Abstract: A compound of the formula (I) ##STR1## Polymer compositions including antioxidants and the compounds or the compound alone are useful as electrical insulation e.g., for copper cable, as heat shrinkable (heat recoverable) parts or as other plastic parts to improve the retention of mechanical and/or electrical properties of the insulation or parts.
Abstract: 16.alpha.-Radiohalo-3,17.beta.-dihydroxy steroidal estrogens and their radiolabelled analogs are described. These steroidal estrogens have high estrogen receptor activity and are prepared by halogen exchange with the corresponding 16.beta.-bromo compound. The radiolabelled estrogens of this invention are useful in estrogen receptor assays, radioimmunoassays, in vivo imaging of tissue having estrogen receptor activity, and for therapeutic treatment of tumors having estrogen receptor activity.
Abstract: Compounds of the formula (I) ##STR1## where Y is H, Cl or Br with at least one Y always being Cl or Br and X is S or S--S.Polymer compositions including antioxidants and the compounds or the compound alone are useful as electrical insulation e.g., for copper cable, as heat shrinkable (heat recoverable) parts or as other plastic parts to improve the retention of mechanical and/or electrical properties of the insulation or parts.
Abstract: A composition for preparing cationic lipophilic technetium complexes is described. The composition comprises an admixture of (a) an accelerator compound selected from the group of water-soluble organic bidentate ligands that are capable of coordinating with technetium to form a 4 to 6 member ring and (b) a target-seeking ligand, or aqueous salt thereof, having the structure indicated in formulas I, II or III. The accelerator compound has a weaker coordinating bond with technetium than the target-seeking ligand has with technetium.
Abstract: A coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta, is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.
Type:
Grant
Filed:
April 30, 1982
Date of Patent:
June 5, 1984
Assignees:
President and Fellows of Harvard College, Massachusetts Institute of Technology
Inventors:
Alun G. Jones, Alan Davison, Michael J. Abrams
Abstract: A normally solid, hydrophilic compound capable of binding with Tc-99m to form a cationic complex is provided. The compound has a formula selected from: ##STR1## wherein: R, R', R", R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each independently selected from hydrogen; or substituted or unsubstituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclic groups; and R plus R.sup.i in formula (A) may be taken together to form a cyclic compound;A, A', A", A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5 and A.sup.6 are independently neutral functional elements, each having a free electron pair available for accepting a proton to provide a charged ligand and having the capability of complexing with Tc-99m to form a cationic complex;Y.sup.1, Y.sup.2, Y.sup.3, Y.sup.4, Y.sup.5 and Y.sup.
Abstract: A syringe for delivering two separated bodies of fluid comprising: a first piston for separating the two bodies of fluid; a second piston for pushing the two bodies of fluid out of the syringe; and a fluid chamber having a no-pass zone in which the pistons can slide and which has a cross section that each of the pistons substantially fills, preventing the passing of fluid around the pistons when they are in the no-pass zone, an output zone to direct fluid pushed out of the syringe by the pistons, and a bypass zone, for receiving the first piston, which connects the no-pass and output zones and which has a cross section that the first piston is unable to fill, so that when the first piston enters the bypass zone the fluid between the first and second pistons can pass around the first piston to the output zone.
Abstract: Electromagnetic energy shielding material in forms such as form stable gaskets, caulking compounds, coatings, adhesives, etc., the material being composed of a plastic binder and electrically conductive particles having an aluminum core, a first metallic layer thereover e.g., of tin and a silver outer layer.
Abstract: Compositions in which organo-mercurial moieties are bound to glass or other inorganic substrates are useful in separating sulfhydryl-containing compounds from mixtures with other compounds, e.g., by affinity chromatography.
Abstract: A method for producing various configurations of permanent magnet quadrupoles so that there is no coupling in the two transverse directions when focusing a charged particle beam is provided. Each configuration comprises a plurality of rotatable quadrupole disks, and means for rotating the quadrupole disks with respect to each other in a predetermined relationship.
