Patents Represented by Attorney Rudolph J. Anderson, Jr.
  • Patent number: 4439194
    Abstract: A drug delivery system designed to deliver water and drug to the site of administration is composed of a core of an aqueous solubulizing system in a wax housing, which melts at body temperature, surrounded by a matrix of drug and water-dispersible excipients. The entire unit may also be coated with a semi-permeable membrane to modulate drug release.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: March 27, 1984
    Assignee: Merck & Co., Inc.
    Inventors: Richard J. Harwood, Joseph V. Bondi
  • Patent number: 4396616
    Abstract: Substituted enantholactam dipeptides and derivatives thereof are disclosed which are useful as converting enzyme inhibitors and as antihypertensives.
    Type: Grant
    Filed: September 4, 1981
    Date of Patent: August 2, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Elbert E. Harris, David Taub, Eugene D. Thorsett
  • Patent number: 4366096
    Abstract: Non-flammable reactive particle compositions useful in forming shaped articles prepared from flammable cellulosic materials and a type of urea/formaldehyde resin. Processes for their preparation and a method of rendering flammable reactive particles substantially inflammable.
    Type: Grant
    Filed: August 14, 1978
    Date of Patent: December 28, 1982
    Inventors: Carl C. Abrams, deceased, Bernice Abrams, administratrix, James R. Jones
  • Patent number: 4358455
    Abstract: Heterocyclic aminoethanols of the formulaHet--CHOH--CH.sub.2 --NH--aralkylwhere het is a 6-10 membered N heterocycle are disclosed. The compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: December 23, 1980
    Date of Patent: November 9, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Joseph G. Atkinson, John J. Baldwin, David E. McClure
  • Patent number: 4294969
    Abstract: Novel substituted (3-loweralkylamino-2-R.sub.1 O-propoxy)pyridines, their pharmaceutically acceptable salts, certain intermediates and their preparation are disclosed. These pyridines have pharmaceutically useful properties such as .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: July 11, 1980
    Date of Patent: October 13, 1981
    Assignee: Merck & Co., Inc.
    Inventors: John J. Baldwin, Gerald S. Ponticello
  • Patent number: 4237160
    Abstract: Novel 3-hydroxymethyldibenzo[b,f]thiepin and derivatives are prepared and employed in the treatment and control of allergic conditions such as allergic asthma.
    Type: Grant
    Filed: November 27, 1979
    Date of Patent: December 2, 1980
    Assignee: Merck Sharp & Dohme (I.A.) Corp.
    Inventors: Pierre A. Hamel, Joshua Rokach
  • Patent number: 4233457
    Abstract: This invention relates to an improved process for preparing 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)-3-indenyl acetic acid.
    Type: Grant
    Filed: May 17, 1979
    Date of Patent: November 11, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Robert F. Czaja, Edward J. J. Grabowski
  • Patent number: 4230105
    Abstract: An improved method for the topical administration of systemically or locally active drugs utilizes a bandage containing one or more layers including a drug useful in the treatment of disease and a heat-generating substance, each dispersed intimately throughout said bandage layers.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: October 28, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Richard J. Harwood
  • Patent number: 4225609
    Abstract: This invention relates to novel interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof. These compounds are exceptionally potent renal vasodilators and antihypertensives which are active when administered orally but which have a more specific type of biological activity than that of many of the natural prostaglandins and their synthetic analogs or derivatives.
    Type: Grant
    Filed: August 30, 1978
    Date of Patent: September 30, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Ta-jyh Lee, John B. Bicking
  • Patent number: 4223788
    Abstract: A rigid blister package includes a rigid thermoformed plastic cover piece and a flexible backing sheet, a score line for opening said package, and a slide fastener for reclosing the blister package, along with stops to hold the slide fastener in the open or closed position.
    Type: Grant
    Filed: November 16, 1978
    Date of Patent: September 23, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Arthur Jaeger, Richard Gunderlock, Richard J. Harwood
  • Patent number: 4217429
    Abstract: Novel polymers having a linear backbone which is free from both branching and cross-linking, comprising quaternized nitrogen atoms linked to each other through trimethylene groups. By the term "linear backbone" is meant that the polymer has only acyclic groups, i.e. trimethylene, linking the nitrogen atoms in a single continuous chain; the polymer is free from "branching" when it has no repeating monomer units extending from the polymer backbone; and it is free from "cross-linking" when there is no joining of two linear backbones. These polymers are useful as antimicrobials, flocculating agents, antistatic agents, electroconductive agents for coating paper, chelating agents and bile acid binding agents, as well as in similar applications where their high charge to weight ratio and fully accessible nitrogen atoms can be employed. The polymers are obtained by the polymerization of dihydro-oxazine, reductive alkylation of the resulting polymer, followed by quaternization.
    Type: Grant
    Filed: April 11, 1979
    Date of Patent: August 12, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Arthur F. Wagner, Nathaniel Grier, Tsung-Ying Shen
  • Patent number: 4207323
    Abstract: Disclosed are antibiotic 6-(substituted methyl) penicillins, derivatives and nuclear analogues thereof; wherein the methyl substituent is, inter alia, hydroxyl, ketonic oxygen, imino nitrogen, amino or thio. Also disclosed are processes for the preparation of such compounds and their pharmaceutically acceptable salt, ester and amide derivatives; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: May 1, 1978
    Date of Patent: June 10, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Beattie, Frank P. Dininno, Burton G. Christensen
  • Patent number: 4201771
    Abstract: The antibiotic A43F is active against a variety of plant pathogenic fungi. The antibiotic A43F is produced by growing an as yet unclassified species of fungus (ATCC No. 20529) on suitable fermentation media and isolating the bioactive component therefrom.
