Patents Assigned to Abbott Laboratories
  • Patent number: 10398715
    Abstract: Disclosed are methods for enhancing learning and/or memory, enhancing memory acquisition, memory retention and recall by inducing a higher long-term potentiation in hippocampal neuronal synapsis in individuals. The methods include administration of 2-fucosyl-lactose to an individual.
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: September 3, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Enrique Vazquez Hernandez, Ricardo Rueda Cabrera, Rachael Buck, Maria Ramirez Gonzalez, Alejandro Barranco Perez
  • Patent number: 10393997
    Abstract: Methods, systems and devices for automatically focusing a microscope on a specimen and collecting a focused image of the specimen are provided. Aspects of the methods include detecting the presence of a substrate in a microscope, determining whether the substrate is in a correct orientation for imaging, focusing the microscope on a specimen that is placed on the substrate, and collecting one or more images of the specimen. Systems and devices for carrying out the subject methods are also provided.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: August 27, 2019
    Assignee: Abbott Laboratories
    Inventors: Trevor David Shields, Robert John Fahey, Damian John Verdnik, Svitlana Y. Berezhna, Mahmoud Janbakhsh, Koshy Thekkadathu Chacko
  • Patent number: 10395368
    Abstract: The present disclosure includes methods of assessing a histologically stained specimen based on a determined color signature of a region of interest of the specimen. Such assessments may be performed for a variety of purposes including but not limited to assessing the quality of the histological stain, as part of identifying one or more biologically relevant features of the image, as part of differentiating one feature of the image from other features of the image, identifying an anomalous area of the stained specimen, classifying cells of the specimen, etc. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: August 27, 2019
    Assignee: Abbott Laboratories
    Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Marilou L. Coleman, Walter G. Stonas, Willie J. Cowart, Wenjing Li, Ema C. Olah
  • Patent number: 10379130
    Abstract: A diagnostic analyzer includes a first sample process path, a second sample processing path, and a reaction vessel exchanger device. The first sample process path includes an incubation track operable to move reaction vessels along the first sample process path. The second sample process path includes a processing track, disposed below the first sample process path, which is operable to move reaction vessels along the second sample process path. The reaction vessel exchanger device is configured to transfer the reaction vessels from the first sample processing path to the second sample processing path.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: August 13, 2019
    Assignee: ABBOTT LABORATORIES
    Inventor: Robert Luoma
  • Patent number: 10369565
    Abstract: Example methods, apparatus, systems for diluting samples are disclosed. An example method includes depositing a first fluid droplet on a first electrode of a plurality of electrodes. The first electrode has a first area. The first fluid droplet has a first volume associated with the first area. The example method includes depositing a second fluid droplet on a second electrode of the plurality of electrodes. The second electrode has a second area. The second fluid droplet has a second volume associated with the second area. The second volume is different than the first volume. The example method includes forming a combined droplet by selectively activating at least one of the first electrode or the second electrode to cause one of the first fluid droplet or the second fluid droplet to merge with the other of the first fluid droplet or the second fluid droplet.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: August 6, 2019
    Assignee: Abbott Laboratories
    Inventor: Andrew Fischer
  • Patent number: 10369164
    Abstract: Disclosed are nutritional compositions including human milk oligosaccharides in combination with long chain polyunsaturated fatty acids and/or carotenoids that can be administered to preterm infants, term infants, toddlers, and children for reducing inflammation and the incidence of inflammatory diseases.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: August 6, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Rachael Buck, Geralyn O. Duska-McEwen, Joseph P. Schaller
  • Patent number: 10342244
    Abstract: Disclosed are infant formulas and corresponding methods of using them to promote retinal health and vision development in infants. The formulas, which are free of egg phospholipids and comprise fat, protein, carbohydrate, vitamins, and minerals, including docosahexaenoic acid and, on a ready-to-feed basis, at least about 50 mcg/liter of lutein, wherein the weight ratio of lutein (mcg) to docosahexaenoic acid (mg) is from about 1:2 to about 10:1. The formulas are also believed to be especially useful in reducing the risk of retinopathy of prematurity in preterm infants.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: July 9, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Bridget Barrett-Reis, Pamela T. Price, Amy Mackey
  • Patent number: 10345218
    Abstract: The present disclosure provides methods for automated slide assessments made in conjunction with digital image-based microscopy. Automated methods of acquiring patient information and specimen information from prepared slides, and digitally linking such information into patient-tagged specimen data, are provided. Also provided are methods that include automatically identifying an optimal area for morphological assessment of a blood smear on a hematological slide, including methods for triggering the analysis of such an area, e.g., using an automated digital image-based hematology system. The present disclosure also provides devices, systems and computer readable media for use in performing processes of the herein described methods.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: July 9, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Kam Lin Wong, Damian John Verdnik, Leigh Whiting, Mahmoud Janbakhsh
  • Patent number: 10345311
    Abstract: The present disclosure provides detection methods employing HCV core lipid binding domain and DNA binding domain monoclonal antibodies. In certain embodiments, the lipid binding domain monoclonal antibody recognizes an epitope in amino acids 141 to 161 of HCV core protein.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: July 9, 2019
    Assignee: Abbott Laboratories
    Inventors: Robert Ziemann, April Ahlberg, David Hawksworth, Bryan Tieman, A. Scott Muerhoff, Christopher Marohnic, Kathy Otis
  • Patent number: 10335791
    Abstract: Methods for detecting target analytes utilizing an array of wells are advantageous for detection of low concentrations of target analytes. Use of an array of wells requires sealing of the wells. The methods provided herein utilize digital microfluidics to seal wells of an array with a fluid that is immiscible with the aqueous liquid present in the wells to prevent evaporation and contamination of the aqueous fluid during analysis of signals from the wells. The disclosed method include generating a biphasic droplet composed of the immiscible fluid and an aqueous fluid. The immiscible fluid present in the biphasic droplet is moved over the array of wells to seal the wells by electrically actuating the aqueous fluid present in the biphasic droplet which in turn pulls the immiscible fluid.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: July 2, 2019
    Assignees: Abbott Laboratories, The Katholieke Universiteit Leuven
    Inventors: Mark A. Hayden, Karen Leirs, Elena PĂ©rez-Ruiz, Jeroen Lammertyn
  • Patent number: 10327760
    Abstract: In accordance with the present invention there is provided apparatuses and methods for using a medical instrument including a sizing and positioning adapter. The apparatus comprises an adapter for a medical instrument, the adapt having a body having a shim portion and an instrument holding portion adjacent the shim portion, wherein the shim portion provides an enlarged peripheral surface adjacent the medical instrument such that when the medical instrument is held in the instrument holding portion and the medical instrument and body are inserted through an opening in a patient tissue, at least a portion of the enlarged peripheral surface is in contact with at least a portion of the periphery of the opening in the patient tissue.
