Patents Represented by Attorney, Agent or Law Firm The firm of Gordon W. Hueschen
  • Patent number: 6034250
    Abstract: A compound selected from those of formula (1): ##STR1## wherein W represents aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each being optionally substituted,R.sub.1 represents alkyl, alkenyl, alkynyl, aryl, cycloalkyl, arylalkyl, or cycloalkylalkyl, each being optionally substituted.R.sub.2 is as defined in the description,its isomers, and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as anti-oxidation agents.
    Type: Grant
    Filed: June 25, 1999
    Date of Patent: March 7, 2000
    Assignee: Adir Et Compagnie
    Inventors: Solo Goldstein, Alain Dhainaut, Andre Tizot, Brian Lockhart, Pierre Lestage
  • Patent number: 6025356
    Abstract: New compounds of formula: ##STR1## wherein: A represents alkyl, alkenyl, alkynyl, cycloalkylalkyl or aralkyl, andE represents: ##STR2## in racemic form or in the form of optical isomers, and the addition salts thereof with pharmaceutically acceptable acids.Those compounds may be used as medicaments.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: February 15, 2000
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Jean-Christophe Harmange, Mark Millan, Francoise Lejeune
  • Patent number: 6020345
    Abstract: The invention concerns novel pyridin-2-yl-methylamine derivatives of formula (I): ##STR1## in which: u represents hydrogen or methyl;v represents hydrogen, chlorine, or methyl;w represents hydrogen, fluorine, or methyl;x represents hydrogen or fluorine;y represents chlorine or methyl;z represents hydrogen, fluorine, chlorine, or methyl;A represents hydrogen, fluorine, chlorine, C.sub.1 -C.sub.5 alkyl, fluoroalkyl, cyclopropyl, a 5-membered aromatic heterocyclic group, alkoxy or alkythio, amino, cyclic amino, or alkoxycarbonyl. These compounds are useful as medicines, in particular as antidepressants or analgesics.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: February 1, 2000
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Wouter Koek
  • Patent number: 6013304
    Abstract: Principal components of spice and herb plant solids are simultaneously extracted and concentrated with an edible solvent in a series of mixing and high temperature and pressure mechanical pressing steps using edible solvent and a countercurrent extraction procedure. The extract may be hydrated and then centrifuged to remove fine particulate solids and gums. A solution having several times the concentration of pigments and other flavor and aroma and/or antioxidant components of the starting raw material is obtained. The residual press solids may be cooled and hydrated following the last pressing operation. The residual press solids and extract have significantly reduced bacterial counts as a result of the temperatures, high pressure, and high shear utilized, as well as the low moisture levels employed, thus producing not only a food grade extract but also a food grade residual solid having low bacterial counts and predictable, standardized levels of the principal components of interest.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: January 11, 2000
    Assignee: Kalamazoo Holdings, Inc.
    Inventor: George N. Todd
  • Patent number: 6013667
    Abstract: Compounds of formula (I): in which:R.sub.a and R.sub.b, identical or different, represent hydrogen or alkyl or together form a bond,R.sub.C represents hydroxyl optionally substituted alkoxy, or optionally substituted amino,R.sub.1 represents hydrogen or --O--NO.sub.2, --O--NO, or --S--NO,R.sub.2 and R.sub.3, identical or different, represent hydrogen, alkyl, or optionally substituted phenyl,X represents oxygen or --NH--CO--,m represents 0 or 1,n represents an integer such that 0.ltoreq.n.ltoreq.6,p represents 0 or 1,R.sub.4 represents hydrogen, optionally substituted alkyl, optionally substituted phenyl, or a group as defined in the description,R.sub.5 represents hydrogen or alkyl,R.sub.6 represents hydrogen or alkyl,or R.sub.5 and R.sub.6 together form a chain --(CH.sub.2).sub.t -- in which t represents 1 or 2,q represents 0, 1, or 2,r represents an integer such that 0.ltoreq.r.ltoreq.6,R.sub.d and R.sub.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: January 11, 2000
    Assignee: Adir Et Compagnie
    Inventors: Gilbert Lavielle, Bernard Cimetiere, Tony Verbeuren, Serge Simonet, Jean-Jacques Descombes
  • Patent number: 6010726
    Abstract: The resistivity properties of an edible base liquid, e.g., a vegetable oil or fluid fat, can be modified by the addition of certain flavoring, coloring, or stabilizing agents such as antioxidants, and if necessary or desirable also an organic diluent, so as to provide an edible liquid flavoring, coloring, or stabilizing composition which is suitable for electrostatic charging and deposition upon an edible food substrate in a uniform and controlled manner.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: January 4, 2000
    Assignee: Kalamazoo Holdings, Inc.
