Abstract: Compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt or solvate thereof, including all tautomers, stereoisomers and polymorphs thereof wherein: R1 represents C2-8alkyl; C2-8alkenyl; —(C1-6alkyl)-aryl; —(C1-6alkyl)-heteroaryl; —(C1-6alkyl)-carbocyclyl; —(C1-6alkyl)-heterocyclyl; -aryl; -heteroaryl; -carbocyclyl or -heterocyclyl; wherein said aryl or heteroaryl groups may be optionally substituted by one or more substituents selected from, C1-4alkyl, C1-4-fluoroalkyl, C1-4alkoxy, C1-4-fluoroalkoxy, hydroxy, —SO2(C1-4alkyl), —SO2N(C1-4alkyl)(C1-4alkyl), —SOC1-4alkyl, —SOC3-6cycloalkyl —C(O)O(C1-4alkyl), benzyloxy and phenyl; and wherein said carbocyclyl and heterocyclyl groups may be optionally substituted by one or more substituents selected from —C1-4 alkyl, —C1-4 alkoxy, hydroxyl, halogen and oxo; R2 represents H; C1-4alkyl or halogen; R3 represents H; C1-4alkyl or halogen; and R4 represents H; C1-4alkyl or halogen.
Type:
Grant
Filed:
March 10, 2008
Date of Patent:
September 28, 2010
Assignee:
Probiodrug AG
Inventors:
Daniel Ramsbeck, Ulrich Heiser, Mirko Buchholz, Andre J. Niestroj
Abstract: The invention relates to the novel cotton variety designated 05V341. Provided by the invention are the seeds, plants, plant parts and derivatives of the cotton variety 05V341. Also provided by the invention are tissue cultures of the cotton variety 05V341 and the plants regenerated therefrom. Still further provided by the invention are methods for producing cotton plants by crossing the cotton variety 05V341 with itself or another cotton variety and plants produced by such methods.
Abstract: Novel blood-brain barrier permeant amyloid-targeting peptides and peptide conjugates are described. The peptide conjugates include a radioisotope or other label in a stable complex that translocates across brain capillary endothelial cell monolayers. The labeled peptide conjugate binds to amyloid plaques (A?) associated with Alzheimer's disease, and is useful for the targeted delivery of therapeutic and diagnostic molecules into the brain.
Abstract: A three-dimensional image-capturing apparatus includes an image-capturing device having a plurality of image-capturing regions and a plurality of optical systems for forming images of a subject in the image-capturing regions. The optical systems includes a plurality of reflectors for reflecting rays from the subject a number of times and at least a lens provided to be closer to the image-capturing device than the reflection means closest to the subject. The reflectors and the lens are used to form, in the image-capturing regions, separate images of the subject which are captured from different viewpoints.
Abstract: In a solid-state imaging device meeting color image pickup, which an AD converter is mounted on the same chip, the circuit scale and the number of transmission signal lines are reduced and a reference signal suitable for color image pickup is fed to an AD conversion comparing portion. DA converter circuits for two pixels of a repeat unit of a separation filter in the horizontal row direction in a unit of readout are prepared as a functional portion to generate a reference signal for AD conversion. The DA converter circuits generate the reference signals having a tilt in accordance with a color property and varying from an initial value based on a non-color property such as a black reference and a circuit offset. Each reference signal independently outputted from the DA converter circuits is basically directly transmitted through common signal lines to a voltage comparing portion which corresponds to color filters having a common color property through independent signal lines.
Abstract: According to the invention, there is provided seed and plants of the corn variety designated CV906975. The invention thus relates to the plants, seeds and tissue cultures of the variety CV906975, and to methods for producing a corn plant produced by crossing a corn plant of variety CV906975 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV906975 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV906975.
Abstract: According to the invention, there is provided seed and plants of the hybrid corn variety designated CH148845. The invention thus relates to the plants, seeds and tissue cultures of the variety CH148845, and to methods for producing a corn plant produced by crossing a corn plant of variety CH148845 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH148845.
Abstract: An inspection system for inspecting an object, the system comprising an illuminator including at least one pulsed light source, a detector assembly, and a relative motion provider operative to provide motion of the object relative to the detector assembly, along an axis of motion, the detector assembly comprising a plurality of 2-dimensional detector units whose active areas are arranged at intervals.
