Abstract: A method for the non-invasive, continuous collection of substances which transdermally migrate to and vaporize at the surface of the skin of a subject comprises providing a binding reservoir material juxtaposed at the surface of the skin of a subject, and continuously maintaining the binding reservoir material in a substantially airtight relation with the skin surface over an entire collection period. The apparatus comprises a binding reservoir material and means for continuously maintaining the binding reservoir material juxtaposed at the skin surface of the subject in a substantially airtight relation wiht the skin surface.

Abstract: A method provides peptides that are antigenic determinants identified by antibodies obtained using intact pathogenic agents that present a restricted set of antigens to surveillance by the immune system.

Abstract: An antimalarial composition contains as the active ingredient a mixture of chemical compound effective in reversing the resistance of cancer cells to chemotherapy drugs and at least one antimalarial agent. A method for treating malaria in mammals comprises administering a composition containing the active ingredient. A method for reducing the resistance of a malarial parasite to an antimalarial agent comprises administering a composition containing the active ingredient.

Abstract: Monoclonal antibodies which demonstrate specific reactivity to cholesterol and methods for the detection of high levels of cholesterol by contacting biological specimens containing cholesterol with the monoclonal antibodies and measuring the formation of antigen-antibody complexes by immunosorbent assay.

Abstract: A method for the specific detection of inositol and phosphatidylinositol within a model membrane such as liposomes or within a cellular system such as T lymphocytes.

Abstract: Amine-carboxyboranes (boron analogues of amino acids) which demonstrate sificant antitumor and antihyperlipidemic (cholesterol and /or triglyceride lowering) activities are disclosed.

Abstract: A highly improved elastomeric composition, process, and articles made thef, wherein the novel composition is characterized by greatly increased wear longevity, thermomechanical stability, highly improved tear and tensile strength at high temperature useage, in addition to high resistance to burning in open flame, as well as high resistance to cutting, chipping, cracking and crack propagation particularly in product use for tank track pads and other related track system elastomeric component products; wherein the improved composition is a unique combination of its respective polymer, filler, curing and antidegradant systems, in which the polymer system either consists of about 100 parts by weight of highly saturated nitrile polymer or of various novel blends of the highly saturated nitrile usually in majority amounts together with minority amounts of carboxylated nitrile, with or without additional minority or near equal parts of nitrile rubber; and wherein the curing system may include various blends of from

Abstract: A method of producing large scale growth of parasites of the genus Toxoplasma is disclosed which comprises inoculating the microorganisms into a non-adherent human cell line, such as a monocytoid lymphoma cell line, and maintaining the cell line in tissue culture media capable of supporting the growth of the microorgranism while the cell line is being maintained. This large scale production allows for the development of vaccines for Toxoplasma microorganisms which previously have been hard to grow in the numbers needed to readily prepare vaccines, and allows for more rapid antibody detection procedures with regard to these microorganisms. There are also disclosed methods for preparing such vaccines, and methods for carrying out antibody detection assays.

Abstract: A dermal substance collection device (DSCD) is described which provides ms for the non-invasive, instantaneous and continuous monitoring of chemical substances which are present in a detectable amount in either or both interstitial fluid or sweat or which are on or in the skin. The transdermal substance collection device of this invention is comprised of three essential components: (1) a substance binding reservoir, wettable by (2) a liquid transfer medium which allows for liquid bridge transfer of a soluble substance from the skin surface to the binding reservoir by virtue of its wettability by the liquid, and (3) an occlusive cover.

Abstract: This invention is directed to a method for inducing protection in an animal gainst poisoning resulting from exposure to toxic levels of cyanide comprising orally administering to said animal a therapeutically effective amount of a compound having the formula: ##STR1## wherein R represents ##STR2## R.sub.1 and R.sub.2 represent hydrogen, methyl or ethyl; R.sub.3 represent hydrogen, alkyl having 1 to 4 represents hydrogen, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; R.sub.4 represents hydrogen or alkyl having 1 to 4 carbon atom; R.sub.5 represents hydrogen, alkyl having 1 to 7 carbon atoms, alkoxy having 1 to 7 carbon atoms, phenyl phenoxy, or substituted phenyl or phenoxy groups having the formula ##STR3## R.sub.6 represents hydrogen, alkyl having 1 to 4 carbon atoms, or alkoxy having 1 to 4 carbon atoms; R.sub.7 represents hydrogen, methyl or ethyl; R.sub.8 and R.sub.

