Patents Represented by Attorney Walter H. Schneider

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  • Platinum complexes containing chemically modified bile acids, having antitumor activity
    Patent number: 7348320
    Abstract: The present invention relates to platinum complexes containing bile acid derivatives having antitumor activity
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: March 25, 2008
    Assignee: ICE s.r.l.
    Inventors: Enzo Bartoli, Beniamino Palmieri, Alessandro Medici
  • Platinum complexes having antitumor activity
    Patent number: 7205287
    Abstract: A platinum complex having antitumor activity in which the metal ligands are dehydrocholic acid and phosphine.
    Type: Grant
    Filed: October 22, 2004
    Date of Patent: April 17, 2007
    Assignee: ICE s.r.l.
    Inventors: Enzo Bartoli, Beniamino Palmieri, Alessandro Medici
  • Process for the preparation of fibrates
    Patent number: 6897333
    Abstract: A process for the preparation of fibrates of formula I in which R1 is a halogen atom, a 2,2-dichloro-cyclopropyl group, a (4-chlorophenyul)-hydroxymethyl group, a-4-chlorobenzoyl group or a 2-(4-chlorobenzamido)-ethyl group, and R2 is hydrogen or a C1-C4 alkyl group.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: May 24, 2005
    Assignee: Solchem Italiana S.p.A.
    Inventor: Giuseppe Guazzi
  • Cross-linked hyaluronic acids and medical uses thereof
    Patent number: 6831172
    Abstract: Cross-linked hyaluronic acids produced by the reaction of the carboxylic acid groups of hyaluronic acid and a polyamine and the sulfated and hemisuccinylated derivates thereof. The cross-linked hyaluronic acids are useful for various pharmaceutical and medical purposes.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: December 14, 2004
    Assignee: Farmila-Thea Farmaceutici S.p.A.
    Inventors: Rolando Barbucci, Roberto Rappuoli
  • Process for the preparation of gabapentin free from inorganic acids anions
    Patent number: 6790986
    Abstract: Gabapentin free from mineral acids anions is obtained by precipitating from a gabapentin aqueous solution a corresponding hydroxybenzoate, from which pure gabapentin is subsequently obtained by dissolution in a lower alcohol and treatment with a tertiary base.
    Type: Grant
    Filed: May 27, 2003
    Date of Patent: September 14, 2004
    Assignee: Farchemia S.r.l.
    Inventors: Gabriele Breviglieri, Sergio Contrini, Cinzia Assanelli
  • Cross-linking process of carboxylated polysaccharides
    Patent number: 6734298
    Abstract: A process for the preparation of cross-linked polysaccharides containg carboxy groups. The process comprises a first step of activating the carboxy groups in an anhydrous aprotic solvent and then reacting with a polyamine. The cross-linked polysaccharide may be subjected to sulfonation of the five hydroxy groups.
    Type: Grant
    Filed: June 18, 2001
    Date of Patent: May 11, 2004
    Assignee: Farmila-Thea Faraceutici S.p.A.
    Inventors: Rolando Barbucci, Giancarlo Sportoletti
  • 3-substituted 5-aryl-4-isoxazolecarbonitriles having antiviral activity
    Patent number: 6414004
    Abstract: 3-Substituted-5-Aryl-4-Isoxazolecarboritriles having anti-viral activity.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: July 2, 2002
    Assignee: Universita' Degli Studi di Catania
    Inventors: Ernesto Geremia, Gianna Tempera, Angelo Castro, Adriana Garozzo, Francesco Guerrera, Rossella Maria Campagna
  • 5-CYANO-10-HYDROXY-10,11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE, THE PROCESSES FOR ITS PREPARATION AND FOR ITS CONVERSION INTO 5-CARBAMOYL-10-OXO-10, 11-DIHYDRO-5H-DIBENZ[B,F]AZEPINE OR INTO 5-CARBAMOYL-5H-DIBENZ[B,F]AZEPINE
    Patent number: 6384217
    Abstract: 5-Cyano-10-Hydroxy-10,11-Dihydro-5H-Dibenzi[b,f]azepine and the process for its preparation.