    Inventors: Robert J. Evans, Gregory S. Reynhout
  • Patent number: 6011032
    Abstract: Substituted N-heterocyclyl-1-aryloxyalkyl-4-piperldineamines of formula (I) ##STR1## wherein each of R.sub.1 to R.sub.4, which are the same or different, is hydrogen, optionally branched C.sub.1-4 alkyl, optionally branched C.sub.1-4 alkyloxy, halo, nitro, hydroxy, or trifluoromethyl or trifluoromethoxyl; R.sub.5 is hydrogen, optionally branched C.sub.1-6 alkyl, optionally branched C.sub.7-12 phenylalkyl optionally substituted on the phenyl by one or more radicals having the same definition as R.sub.1 ; W and X are oxygen or sulphur; Y is C.sub.2-6 polymethylene or --CH.sub.2 --CH(OH)--CH.sub.2 --; and n is 0 or 1; and pure R or S isomers of said compounds, where applicable, as well as mixtures thereof, as well as therapeutically-acceptable organic or inorganic salts and hydrates of the compounds and a method for preparing the compounds and their use as drugs are all disclosed.
    Type: Grant
    Filed: January 26, 1998
    Date of Patent: January 4, 2000
    Assignee: Pierre Fabre Medicament
    Inventors: Jean-Pierre Rieu, Jean-Fran.cedilla.ois Patoiseau, Gareth W. John, Bruno Legrand, Jean-Pierre Valentin
  • Patent number: 6008382
    Abstract: A method for synthesizing a 4'-demethylepipodophyllotoxin of formula (II) from a podophyllotoxin of formula (I) by treating it with a pair of reagents, i.e. a strong acid and an aliphatic, aromatic or functionalized sulphide, in the present of an organic or inorganic acid, or in the presence of water with or without a water-miscible organic solvent.
    Type: Grant
    Filed: June 12, 1998
    Date of Patent: December 28, 1999
    Assignee: Pierre Fabre Medicament
    Inventors: Thierry Imbert, Yves Guminski
  • Patent number: 5985352
    Abstract: Principal components of herb or spice plant materials are simultaneously extracted and concentrated in at least one high temperature and pressure mechanical pressing step. The extract may be hydrated and then centrifuged to remove fine particulate solids and gums. A solution having several times the concentration of the pigments and flavor and aroma components of the starting raw material is obtained. The residual press solids and extract have significantly reduced bacterial counts as a result of the temperatures, high pressure, and high shear utilized, as well as the low moisture levels employed, thus producing not only a food grade extract but also a food grade residual solid having low bacterial counts and predictable, standardized levels of the principal components of interest. Additionally, edible antioxidants can be included in the process to enhance the stability of both the extract and the residual solids.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: November 16, 1999
    Assignee: Kalamazoo Holdings, Inc.
    Inventor: George N. Todd
  • Patent number: 5984999
    Abstract: The charge well of a metal melting furnace is provided with an internal cavity having a circular cross section when viewed from the top, preferably a cavity of cylindrical or conical configuration, and with a peripheral exit port located tangentially with respect to said cavity at a lower level thereof for exit of molten metal into the main chamber of the furnace. An inert gas bubble-actuated molten metal pump brings molten metal from a hotter section of the furnace, advantageously directly from the main chamber, and has its exit port located tangentially to the periphery of the cavity at an upper level thereof, thereby creating vortical flow of molten metal within the charge well for the more rapid and efficient melting of metal chips and scraps into the molten metal therein and for circulation of hotter molten metal throughout the furnace.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: November 16, 1999
    Assignee: Premelt Pump, Inc.
    Inventor: Larry D. Areaux
  • Patent number: 5985345
    Abstract: Principal components of herb or spice plant materials are simultaneously extracted and concentrated in at least one high temperature and pressure mechanical pressing step. The extract may be hydrated and then centrifuged to remove fine particulate solids and gums. A solution having several times the concentration of the pigments and flavor and aroma components of the starting raw material is obtained. The residual press solids and extract have significantly reduced bacterial counts as a result of the temperatures, high pressure, and high shear utilized, as well as the low moisture levels employed, thus producing not only a food grade extract but also a food grade residual solid having low bacterial counts and predictable, standardized levels of the principal components of interest. Additionally, edible antioxidants can be included in the process to enhance the stability of both the extract and the residual solids.
    Type: Grant
    Filed: December 12, 1997
    Date of Patent: November 16, 1999
    Assignee: Kalamazoo Holdings, Inc.
