Patents Represented by Attorney Theresa Y. Cheng

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  • Bacterial or bacterial antibody assay
    Patent number: 4288539
    Abstract: Automated tests to evaluate the antibody titer of a sample by incubating a test sample, bacteria, and complement, and detecting bacterial growth in the incubated mixture, and to identify bacteria and its titer in a sample by incubating a test sample, bacterial antiserum, and complement, and detecting inhibition of bacterial growth in the incubated mixture. The automated tests lend themselves to diagnostic use and may be provided in the form of diagnostic test kits.
    Type: Grant
    Filed: February 28, 1979
    Date of Patent: September 8, 1981
    Assignee: Merck & Co., Inc.
    Inventors: William J. McAleer, Henry Z. Markus, Roy A. Machlowitz
  • Vaccine for dental caries
    Patent number: 4287173
    Abstract: A vaccine against dental caries is prepared from capsular polysaccharides (one or more strains), of Streptococcus pneumoniae.
    Type: Grant
    Filed: September 24, 1979
    Date of Patent: September 1, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Dennis J. Carlo, Jesse J. Jackson, Thomas H. Stoudt
  • Treatment of pain, fever, and inflammation with compositions containing piperidinobutan-and 3-buten-2-ones
    Patent number: 4273781
    Abstract: A method of treating pain, fever, and inflammation and pharmaceutical compositions for use therein, wherein the active ingredient comprises a compound of the formula; ##STR1##
    Type: Grant
    Filed: July 17, 1980
    Date of Patent: June 16, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Nathaniel Grier, Richard A. Dybas, Bruce E. Witzel
  • Process for preparing methylvanillyl ketone from isoeugenol
    Patent number: 4273943
    Abstract: Methylvanillyl ketone is prepared from a "through process" involving oxidation of isoeugenol followed by subsequent acidic hydrolysis.
    Type: Grant
    Filed: September 28, 1979
    Date of Patent: June 16, 1981
    Assignee: Merck & Co., Inc.
    Inventors: George Gal, Seemon H. Pines
  • Method of treating inflammation employing acyl cyanoguanidines
    Patent number: 4265905
    Abstract: Certain novel acyl cyanoguanidines, their preparation, pharmaceutical compositions and novel methods of treating inflammation and autoimmune diseases such as rheumatoid arthritis are disclosed.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: May 5, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Tsung-Ying Shen, Howard Jones
  • Meningitis vaccine
    Patent number: 4264764
    Abstract: A high molecular weight capsular polysaccharide from H. influenza type b is an effective immunogenic agent against infection caused by the H. influenza type b bacterium.
    Type: Grant
    Filed: September 24, 1979
    Date of Patent: April 28, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Peter J. Kniskern, Arpi Hagopian, Dennis J. Carlo
  • Dehydroabietylammonium salts of 6-oxo-2-piperidinecarboxylic acid
    Patent number: 4254261
    Abstract: 6-Oxo-2-piperidinecarboxylic acid has been resolved via direct crystallization of pure S-6-oxo-2-piperidinecarboxylic acid dehydroabietylammonium salt from a solvent system consisting of dimethylformamide, cyclohexane and acetone. The S-enantiomer is a required component for making certain tripeptides related to thyrotropin releasing hormone (TRH) which are central nervous system stimulants.
    Type: Grant
    Filed: October 15, 1979
    Date of Patent: March 3, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Stewart M. Miller, John L. Smith
  • Method of obtaining an antigenic fraction from Bordetella bronchiseptica
    Patent number: 4250265
    Abstract: A sub-cellular antigenic fraction of Bordetella bronchiseptica protects against the incidence and severity of swine atropic rhinitis.
    Type: Grant
    Filed: October 15, 1979
    Date of Patent: February 10, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Dennis J. Carlo, Arpi Hagopian, Peter J. Kniskern
  • High molecular weight meningococcal group C vaccine and method for preparation thereof
    Patent number: 4235994
    Abstract: A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The polysaccharide was isolated from Group C hexadecyl trimethylammonium bromide cell paste with 1.0M CaCl.sub.2 extraction and purified by phenol extraction, ultracentrifugation at 100,000 g. and ethanol fractionation (30%-45% v/v in ethanol).
    Type: Grant
    Filed: June 26, 1978
    Date of Patent: November 25, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Thomas H. Stoudt, Dennis J. Carlo, Arpi Hagopian
  • 1,1-Di(4-hydroxy-3-methoxyphenyl)-2-alkoxypropane
    Patent number: 4230893
    Abstract: 4-Hydroxy-3-methoxyphenylacetone, an intermediate for methyldopa, has been prepared from reacting two moles of guaiacol and one mole of a 2-alkoxy propanol followed by basic elimination to form the enol ether of 4-hydroxy-3-methoxy phenyl acetone. The enol ether is subsequently converted to 4-hydroxy-3-methoxy phenyl acetone upon treatment with a strong acid.
    Type: Grant
    Filed: September 13, 1979
    Date of Patent: October 28, 1980
    Assignee: Merck & Co., Inc.
    Inventor: George Gal
  • E. coli enterotoxin vaccine for veterinary and human use
    Patent number: 4220584
    Abstract: A vaccine against E. coli caused diarrhea is prepared from an isolate of the homogeneous heat-labile enterotoxin of human strain MB3353 of Escherichia coli, ATCC 31361, or of the porcine strain MB3708, ATCC 31362. The toxin, which is a protein, is a low molecular weight species of 10,000-13,000.
    Type: Grant
    Filed: January 30, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Guadalupe A. Limjuco, Yashwant D. Karkhanis, Dennis J. Carlo
  • Antigenic complex from N. Gonorrhoeae
    Patent number: 4220638
    Abstract: An antigenic, immunogenic, non-toxic complex is obtained from the cell surface of N. gonorrhoeae.
    Type: Grant
    Filed: October 12, 1978
    Date of Patent: September 2, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Yashwant D. Karkhanis, Dennis J. Carlo
  • Swine atropic rhinitis vaccine
    Patent number: 4203970
    Abstract: A sub-cellular antigenic fraction of Bordetella bronchiseptica protects against the incidence and severity of swine atropic rhinitis.
    Type: Grant
    Filed: March 5, 1979
    Date of Patent: May 20, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Dennis J. Carlo, Arpi Hagopian, Peter J. Kniskern