Patents Represented by Attorney Stephen L. Nesbitt
  • Patent number: 4707498
    Abstract: Novel fluorinated diaminoalkyne derivatives are inhibitors of ornithine decarboxylase enzyme and have the following general Formula I: ##STR1## wherein R represents C.sub.1 -C.sub.4 alkyl, or preferably, hydrogen.
    Type: Grant
    Filed: January 14, 1986
    Date of Patent: November 17, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Michael Kolb, David A. Kendrick
  • Patent number: 4704389
    Abstract: This invention relates to aromatic .omega.-alkylimino-tetrahydro-6H-1,3-thiazine-6-one derivatives, to a process for the preparation of same, and to their use as anxiolytic and antihypertensive agents.
    Type: Grant
    Filed: January 16, 1987
    Date of Patent: November 3, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Maurice W. Gittos, Marcel Hibert
  • Patent number: 4701541
    Abstract: The compounds 1-(3,4-methylenedioxyphenyl)-3-(N-benzylamino)butane and methyl 5-[[4-(3,4-methylenedioxyphenyl)-N-benzyl-2-butylamino]acetyl]salicylate are intermediates in the preparation of medroxalol.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: October 20, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard E. Donaldson, John F. Hoops
  • Patent number: 4699977
    Abstract: The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called teicoplanin (formerly teichomycin) by chemical treatment. The new compound possesses antimicrobial activity expecially against gram-positive bacteria.
    Type: Grant
    Filed: November 10, 1986
    Date of Patent: October 13, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Angelo Borghi, Paolo Strazzolini, Bruno Cavalleri, Carolina Coronelli
  • Patent number: 4698353
    Abstract: Heterocyclic oxazolones enhance myocardial contractile force and cardiac function and are used as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: October 6, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schnettler, Winton D. Jones, Jr., George P. Claxton
  • Patent number: 4698418
    Abstract: This invention relates to a process for converting a teicoplanin-like compound into antibiotic L 17046 characterized in that a teicoplanin-like compound selected from teicoplanin complex, any further purified preparation thereof, teicoplanin factor A.sub.2, teicoplanin factor A.sub.3, each of the main components of teicoplanin factor A.sub.2, antibiotic L 17054 and a mixture of two or more of the above substances in any proportion is submitted to hydrolysis with a strong acid in the presence of a polar aprotic organic solvent selected from ethers, ketones and mixtures thereof that a room temperature are liquid.
    Type: Grant
    Filed: September 20, 1985
    Date of Patent: October 6, 1987
    Assignee: Gruppo Lepetit, S.p.A.
    Inventors: Adriano Malabarba, Bruno Cavalleri
  • Patent number: 4696927
    Abstract: This invention relates to 4-(2-pyrimidinyl)-1-piperazinyl heterocyclic carbonyl derivatives, to a process for their preparation, and to their use as anxiolytic agents.
    Type: Grant
    Filed: December 17, 1986
    Date of Patent: September 29, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Maurice W. Gittos, Marcel Hibert
  • Patent number: 4697024
    Abstract: The compounds 1-(3,4-methylenedioxyphenyl)-3-(N-benzylamino)butane and methyl 5-[[4-(3,4-methylenedioxyphenyl)-N-benzyl-2-butylamino]acetyl]salicylate are intermediates in the preparation of medroxalol.
    Type: Grant
    Filed: November 24, 1986
    Date of Patent: September 29, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard E. Donaldson, John F. Hoops
  • Patent number: 4692333
    Abstract: New antibiotic substances arbitrarily designated M 9026 complex, antibiotic M 9026 factor 1, antibiotic M 9026 factor 2, and antibiotic M 9026 factor 3, produced by fermentation of a strain of the Micromonospora genus. The antibiotics of the invention are antimicrobial and antitumor agents.
    Type: Grant
    Filed: August 4, 1983
    Date of Patent: September 8, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Giorgio Pirali, Maria Grandi, Hermes Pagani, Manuela Paternoster, Giorgio Tamoni, Giovanni Cassani
  • Patent number: 4684644
    Abstract: The present invention is directed to a class of basic monocarboxyamide derivatives of actagardine. Actagardine (INN) is an antibiotic substance produced by actinoplanes strains such as Actinoplanes Sp. ATCC 31048 and Actinoplanes Sp. ATCC 31049 which are described in U.S. Pat. No. 4,022,884. Actagardine shows antimicrobial in vitro and in vivo activity against gram-positive organisms. Its complete chemical structure is not yet known but there is only information on its chemical functions and main fragments. In particular, it has been found that actagardine has two carboxylic functions and a primary amino function and can therefore be represented as follows: ##STR1## The compounds of the invention are monoamide derivatives at one of the carboxy functions of actagardine.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: August 4, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Bruno Cavalleri
  • Patent number: 4671823
    Abstract: The present invention relates to an improved process for preparing sucrose encrusted methylcellulose particles which readily disperse in cold aqueous liquids. These encrusted particles are suitable for use in bulk laxative compositions. In the improved process, hot sucrose syrup is mixed with powdered methylcellulose, dried and milled.