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: June 25, 2019
    Assignee: Abbott Laboratories
    Inventors: Laveille Kao Voss, Erik Kristian Walberg
  • Patent number: 10328049
    Abstract: This invention relates to a method of improving CNS maturation in an infant by administering a mixture of natural tocopherols, wherein the composition contains an optimum tocopherol profile similar to that found in human breast milk, and can encompass a tocopherol profile from early stage to transitional to mature human breast milk. For ease of administration and maximized efficacy, the optimized mixture of natural tocopherols are typically delivered in an oral dosage form with a limited level of non-RRR alpha-tocopherols to maximize efficacy of the RRR alpha-tocopherol on stimulating post-natal CNS development.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Chron-Si Lai, Matthew Kuchan, Gary Katz
  • Patent number: 10330691
    Abstract: A diagnostic analyzer includes a track, a light-blocking member, a motor, and an optical testing device. The track moves a reaction vessel held by the track. The light-blocking member is disposed adjacent to the track. The light-blocking member moves from a first position apart from the track to a second position closer to the track. When the light-blocking member is disposed in the first position a sample contained within the reaction vessel held by the track is exposed to light. When the light-blocking member is disposed in the second position the sample contained within the reaction vessel held by the track is blocked from exposure to the light. The motor moves the light-blocking member between the first and the second positions. The optical testing device is disposed adjacent to the track for optically testing the sample contained within the reaction vessel held by the track when the at least one light-blocking member is disposed in the second position.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: June 25, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Joseph P. Donohue, Ryan Patrick Johnson
  • Patent number: 10316353
    Abstract: Disclosed are methods for detecting a target nucleic acid in a sample. The methods include contacting said sample, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide. Also disclosed are methods for detecting a target nucleic acid in a sample in which said sample is contacted, in the presence of a polymerase and an endonuclease, with a sequence conversion oligonucleotide and a signal amplifier oligonucleotide. The disclosure also provides compositions and kits comprising such sequence conversion and signal amplifier oligonucleotides.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: June 11, 2019
    Assignees: Abbott Laboratories, Tokyo Institute of Technology
    Inventors: Ken Komiya, Makoto Komori, Toru Yoshimura
  • Patent number: 10308709
    Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: June 4, 2019
    Assignee: Abbott Laboratories
    Inventors: Bailin Tu, Robert N. Ziemann, Bryan C. Tieman, Philip M. Hemken, Carol S. Ramsay, Carolyn J. Strobel, David J. Hawksworth, Larry G. Birkenmeyer, Cheng Zhao, Susan E. Brophy, Barry L. Dowell, Anthony S. Muerhoff
  • Patent number: 10288633
    Abstract: A diagnostic analyzer includes a rotating device, a first optical reader, and a second optical reader. The rotating device includes a first darkened compartment, a second darkened compartment, and an optical path along which the first darkened compartment and the second darkened compartment travel. The first optical reader is operable to read the first darkened compartment and the second optical reader is operable to read the second darkened compartment.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: May 14, 2019
    Assignee: ABBOTT LABORATORIES
    Inventors: Robert Luoma, Ryan Patrick Johnson
  • Patent number: 10288557
    Abstract: The instant disclosure provides spectrophotometric methods for assessing histological stains used in a histology analyzer. The methods find use in various assessments including determinations of the identity of a histological stain, determinations of the quality of a histological stain, etc. Also included are devices and systems for practicing the described methods. The instant disclosure also provides computer readable media containing libraries of reference spectrophotometric characteristics of histological stains useful in assessing a histological stain used in a histology analyzer. Also provided is computer readable media containing instructions that cause a computing device to perform steps for making an assessment of a histological stain.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: May 14, 2019
    Assignee: Abbott Laboratories
    Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Ema C. Olah
  • Patent number: D850955
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: June 11, 2019
    Assignee: Abbott Laboratories
    Inventors: Christina A. Barton, Vladlena Belozerova, Ami Marie Verhalen, Jesse Charles Darley, Sherry Sue Eckholm
  • Patent number: D850956
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: June 11, 2019
    Assignee: Abbott Laboratories
    Inventors: Christina A. Barton, Vladlena Belozerova, Ami Marie Verhalen, Jesse Charles Darley, Sherry Sue Eckholm
  • Patent number: D851519
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 18, 2019
    Assignee: Abbott Laboratories
    Inventors: Christina A. Barton, Rachel Elizabeth Wallace, Ami Marie Verhalen, Christopher Alan Harris, Daniel Roger Nett