    Type: Grant
    Filed: February 17, 2001
    Date of Patent: May 7, 2002
    Assignee: Farchemia S.R.L.
    Inventors: Citterio Attilio, Breviglieri Gabriele, Giacomo Bruno
  • Oligopeptides derived from C-reactive protein fragments
    Patent number: 6342481
    Abstract: The present invention relates to oligopeptide derived from fragments of the C-reactive protein (CRP), and to their use in the therapy of cardiovascular and inflammatory diseases.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: January 29, 2002
    Assignee: Italfarmaco S.p.A.
    Inventors: Flavio Leoni, Silvio Agozzino, Paolo Mascagni
  • Lactobacilli strains having inhibitory and/or microbicidal activity against pathogenic microorganisms and a method for inducing and keeping said activity in lactobacilli cultures
    Patent number: 6342366
    Abstract: A method for the treatment of lactobacilli cultures is disclosed, characterized in that said cultures are added with an aliquot of culture supernatant of pathogenic microorganisms, or with the same pathogenic microorganisms optionally suitably inactivated. In particular, Lactobacillus gasseri BCCM LMG P-18137, Lactobacillus gasseri BCCM LMG P-17632 and Lactobacillus crispatus BCCM LMG P-17631.
    Type: Grant
    Filed: April 3, 1999
    Date of Patent: January 29, 2002
    Assignee: Proge Farm S.r.L.
    Inventors: Giancarla Dondi, Lorenzo Morelli
  • Oligopeptides derived from C-reactive protein fragments
    Patent number: 6057295
    Abstract: Oligopeptides derived from fragments of C-reactive proteins and their use as immunomodulating agents in the therapy of cardiovascular and inflammatory diseases.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: May 2, 2000
    Assignee: Italfarmaco S.p.A.
    Inventors: Patrizia Caretto, Flavio Leoni, Fabrizio Marcucci, Gianni Gromo, Paolo Mascagni, Massimo Pinori, Silvana Cappelletti
  • Acyclovir dihydrate sodium salt and the preparation thereof
    Patent number: 6040445
    Abstract: 9-[(2-Hydroxyethoxy)methyl]guanine (acyclovir) dihydrate sodium salt and the process for the preparation thereof comprising the dissolution of acyclovir monosodium salt in an aqueous medium and the precipitation of the resultant dihydrate sodium salt in an organic solvent.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: March 21, 2000
    Assignee: Solchem Italiana S.p.A.
    Inventor: Giuseppe Guazzi
  • Dimethylamine benzoate or p-anisate catalysed process for the preparation of 4-(nitrophenyl)-dihydropyridines
    Patent number: 6015906
    Abstract: A method for the preparation of 4-(nitrophenyl)-dihydro-pyridines by reacting a benzaldehyde with an acetoacetate and reacting the resulting benzylidene derivative with an enamine derivative. Both reactions are catalyzed by dimethylamine benzoate or p-anisate.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: January 18, 2000
    Assignee: Lusochimica S.p.A.
    Inventors: Bruno Perego, Elso Manghisi
  • Process for the preparation of 4-(6'-methoxy-2'-naphthyl) butan-2-one
    Patent number: 5955635
    Abstract: An improved process for the preparation of Nabumetone, which comprises the following steps:a) condensation between 6-methoxy-naphthaldehyde I and t-butyl acetoacetate II, to give 3-t-butoxycarbonyl-4-(6'-methoxy-2'-naphthyl)-but-3-en-2-one III as an E/Z mixture;b) hydrogenation of III in the presence of a palladium catalyst, to give 3-t-butoxycarbonyl-4-(6'-methoxy-2-naphthyl)-butan-2-one IV;c) cleavage of the t-butyl ester by acid catalysis; andd) recrystallization of the crude with methanol.
