Patents Represented by Attorney Stephen L. Nesbitt
  • Patent number: 5373005
    Abstract: Drug-resistant malarial infection in humans can be effectively treated with standard antimalarial agents if administered in conjunction with desipramine.
    Type: Grant
    Filed: March 5, 1993
    Date of Patent: December 13, 1994
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Peter P. McCann, Albert Sjoerdsma, Alan J. Bitonti
  • Patent number: 5190957
    Abstract: This invention relates to quinolyloxazole-2-ones which are useful in the treatment of multi-drug resistant tumors. The quinoloyloxazole-2-ones act to prevent drug resistance and thus allow conventional chemotherapeutic agents to kill tumor cells as if drug resistance were not present.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: March 2, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Sai P. Sunkara, Winton D. Jones
  • Patent number: 5182293
    Abstract: This invention relates to pyridinyloxazole-2-ones which are useful in the treatment of multi-drug resistant tumors. The pyridinyloxazole-2-ones act to prevent drug resistance and thus allow conventional chemotherapeutic agents to kill tumor cells as if drug resistance were not present.
    Type: Grant
    Filed: October 3, 1990
    Date of Patent: January 26, 1993
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Sai P. Sunkara, Winton D. Jones
  • Patent number: 5157116
    Abstract: This invention relates to novel N-derivatives of 1-deoxy-nojirimycin, to the processes for their preparation and to their end-use applications, particularly as to their use in the treatment of diabetes.
    Type: Grant
    Filed: February 18, 1992
    Date of Patent: October 20, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jean-Bernard Ducep, Charles Danzin
  • Patent number: 5145861
    Abstract: Fluorinated arachidonic derivatives are 5-lipoxygenase inhibitors which have the useful pharmacologic activity as antiallergy and anti-imflammatory agents and are useful for treating, for example, asthma, anaphylaxis, allergy, rheumatoid arthritis, and psoriasis.
    Type: Grant
    Filed: August 5, 1991
    Date of Patent: September 8, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Jean B. Ducep, Jean-Francois Nave
  • Patent number: 5134168
    Abstract: Drug-resistant protozoal infection, particularly, drug-resistant malarial infection in humans, can be effectively treated with standard antiprotozoal agents if administered in conjunction with a phenoxyamino-substituted benzocycloalkane derivative.
    Type: Grant
    Filed: March 13, 1991
    Date of Patent: July 28, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Alan J. Bitonti, Jules Freedman
  • Patent number: 5120764
    Abstract: This invention relates to certain inhibitors of lysyl oxidase and their use in the treatment of diseases and conditions associated with the abnormal deposition of collagen.
    Type: Grant
    Filed: November 1, 1988
    Date of Patent: June 9, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: James R. McCarthy, Charlotte L. Barney, Donald P. Matthews, Philippe Bey
  • Patent number: 5114927
    Abstract: This invention relates to novel analogs of certain peptidase substrates in which the nitrogen atom of the scissile amide bond has been replaced with a difluoromethylene moiety and in which the carbonyl moiety of its adjacent amide bond has been replaced with a terminal amine function, said novel analogs having the property of inhibiting renin and which are useful in the treatment of hypertension.
    Type: Grant
    Filed: September 5, 1991
    Date of Patent: May 19, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Daniel G. Schirlin
  • Patent number: 5112969
    Abstract: A cyano glycidic acid ester compound can be prepared by reaction of an alkyl haloester and a cyano-aldehyde in the presence of an alkali metal alkoxide; an amino-acid ester cyano compound can be prepared by reaction of the cyano glycidic acid ester compound and an attachable amino compound, and a cyclic amido-carbonyl cyano compound can be prepared by contact of the amino-acid ester cyano compound in a liquid medium with a heterogeneous acidic ion-exchange substance.
    Type: Grant
    Filed: May 30, 1991
    Date of Patent: May 12, 1992
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventor: Daniel E. Martin
  • Patent number: 5066828
    Abstract: This invention relates to certain conjugates of folates and antifolates with difluoroglutamic acid which are useful in the treatment of patients suffering from certain neoplastic diseases including leukemia, melanomas, carcinomas, sarcomas and mixed neoplasias.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: November 19, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Philippe Bey, H. Michael Kolb
  • Patent number: 5063238
    Abstract: This invention relates to pyridinyloxazole-2-ones which are useful anti-enveloped virus agents by virtue of their ability to act as protein kinase C inhibitors. These derivatives are disclosed to be effective in treating enveloped virus infections including HIV infections and are thus useful in the treatment of AIDS and ARC.
