Abstract: The present invention relates to an alcohol-free liquid pharmaceutical composition comprising thyme liquid extract and primula root liquid extract and a non-alcoholic solvent and optionally non-alcoholic excipients, preferably chosen from sucrose, invert sugar, water and mixtures thereof. The alcohol-free liquid pharmaceutical composition of present invention intends preferably to have a herbal fingerprint that is comparable to the Bronchicum Elixir alcohol-containing composition. The invention also discloses methods for preparing said alcohol-free liquid pharmaceutical composition. The invention relates also to thyme and primula root liquid extract that may be obtained according to one of the methods described and to the use of the said thyme and primula root liquid extract for the preparation of a pharmaceutical composition.
Type:
Application
Filed:
May 16, 2012
Publication date:
March 13, 2014
Applicant:
A NATTERMANN & CIE GMBH
Inventors:
Verena Hoffmann, Werner Holzstein, Joern Weissenfeld
Abstract: The present invention is directed to a drug for preventing or remedying Alzheimer's disease. The drug contains as the active ingredient 2-phenyl-1,2-benzisoselenazol-3(2H)-one (referred as compound (A)), whose effect is based on the action of reducing neuron toxicity induced by .beta.-amyloid protein.
Abstract: An aqueous liposome system which contains at least one phospholipid and selectively a non-toxic organic solvent. In addition to the at least one phospholipid the liposome system contains at least one phospholipidic charge carrier.
Type:
Grant
Filed:
May 20, 1996
Date of Patent:
April 21, 1998
Assignee:
A. Nattermann & Cie GmbH
Inventors:
Jorg Hager, Manfred Durr, Ernst Lunebach
Abstract: An aqueous liposome system which contains at least one phospholipid and selectively a non-toxic organic solvent. In addition to the at least one phospholipid the liposome system contains at least one phospholipidic charge carrier.
Type:
Grant
Filed:
January 11, 1995
Date of Patent:
September 17, 1996
Assignee:
A. Nattermann & Cie. GmbH
Inventors:
J org Hager, Manfred D urr, Ernst L unebach
Abstract: A process of producing phosphatidylcholine derivatives by the reaction of glycerophosphatidylcholine with at least one fatty acid anhydride in the presence of a pyridine catalyst is described. The reaction is carried out in a melt of the glycerophosphatidylcholine, the at least one fatty acid anhydride and the catalyst.
Abstract: The present invention is related to new parenteral preparations of 2-phenyl-1.2-benzisoselenazol-3(2H)-one (Ebselen) comprising additionally one or several phospholipids and, possibly, one or several auxiliary agents. The invention is further related to a process for producing such solutions and their use in the preparation of drug preparations ob Ebselen.
Type:
Grant
Filed:
July 31, 1991
Date of Patent:
February 22, 1994
Assignee:
A. Nattermann & CIE GmbH
Inventors:
Joerg Hager, Andrea M. Huether, Joachim Roeding
Abstract: A baking agent and a process for producing a baking agent for leavened doughs includes a phospholipid fraction whereby the portion of phosphatidyl choline to phophtidyl ethanolamine is lower than 1.
Type:
Grant
Filed:
August 8, 1991
Date of Patent:
February 2, 1993
Assignee:
A. Nattermann & Cie. GmbH Corporation of the Federal Republic of Germany
Abstract: A baking agent for breakfast-roll doughs includes a phospholopid fraction in which the portion of phosphatidyl choline to phosphatidyl ehtanolamine is greater than 1. A method for producing such a baking agent is also included.
Type:
Grant
Filed:
June 16, 1992
Date of Patent:
January 5, 1993
Assignees:
Vereinigte Kunstmuhlen AG, A. Nattermann & Cie. GmbH
Abstract: Anti-inflammatory benzylselanobenzamides made from anilines and benzylamines have the formula I ##STR1## are disclosed wherein R is hydrogen, methyl or ethyl;R.sup.1 and R.sup.2 are the same or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano, amino, dimethylamino or nitro; andR.sup.3 and R.sup.4 are the same or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano, or nitro and, taken together, represent methylenedioxy; andn is 0.1 or 2.
