Patents Represented by Attorney Walter Patton

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  • Spiro-pyridazines and analogs thereof useful as aldose reductase inhibitors
    Patent number: 5081241
    Abstract: This invention relates to spiro-pyridazines, to processes for their preparation, to methods for using the compounds, and to pharmaceutical prepartions thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.
    Type: Grant
    Filed: October 11, 1990
    Date of Patent: January 14, 1992
    Assignee: American Home Products Corporation
    Inventor: Michael S. Malamas
  • Imidazo(4,5-C)pyridines as antiosteoporotic agents
    Patent number: 5081253
    Abstract: This invention relates to 2-substituted-imidazo[4,5-c]pyridines, to the process for their preparation, to pharmaceutical compositions containing said 2-substituted-imidazo[4,5-c]pyridines and to the use of said 2-substituted-imidazo[4,5-c]pyridines for modifying the balance between bone production and bone resorption in a host animal, including man.
    Type: Grant
    Filed: July 24, 1990
    Date of Patent: January 14, 1992
    Assignee: American Home Products Corporation
    Inventors: Arthur A. Santilli, Anthony C. Scotese, Donald P. Strike
  • Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones useful as aldose reductase inhibitors
    Patent number: 5068332
    Abstract: This invention relates to alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones, represented by formula (I): ##STR1## to processes for the preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.
    Type: Grant
    Filed: October 11, 1990
    Date of Patent: November 26, 1991
    Assignee: American Home Products Corporation
    Inventor: Michael S. Malamas
  • Rapamycin in treatment of tumors
    Patent number: 5066493
    Abstract: Methods of using rapamycin in the treatment of cancers or tumors are disclosed.
    Type: Grant
    Filed: April 9, 1991
    Date of Patent: November 19, 1991
    Assignee: American Home Products Corporation
    Inventors: Surendra N. Sehgal, Claude Vezina
  • Preparation of 2,3,4,9-tetrahydro-1H-carbazole acetic acid derivatives
    Patent number: 5055590
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful anti-inflammatory agents.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: October 8, 1991
    Assignee: American Home Products Corporation
    Inventor: Dominick Mobilio
  • 4-substituted-3-1H-imidazol-1-,2,5-thiadiazoles as antiarrhythmic agents
    Patent number: 5051420
    Abstract: Invention compounds of the formula: ##STR1## wherein Z is ##STR2## are novel. Compounds of the above formula have shown antiarrhythmic activity in an electrophysiological assay.
    Type: Grant
    Filed: March 4, 1991
    Date of Patent: September 24, 1991
    Assignee: A. H. Robins Company, Incorporated
    Inventors: Mark R. Hellberg, James R. Shanklin, Jr.
  • Process for preparing benzopyran derivatives
    Patent number: 5047552
    Abstract: Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
    Type: Grant
    Filed: February 7, 1990
    Date of Patent: September 10, 1991
    Assignee: American Home Products Corporation
    Inventors: Dominick A. Quagliato, Leslie G. Humber
  • N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors
    Patent number: 5045544
    Abstract: This invention relates to N'-alkyl-spiro-isoquinoline-pyrrolidine tetrones and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical perparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes melitus associated complications.
    Type: Grant
    Filed: May 21, 1990
    Date of Patent: September 3, 1991
    Assignee: American Home Products Corporation
    Inventor: Michael S. Malamas
  • Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
    Patent number: 5037831
    Abstract: This invention relates to spiro-isoquinoline-pyrrolidines and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.