    Type: Grant
    Filed: March 12, 1979
    Date of Patent: May 6, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Janet C. Onishi, Gerald L. Rowin, John E. Miller, Jr.
  • Patent number: 4196211
    Abstract: Disclosed are 6-(.alpha.-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and its 2,3-dihydro analogue, 6-(.alpha.-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]heptane-2-carboxylic acid. Such compounds and their pharmaceutically acceptable salt, ester, ether and aide derivatives (derivatives involving both the secondary alcohol and the carboxyl group) are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: May 8, 1978
    Date of Patent: April 1, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Burton G. Christensen, David H. Shih
  • Patent number: 4194424
    Abstract: This invention relates to an apparatus for slicing cylindrically shaped columns of gels. More particularly, it relates to an apparatus for firmly holding cylindrical columns of acrylamide gel while making a longitudinal slice through the entire length of the column.
    Type: Grant
    Filed: November 13, 1978
    Date of Patent: March 25, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward C. O'Rourke, W. Wardle Fullerton
  • Patent number: 4187284
    Abstract: This invention relates to a novel diagnostic kit for use in radiographic bone scanning. More particularly, it relates to a kit comprising ingredients employed in the preparation of an intravenous injection of a complex of Technetium-99m, stannous ion, and an organic phosphonate identified as triethylene tetramine hexa (methylene phosphonic acid).
    Type: Grant
    Filed: October 3, 1977
    Date of Patent: February 5, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Richard E. Rolleston, Jacques A. Nadeau
  • Patent number: 4185088
    Abstract: The invention disclosed herein relates to novel non-adhesive, free-flowing, pharmacologically acceptable compositions comprising ionene quaternary polymers effective as bile acid sequestrants, such as poly-[{methyl-(3-trimethylammoniopropyl)iminio}trimethylene dichloride], adsorbed on a pulverulent, solid aggregate of large surface to mass ratio, such as fumed silicas and silica aerogels. It also relates to the novel process for preparing such adsorbate compositions which comprises forming a substantially, uniform suspension of the finely-divided solid aggregate in an aqueous solution of poly-[{methyl-(3-trimethylammoniopropyl)iminio}trimethylene dichloride], evaporatively removing the water from the suspension, and drying the adsorbate thus produced.
    Type: Grant
    Filed: October 19, 1978
    Date of Patent: January 22, 1980
    Assignee: Merck & Co., Inc.
    Inventor: Arthur F. Wagner
  • Patent number: 4175203
    Abstract: Novel interphenylene derivatives of 11,12-secoprostaglandins are prepared by the stepwise alkylation of the ethyl ester or the t-butyl ester of acetoacetic acid. One such method involves treatment of the t-butyl ester of acetoacetic acid with a strong base to form the anion followed by treatment with ethyl p-(3-bromopropyl)benzoate to produce ethyl 4-(4-tert-butoxycarbonyl-5-oxo-hexyl)benzoate, subsequently reacting the anion of the thus-formed benzoate with 1-chloro-4-acetoxynonane to produce ethyl 4-(4-acetyl-4-tert-butoxycarbonyl-8-acetoxytridecyl)benzoate followed by decarboxylation and alkaline hydrolysis to produce the desired product 4-(4-acetyl-8-hydroxytridecyl)benzoic acid which is useful as a pharmaceutical in the treatment of patients with renal failure and in the prevention of transplant rejection.
    Type: Grant
    Filed: December 13, 1978
    Date of Patent: November 20, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking
  • Patent number: 4155908
    Abstract: This invention relates to 9-thia- , 9-oxothia, and 9-dioxothia-11,12-seco-prostaglandins and processes for their manufacture. These compounds have prostaglandin-like biological activity and are particularly useful for the treatment of skin diseases such as psoriasis, for the prevention of thrombus formation, in stimulating the production of growth hormone in intact animals, and as regulators of the immune response.
    Type: Grant
    Filed: October 25, 1977
    Date of Patent: May 22, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking, Robert L. Smith
  • Patent number: 4150235
    Abstract: Novel interphenylene derivatives of 11,12-secoprostaglandins are prepared by the stepwise alkylation of the ethyl ester or the t-butyl ester of acetoacetic acid. One such method involves treatment of the t-butyl ester of acetoacetic acid with a strong base to form the anion followed by treatment with ethyl p-(3-bromopropyl)benzoate to produce ethyl 4-(4-tert-butoxycarbonyl-5-oxo-hexyl)benzoate, subsequently reacting the anion of the thus-formed benzoate with 1-chloro-4-acetoxynonane to produce ethyl 4-(4-acetyl-4-tert-butoxycarbonyl-8-acetoxytridecyl)benzoate followed by decarboxylation and alkaline hydrolysis to produce the desired product 4-(4-acetyl-8-hydroxytridecyl)benzoic acid which is useful as pharmaceutical in the treatment of patients with renal failure and in the prevention of transplant rejection.
    Type: Grant
    Filed: December 17, 1976
    Date of Patent: April 17, 1979
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., John B. Bicking