Abstract: The invention is related to the use of certain water-soluble compounds known as such and having the FormulaR.sup.1 --CO--NH--R.sup.2for the modulation of membrane dependent metabolism processes within living cells, in particular with relation to transport phenomena and cell procedures which are induced or influenced by active agents supplied from outside the cell, products containing these substances for the above described uses and processes using these products.
Abstract: A compound or a pharmaceutically acceptable salt thereof, having anti-inflammatory activity, is disclosed according to the Formula (I) ##STR1## wherein R is hydrogen, methyl or ethyl,R.sub.1 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group or is phenyl, chlorophenyl or fluorophenyl,R.sub.2 is a 2-pyridyl, 3-pyridyl or 4-pyridyl group,R.sub.3 and R.sub.4 are identical or different and, taken separately, are hydrogen, fluorine, chlorine, bromine, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.4 alkoxy, hydroxy, cyano or nitro or, taken together, are methylenedioxy, and n is 0 or 1.
Type:
Grant
Filed:
November 8, 1990
Date of Patent:
June 30, 1992
Assignee:
A. Nattermann & Cie. GmbH
Inventors:
Michel Evers, Michael Parnham, Axel Romer, Hartmut Fischer, Norbert Dereu
Abstract: The invention relates to a solid phospholipid composition with a high phosphatidylcholine content which, in addition to the corresponding phospholipids, contains Palatinit and if appropriate one or more other auxiliaries, and a process for its preparation and its use as an oral presentation form.
Abstract: A method of treating obstruction dermatoses, ulcus cruris, ulcus cruris venosum and decubital ulcers, is disclosed, which comprises topically treating an affected patient with a therapeutically effective amount of a pharmaceutical composition containing as active ingredient a therapeutically effective amount of 2',4',6'-trimethoxy-4-(1-pyrrolidinyl) butyrophenone or p-desmethyl-2', 4',6'-trimethoxy-4-(1-pyrrolidinyl) butyrophenone, or a pharmaceutically acceptable salt thereof.
Abstract: The invention is related to solid drug preparations of 2-phenyl-1,2-benzisoselenazol-3(2H)-one (EBSELEN) with high bioavailability comprising EBSELEN in the form of micronized crystals, and a method of manufacturing the same.
Abstract: A process for isolating a phosphatidylcholine from vegetable lipid mixtures wherein the lipid mixture is dissolved in a solvent mixture of a low boiling petroleum ether fraction (40.degree.-80.degree. C.), a lower C.sub.1 -C.sub.4 -alkanol and water, the solution is introduced into a column filled with silica gel at a temperature in the range of 20.degree. to 50.degree. C., the elution is carried out at that temperature with the same solvent mixture and the main run is collected and a pure phosphatidylcholine free of other phospholipids present in the starting vegetable lipid mixture is isolated therefrom in a usual manner.
Abstract: The present invention is related to new diselenobis benzoic acid amides of primary heterocyclic amines of the general formula I ##STR1## process for producing the same and process for treating certain diseases in human beings by administration of the same to the humans suffering from such diseases.
Type:
Grant
Filed:
August 6, 1987
Date of Patent:
March 20, 1990
Assignee:
Nattermann & CIE GmbH
Inventors:
Andre Welter, Axel Roemer, Sigurd Leyck, Michael J. Parnham
Abstract: Process and device for applying markings (9) and/or providing break notches on moulded items or tablets (4) by means of laser beams. The installation (16) which produces the laser beam (3) is arranged on a tablet-producing press, to which it is functionally connected by synchronization systems (18). A deflection system (17) is arranged on the die support (5) of the press in order to deflect the laser beam (3) onto the surface of the moulded item or tablet (4). The laser (16) is provided with an optical system (15) having interchangeable masks provided with openings through which the laser beam passes (3).
Abstract: Liquid phospholipid-containing products in an aqueous medium which contains 5-80% by weight of phospholipids and 3-10% by weight of one or more compounds of the general formulaRO--A--NR.sub.1 R.sub.2 R.sub.3their preparation and their use, for example as additives for improving plant treatment agents.
Type:
Grant
Filed:
March 11, 1987
Date of Patent:
October 17, 1989
Assignee:
A. Nattermann & Cie. GmbH
Inventors:
Hager, Jorg, Miklos Ghyczy, Vincent Feyen, Paul Imberge, Ulrich Brandenburg, Peter Wilperath