Abstract: Compositions and methods effective to minimize or eliminate the presence of oxidative degradation products in solid dosage forms comprising sufentanil are provided.
Type:
Grant
Filed:
November 21, 2008
Date of Patent:
February 3, 2015
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Shamim Pushpala, Larry Hamel, Stelios Tzannis, Evangeline Cruz
Abstract: Drug storage and dispensing devices for dispensing a drug dosage form to a patient are disclosed. A cartridge includes a cartridge housing and a pusher. The cartridge housing defines a channel within which multiple tablets are disposed. The cartridge housing is configured to be removably coupled to a tablet dispensing device. A first portion of the pusher is disposed outside of the channel. A second portion of the pusher is movably disposed within the channel, and is configured to exert a force on the plurality of tablets to convey a first tablet from the channel into the tablet delivery device when the force is exerted on the first portion of the pusher.
Type:
Grant
Filed:
January 18, 2013
Date of Patent:
December 9, 2014
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew I. Poutiatine, Charles Rampersaud, Thomas Schreck, William Kolosi, Sascha Retailleau
Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.
Type:
Application
Filed:
June 5, 2014
Publication date:
November 27, 2014
Applicant:
ACELRX PHARMACEUTICALS, INC.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, Andrew I. Poutiatine
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
Type:
Grant
Filed:
November 14, 2007
Date of Patent:
October 21, 2014
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards
Abstract: Bioadhesive drug formulations that adhere to an oral mucosal membrane of a subject are provided together with single dose applicators and devices for delivering the drug formulations to the oral mucosa, and methods for using the same.
Type:
Grant
Filed:
August 27, 2012
Date of Patent:
October 21, 2014
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Stelios Tzannis, Larry Hamel, Pamela Palmer, Thomas Schreck, Andrew I. Poutiatine
Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.
Type:
Grant
Filed:
July 30, 2012
Date of Patent:
July 15, 2014
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine
Abstract: Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
Type:
Grant
Filed:
July 23, 2012
Date of Patent:
July 15, 2014
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards
Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
Type:
Grant
Filed:
November 15, 2012
Date of Patent:
June 17, 2014
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Andrew Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Lawrence Hamel, William Kolosi, Sascha Retailleau
Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
Type:
Application
Filed:
September 30, 2013
Publication date:
January 30, 2014
Applicant:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew Poutiatine, Bruce Edwards, Charles Rampersaud, Pamela Palmer, Bradley Blackwood, Benjamin K. Yaffe
Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
Type:
Grant
Filed:
March 9, 2012
Date of Patent:
November 5, 2013
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew Poutiatine, Bruce Edwards, Charles Rampersaud, Pamela Palmer, Bradley Blackwood, Benjamin K. Yaffe
Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
Type:
Grant
Filed:
March 16, 2010
Date of Patent:
October 1, 2013
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew Poutiatine, Bruce Edwards, Charles Rampersaud, Pamela Palmer, Bradley Blackwood, Benjamin K. Yaffe
Abstract: Compositions, systems and methods for administration of small volume sufentanil drug dosage forms via the oral transmucosal route of a subject for treatment of pain.
Type:
Grant
Filed:
October 18, 2011
Date of Patent:
September 17, 2013
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Thomas Schreck, Lawrence Hamel, Stelio Tzannis, Andrew Poutiatine
Abstract: A method of administering small, bioadhesive drug tablets includes moving an end portion of a delivery member. A surface of the delivery member can be positioned to prevent movement of the drug tablet from a tablet cartridge channel to a delivery passage of a delivery device when the end portion of the delivery member is in a first stopped position. The end portion of the delivery member can be moved to a second position within the delivery passage such that the tablet cartridge channel is in communication with the delivery passage. The drug tablet can be conveyed into the delivery passage via the tablet cartridge channel. The end portion of the delivery member can be moved to a third position within the delivery passage to convey the drug tablet through an exit opening of the delivery device.
Type:
Grant
Filed:
December 28, 2007
Date of Patent:
August 6, 2013
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Pamela Palmer, Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards, Edmond Chiu, Thomas Schreck, Stelios Tzannis, Larry Hamel
Abstract: Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.
Type:
Application
Filed:
July 30, 2012
Publication date:
June 27, 2013
Applicant:
ACELRX PHARMACEUTICALS, INC
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine
Abstract: Bioadhesive drug formulations that adhere to an oral mucosal membrane of a subject are provided together with single dose applicators and devices for delivering the drug formulations to the oral mucosa, and methods for using the same.
Type:
Application
Filed:
August 27, 2012
Publication date:
June 20, 2013
Applicant:
ACELRX PHARMACEUTICALS, INC.
Inventors:
Stelios Tzannis, Larry Hamel, Pamela Palmer, Thomas Schreck, Andrew I. Poutiatine
Abstract: Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
Type:
Application
Filed:
July 23, 2012
Publication date:
June 20, 2013
Applicant:
ACELRX PHARMACEUTICALS, INC
Inventors:
Pamela Palmer, Thomas Schreck, Stelios Tzannis, Larry Hamel, Andrew I. Poutiatine, Charles Rampersaud, Bruce Edwards
Abstract: Drug storage and dispensing devices for dispensing a drug dosage form to a patient are disclosed. The dispensing device has a programmable lock-out feature for locking the dispensing device and is capable of detecting the identity of a user. The invention further provides a method for the treatment of subject, by administering to the subject a drug dosage form using a dispensing device of the invention.
Abstract: Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
Abstract: Drug storage and dispensing devices for dispensing a drug dosage form are disclosed. Devices having a housing defining a nonlinear passageway and a flexible push rod to move within the nonlinear passageway are disclosed. Devices having a flexible push rod coupled to a rotation actuating member at at an end portion thereof are also disclosed.
Type:
Grant
Filed:
January 5, 2007
Date of Patent:
January 22, 2013
Assignee:
AcelRx Pharmaceuticals, Inc.
Inventors:
Andrew I. Poutiatine, Charles Rampersaud, Thomas Schreck, William Kolosi, Sascha Retailleau
Abstract: Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
Type:
Application
Filed:
March 9, 2012
Publication date:
September 13, 2012
Applicant:
ACELRX PHARMACEUTICALS, INC.
Inventors:
Andrew Poutiatine, Bruce Edwards, Charles Rampersaud