other stable plasmids.
    Type: Grant
    Filed: February 25, 1982
    Date of Patent: August 30, 1983
    Assignee: The Upjohn Company
    Inventors: Jack J. Manis, Sarah K. Highlander
  • Composition of matter and process
    Patent number: 4400518
    Abstract: Novel antibacterially-active compound, 1,2,8,8a-cyclopropa[c]-benzo[1,2-b:-4,3-b']dipyrol-4(5H)one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example, B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.
    Type: Grant
    Filed: February 8, 1982
    Date of Patent: August 23, 1983
    Assignee: The Upjohn Company
    Inventor: Wendell Wierenga
  • Lincomycin 3-(5'-adenylate) as anesthetic
    Patent number: 4397845
    Abstract: The 3-(5'-adenylate) of lincomycin- and clindamycin-type compounds in which the propyl hygric acid moiety has been replaced by different cyclic amino acids can be used as a local anesthetic in humans and animals.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: August 9, 1983
    Assignee: The Upjohn Company
    Inventor: Harry R. Allen
  • Process for production of antibiotic U-64,767 using Streptomyces macronensis NRRL 12566
    Patent number: 4397950
    Abstract: Novel antibiotic U-64,767 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Streptomyces macronensis Dietz sp.n., NRRL 12566. This antibiotic is active against various Gram-positive bacteria, for example, Staphylococcus aureus and Streptococcus pyogenes. It is also active against the Gram-negative bacterium Streptococcus pneumoniae. Thus, antibiotic U-64,767 can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: August 9, 1983
    Assignee: The Upjohn Company
    Inventors: Lester A. Dolak, Fritz Reusser, Thomas M. Castle, Betty R. Hannon, Alice L. Laborde, Charles K. Marschke
  • Cloning plasmid for streptomyces
    Patent number: 4393137
    Abstract: Novel chemical compound plasmid pUC1061 obtained by deletion of .about.2.0 kilobases of DNA from the Streptomyces espinosus plasmid pUC6. This plasmid is useful as a cloning vehicle in recombinant DNA work. For example, using DNA methodology, a desired gene, for example, the glucose isomerase gene, can be inserted into the plasmid and the resulting plasmid can then be transformed into a suitable host microbe which, upon culturing, produces the desired glucose isomerase.
    Type: Grant
    Filed: June 22, 1981
    Date of Patent: July 12, 1983
    Assignee: The Upjohn Company
    Inventors: Jack J. Manis, Sarah K. Highlander
  • Method of treating cardiac arrhythmia
    Patent number: 4393054
    Abstract: The 3-(5'-adenylate) of lincomycin- and clindamycin-type compounds in which the propyl hygric acid moiety has been replaced by different cyclic amino acids can be used to treat cardiac arrhythmia in humans and animals.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: July 12, 1983
    Assignee: The Upjohn Company
    Inventor: Harry R. Allen
  • Phyllanthostatin compounds
    Patent number: 4388457
    Abstract: New antineoplastic glycosides, phyllanthostatin 1, 2 and 3, and the related glycoside, phyllanthoside, have been isolated from the Central American tree, Phyllanthus acuminatus Vahl. These compounds exhibit activity against the National Cancer Institute's P388 lymphocytic leukemia. Also, phyllanthoside was found to possess a curative level of activity against the murine B16 malanoma.
    Type: Grant
    Filed: February 11, 1982
    Date of Patent: June 14, 1983
    Assignee: University Patents, Inc.
    Inventor: George R. Pettit
  • Lincomycin nucleotides
    Patent number: 4383109
    Abstract: Novel and useful ribonucleotides of analogs of the well known antibiotics lincomycin and clindamycin. These ribonucleotides are unexpectedly highly active against Streptococcus hemolyticus and Staphylococcus aureus in vivo.
    Type: Grant
    Filed: April 20, 1981
    Date of Patent: May 10, 1983
    Assignee: The Upjohn Company
    Inventors: Alexander D. Argoudelis, David W. Stroman
  • Process for treating malaria
    Patent number: 4368193
    Abstract: A process for treating a protozoan disease, for example, malaria, by the systemic administration to a subject hosting a malarial parasite of the 3-(5'-ribonucleotide) of a novel analog of the well-known antibiotics lincomycin and clindamycin. The analogs are prepared by condensing a cyclic acid with a sugar amine. The 3-ribonucleotides of these analogs can be prepared by microbiological transformation procedures.