    Type: Grant
    Filed: October 3, 1990
    Date of Patent: November 5, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Sai P. Sunkara, Winton D. Jones
  • Patent number: 5061715
    Abstract: This invention relates to quinolyloxazole-2-ones which are useful anti-enveloped virus agents by virtue of their ability to act as protein kinase C inhibitors. These derivatives are disclosed to be effective in treating enveloped virus infections including HIV infections and are thus useful in the treatment of AIDS and ARC.
    Type: Grant
    Filed: October 3, 1990
    Date of Patent: October 29, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Sai P. Sunkara, Winton D. Jones
  • Patent number: 5039688
    Abstract: Quaternary ammonium salts such as the benzalkonium chlorides and cetylpyridinium chloride can prevent the transmission of AIDS-causing virus through blood transfusions and through the use of blood products prepared using the blood of an AIDS infected individual.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: August 13, 1991
    Assignee: Merrell Dow Pharmaceuticals, Inc.
    Inventor: Peter J. Lewis
  • Patent number: 5004746
    Abstract: Certain Castanospermine ester derivatives are disclosed to be effective in treating retroviral infections including HIV infections and are thus useful in the treatment of AIDS and ARC.
    Type: Grant
    Filed: September 29, 1987
    Date of Patent: April 2, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Paul S. Liu, Sai P. Sunkara, Terry L. Bowlin
  • Patent number: 5002879
    Abstract: Ornithine decarboxylase inhibitors when administered in conjunction with autologous LAK cells and interleukin-2 provide for an enhanced treatment of neoplastic disease states. This enhancement is provided by the ability of an ornithine decarboxylase inhibitor to reduce tumor load and to enhance interleukin-2 production in T helper cells.
    Type: Grant
    Filed: December 5, 1989
    Date of Patent: March 26, 1991
    Assignee: Merrell Dow Pharmaceuticals
    Inventors: Terry L. Bowlin, Sai P. Sunkara
  • Patent number: 4988680
    Abstract: Halogenated 9-phosphonoalkyl derivatives of guanine and hypoxanthine are inhibitors of purine nucleoside phosphorylase and are useful as immuno suppressant and antiparasitic agents as well as against T cell leukemia and antiureicopoietic agents.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: January 29, 1991
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Serge J. Halazy, Charles Danzin
  • Patent number: 4971953
    Abstract: This invention relates to peptide derivatives which are useful anticoagulant agents.
    Type: Grant
    Filed: April 3, 1990
    Date of Patent: November 20, 1990
    Assignee: Merrell Dow Pharmaceuticals
    Inventor: John L. Krstenansky
  • Patent number: 4954508
    Abstract: The present invention is directed to new 4,7-dihydro-pyrazolo[3,4-b]pyridines. The compounds possess Ca.sup.2+ -antagonist, antihypertensive, vasodilating and antiangina activity. A process for producing them as well as pharmaceutical compositions containing them are also described.
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: September 4, 1990
    Assignee: Gruppo Lepetit S.p.A.
    Inventor: Giorgio Winters
  • Patent number: 4946856
    Abstract: This invention relates to 5-phenyl-3H-1,2,4-triazol-3-ones and to their use as anticonvulsants for treatment of seizure disorders.
    Type: Grant
    Filed: March 1, 1989
    Date of Patent: August 7, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: John M. Kane, Francis P. Miller
  • Patent number: 4939173
    Abstract: Aryloxyalkanol derivatives having the formulaAr--O(CH.sub.2).sub.n OHwherein n is an integer from 3 to 8 and Ar is (1) 1- or 2-naphthylenyl, (2) phenyl optionally substituted by from 1 to 3 C.sub.1-4 lower alkyl groups, or (3) a diphenyl moiety of structure ##STR1## wherein Y is a bond, CH.sub.2 or CH.sub.2 O, and esters thereof have antiretrovirus activity and are effective in a method for treating a retrovirus infection.
    Type: Grant
    Filed: December 14, 1988
    Date of Patent: July 3, 1990
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Roger A. Parker, Sai P. Sunkara