Patents Represented by Attorney William T. Ratner & Prestia Han
  • Patent number: 6165766
    Abstract: hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.
    Type: Grant
    Filed: July 22, 1999
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Caretha L. Creasy, Wei Xie
  • Patent number: 6166182
    Abstract: Human neurotensin type 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human neurotensin type 2 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: August 11, 1999
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Jon Bergsma, Usman Shabon
  • Patent number: 6165752
    Abstract: The HSSCRG1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HSSCRG1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: October 28, 1998
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham plc
    Inventor: David Malcolm Duckworth
  • Patent number: 6165771
    Abstract: The HE2NW40 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE2NW40 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: June 1, 1998
    Date of Patent: December 26, 2000
    Assignee: SmithKline Beecham, P.L.C.
    Inventors: Nicola Anne Burgess, Helen Elizabeth Clinkenbeard, Christopher Donald Southan
  • Patent number: 6162630
    Abstract: ASP1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ASP1 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimers's Disease, cancer, and melanoma, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: December 19, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: David J Powell, Christopher Southan, Conrad G Chapman, Joanne R Evans
  • Patent number: 6162899
    Abstract: HNEAA81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are screening methods for identifying agonists and antagonists of the interaction of the HNEAA81 receptor and its ligands in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: December 28, 1999
    Date of Patent: December 19, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Ganesh Madhusudan Sathe, Wendy S Halsey, Jon Chambers, Alison Muir, Philip Szekeres
  • Patent number: 6159716
    Abstract: hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.
    Type: Grant
    Filed: July 9, 1999
    Date of Patent: December 12, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Caretha L. Creasy, George P. Livi, Damien J. Dunnington, Usman Shabon
  • Patent number: 6159700
    Abstract: Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of ischemic coronary artery disease (angina and myocardial infarction); atherosclerosis; metabolic diseases (e.g. diabetes); CHF/myocardial dysfunction; arrhythmias; restenosis; hypertension; hypotension; pulmonary disease (hypertension, COPD, asthma); fibrotic vasculopathies (diabetes, SLE, AS, Reynaud's); cerebrovascular events (e.g. hemnorrhagic and ischemic stroke); neurogenic inflammation/migraine; hematopoictic disorders; ARDS; cancer; autoimmune diseases (e.g. HIV-1 and -2 infection and AIDS); gastrointestinal and genitourinary disturbances (e.g. ulcers) endocrine disorders; fibroproliferative disorders (e.g. psoriasis); inflammatory disease (e.g.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: December 12, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc, SB Laboratoires Pharmaceutiques
    Inventors: Nambi V Aiyar, Robert S Ames, Anne Romanic Arnold, Kamal Al-Barazanji, Derk J Bergsma, Jon Chambers, Stephen A Douglas, James J Foley, Bernard Gout, Nassirah Khandoudi, Henry M Sarau, Usman Shabon, Robert N Willette
  • Patent number: 6133006
    Abstract: HTLAR33 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTLAR33 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 20, 1998
    Date of Patent: October 17, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Derk Bergsma, Usman Shabon
  • Patent number: 6133420
    Abstract: Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: October 17, 2000
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Robert S. Ames, Jr., Henry M. Sarau, James J. Foley, Usman Shabon, Derk Bergsma, Jonathan K. Chambers
  • Patent number: 6121018
    Abstract: ICE-LAP-10 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ICE-LAP-10 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: February 12, 1998
    Date of Patent: September 19, 2000
    Assignee: SmithKline Beecham Corporation
    Inventor: Kristine Kay Kikly
  • Patent number: 6114515
    Abstract: PIGRL-1 polypeptide and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGRL-1 polypeptide and polynucleotides in the design of protocols for the treatment of Hyper-IgM Immunodeficiency (HIM), X-linked Severe Combined Immunodeficiency (XSCID), and IgA deficiency (IgA-D), among others and diagnostic assays for such conditions.
    Type: Grant
    Filed: October 30, 1997
    Date of Patent: September 5, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Shujian Wu, Raymond W. Sweet, Alemseged Truneh
  • Patent number: 6111076
    Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: August 29, 2000
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Shoji Fukusumi, Shuji Hinuma, Ryo Fujii
  • Patent number: 6100060
    Abstract: Wnt-5b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-5b polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: August 8, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Michael R Barnes, Tania Tamson Testa, David P Kelsell
  • Patent number: 6100062
    Abstract: The use of HSCLOCK polypeptides and polynucleotides in the design of protocols for the treatment of sleep disorders, jet lag, pathologies that occur in advanced age, among others, and diagnostic assays for such conditions. Also disclosed are methods for producing such polypeptides by recombinant techniques.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: August 8, 2000
    Assignee: SmithKline Beecham plc
    Inventors: David Malcolm Duckworth, David Michalovich
  • Patent number: 6096517
    Abstract: HNBC1A polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNBC1A polypeptides and polynucleotides in the design of protocols for the treatment of ischemia heart disease, arrhythmia, congestive heart disease, stroke and renal failure, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: August 19, 1998
    Date of Patent: August 1, 2000
    Assignees: SmithKline Beecham Laboratories, Pharmaceutiques and Yale University School of Medicine
    Inventors: Antoine Michel Alain Bril, Nassirah Khandoudi, Xavier Martin, Walter F Boron
  • Patent number: 6096868
    Abstract: ECR673 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ECR673 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: June 8, 1999
    Date of Patent: August 1, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Wendy S. Halsey, Joyce Yue Mao, Ganesh M. Sathe
  • Patent number: 6090583
    Abstract: HTEGU07 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTEGU07 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: July 18, 2000
    Assignee: SmithKline Beecham p.l.c.
    Inventors: Helen Elizabeth Clinkenbeard, Christopher Donald Southan, Nicola Anne Burgess
  • Patent number: 6090579
    Abstract: SDR2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SDR2 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammation, autoimmunity, allergy, asthma, rheumatoid arthritis, CNS inflamation, cerebellar degeneration, Alzheimer's disease, Parkinsons disease, multiple sclerosis, amylotrophic lateral sclerosis, head injury damage, and other neurological abnormalities, septic shock, sepsis, stroke, osteoporosis, osteoarthritis, ischemia reperfusion injury, cardiovascular disease, kidney disease, liver disease, ischemic injury, myocardial infarction, hypotension, hypertension, AIDS, myelodysplastic syndromes and other hematologic abnormalities, aplastic anemia, male pattern baldness, and bacterial, fungal, protozoan and viral infections, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: July 18, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Earl Francis Albone, Kristine Kay Kikly
  • Patent number: 6087169
    Abstract: HKABY60 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HKABY60 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammatory disorders, immune disorders and viral diseases, among others, and diagnostic assays for such conditions.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: July 11, 2000
    Assignee: SmithKline Beecham plc
    Inventor: David Michalovich