Abstract: This invention provides a collecting device comprising a container for collection of a specimen, an annular intermediate member removably secured to the open end of the container, a cap protector removably secured to said annular member to close the opening of the annular member and thereby the container, and a cap secured to the cap protector so that the internal surfaces of the cap are protected from contamination. Preferably the annular member, cap protector and cap have identification means and are coded to facilitate recognition and instruction of the user.
Abstract: A sterilization indicator for testing the effectiveness of a sterilization process and a sterilization process using such an indicator are described.
Abstract: A stabilized composition comprising a solution of a radiolabeled compound and a diethylenetriamine is described. Preferred diethylenetriamines include, N,N-bis(2-aminoethyl) dithiocarbamic acid, di(2-dithiocarbamyl-ethyl) amine, and salts thereof.
Abstract: Improved disposable syringe for taking arterial blood samples for blood gas testing and for administering epidural anaesthesia, wherein the syringe plunger has a compressible elastomeric tip member which has a peripheral annular wiper extending axially forwardly toward the syringe floor and radially outwardly at an acute angle to the longitudinal center line of the barrel and plunger to form an excellent seal with the inner surface of the syringe barrel while at the same time providing only a gentle pressure against such surface and hence an exceptionally low resistance to axial movement of the tip member and plunger.
Abstract: Citric acids are produced by culturing a citric acids-accumulating and hydrocarbon-assimilating strain of a yeast of the genus Candida in an aqueous medium containing, as main carbon source, at least one normal paraffin with from 9 to 20 carbon atoms, inclusive, in the molecule, at a specific pH, and recovering accumulated citric acids from the culture broth.
Abstract: A method of stabilizing a solution of a radiolabeled compound comprising adding to such solution a compound having a substantially insoluble backbone, to which has been bound a quaternary ammonium group; or a water soluble primary, secondary or tertiary aliphatic amine. The present invention also includes a solution of a radiolabeled compound maintained in contact with such a compound, and as an article of manufacture, a sealed vial containing such a solution.
Abstract: Citric acids are produced by culturing a citric acids-accumulating and hydrocarbon-assimilating strain of a yeast of the Genus Candida in an aqueous medium containing, as main carbon source, at least one normal paraffin with from 9 to 20 carbon atoms, inclusive, in the molecule, at a specific pH, and recovering accumulated citric acids from the culture broth.
Abstract: A self-contained refrigerant package and method for shipment of a perishable or degradable product is described. The shipping package comprises an insulated container having therein a predetermined quantity of dry ice and a predetermined quantity of refrigerant gel that separates the product from the dry ice to prevent contact with the dry ice. The shipping package maintains the desired temperature range for periods in excess of 48 hours thus providing a safety factor for delays in shipment of such products.
Abstract: An improved method for taking a sample of blood using a disposable syringe and hypodermic needle assembly comprising the steps of moving the plunger tip of the syringe axially forwardly to expel liquid anti-coagulant and air from the syringe barrel until initial contact of the tip with the barrel end is made, whereby a predetermined amount of the anti-coagulant remains in the barrel; followed by inserting the needle into a blood vessel of the patient and permitting the blood pressure in the blood vessel to move the plunger tip and plunger axially rearwardly in the barrel to take a sample of blood.
Abstract: An improved disposable syringe for taking arterial blood samples for blood gas testing, and the like, wherein the syringe barrel has a reverse-taper section at the forward end thereof so that, in such section, the inner diameter of the barrel is progressively larger the closer it is to the forward end of the barrel. Preferably, the syringe plunger has a compressible elastomeric tip member which has a peripheral annular wiper that extends axially toward the forward end of the syringe and radially outwardly at an acute angle to the longitudinal center line of the barrel and plunger to form an excellent seal with the inner surface of the syringe barrel while at the same time providing only a gentle pressure against such surface and hence an exceptionally low resistance to axial movement of the tip member and plunger.