Patents Assigned to Accelr8 Technology Corporation
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Publication number: 20120288717Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: ApplicationFiled: May 10, 2012Publication date: November 15, 2012Applicant: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven W. Metzger, Michael J. Lochhead
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Patent number: 8178602Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: GrantFiled: December 7, 2009Date of Patent: May 15, 2012Assignee: Accelr8 Technology CorporationInventors: Guoqiang Mao, Steven W. Metzger, Michael J. Lochhead
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Publication number: 20120077206Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: ApplicationFiled: December 5, 2011Publication date: March 29, 2012Applicant: Accelr8 Technology CorporationInventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Patent number: 8071319Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: GrantFiled: January 28, 2008Date of Patent: December 6, 2011Assignee: Accelr8 Technology CorporationInventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Publication number: 20100081735Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: ApplicationFiled: December 7, 2009Publication date: April 1, 2010Applicant: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven W. Metzger, Michael J. Lochhead
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Patent number: 7629029Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: GrantFiled: October 13, 2004Date of Patent: December 8, 2009Assignee: Accelr8 Technology CorporationInventors: Guoqiang Mao, Steven W. Metzger, Michael J. Lochhead
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Patent number: 7501157Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: GrantFiled: January 13, 2005Date of Patent: March 10, 2009Assignee: Accelr8 Technology CorporationInventors: Guoqiang Mao, Steven W. Metzger, Michael J. Lochhead, David A. Goldberg, Charles H. Greef, David W. Grainger
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Patent number: 7341841Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: GrantFiled: December 16, 2005Date of Patent: March 11, 2008Assignee: Accelr8 Technology CorporationInventors: Steven W. Metzger, David C. Howson, David A. Goldberg, Daniel A. Buttry
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Publication number: 20070298513Abstract: This invention is directed to an optically-based method and system for analyte detection using solid phase immobilization, specific analyte labels adapted for signal generation and corresponding processes for the utilization thereof. The enumeration detection method disclosed herein narrows the area for signal observation, thus, improving detectable signal to background ratio. The system is comprised of a platform/support for immobilizing a sample stage having a labeled sample (analyte complex) bound thereto, a radiation source, an optical apparatus for generating and directing radiation at said sample and a control that obtains data and then conducts analyses using digital image data. Upon engagement of the system, the sample generates a signal capable of differentiation from background signal, both of which are collected and imaged with a signal detector that generated a sample image to a data processing apparatus.Type: ApplicationFiled: October 23, 2006Publication date: December 27, 2007Applicant: Accelr8 Technology CorporationInventors: Timothy Starzl, Scott Clark, Mary Vellequette, H. Hanlin, Steven Metzger
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Publication number: 20070037225Abstract: A method for the detection of microorganisms in a sample comprising contacting said sample with a biosensor concentration module, allowing microorganisms to grow for a first period of time and detecting growth of discrete microorganisms as an indication of the presence of said microorganisms.Type: ApplicationFiled: December 16, 2005Publication date: February 15, 2007Applicant: Accelr8 Technology CorporationInventors: Steven Metzger, David Howson, David Goldberg, Daniel Buttry
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Patent number: 7067194Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: GrantFiled: November 21, 2003Date of Patent: June 27, 2006Assignee: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven W. Metzger, Michael J. Lochhead
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Publication number: 20050100675Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: ApplicationFiled: October 13, 2004Publication date: May 12, 2005Applicant: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven Metzger, Michael Lochhead
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Patent number: 6844028Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: GrantFiled: June 25, 2002Date of Patent: January 18, 2005Assignee: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven W. Metzger, Michael J. Lochhead
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Publication number: 20030022216Abstract: Compositions and methods of preparing functional thin films or surface coatings with low non-specific binding are described. The thin films contain specified functional groups and non-specific binding repellant components. The thin films are either covalently bound to or passively adsorbed to various solid substrates. The specified functional group provides specified activity for the thin film modified solid surfaces and non-specific binding repellant components significantly reduce the non-specific binding to the thin film modified solid surfaces. Non-specific binding repellant components do not affect specified functional group's activity in the thin films. In these methods, specified functional groups are anchored to the solid substrates through a spacer.Type: ApplicationFiled: June 25, 2002Publication date: January 30, 2003Applicant: Accelr8 Technology CorporationInventors: Guoqiano Mao, Steven W. Metzger, Michael J. Lochhead
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Publication number: 20010029050Abstract: A system for detecting a specific substance or analyte of interest is provided that includes one or more sensing units and an instrument for analyzing the sensing units. Each sensing unit preferably includes a substrate, an attachment layer and at least one capture layer that includes a ligand layer. In one embodiment, the attachment layer is tripartite and includes a lower binding surface held to the substrate and an upper binding surface that holds the ligand layer, together with an insulating layer disposed between these two surfaces. The lower binding surface provides a durable and stable attachment to the substrate. The upper binding surface holds the ligand layer and does not jeopardize the integrity or viability thereof. The insulating layer prevents any unwanted interaction between the lower and upper binding surfaces. Each sensing unit is supported on a test piece received by the instrument. The instrument controllably positions the test piece using marks and/or codes on the test piece.Type: ApplicationFiled: June 14, 2001Publication date: October 11, 2001Applicant: Accelr8 Technology CorporationInventors: Timothy W. Starzl, David W. Nunnery, MaryBeth Robinson, H. John Hanlin
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Patent number: 6274384Abstract: A system for detecting a specific substance or analyte of interest is provided that includes one or more sensing units and an instrument for analyzing the sensing units. Each sensing unit preferably includes a substrate, an attachment layer and at least one capture layer that includes a ligand layer. In one embodiment, the attachment layer is tripartite and includes a lower binding surface held to the substrate and an upper binding surface that holds the ligand layer, together with an insulating layer disposed between these two surfaces. The lower binding surface provides a durable and stable attachment to the substrate. The upper binding surface holds the ligand layer and does not jeopardize the integrity or viability thereof. The insulating layer prevents any unwanted interaction between the lower and upper binding surfaces. Each sensing unit is supported on a test piece received by the instrument. The instrument controllably positions the test piece using marks and/or codes on the test piece.Type: GrantFiled: July 6, 1999Date of Patent: August 14, 2001Assignee: Accelr8 Technology CorporationInventors: Timothy W. Starzl, David W. Nunnery, MaryBeth Robinson, H. John Hanlin