Abstract: Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.

Abstract: The present invention provides methods for detecting the presence of methylation at a locus within a population of nucleic acids.

Abstract: In pre-cast slab gel cassettes, the formation of pathways in which proteins can migrate between the gel and the walls of the cassette to form shadow bands is avoided by the application of a coating of a nonionic amphiphilic polymer to the cassette walls. The coating also prevents the gel from sticking to the walls when the gel is to be removed from the cassette after electrophoresis.

Abstract: The present invention is directed to novel apoptosis polypeptides such as the Apop1, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided here are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.

Abstract: A quick clamping device includes a main body adapted to be mounted on a mold holder, a clamp piece including first and second arm sections and pivoted to the main body between the first and second arm sections, a wedge body mounted movably on the main body below the second arm section, and a driving unit connected to the wedge body. The first arm section has a press end adapted to clamp a mold unit against the mold holder. The wedge body is movable between a first position, in which the wedge body lifts the second arm section so as to move downward the press end toward the mold unit, and a second position, in which the wedge body moves away from the first position.

Abstract: An anti-counterfeit method and system by using a nano metal grating, wherein an object to be recognized is formed with the nano metal grating. During the recognition process, an incidental light is applied on the metal grating. In response to the incidental light, the metal grating has its specific optical incidence and reflection characteristics. The object is then identified whether it is genuine or fake by observing the refraction light passing through and reflection light reflected from the metal grating. Further, the incident light beam can be polarized to generate polarized light beams and then irradiated on the metal grating, whereafter the recognition of the object is performed by observing the reflection and refraction lights of the irradiated polarized light beam. The recognition further can be accomplished by rotating the metal grating, thus the intensity of the refraction and reflection lights will accordingly be changed, thereby identifying the object.

Abstract: The invention relates to a screw-driving tool for implant screws having an elongate handle (2) and having a bar-shaped tool which is anchored in the elongate handle (2). An elastic, hollow spiral (10) is provided for the transmission of a predetermined torque, with a bar (3) being guided through the spiral (10) and being fixedly connected to the rotatable side of the spiral and indicating a rotational angle or a torque respectively at the opposite side.

Abstract: Within a process for recycling of PET-material and/or objects of PET, the PET-material to be processed is heated and dried in the course of a pre-treatment step and simultaneously is crystallized at elevated temperature. This pre-treatment step is followed by a main-treatment step under vacuum. In this main-treatment step, the processed material is again dried and crystallized at a temperature that is higher than the temperature of the pre-treatment step. Preferably, also in the main-treatment step no plasticizing of the material takes place; the plasticizing or, respectively, melting of the material takes place only after the main-processing step. An apparatus for performing this process comprises a pre-processing device (3) in which the processed material is dried and simultaneously crystallized at elevated temperature, and, if desired, is also comminuted.

Abstract: A purified thermostable enzyme is derived from the thermophilic archaebacterium Archaeoglobus fulgidus. The enzyme can be native or recombinant, is stable under PCR conditions and exhibits double strand specific exonuclease activity. It is a 3?–5? exonuclease and cleaves to produce 5?-mononucleotides. Thermostable exonucleases are useful in many recombinant DNA techniques, in combination with a thermostable DNA polymerase like Tag especially for nucleic acid amplification by the polymerase chain reaction (PCR).

Abstract: Compositions comprising biologically pure Pfs230 and nucleic acids which encode them are provided. The proteins can be used induce transmission blocking immune responses in susceptible hosts.

Abstract: This invention provides compositions and methods for the elimination of T cells that recognize specific preselected targets. The methods involve providing killer cells (e.g. natural killer cells or cytotoxic T lymphocytes) having a T cell receptor in which the zeta chain is joined to the antigen target of the T cell population it is desired to eliminate. Recognition of the antigen target activates the killer cell thereby inhibiting or destroying the T cell. Where the antigen target is the extracellular domain of a major histocompatibility complex, the method provides a means of mitigating graft rejection or an autoimmune response.

Abstract: The invention provides tissue specific promoters from potato UDP-glucose pyrophosphorylase (UGPase) genes. The promoters are useful in production of transgenic plants.

Abstract: A multi-octave ferrite oscillator topology that utilizes transformer coupling to provide the proper phase shift in the feedback loop. In a specific embodiment, a 10 mil YIG sphere is loosely coupled to 20 mil input and output loops, both of which are connected to a GaAs integrated circuit that includes a Darlington pair of bipolar transistors. The Darlington pair provides high gain, high output power, and low parasitic reactance up to about 10 GHz. A resistor bridge across the base of the input transistor of the Darlington pair insures a substantially real input impedance over a wide bandwidth.