    Type: Grant
    Filed: August 26, 1986
    Date of Patent: June 9, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Dhiren N. Shah, Gregory V. Hammer, Jack Domet
  • Patent number: 4670450
    Abstract: Thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: November 13, 1985
    Date of Patent: June 2, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Richard A. Schenttler, Winton D. Jones, Jr., George P. Claxton
  • Patent number: 4661470
    Abstract: The present invention is directed to ester derivatives at the carboxylic function of the glycopeptidic antibiotic substance called antibiotic L 17046 with antimicrobial activity mainly against gram-positive bacteria.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: April 28, 1987
    Assignee: Gruppo Lepetit S.P.A.
    Inventors: Adriano Malabarba, Ambrogio Magni, Paolo Strazzolini, Bruno Cavalleri, Aldo Trani
  • Patent number: 4650907
    Abstract: Novel nonaromatic fluoroallylamines are potent MAO inhibitors and at low dose selectively inhibit MAO-B. They are useful in the treatment of depression and coadministered with L-dopa, in the treatment of Parkinsonism.
    Type: Grant
    Filed: December 5, 1985
    Date of Patent: March 17, 1987
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Philippe Bey, Michael G. Palfreyman, Ian A. McDonald
  • Patent number: 4650855
    Abstract: The present invention is directed to a new antibiotic substance arbitrarily denominated antibiotic L 17046. This antibiotic substance is obtained from the known antibiotic substance called teicoplanin (formerly teichomycin) by chemical treatment. The new compound possesses antimicrobial activity especially against gram-positive bacteria.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: March 17, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Paolo Strazzolini, Angelo Borghi, Bruno Cavalleri, Carolina Coronelli
  • Patent number: 4645827
    Abstract: The present invention is directed to the essentially pure preparation of an antibiotic substance arbitrarily designated antibiotic L 17054. This antibiotic substance is obtained from the known antibiotic substance named teicoplanin (formerly teichomycin) by chemical treatment. The new compound and the pharmaceutically acceptable salts possess antimicrobial activity.
    Type: Grant
    Filed: March 19, 1984
    Date of Patent: February 24, 1987
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Adriano Malabarba, Paolo Strazzolini, Angelo Borghi, Bruno Cavalleri, Carolina Coronelli
  • Patent number: 4632994
    Abstract: New process for preparing olefinic lactams by decomposing the corresponding N,N-dimethyl-N-oxides in a suitable solvent in the presence of a base at a temperature of at least 100.degree. C.
    Type: Grant
    Filed: November 4, 1983
    Date of Patent: December 30, 1986
    Assignee: Gruppo Lepetit S.p.A.
    Inventor: Aldo Trani
  • Patent number: 4629781
    Abstract: The present invention is directed to a chemical process for preparing antibiotic L 17392 (deglucoteicoplanin) and its salts with bases and acids by submitting a teicoplanin compound or a teicoplanin-like compound to controlled strong acidic hydrolysis conditions.
    Type: Grant
    Filed: December 11, 1984
    Date of Patent: December 16, 1986
    Assignee: Gruppo Lepetit S.p.A.
    Inventors: Paolo Strazzolini, Adriano Malabarba, Bruno Cavalleri
  • Patent number: 4626287
    Abstract: The present invention relates to an improved process for preparing sucrose encrusted methylcellulose particles which readily disperse in cold aqueous liquids. These encrusted particles are suitable for use in bulk laxative compositions. In the improved process, hot sucrose syrup is mixed with powdered methylcellulose, dried and milled.
    Type: Grant
    Filed: January 29, 1985
    Date of Patent: December 2, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: Dhiren N. Shah, Jack Domet, Gregory V. Hammer
  • Patent number: 4623651
    Abstract: Heterocyclocarbonyl- and acetyl-thiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.
    Type: Grant
    Filed: October 15, 1985
    Date of Patent: November 18, 1986
    Assignee: Merrell Dow Pharmaceuticals Inc.
    Inventors: J. Martin Grisar, Richard C. Dage, Richard A. Schnettler