Abstract: This invention is directed to a fiber collection and storage device comprising in combination (1) a stable, transparent carrier base material preponderate on a surface thereof with a grid and label, the grid having uniquely identified areas wherein collected fibers are located and the label providing identification indicia, (2) an adhesive layer is disposed on the surface of the carrier base material, the adhesive layer being capable of collecting and recovering transferred-fibers from textile articles, and (3) a transparent and flexible cover for occlusively covering the adhesive layer and the method for using the device.

Abstract: This invention relates to novel dihydroartemisinin derivatives, including their pharmaceutically-acceptable salts, which are therapeutically-effective in the pre- and post-treatment of malarial infections.

Abstract: This invention relates to various compositions, comprising a 2-acetylprid thiosemicarbazone and a diol, which are useful in the treatment of viral infections.

Abstract: Solid propellant is first placed in a closed container with a solution of ter and detergent. A water slurry is then created by injecting compressed air in superheated steam into the solution to place the propellant and solution under several atmospheres of pressure and at the same time to raise the temperature of the solution to 400.degree.-600.degree. F. This results in oxidation of the propellant into such constituents as carbon dioxide, water, nitrous oxide and etc. These constituents are then removed by absorption.

Abstract: Disclosed is a liner-barrier system which is impermeable when cured to the igh concentrations of carboranyl burning rate accelerator which are incorporated into ultrahigh-burning rate propellants which are being developed for advanced interceptors. The liner-barrier composition, when uncured, comprises a polyvinyl butyral resin coblended with thermosetting resins, such as, phenolic, epoxy etc., that employs triphenylbismuthine as a quick cure catalyst, 4,5-epoxycyclohexylmethyl 4',5'-epoxycyclohexyl carboxylate and polyisocyanate as curative and crosslinking agents to further modify the liner-barrier formulation by reacting with the secondary hydroxyl groups. Further modification of the liner-barrier formulation is achieved by incorporation of aluminum powder to impart additional properties of impermeability. The uncured liner-barrier composition contains from 8.90 to about 10.21 weight percent solids in a solvent blend of isopropyl acetate and isopropyl alcohol which comprises from about 89.79 to about 91.

Abstract: A human monoclonal antibody produced by a self-reproducing carrier cell, the antibody being reactive with PRP capsular polysaccharide. Also disclosed is a process of preparing the antibody from the carrier cell, which is conveniently a hybridoma. Additionally, diagnostic, prophylactic and therapeutic compositions and methods employing the antibody are disclosed. Moreover, a laboratory reagent containing the antibody is described.

Abstract: This invention relates to various 2-acetyl- and 2-propionylpyridine thiosemicarbazones which are substituted on the 4-nitrogen atom. These compounds are useful in the treatment of gonorrhea and, in addition, many are useful either in the treatment of malaria or bacterial infection. Also disclosed are several synthetic procedures used to prepare the thiosemicarbazones.

Abstract: The embodiments of the invention provide mechanical and electrical appara for inexpensively and swiftly converting conventional firearms temporarily into marksmanship training devices. Illustratively, a number of different devices are shown for attaching marksmanship training and scoring apparatus to the weapon or weapon launcher and to enhance training realism without expending ammunition. Electrical circuits for improved marksmanship training and scoring also are shown and described.

Abstract: This invention relates to novel compositions, their preparation and the use thereof as anticholinergic agents in the treatment or prophylaxis of organophosphate or nerve gas poisoning in animals. These compositions and pharmaceutical preparations containing them in their free base form and acid addition salts thereof are represented by the formula ##STR1## wherein R represents lower alkyl groups containing 1 to 7 carbon atoms; R.sup.1 represents hydrogen, phenyl, cyclohexyl, and cyclopentyl; and R.sup.2 represents lower alkyl groups containing 1 to 7 carbon atoms, hydroxymethyl, and hydroxyl.