    Inventor: George N. Todd
  • Patent number: 5980952
    Abstract: A novel pharmaceutical composition allowing the programmed release of dexfenfluramine containing a water-soluble acid addition salt of dexfenfluramine on a mixture of minigranules, both rapid release and slow release minigranules, permits the attainment of two concentration peaks in the plasma of patients treated therewith.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: November 9, 1999
    Assignee: Adir Et Compagnie
    Inventors: Bruno Huet De Barochez, Claude Dauphant, Patrick Wuthrich
  • Patent number: 5972968
    Abstract: A compound of formula (I): ##STR1## in which: R.sub.1 represents halogen or hydroxyl, alkoxy, trihalomethyl, amino, mercapto, alkylthio, trialkylammonium, aryloxy, arylthio, arylsulfonyl, arylsulfonyloxy, cycloalkyloxy, cycloalkylthio, bicycloalkyloxy or bicycloalkylthio,R.sub.a and R.sub.b, which may be identical or different, represent hydrogen or alkyl,X represents oxygen or sulfur or NR,Y represents the group as defined in the description,R.sub.2 represents an optionallly substituted aryl,its optical isomers as well as its addition salts with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as interleukin-1.beta. inhibitor.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: October 26, 1999
    Assignee: Adir et Compagnie
    Inventors: Guillaume de Nanteuil, Bernard Portevin, Jacqueline Bonnet, Armel Fradin
  • Patent number: 5968954
    Abstract: New 2-aminoindan compounds of formula: ##STR1## wherein: n, Ar, R, E, X.sub.1, X.sub.2, X.sub.3, and X.sub.4 are as defined in the description, in the form of a racemic mixture and in the form of optical isomers, and physiologically-tolerable acid addition salts thereof. The products of the invention are useful as medicaments and exhibit selective binding affinity for the 5HT.sub.1B receptors.
    Type: Grant
    Filed: February 26, 1998
    Date of Patent: October 19, 1999
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Alain Gobert
  • Patent number: 5965575
    Abstract: New N-arylpiperidine compounds of formula: ##STR1## wherein: A, m, R, E, n and Ar are as defined in the description, the isomers thereof and the addition salts thereof with a pharmaceutically acceptable acid, and medicinal products containing the same are useful in the treatment of disorders involving the serotininergic system.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: October 12, 1999
    Assignee: Adir Et Compagnie
    Inventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Alain Gobert, Valerie Audinot
  • Patent number: 5958927
    Abstract: A compound of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X-Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid addition salts thereof, and medicinal products containing the same are useful in the treatment of diseases of the central nervous system or of manifestations of pain.
    Type: Grant
    Filed: October 2, 1998
    Date of Patent: September 28, 1999
    Assignee: Adir et Compagnie
    Inventors: Jean-Louis Peglion, Bertrand Goument, Mark Millan, Adrian Newman-Tancredi, Anne Dekeyne
  • Patent number: 5958945
    Abstract: The invention pertains to novel azabicyclo-naphthalene-carboxamide derivatives, a method for preparing same and the use thereof as a medicament. The compounds of the invention are of formula (I).
    Type: Grant
    Filed: March 12, 1998
    Date of Patent: September 28, 1999
    Assignee: Pierre Fabre Medicament
    Inventors: Thierry Imbert, Barbara Monse, Wouter Koek
  • Patent number: 5958938
    Abstract: Compounds of the formula: ##STR1## in which R.sub.1, R.sub.2, A and B are as defined in the description, their optical isomers, N-oxides and addition salts with a phar-maceutically acceptable acid, and their use as anti-tumor agents.
    Type: Grant
    Filed: July 22, 1998
    Date of Patent: September 28, 1999
    Assignee: Adir et Compagnie
    Inventors: Claude Guillonneau, Yves Charton, Ghanem Atassi, Alain Pierre, Nicolas Guilbaud
  • Patent number: 5955454
    Abstract: The invention relates to a nasal pharmaceutical preparation suitable for nasal administration containing a progestogen and a methylated .beta.-cyclodextrin having a degree of substitution of between 0.5 and 3.0 and hard gelatin capsules containing the same.
    Type: Grant
    Filed: September 11, 1995
    Date of Patent: September 21, 1999
    Assignee: Adir et Compagnie
    Inventor: Franciscus Merkus
  • Patent number: RE36477
    Abstract: Benzoic acid derivatives represented by the formula (I): ##STR1## wherein R.sub.1 represents hydrogen or lower-alkyl, R.sub.2 and R.sub.4 represent hydrogen, trimethylsilyl, or trimethylgermyl, R.sub.3 represents hydrogen, lower-alkyl, trimethylsilyl, or trimethylgermyl, R.sub.5 represents hydrogen, lower-alkyl, acetyl, or hydroxy, at least one of R.sub.2 and R.sub.3 being trimethylsilyl or trinethylgermyl, and R.sub.6 means hydroxy, lower-alkoxy, or a group of the formula --NR.sub.7 R.sub.8, wherein R.sub.7 and R.sub.8 mean hydrogen or lower-alkyl, and X represents a group of the formula --CONH--, --NHCO--, --COO--, --OCO--, --COCH.dbd.CH--, --COCH.dbd.C(OH), or --CH.dbd.CH--, which exhibit excellent effect as differentiation-inducing agents for neoplastic cells, especially leukemia cells, or a therapeutic agent for psoriasis or immune and inflammatory diseases, and a process for the preparation thereof, are disclosed.
    Type: Grant
    Filed: June 25, 1998
    Date of Patent: December 28, 1999
    Assignee: Taiho Pharmaceutical Co., Ltd.
    Inventor: Koichi Shudo