Patents Represented by Attorney William T. Ratner & Prestia Han
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Patent number: 6165766Abstract: hYAK3 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.Type: GrantFiled: July 22, 1999Date of Patent: December 26, 2000Assignee: SmithKline Beecham CorporationInventors: Caretha L. Creasy, Wei Xie
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Patent number: 6166182Abstract: Human neurotensin type 2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing human neurotensin type 2 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: August 11, 1999Date of Patent: December 26, 2000Assignee: SmithKline Beecham CorporationInventors: Derk Jon Bergsma, Usman Shabon
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Patent number: 6165752Abstract: The HSSCRG1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HSSCRG1 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: October 28, 1998Date of Patent: December 26, 2000Assignee: SmithKline Beecham plcInventor: David Malcolm Duckworth
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Patent number: 6165771Abstract: The HE2NW40 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HE2NW40 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: June 1, 1998Date of Patent: December 26, 2000Assignee: SmithKline Beecham, P.L.C.Inventors: Nicola Anne Burgess, Helen Elizabeth Clinkenbeard, Christopher Donald Southan
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Patent number: 6162630Abstract: ASP1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ASP1 polypeptides and polynucleotides in the design of protocols for the treatment of Alzheimers's Disease, cancer, and melanoma, among others, and diagnostic assays for such conditions.Type: GrantFiled: November 4, 1999Date of Patent: December 19, 2000Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: David J Powell, Christopher Southan, Conrad G Chapman, Joanne R Evans
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Patent number: 6162899Abstract: HNEAA81 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are screening methods for identifying agonists and antagonists of the interaction of the HNEAA81 receptor and its ligands in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: December 28, 1999Date of Patent: December 19, 2000Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Ganesh Madhusudan Sathe, Wendy S Halsey, Jon Chambers, Alison Muir, Philip Szekeres
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Patent number: 6159716Abstract: hYAK1 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed.Type: GrantFiled: July 9, 1999Date of Patent: December 12, 2000Assignee: SmithKline Beecham CorporationInventors: Caretha L. Creasy, George P. Livi, Damien J. Dunnington, Usman Shabon
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Patent number: 6159700Abstract: Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of ischemic coronary artery disease (angina and myocardial infarction); atherosclerosis; metabolic diseases (e.g. diabetes); CHF/myocardial dysfunction; arrhythmias; restenosis; hypertension; hypotension; pulmonary disease (hypertension, COPD, asthma); fibrotic vasculopathies (diabetes, SLE, AS, Reynaud's); cerebrovascular events (e.g. hemnorrhagic and ischemic stroke); neurogenic inflammation/migraine; hematopoictic disorders; ARDS; cancer; autoimmune diseases (e.g. HIV-1 and -2 infection and AIDS); gastrointestinal and genitourinary disturbances (e.g. ulcers) endocrine disorders; fibroproliferative disorders (e.g. psoriasis); inflammatory disease (e.g.Type: GrantFiled: January 15, 1999Date of Patent: December 12, 2000Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc, SB Laboratoires PharmaceutiquesInventors: Nambi V Aiyar, Robert S Ames, Anne Romanic Arnold, Kamal Al-Barazanji, Derk J Bergsma, Jon Chambers, Stephen A Douglas, James J Foley, Bernard Gout, Nassirah Khandoudi, Henry M Sarau, Usman Shabon, Robert N Willette
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Patent number: 6133006Abstract: HTLAR33 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTLAR33 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: February 20, 1998Date of Patent: October 17, 2000Assignee: SmithKline Beecham CorporationInventors: Derk Bergsma, Usman Shabon
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Patent number: 6133420Abstract: Human GPR14 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Human GPR14 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.Type: GrantFiled: April 10, 1998Date of Patent: October 17, 2000Assignees: SmithKline Beecham Corporation, SmithKline Beecham plcInventors: Robert S. Ames, Jr., Henry M. Sarau, James J. Foley, Usman Shabon, Derk Bergsma, Jonathan K. Chambers
