Abstract: A method of replenishing plasmalogens in mammals comprising treatment with a plasmalogen-replenishing-effective amount of one or more stantially pure monoethers of glycerols and their carboxylic acid ester derivatives of Formula I:
wherein R is a C12-C22 linear or branched alkyl or alkenyl group; and R1 and R2 are, each independently, hydrogen or an acyl moiety {—C(═O)—R3} wherein R3 is a linear or branched C1-C30 alkyl or alkenyl; and pharmaceutically-acceptable salts thereof, is disclosed. Nutritional supplements, dietary supplements and food additives comprising one or more substantially pure compounds of Formula I is also disclosed.
Abstract: Novel piperidinyl intermediates as set forth below wherein R, R.sup.1 and Ar are as set forth in the specification and W is either hydrogen or benzyloxycarbonyl. The intermediates are useful in the preparation of N-phenyl-N-(4-piperidinyl) amides having potent analgesic activity.
Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X, Ar, R and R.sup.1 are defined, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X, Ar, R and R.sup.1 are defined, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
Abstract: A method of preparing certain substituted alkali metal 4-carboxy-piperidine salts (I) by alkaline hydrolysis of certain novel substituted 1,3,8-triazaspiro[4.5]decane-2, 4-diones (IV) which in turn are obtained from certain novel substituted chlorosulphonylamido piperidines (III).
Abstract: A method of preparing certain substituted alkali metal 4-carboxy-piperidine salts (I) by alkaline hydrolysis of certain novel substituted 1,3,8-triazaspiro[4.5]decane-2, 4-diones (IV) which in turn are obtained from certain novel substituted chlorosulphonylamido piperidines (III).
Abstract: N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X is a member selected from the group consisting of alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C.sub.1-2)alkoxy-(C.sub.1-2)-alkoxy-carbonyl-lower alkyl, and Ar, R, R.sup.1 and R.sup.2 are defined hereinafter, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
Type:
Grant
Filed:
December 11, 1989
Date of Patent:
May 28, 1991
Assignee:
Glaxo Inc.
Inventors:
Paul L. Feldman, Michael K. James, Marcus F. Brackeen, Michael R. Johnson, Harry J. Leighton
Abstract: A pressurized aerosol composition containing zeolite, surfactant, water and propellant in prescribed amounts and ratios which, upon discharge from an aerosol container, produces a characteristically dry foam.
Abstract: Method and pharmaceutical composition for topically treating skin inflammatory disorders by administering to the inflamed area a therapeutically effective amount of candelilla wax or a saturated hydrocarbon fraction from candelilla wax comprising a mixture of saturated straight chain C.sub.29 -C.sub.33 hydrocarbons, predominantly C.sub.31 hydrocarbon.
Abstract: A stable water-in-oil emulsion composition for topical therapeutic administration comprising:a. a dispersed aqueous phase comprising water optionally containing a pharmaceutically acceptable electrolyte dissolved therein;b. a pharmaceutically acceptable continuous oil phase comprising mineral oil and a volatile silicone fluid;c. an organopolysiloxane emulsifier of Formula (I) hereinafter described;d. PPG-20 Methyl Glucose Ether Distearate; ande. an active drug component for topical application.
Abstract: An improved hair treating or conditioning composition that decreases the friction between hairs thereby facilitating in combing and brushing of hair treated therewith contains a formulation which is a mixture of d-panthenyl ethyl ether and d-panthenol in a weight ratio of about 9 parts d-panthenol ethyl ester to about 1 part d-panthenol. Such hair treating or conditioning compositions also exhibit decreased damaged to hair treated therewith due at least in part to a decrease or reduction in abrasion between hairs.
Abstract: Antidiarrheal compositions showing enhanced antidiarrheal activity comprise a non-steroidal anti-inflammatory drug compound and a polymeric hydroabsorptive agent. A patient in need of remedial or preventive treatment of diarrhea symptoms is administered an antidiarrheally effective amount of said antidiarrheal compositions.
Type:
Grant
Filed:
September 4, 1984
Date of Patent:
May 19, 1987
Assignee:
Richardson-Vicks Inc.
Inventors:
Bhogilal B. Sheth, Sheri A. Gilbert, Jane F. Kinsel
Abstract: A stable aqueous hair conditioning shampoo composition comprising an aqueous solution of hydrogen peroxide, a specific anionic surfactant, at least one nonionic surfactant, an acidic pH-producing agent and one or more hair conditioning components.
Abstract: Preparation being effective against bad breath, particularly caused by strongly smelling food stuffs or cigarettes, alcohol and the like, consisting of cardamom seeds which are individually or jointly coated by a shell mass comprising a sugar mass or the like.
Type:
Grant
Filed:
September 16, 1985
Date of Patent:
December 2, 1986
Assignee:
Richardson-Vicks Inc.
Inventors:
Horst G. P. Wienecke, Karl-Wilhelm Stock
Abstract: Method and pharmaceutical composition for topically treating skin inflammatory disorders by administering to the inflamed area a therapeutically effective amount of a substantially non-polar hydrocarbon fraction from beeswax comprising a mixture of (i) a major proportion of saturated straight chain C.sub.21 -C.sub.33 hydrocarbons and (ii) a minor proportion of mono-unsaturated long chain hydrocarbons.
Abstract: An oil-in-water-in-oil coating composition comprising (a) an oil continuous phase comprising a solution of an oil soluble resin or drying oil or mixtures thereof in a water immiscible solvent, (b) an aqueous discontinuous phase comprising an emulsion with pH of about 4 to 10 of water insoluble resin in an aqueous medium, and (c) an effective dispersing amount of a dispersing agent for dispersing (b) in (a) consisting essentially of hydrated starch or a hydrated starch component.
Abstract: An improved herbicidal formulation comprising a mixture of the isopropylamine salt of glyphosate and an effective potentiating amount of an ammonium, quaternary alkyl ammonium, alkali metal or alkaline earth metal thiocyanate.
Abstract: A stabilized clear benzoyl peroxide composition is provided comprising from about 0.1 to about 3.8% by weight anhydrous benzoyl peroxide in C.sub.6 -C.sub.10 triglycerides.
Abstract: A method of separating and recovering immunoglobulin G from biological fluids by liquid chromatographic or solid phase extraction processes utilizing, as the solid phase, a carboxylated form of silica gel or controlled pore glass bearing non-cross-linked covalently bound polyethylenimine functions.