    Type: Grant
    Filed: April 20, 1981
    Date of Patent: January 11, 1983
    Assignee: The Upjohn Company
    Inventors: Alexander D. Argoudelis, David W. Stroman
  • Esters of antibiotic nodusmicin
    Patent number: 4363922
    Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.
    Type: Grant
    Filed: June 15, 1981
    Date of Patent: December 14, 1982
    Assignee: The Upjohn Company
    Inventors: Barney J. Magerlein, Howard A. Whaley
  • Hybrid plasmid and process of making same
    Patent number: 4362817
    Abstract: A novel chemical compound, plasmid pUC1060, which was constructed from Streptomyces sp. 3022a chromosomal DNA and plasmid pBR322. Hybrid plasmid pUC1060 contains a functional tet gene promoter composed of streptomycete and E. coli DNA, and, thus, is useful as a cloning vehicle in recombinant DNA work. For example, using well known DNA methodology, a desired gene, for example, the insulin gene, can be inserted into pUC1060 and the resulting plasmid can then be transformed into a suitable host microbe which, upon culturing, produces the desired insulin.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: December 7, 1982
    Assignee: The Upjohn Company
    Inventor: Fritz Reusser
  • Hybrid plasmid and process of making same
    Patent number: 4362816
    Abstract: A novel chemical compound, plasmid pUC1031, which was constructed from Streptomyces sp. 3022a chromosomal DNA and plasmid pBR322. Hybrid plasmid pUC1031 contains a functional tet gene promoter composed of streptomycete and E. coli DNA, and, thus, is useful as a cloning vehicle in recombinant DNA work. For example, using well known DNA methodology, a desired gene, for example, the insulin gene, can be inserted into pUC1031 and the resulting plasmid can then be transformed into a suitable host microbe which, upon culturing, produces the desired insulin.
    Type: Grant
    Filed: November 13, 1980
    Date of Patent: December 7, 1982
    Assignee: The Upjohn Company
    Inventor: Fritz Reusser
  • Antibiotic nodusmicin derivatives
    Patent number: 4360683
    Abstract: Novel antibacterially-active esters of antibiotic nodusmicin. Activity is demonstrated against Staphylococcus aureus, Streptococcus pyogenes, and Sarcina lutea. Thus, these esters can be used in various known environments, using well-known procedures, to eradicate or control susceptible microbes.
    Type: Grant
    Filed: August 6, 1980
    Date of Patent: November 23, 1982
    Assignee: The Upjohn Company
    Inventors: Barney J. Magerlein, Howard A. Whaley
  • Mycobacterium fortuitum mutant
    Patent number: 4358538
    Abstract: Mutant which is used in a novel microbiological process to selectively transform steroids having 17-alkyl side chains of from 2 to 10 carbon atoms, inclusive, to yield sole transformed product. AD is a valuable intermediate to make useful steroids.
    Type: Grant
    Filed: September 8, 1980
    Date of Patent: November 9, 1982
    Assignee: The Upjohn Company
    Inventors: Merle G. Wovcha, Kevin E. Brooks
  • Process for preparing glyceraldehyde from glycerol with methanol dehydrogenase
    Patent number: 4353987
    Abstract: Novel processes for preparing the useful chemical glyceraldehyde. This compound can be prepared by contacting glycerol with the enzyme methanol dehydrogenase. The enzyme can be in the pure form or crude form. Glycerol also can be converted to glyceraldehyde by contacting it with a methanol dehydrogenase-producing bacterium.
    Type: Grant
    Filed: June 11, 1981
    Date of Patent: October 12, 1982
    Assignee: The Upjohn Company
    Inventor: Holly J. Wolf
  • Antibiotic composition of matter
    Patent number: 4351769
    Abstract: Novel antibiotic U-61,732 producible in a fermentation under controlled conditions using a biologically pure culture of the microorganism Saccharopolyspora hirsuta strain 367, NRRL 12045. This antibiotic is active against gram-positive bacteria, for example, Staphylococcus aureus. Also disclosed are the 11-acyl esters of U-61,732. Thus, these compounds can be used in various environments to eradicate or control such bacteria.
    Type: Grant
    Filed: August 25, 1980
    Date of Patent: September 28, 1982
    Assignee: The Upjohn Company
    Inventors: Howard A. Whaley, John H. Coats