Patents Assigned to 9 METERS BIOPHARMA, INC.
  • Compounds and methods for treating tight junction permeabtility
    Patent number: 11608359
    Abstract: The present invention provides Larazotide derivative compositions that resist protease degradation, and in various embodiments, do not demonstrate an inverse dose response, and/or can be delivered at higher doses without loss of potency or efficacy, thereby allowing improved therapy and more desirable dosing schedules.
    Type: Grant
    Filed: February 25, 2019
    Date of Patent: March 21, 2023
    Assignee: 9 Meters Biopharma, Inc.
    Inventors: Jay P. Madan, Balasingham Radhakrishnan, Sandeep Laumas, Christopher Prior
  • Treatment of cancer with larazotide derivatives in combination with immune checkpoint inhibitors
    Patent number: 11278587
    Abstract: The present invention provides compositions and methods for treating a patient having cancer, as well as methods for potentiating an immune checkpoint inhibitor therapy. The methods comprise administering larazotide or a derivative thereof such as (d)-larazotide to a subject in need, including subjects undergoing checkpoint inhibitor therapy, and subjects scheduled to undergo immune checkpoint inhibitor therapy.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: March 22, 2022
    Assignee: 9 METERS BIOPHARMA, INC.
    Inventors: Jay Madan, Sandeep Laumas
  • Compositions and methods for treating disease associated with permeability of intestinal epithelium
    Patent number: 11058902
    Abstract: The present invention provides methods for treating disorders associated with intestinal barrier dysfunction and increased intestinal permeability. The invention involves administering an effective amount larazotide or a larazotide derivative to a subject or a patient in need thereof.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: July 13, 2021
    Assignees: 9 METERS BIOPHARMA, INC., NORTH CAROLINA STATE UNIVERSITY
    Inventors: Jay P. Madan, Anthony Blikslager, Sandeep Laumas