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Patent number: 6121018Abstract: ICE-LAP-10 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ICE-LAP-10 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: February 12, 1998Date of Patent: September 19, 2000Assignee: SmithKline Beecham CorporationInventor: Kristine Kay Kikly
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Patent number: 6114515Abstract: PIGRL-1 polypeptide and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing PIGRL-1 polypeptide and polynucleotides in the design of protocols for the treatment of Hyper-IgM Immunodeficiency (HIM), X-linked Severe Combined Immunodeficiency (XSCID), and IgA deficiency (IgA-D), among others and diagnostic assays for such conditions.Type: GrantFiled: October 30, 1997Date of Patent: September 5, 2000Assignee: SmithKline Beecham CorporationInventors: Shujian Wu, Raymond W. Sweet, Alemseged Truneh
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Patent number: 6111076Abstract: Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.Type: GrantFiled: September 30, 1998Date of Patent: August 29, 2000Assignee: Takeda Chemical Industries, Ltd.Inventors: Shoji Fukusumi, Shuji Hinuma, Ryo Fujii
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Patent number: 6100060Abstract: Wnt-5b polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Wnt-5b polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: May 20, 1998Date of Patent: August 8, 2000Assignee: SmithKline Beecham p.l.c.Inventors: Michael R Barnes, Tania Tamson Testa, David P Kelsell
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Patent number: 6100062Abstract: The use of HSCLOCK polypeptides and polynucleotides in the design of protocols for the treatment of sleep disorders, jet lag, pathologies that occur in advanced age, among others, and diagnostic assays for such conditions. Also disclosed are methods for producing such polypeptides by recombinant techniques.Type: GrantFiled: June 30, 1998Date of Patent: August 8, 2000Assignee: SmithKline Beecham plcInventors: David Malcolm Duckworth, David Michalovich
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Patent number: 6096517Abstract: HNBC1A polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HNBC1A polypeptides and polynucleotides in the design of protocols for the treatment of ischemia heart disease, arrhythmia, congestive heart disease, stroke and renal failure, among others, and diagnostic assays for such conditions.Type: GrantFiled: August 19, 1998Date of Patent: August 1, 2000Assignees: SmithKline Beecham Laboratories, Pharmaceutiques and Yale University School of MedicineInventors: Antoine Michel Alain Bril, Nassirah Khandoudi, Xavier Martin, Walter F Boron
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Patent number: 6096868Abstract: ECR673 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ECR673 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: June 8, 1999Date of Patent: August 1, 2000Assignee: SmithKline Beecham CorporationInventors: Wendy S. Halsey, Joyce Yue Mao, Ganesh M. Sathe
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Patent number: 6090583Abstract: HTEGU07 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HTEGU07 polypeptides and polynucleotides in therapy, and diagnostic assays for such.Type: GrantFiled: May 20, 1998Date of Patent: July 18, 2000Assignee: SmithKline Beecham p.l.c.Inventors: Helen Elizabeth Clinkenbeard, Christopher Donald Southan, Nicola Anne Burgess
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Patent number: 6090579Abstract: SDR2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing SDR2 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammation, autoimmunity, allergy, asthma, rheumatoid arthritis, CNS inflamation, cerebellar degeneration, Alzheimer's disease, Parkinsons disease, multiple sclerosis, amylotrophic lateral sclerosis, head injury damage, and other neurological abnormalities, septic shock, sepsis, stroke, osteoporosis, osteoarthritis, ischemia reperfusion injury, cardiovascular disease, kidney disease, liver disease, ischemic injury, myocardial infarction, hypotension, hypertension, AIDS, myelodysplastic syndromes and other hematologic abnormalities, aplastic anemia, male pattern baldness, and bacterial, fungal, protozoan and viral infections, among others, and diagnostic assays for such conditions.Type: GrantFiled: December 16, 1997Date of Patent: July 18, 2000Assignee: SmithKline Beecham CorporationInventors: Earl Francis Albone, Kristine Kay Kikly
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Patent number: 6087169Abstract: HKABY60 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HKABY60 polypeptides and polynucleotides in the design of protocols for the treatment of cancer, inflammatory disorders, immune disorders and viral diseases, among others, and diagnostic assays for such conditions.Type: GrantFiled: July 29, 1998Date of Patent: July 11, 2000Assignee: SmithKline Beecham plcInventor: David Michalovich