Type:
Grant
Filed:
December 10, 2008
Date of Patent:
September 28, 2010
Assignee:
Applied Materials South East Asia Pte. Ltd.
Abstract: According to the invention, there is provided seed and plants of the corn variety designated CV603860. The invention thus relates to the plants, seeds and tissue cultures of the variety CV603860, and to methods for producing a corn plant produced by crossing a corn plant of variety CV603860 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV603860 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV603860.
Abstract: A system and method for determining if a set of images in a large collection of images are near duplicates allows for improved management and retrieval of images. Images are processed, image signatures are generated for each image in the set of images, and the generated image signatures are compared. Detecting similarity between images can be used to cluster and rank images.
Type:
Grant
Filed:
September 30, 2005
Date of Patent:
September 21, 2010
Assignee:
IAC Search & Media, Inc.
Inventors:
Antonino Gulli', Antonio Savona, Tao Yang, Xin Liu, Beitao Li, Ankur Choksi, Filippo Tanganelli, Luigi Carnevale
Abstract: A system and method to securely deliver software updates to an appliance are provided. The system comprises a key generator, a reporting module, and a certificate signing request (CSR) module. The key generator may be configured to generate, at the processing system, verification data for the processing system. The reporting module may be configured to communicate the verification data from the processing system to a verification database. The certificate signing request (CSR) module may be configured to obtain a signed certificate from a certificate authority (CA) based on the verification data stored in the verification database.
Abstract: In an embodiment of the present invention, basic reference voltages VRT, VRB, VR, VG, and VB are divided by resistors to produce plural reference voltages V0 to V15, and voltages are selected from these plural reference voltages V0 to V15 for digital-analog conversion processing of image data DR, DG, and DB. At least the basic reference voltage VRB for the black level is shared by the respective color data DR, DG, and DB. The basic reference voltages VR, VG, and VB for setting of an intermediate grayscale closer to the black level can be varied individually for each of the color data DR, DG, and DB. When this embodiment is applied to a display device employing current-driven light-emitting elements such as organic EL elements, contrast deterioration due to floating black and sinking black can be prevented with a simple configuration.
Abstract: A cartridge, including a cartridge frame, formations on the cartridge frame for mounting the cartridge frame in a fixed position to an apparatus frame, a contactor support structure, a contactor interface on the contactor support structure, a plurality of terminals, held by the contactor support structure, for contacting contacts on a device, and a plurality of conductors, held by the contactor support structure, connecting the interface to the terminals.
Type:
Grant
Filed:
December 19, 2007
Date of Patent:
September 21, 2010
Assignee:
AEHR Test Ststems
Inventors:
Scott E. Lindsey, Jovan Jovanovic, David S. Hendrickson, Donald P. Richmond, II
Abstract: A liquid crystal display includes a pair of substrates and a liquid crystal layer interposed between the substrates and has a reflective area and a transmissive area. At least one of the substrates is provided with a retardation film whose phase difference differs between the reflective area and the transmissive area. Alternatively, at least one of the substrates is provided with a retardation film whose slow axis differs between the reflective area and the transmissive area.
Abstract: A solid-state image pickup device includes a semiconductor substrate 11, a photoelectric-conversion sensor portion 13 formed on the surface of the semiconductor substrate 11, a pixel area including an effective pixel portion 31 and an optical black portion 32 and a low reflective film 21 with low reflectance of infrared light formed on the back of the substrate 11. The solid-state image pickup device has satisfactory image pickup characteristics by suppressing an optical black optical level of the optical black portion from being fluctuated due to incidence of infrared light.
Abstract: A liquid crystal display device capable of improving response characteristics while maintaining display characteristics, and a liquid crystal display using such a liquid crystal display device are provided. Provided is the liquid crystal display device including a pair of substrates facing each other, and electrodes and a liquid crystal layer provided between the pair of substrates, where the liquid crystal layer is composed of liquid crystal material including a liquid crystal molecule showing a nematic liquid crystal phase and a molecule providing tilt to the liquid crystal molecule.
Abstract: A method for correcting a mask pattern to be formed on a photomask used in a lithographic step of a semiconductor device fabrication process. The method includes the steps of extracting an isolated pattern having an optically isolated portion from the mask pattern and providing, in an adjacent pattern extending parallel to the isolated portion of the isolated pattern and having a terminal end, an extended portion extending from the terminal end next to the isolated portion of the isolated pattern along a direction in which the isolated portion of the isolated pattern extends.