Patents Represented by Attorney Susan T. Evans
  • Patent number: 5766840
    Abstract: Polypeptide antigens are disclosed which are immunoreactive with sera from individuals having a non-A, non-B, non-C, non-D, non-E Hepatitis, herein designated Hepatitis G Virus (HGV). Corresponding genomic-fragment clones containing polynucleotides encoding the open reading frame sequences for the antigenic polypeptides are taught. The antigens are useful in diagnostic methods for detecting the presence of HGV in test subjects. The antigens are also useful in vaccine and antibody preparations. In addition, the entire coding sequences of two HGV isolates are disclosed. Methods are presented for nucleic acid-based detection of HGV in samples and also methods for the isolation of further genomic sequences corresponding to HGV.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 16, 1998
    Assignee: Genelabs Technologies, Inc.
    Inventors: Jungsuh P. Kim, Kirk E. Fry, LaVonne Marie Young, Jeffrey M. Linnen, John Wages
  • Patent number: 5750864
    Abstract: The use of AdoMetase to reduce ethylene biosynthesis in plants is facilitated by the exploitation of the tissue and stage specific properties of the E4 promoter from tomato.The E4 promoter, isolated from tomato or other plants by methods described herein, provides a useful regulatable promoter for the expression of a variety of heterologous genes, including the AdoMetase gene.
    Type: Grant
    Filed: June 17, 1994
    Date of Patent: May 12, 1998
    Assignee: Epitope, Inc.
    Inventors: Richard Keith Bestwick, Adolph J. Ferro
  • Patent number: 5750870
    Abstract: An efficient transformation system for plants has been developed that yields high transformation efficiencies and pure transgenic plants. Genomic integration of transgenes was confirmed by genomic DNA hybridization analysis. Pure transgenic plants have been successfully established in soil.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: May 12, 1998
    Assignee: Agritope, Inc.
    Inventors: Helena V. Mathews, Richard Keith Bestwick, Adolph J. Ferro
  • Patent number: 5723746
    Abstract: The use of AdoMetase to reduce ethylene biosynthesis in plants is facilitated by the exploitation of the tissue and stage specific properties of the E8 promoter from tomato. Expression of AdoMetase is shown to be limited to the ripening tomato fruit. The functional properties of several regions of the E8 promoter are also described. The E8 promoter, and variants described herein, provides a useful regulatable promoter for the expression of other genes as well as the AdoMetase gene.
    Type: Grant
    Filed: April 9, 1993
    Date of Patent: March 3, 1998
    Assignee: Epitope, Inc.
    Inventors: Richard Keith Bestwick, Adolph J. Ferro
  • Patent number: 5700642
    Abstract: The present invention provides modified oligonucleotide primers that (i) are designed for attachment to a solid support in a manner that does not block the ability to extend the primer from its 3' end, and (ii) incorporate a clearable moiety so that a 3' portion of the primer (linked to an extension product) can be released from an immobilized 5' portion. Upon selective cleavage of the cleavable site, a large portion of the primer fragment remains affixed to the solid support. This enables the release of primer extension products that contain about five or fewer base pairs of the primer sequence, to provide more useful sizing and sequence information per fragment than extension products containing the entire primer.
    Type: Grant
    Filed: May 22, 1995
    Date of Patent: December 23, 1997
    Assignee: SRI International
    Inventors: Joseph Albert Monforte, Christopher Hank Becker, Thomas Andrew Shaler, Daniel Joseph Pollart
  • Patent number: 5684636
    Abstract: A polymer composition is provided for use as a liquid lens element in a compound lens designed to reduce chromatic aberration. The polymer composition (i) has an abnormal optical dispersion and (ii) is more easily fabricated into the compound lens than a conventional optical liquid. The composition contains an abnormal optical liquid characterized by an abnormal optical dispersion and a polymer component. The polymer is soluble in the optical liquid and is present in an amount effective to impart a viscosity that is at least an order of magnitude greater than that of the liquid alone at a selected temperature.
    Type: Grant
    Filed: August 24, 1995
    Date of Patent: November 4, 1997
    Assignee: Lockheed Martin Corporation
    Inventors: Andrea W. Chow, Hope B. Warren, Susan P. Ermer
  • Patent number: 5646185
    Abstract: Disclosed is a method of treating a solid tumor, where the tumor contains regions of hypoxic cells, either because of poor vascularization in the tumor or because of vasoconstrictive or vaso-occlusive measures brought to bear on the tumor. The method includes administering to a subject, a compound effective to activate protein kinase C activity in the cells of the tumor, via a route effective to direct the compound to such regions of hypoxia in the tumor. Preferred compounds include phorbol esters, diacylglycerols, and thapsigargin. Also disclosed is a vaso-occlusive composition containing a protein kinase C activator, for use in the treatment method.
