Abstract: The invention provides systems and methods for purification of fluids such as water and air. The fluids are passed through a filter comprising chlorhexidine citrate (CXC), wherein either in the same filter or downstream from it a sorbing mixture of porous calcium phosphate, calcium carbonate and activated carbon is also provided. The invention enables rapid, economical fluid purification without byproducts. The materials can be regenerated for reuse, and the invention can be used for either high volume applications or disposable single-use applications.