Patents Assigned to Aciex Therapeutics, Inc.
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Patent number: 9254286Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.Type: GrantFiled: March 15, 2010Date of Patent: February 9, 2016Assignee: Aciex Therapeutics, Inc.Inventors: Mark B. Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
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Publication number: 20150337006Abstract: The present invention further provides method of preparing nanocrystals or microcrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).Type: ApplicationFiled: November 13, 2013Publication date: November 26, 2015Applicant: Aciex Therapeutics, Inc.Inventors: Shikha P. Barman, Ritesh Vasudevan Thekkedath, Koushik Barman, Thomas Cavanagh, Tian Hao, Thomas Bovard Leland
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Publication number: 20140364475Abstract: The invention features topical formulations comprising an osmotically active agent and/or a vasoconsgtrictor and/or an astringent agent for the treatment and prevention of eyelid swelling, and methods of use thereof.Type: ApplicationFiled: April 10, 2014Publication date: December 11, 2014Applicant: ACIEX THERAPEUTICS, INC.Inventors: Matthew Jonathan CHAPIN, Mark Barry ABELSON, Keith Jeffrey LANE, George MINNO
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Patent number: 8829005Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.Type: GrantFiled: May 21, 2013Date of Patent: September 9, 2014Assignee: Aciex Therapeutics, Inc.Inventors: Mark Barry Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
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Patent number: 8765725Abstract: The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).Type: GrantFiled: January 7, 2013Date of Patent: July 1, 2014Assignee: Aciex Therapeutics, Inc.Inventors: Thomas Cavanagh, Shikha P. Barman
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Publication number: 20140161903Abstract: The invention features topical formulations comprising an osmotically active agent and/or a vasoconstrictor and/or an astringent agent for the treatment and prevention of eyelid swelling, and methods of use thereof.Type: ApplicationFiled: February 12, 2014Publication date: June 12, 2014Applicant: ACIEX THERAPEUTICS, INC.Inventors: Matthew J. Chapin, Mark Barry Abelson, Keith Jeffrey Lane, Akimitsu Makino
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Patent number: 8685439Abstract: The invention features novel topical ophthalmic formulations comprising an osmotically active agent and a vasoconstrictor. Suitable osmotically active agents for use in the ophthalmic formulations of the invention include, without limitation, sodium chloride, dextrose, glycerine, sucrose, mannitol, and sorbitol; suitable vasoconstritors include, without limitation, naphazoline and oxymetazoline. Also provided are methods of using the ophthalmic formulations of the invention for the treatment and prevention of eyelid swelling by administering the ophthalmic formulations of the invention to the eye surface of a subject in need thereof.Type: GrantFiled: April 26, 2007Date of Patent: April 1, 2014Assignee: Aciex Therapeutics, Inc.Inventors: Matthew Jonathan Chapin, Mark Barry Abelson, Keith Jeffrey Lane, Akimitsu Makino
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Publication number: 20130303502Abstract: The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).Type: ApplicationFiled: January 7, 2013Publication date: November 14, 2013Applicant: ACIEX THERAPEUTICS, INC.Inventors: Thomas Cavanagh, Shikha P. Barman
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Patent number: 8569273Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis rhinitis, and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.Type: GrantFiled: September 22, 2010Date of Patent: October 29, 2013Assignee: Aciex Therapeutics, Inc.Inventors: Mark Barry Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
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Publication number: 20130252971Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.Type: ApplicationFiled: May 21, 2013Publication date: September 26, 2013Applicant: ACIEX THERAPEUTICS, INC.Inventors: Mark Barry Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
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Publication number: 20120021072Abstract: The invention features topical formulations comprising an osmotically active agent and/or a vasoconstrictor and/or an astringent agent for the treatment and prevention of eyelid swelling, and methods of use thereof.Type: ApplicationFiled: September 21, 2011Publication date: January 26, 2012Applicant: Aciex Therapeutics, Inc.Inventors: Matthew Jonathan Chapin, Mark Barry Abelson, Keith Jeffrey Lane, Akimitsu Makino
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Publication number: 20110257136Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis rhinitis, and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.Type: ApplicationFiled: September 22, 2010Publication date: October 20, 2011Applicant: Aciex Therapeutics, Inc.Inventors: Mark B. Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
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Publication number: 20110105450Abstract: The present invention provides ophthalmic formulations of fluticasone that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic conjunctivitis in a subject in need of such treatment by topical application of the fluticasone formulations of the invention directly to the eye.Type: ApplicationFiled: June 4, 2010Publication date: May 5, 2011Applicant: Aciex Therapeutics, Inc.Inventors: Matthew J. Chapin, George Minno, Jackie Nice, Paul Gomes, Mark Barry Abelson
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Publication number: 20100311688Abstract: The present invention provides compositions for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye. Methods of manufacture are also provided.Type: ApplicationFiled: June 4, 2010Publication date: December 9, 2010Applicant: Aciex Therapeutics, Inc.Inventors: Matthew J. Chapin, George Minno, Jackie Nice, George W. Ousler, III, Mark B. Abelson
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Publication number: 20100240625Abstract: The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.Type: ApplicationFiled: March 15, 2010Publication date: September 23, 2010Applicant: Aciex Therapeutics, Inc.Inventors: Mark B. Abelson, Matthew J. Chapin, Paul Gomes, George Minno, Jackie Nice
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Publication number: 20100240624Abstract: The present invention provides topical formulations of ketotifen that provide a comfortable formulation when instilled in the eye and are effective in the treatment and prevention of ocular allergy, particularly allergic conjunctivitis. The invention further provides methods of treating and preventing ocular allergy by in a subject in need of such treatment by topical application of the ketotifen formulations of the invention to the eye of a subject in need thereof.Type: ApplicationFiled: February 5, 2010Publication date: September 23, 2010Applicant: Aciex Therapeutics, Inc.Inventors: Matthew J. Chapin, Mark B. Abelson, George Minno, Jackie Nice, Paul Gomes
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Publication number: 20100130580Abstract: The present invention provides compositions comprising a low dose amount of an ophthalmic NSAID for treating and/or preventing signs and symptoms associated with dry eye and/or ocular irritation, and methods of use thereof. Such compositions are provided in novel ophthalmic formulations that are comfortable upon instillation in the eye and safe for chronic use.Type: ApplicationFiled: October 19, 2009Publication date: May 27, 2010Applicant: Aciex Therapeutics, Inc.Inventors: George W. Ousler, III, Matthew J. Chapin, Mark B. Abelson