Abstract: New compounds (3-alkyl-5-hydroxy-3,4-dihydrofuran-2-ones) of the following general structure: ##STR1## wherein R is an alkyl group or a phenylalkyl group with the alkyl moiety containing at least 6 carbon atoms, are disclosed as useful in inhibiting phospholipase A.sub.2.
Type:
Grant
Filed:
August 29, 1991
Date of Patent:
April 13, 1993
Assignee:
Bristol-Myers Squibb Co.
Inventors:
F. Christopher Zusi, Suresh Marathe, William Somerville, Kenneth M. Tramposch
Abstract: The present invention provides for a composition containing a pharmacologically active agent and a selected imidazole or an imidazole derivative, such composition exhibiting enhanced penetration of the pharmacologically active agent component when a composition containing the aforementioned components is applied to skin.A method of enhancing dermal penetration of compositions containing a pharmacologically active agent is also provided.
Type:
Grant
Filed:
May 22, 1989
Date of Patent:
November 17, 1992
Assignee:
Bristol-Myers Squibb Co.
Inventors:
Michael D. Helman, Alison B. Lukacsko, Thomas A. Re, F. Christopher Zusi
Abstract: Stable anhydrous gel formulations for topical antifungal use contain an imidazole, a steroid, a co-solvent system comprising monohydric and dihydric alcohols, and a hydroxyalkylcellulose gellant.
Type:
Grant
Filed:
October 23, 1990
Date of Patent:
May 5, 1992
Assignee:
Bristol-Myers Squibb Company
Inventors:
Jonas Wang, Bhiku Patel, Stacley Au, Hemanshu Shah
Abstract: Topical compositions are described which contain a vehicle which is free of lower alkanols, a pharmacologically active agent whose dermal penetration can be enhanced and a unique penetration control system. The control system contains an imidazole penetration enhancer and either propylene glycol alone or propylene glycol with an isopropyl ester of a fatty acid.
Abstract: This invention relates to an anthralin composition having improved stability. The invention further relates to a method for increasing the stability of anthralin in dermatological compositions by incorporating therein a stability enhancing amount of an acid stable anionic surfactant and a water soluble antioxidant.
Abstract: This invention relates to novel compositions of the antitumor agent [4'-9-(acridinylamino) methanesulfon-m-anisidide], (m-AMSA). Acid salts of m-AMSA are dissolved in 1-methyl-2-pyrrolidinone to provide highly stable solutions. The solutions may be diluted with Sterile Water for Injection, U.S.P. to provide stable, non-precipitating solutions for intravenous use.
Abstract: A composition for coloring skin comprising a carrier containing an alcohol component consisting of an aromatic alcohol, an aliphatic alcohol or mixtures thereof and certain certified acid dyes, said composition having an acid pH equal to or less than 4.
Abstract: An antifungal gel composition, effective at 0.2-2.0% by weight of an imidazole antifungal agent and 0.01-2.5% by weight of a 17-ester corticosteroid antiinflammatory agent, is provided for topical administration. This composition is highly effective in treating fungal infections and is capable of being stored without refrigeration for long periods of time without losing therapeutic effectiveness and while maintaining the uniformity and stability of the gel.
Type:
Grant
Filed:
March 15, 1989
Date of Patent:
March 26, 1991
Assignee:
Bristol-Myers Squibb Company
Inventors:
Jonas Wang, Bhiku Patel, Stacley Au, Hemanshu Shah
Abstract: A novel air freshener composition and a combination product which uses same in an a device which has an emanator are described. The composition employs a combination of reagents which inhibit its evaporation so that the useful life of the air freshener is significantly lengthened.
Type:
Grant
Filed:
April 18, 1989
Date of Patent:
January 8, 1991
Assignee:
The Drackett Company
Inventors:
Donald Cashman, John A. Ferguson, George B. Keyes
Abstract: The present invention relates to a method of imparting a controlled tanning of skin by treating the skin with an aqueous medium containing melanin or a precursor of melanin.
Type:
Grant
Filed:
August 26, 1988
Date of Patent:
November 6, 1990
Assignee:
Clairol Incorporated
Inventors:
Leszek Wolfram, Alexander C. Chan, Thomas M. Schultz, Bryan P. Murphy
Abstract: Aqueous cleaner compositions containing an alkali metal halogenite, for example, sodium chlorite; a perfume normally chemically incompatible with the halogenite in aqueous media, and a stabilizing amount of an anionic surfactant, the inclusion of which enhances the stability of the perfume-containing aqueous halogenite compositions.
Type:
Grant
Filed:
November 1, 1988
Date of Patent:
October 16, 1990
Assignee:
The Drackett Company
Inventors:
Richard S. Hutchings, Saundra L. Nolte, Jeffrey S. Weaver
Abstract: The unpleasant taste of ibuprofen or other bad-tasting pharmaceuticals can be mediated via wet granulation using certain taste masking agents.
Abstract: A composition of matter for depositing reflective particles on hair, said composition comprising solid reflective particles dispersed in a moderately fast-breaking foam, said foam being suitable for application to the hair.
Abstract: A process for coloring hair in which a functional metal ion and aminoalkyl or aminohydroxyalkyl catechols are used in combination or applied sequentially to dye the hair rapidly.
Type:
Grant
Filed:
May 12, 1988
Date of Patent:
February 27, 1990
Assignee:
Clairol Incorporated
Inventors:
Thomas M. Schultz, Leszek J. Wolfram, Keith C. Brown, Giuseppe Prota
Abstract: The neutralization of odors and removal of soil from fibrous surfaces, e.g., carpets, can be carried out using fabric treatment compositions containing certain combinations of metal salts and carriers.
Abstract: Aqueous cleaner compositions containing an alkali metal halogenite, for example, NaClO.sub.2 ; a stabilizable colorant; and a stabilizing amount of a stabilizer compound selected from the group consisting of alkali metal carbonates, borates and mixtures thereof. The preferred embodiment further includes an anionic or anionic fluorocarbon surfactant.