    Type: Grant
    Filed: May 21, 1990
    Date of Patent: August 6, 1991
    Assignee: American Home Products Corporation
    Inventor: Michael S. Malamas
  • Inhibition of bone loss by 4-substituted-5-hydroxy-2(5H)-furanones
    Patent number: 5026725
    Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: June 25, 1991
    Assignee: American Home Products Corporation
    Inventors: Marshall A. Hayward, Joseph P. Sabatucci, Ivo L. Jirkovsky, Yvon Lefebvre
  • Antihypertensive benzopyran compounds
    Patent number: 5021418
    Abstract: Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
    Type: Grant
    Filed: September 11, 1990
    Date of Patent: June 4, 1991
    Assignee: American Home Products Corporation
    Inventors: Dominick A. Quagliato, David D. Deininger
  • 4-azatricyclo[4.3.1.1(3,8)]undecylarylpiperazines with anxiolytic activity
    Patent number: 5021569
    Abstract: 4-Azatricyclo[4.3.1.1(3,8)]undecylarylpiperazine compounds of this invention demonstrated affinity for the 5-hydroxytryptamine-1A receptor site (5-HT.sub.1A) and to a lesser extent, for dopamine-2 receptor sites (D.sub.2). Compounds with such a profile provide a treatment for CNS disorders such as anxiety, depression, and sexual disturbances without EPS liability.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: June 4, 1991
    Assignee: American Home Products Corporation
    Inventors: William A. Kinney, Nancy E. Lee
  • Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity
    Patent number: 5010078
    Abstract: There are disclosed compounds of the formula (I) ##STR1## wherein R.sup.1 is 1-adamantyl, 3-methyl-1-adamantyl, 3-noradamantyl, unsubstituted or substituted-2-indolyl, 3-indolyl, 2-benzofuranyl and 3-benzofuranyl wherein the substituents are selected from lower alkyl, lower alkoxy and halo; R.sup.2 is unsubstituted or substituted phenyl, benzyl, pyridinyl, pyrimidinyl or pyrazinyl, wherein the substituents are selected from lower alkyl, lower alkoxy, trifluoromethyl and halo; R.sup.3 is H or lower alkyl of 1 to 3 carbon atoms; n is the integer 0 or 1; m is the integer from 2 to 5; and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: March 14, 1990
    Date of Patent: April 23, 1991
    Assignee: American Home Products Corporation
    Inventors: Magid A. Abou-Gharbia, John P. Yardley, Wayne E. Childers, Jr.
  • Production of certain 2-phenylalkylthio-and 2-phenylalkylsulfinyl imidazo[4,]pyridines
    Patent number: 5001238
    Abstract: This invention relates to the process for the preparation of certain 2-phenylalkylthio- and phenylalkylsulfinyl-imidazo[4,5-c]pyridines useful for the treatment of osteoporosis.
    Type: Grant
    Filed: June 19, 1990
    Date of Patent: March 19, 1991
    Assignee: American Home Products Corporation
    Inventors: Chia-Cheng Shaw, Razzak Noureldin, Gregory Gavin
  • Aryloxypropane substituted piperazine derivatives with antiarrhythmic and antifibrillatory activity
    Patent number: 4994459
    Abstract: This invention relates to certain substituted piperazines possessing anti-arrhythmic activity, to pharmaceutical compositions and to methods for production thereof.
    Type: Grant
    Filed: December 11, 1989
    Date of Patent: February 19, 1991
    Assignee: American Home Products Corporation
    Inventors: John A. Butera, Jehan F. Bagli
  • N-[[6 -methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxomethyl]-N-methylglycin e S-oxide and the amide thereof
    Patent number: 4994381
    Abstract: Disclosed herein are N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]-thioxmethyl]-N-methylgly cine S-oxide (tolrestat S-oxide) and the amine thereof and methods of their preparation. The S-oxides are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: February 19, 1991
    Assignee: American Home Products Corporation
    Inventors: Eckhardt S. Ferdinandi, Michael S. Malamas, Kazimir Sestanj, Surendra N. Sehgal
  • Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, composition and use
    Patent number: 4988726
    Abstract: Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives and methods for their preparation and use are disclosed. The compounds are useful analgesic, anti-inflammatory, anti-asthmatic and anti-allergic agents.
    Type: Grant
    Filed: September 29, 1989
    Date of Patent: January 29, 1991
    Assignee: American Home Products Corporation
    Inventor: Dominick Mobilio
  • Isoquinoline acetic acids and acetyl carbamates useful as aldose reductase inhibitors
    Patent number: 4983613
    Abstract: This invention relates to isoquinoline acetic acids and acetyl carbamates and their pharmaceutically acceptable salts thereof, to processes for their preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the treatment of diabetes mellitus and associated conditions.
    Type: Grant
    Filed: April 21, 1989
    Date of Patent: January 8, 1991
    Assignee: American Home Products Corporation
    Inventor: Michael S. Malamas
  • Antihypertensive benzopyran derivatives
    Patent number: 4983612
    Abstract: Disclosed herein are novel benzopyrans having pharmacological activity, to a process for preparing them, to pharmaceutical compositions containing them, and to their use in the treatment of hypertension.
    Type: Grant
    Filed: October 5, 1989
    Date of Patent: January 8, 1991
    Assignee: American Home Products Corporation
    Inventors: Dominick Quagliato, David D. Deininger
  • Substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
    Patent number: 4971960
    Abstract: Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1 and 4. The nucleus may be optionally substituted at positions 5, 6, 7 and 8. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.
    Type: Grant
    Filed: February 14, 1989
    Date of Patent: November 20, 1990
    Assignee: American Home Products Corporation
    Inventors: Alan H. Katz, Christopher A. Demerson, Leslie G. Humber