Abstract: The present invention relates to Escitalopram having a small median particle size and a solid pharmaceutical composition comprising the same.

Abstract: Compounds of the general formula are disclosed with activity towards treating diseases related to inflammation, such as cancer, neurodegenerative and cardiovascular diseases. Pharmaceutical compositions and methods of use are also described.

Abstract: Conventional vasectomy techniques suffer from a number of disadvantages, including, for example, a substantial risk for the development of hematomas and swelling, a potential for spontaneous regeneration and undesired resumption of fertility, a need for a highly skilled surgical professional, as well as a long recovery period, accompanied by severe limitations on post-surgical activity. The invention disclosed herein overcomes the disadvantages and deficiencies of the prior art by providing a rapid, reliable, less invasive male sterilization procedure as well as a vasectomy device and kit for use therewith.

Abstract: The present invention is directed to improving the cutting efficiency and reducing the manufacturing costs associated with endoscopic cutting instruments by eliminating the distal bearing surfaces or providing means for making the contact at the distal bearing intermittent so that surfaces do no undergo high localized heat and galling. In one embodiment, this goal is achieved by modifying or removing the axial constraints on the inner sliding member that are characteristic of conventional endoscopic shavers. In another embodiment, the improved cutting efficiency and reduced manufacturing cost is achieved by eliminating a closed end characteristic of conventional endoscopic shavers (e.g., removing the closed end of either the inner sliding member or the outer sliding member to thereby eliminate the associated bearing surface formed therebetween).

Abstract: Disclosed herein are embodiments of an electrosurgical device that include one or more floating electrodes and are specifically adapted to remove, cut, resect, ablate, vaporize, denaturize, drill, coagulate and form lesions in soft tissues, with or without externally supplied liquids, preferably in combination with a resectoscope, particularly in the context of urological, gynecological, laparoscopic, arthroscopic, and ENT procedures. Specific adaptations for urological and gynecological applications, for example kidney stone removal and BPH treatment, are also described.

Abstract: According to the invention, a sliding coating for winter sports equipment is provided, which has a copolymer (I) and optionally a copolymer (II), wherein the sliding coating for a winter sports equipment comprises a copolymer (I) having 10% or more of structural building blocks derived from propylene monomers, based on the total number of the structural building blocks of the copolymer (I), and 1% or more of structural building blocks derived from another olefin, based on the total number of the structural building blocks of the copolymer (I), wherein the sliding coating does not have a copolymer, which has 50% or more of structural building blocks derived from ethylene monomers, based on the total number of the structural building blocks of the copolymer.

Abstract: Disclosed herein is an endoscopic surgical assembly having improved cutting efficiency. In particular, the present invention provides an endoscopic shaver assembly configured for automated axial as well as rotational motion so as to enhance tissue resection.

Abstract: This invention relates to a process for the production of a von Willebrand factor preparation, hydroxylapatite being used as a chromatography medium.

Abstract: The present invention relates to a process for preparing pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process formula (I).

Abstract: A suture punch system that is capable of directly passing braided suture through tissue in a simple, one-step process. The system includes three principle components: a malleable needle capable of delivering the suture to the tissue, a handheld instrument for grasping tissue and controlling needle placement, and a force-supplying mechanism to supply the force required for needle placement. Needle deformation begins at the tip of the instrument, which beneficially includes a curved segment. As the distal tip of the needle pierces the tissue, it continues its radial path through the tissue. When the proximal end of the needle exits from the instrument, the needle may be radial in shape and traverses an essentially radial path through the tissue. Once the needle has passed entirely through the tissue, it may be retrieved using the jaws of the punch or another instrument.

Abstract: Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.

Abstract: The invention relates to a method for separating fibronectin from plasma fractions by adjusting a pH value of less than 5.4 such that fibronectin is precipitated and extracted from the solution.

Abstract: A high efficiency electrosurgical electrode with an advanced electrically conductive tip and aspiration port, and a method of conducting an electrosurgical procedure with such electrode. The electrosurgical electrode comprises an electrically conductive body portion of various geometries, an electrically conductive tip and a dielectric insulator adjacent the metallic body portion. The electrically conductive tip comprises a plurality of protuberances of various forms and geometries that define a plurality of recesses. The aspirating member includes a wall surrounding the aspirating port, to separate the aspirating port from adjacent recesses and prevent the flow of fluid from the recesses directly into the aspirating port.

Abstract: The present invention relates to processes for preparing a compound of the general formula (Ia) wherein X is a halogen atom, or a pharmaceutically acceptable salt thereof, wherein a compound of the formula (II) wherein X is as defined above and Y and Z independently represent a leaving group each, is reacted with an optically active amino alcohol to form a first mixture of diastereomers.

Abstract: An improved patient monitoring system is described herein. In particular, the present invention provides an improved system, method, and kit for positioning and removably mounting, often repeatedly, a monitor transducer on a patient, for example, an external fetal monitor used during pregnancy and childbirth labor. The improved system of the present invention avoids many of the disadvantages of conventional monitoring systems in that it maintains transducer position during patient movement, allows the position of the transducer to be changed without repositioning the patient, allows for simple and expeditious adjustment so as to maximize signal quality without causing patient discomfort, eliminates the need for a belt circumferentially disposed about the patient's abdomen, and can be applied to a wide array of body types, including patients having round abdomens. The system, method, and kit of the present invention is not only both efficient and effective but also economical.

Abstract: The present invention relates to an adsorbate, comprising an adsorbent and bicalutamide adsorbed on said adsorbent, a process for preparing same, and a pharmaceutical composition thereof.

Abstract: The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], or a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B] wherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent. In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

Abstract: The present invention is directed to the novel polymorphic Form A and Form B of Rizatriptan benzoate, processes for the preparation thereof and pharmaceutical compositions comprising these crystalline forms.

Abstract: Herein is disclosed a biomedical dispersive electrode which can redistribute the current in the subject body, increase subject safety, reduce the chance for burns and other tissue damage as well as discomfort experienced by subject during or after usage. Electrodes based on the principles of this invention can be made smaller than electrodes based on the principles of the prior art.