    Type: Grant
    Filed: April 24, 1998
    Date of Patent: September 21, 1999
    Assignee: Secifarma S.P.A.
    Inventors: Walter Cabri, Domenico Magrone, Roberto Angelini, Erminio Oldani
  • Salts of omega-3-polyunsaturated fatty acids and pharmaceutical formulations containing them
    Patent number: 5869714
    Abstract: Salts of formula RCOOR'R".sub.2 N.sup.+ (CH.sub.2).sub.n OH wherein R represents the alkenyl radical of a C.sub.20 -C.sub.22 omega-3-polyunsaturated acid; R' represents a hydrogen atom or a C.sub.1 -C.sub.2 alkyl radical; R" represents R', as above defined, or (CH.sub.2).sub.n OH hydroxyalkyl radical where n is 2 or 3; and their use as cardiovascular agents.
    Type: Grant
    Filed: June 11, 1997
    Date of Patent: February 9, 1999
    Assignee: Prospa B.V.
    Inventor: Tiberio Bruzzese
  • Peptides endowed with antiinflammatory activity
    Patent number: 5856305
    Abstract: Peptides endowed with antiinflammatory activity consisting of 25 aminoacids having a sequence with an homology of at least 25% with the 1-25 fragment of the 10 Kda heat shock protein from Mycobacterium tuberculosis.
    Type: Grant
    Filed: July 17, 1997
    Date of Patent: January 5, 1999
    Assignee: Italfarmaco S.P.A.
    Inventors: Pierluigi Lucietto, Paola Giuliani, Gianluca Fossati, Paolo Mascagni, Gianni Gromo
  • Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity
    Patent number: 5827881
    Abstract: Diesters of carbonic acid disubstituted with primary, secondary or tertiary amine groups, pharmaceutically acceptable salts thereof, and their use as antiviral and inti-inflammatory agents.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: October 27, 1998
    Assignee: Italfarmaco S.P.A.
    Inventors: Alberto Sala, Giorgio Bertolini, Gianfranco Pavich, Fabrizio Marcucci, Gianni Gromo, Giuliana Porro
  • Pyrimidinone derivatives fused to nitrogen heterocycles having a II antagonistic activity
    Patent number: 5804583
    Abstract: Derivatives of bicyclic heterocycles comprising a pyrimidone ring fused to another 5, 6, or 7 membered nitrogen heterocycle which is C-substituted, through a methylene bridge, by a biphenyl group.
    Type: Grant
    Filed: December 18, 1996
    Date of Patent: September 8, 1998
    Assignee: Istituto Luso Farmaco D'Italia
    Inventors: Aldo Salimbeni, Davide Poma, Anna Renzetti, Carlo Scolastico
  • Process for the resolution of 6-methoxy-alpha-methyl-2-naphthaleneacetic racemic acid into its enantiomers
    Patent number: 5760287
    Abstract: Naproxene ((+)-6-methoxy-.alpha.-methyl-2-naphthaleneacetic acid) is recovered from the corresponding racemic acid by treatment of the latter with N-substituted R-(-)-2-amino-1-butanols and recovery of the resulting diastereomeric salt.
    Type: Grant
    Filed: April 16, 1996
    Date of Patent: June 2, 1998
    Assignee: Farchemia S.R.L.
    Inventors: Pierre Loosen, Gabriele Breviglieri, Bruno Giagomo, Sergio Contrini, Cineia Assanelli
  • Salts of a polyunsaturated fatty acid and pharmaceutical formulations containing them
    Patent number: 5750572
    Abstract: 4,7,10,13,16,19-cis-Docosahexaenoic acid (DHA) salts with basic amino acids, in particular arginine and lysine, have favorable therapeutic and technological characteristics compared with the acid.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: May 12, 1998
    Assignee: Prospa B.V.
    Inventor: Tiberio Bruzzese