    Type: Grant
    Filed: October 14, 1993
    Date of Patent: July 8, 1997
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Amato J. Giaccia, Albert C. Koong
  • Patent number: 5602021
    Abstract: The present invention describes methods for screening or selecting novel proteolytic enzymes. These enzymatic functions can be selected from isolated chromosomal DNA libraries or from pools of mutagenized DNA encoding a proteolytic function. In particular, the selection method of the present invention, a phage gene is chosen that encodes a gene product necessary for the production of a phage. The phage carrying the modified gene is introduced into a host. Also, DNA libraries present within a cloning vector are introduced into host cells. The host cells are grown under conditions where the introduced libraries are expressed in the host cells. The presence of an enzymatic function capable of cleaving the target peptide is identified on the basis of production of infective phage.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: February 11, 1997
    Assignee: Catalytic Antibodies, Inc.
    Inventors: Claude G. Davis, Gordon G. Guay
  • Patent number: 5597700
    Abstract: A method and device for detecting fetal membrane rupture by detecting only that insulin-like growth-factor-binding protein 1 (IGFBP-1) which is free of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) are disclosed. The method is based on the fact that the concentration of free IGFBP-1 in the blood serum is about 10 times lower than that of the IGFBP-1 bound to IGF-1 and IGF-2, while in the amniotic liquid which is contained in the amnion has more than 1000 times the concentration of free IGFBP-1 than the blood serum. Therefore, when even a small amount of amniotic liquid is contained in the vaginal secretion sample, this is clear evidence of the rupture of the fetal membrane having taken place. The method and the device make it possible to diagnose fetal membrane rupture with an extremely high accuracy. Because of the low concentration of the IGFBP-1 in the blood, the admixture of the blood serum to the sample does not affect the results of the test.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: January 28, 1997
    Assignee: California Research, LLC
    Inventors: Alexander Konstantinov, Boris Foux, Alexander Stepanov, Evgeny Zaraisky, Svetlana Nazimova, Marina Boltovskaya, Nelli Starosvetskaya
  • Patent number: 5589623
    Abstract: A method for control of ethylene biosynthesis in plants comprising a vector containing a selective gene under plant promoter control, and a DNA insert comprising codons for a functional heterologous polypeptide having AdoMetase activity and flanked by a plant promoter on one side and a polyA signal sequence on the other side; and, transforming a plant host with said vector wherein the plant host transformed thereby is capable of expressing the heterologous polypeptide having AdoMetase activity under the control of said control region. The presence of the AdoMetase gene and the expression of AdoMetase in transgenic plants lowers AdoMet levels and generates an inhibitor of ACC synthase causing a corresponding decrease in ethylene biosynthesis and precursor availability.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: December 31, 1996
    Assignee: Agritope, Inc.
    Inventors: Adolph J. Ferro, Richard K. Bestwick, Lyle R. Brown
  • Patent number: 5573738
    Abstract: Soil, contaminated with radioactive material such as uranium, is treated to remove the radioactive contaminant. The soil is first pre-processed to remove and clean oversized particles for release back to the environment as recovered soil. Pre-processing also includes removal of metallic uranium from the soil by gravimetric separation for off-site disposal. An aqueous slurry is formed from the pre-processed feed which is fed to a mechanical separation device. Particles greater than 10 mesh are crushed to provide a uniform feed slurry. The slurry is processed in an aqueous leaching solution of sulfuric acid, hydrogen peroxide and iron to remove uranium. Particulate matter is removed from the acidic slurry; the remaining fine particulate matter is then submitted to a second-stage leaching to remove residual uranium. Uranium is recovered from the combined leaching solutions by either a two-stage precipitation process or by passage over an ion-exchange material.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: November 12, 1996
    Assignee: Lockheed Martin Corporation
    Inventors: Jonathan K. Ma, Andrea W. Chow, Scott A. Ranger, David W. Peters, Ronald F. May
  • Patent number: 5571822
    Abstract: A method of inhibiting tumor-cell growth in a mammalian subject, by administering a therapeutically effective amount of a selected 2-phenyl-4-quinolone compound. The selected compound shows unexpectely high activity against a variety of solid tumor cells.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: November 5, 1996
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Sheng-Chu Kuo, Tian-Shung Wu, Hui K. Wang, Leping Li
  • Patent number: 5569649
    Abstract: A method of treating inflammation in a subject by administering a therapeutically effective amount of a compound having the structure: ##STR1## where R.sub.1 to R.sub.4 are the same or different and are each selected from the group consisting of H, an alkylacyl group, an arylacyl group, or a C-1-linked saccharide.
    Type: Grant
    Filed: June 14, 1994
    Date of Patent: October 29, 1996
    Assignee: Phytopharm (NA) N.V.
    Inventors: Anthony C. Allison, Carl F. de Vos Albrecht, Petrus B. Kruger, Marthinus J. van der Merwe