Patents Assigned to Affymax Technologies N.V.
-
Patent number: 5773569Abstract: Peptides of 10 to 40 or more amino acid residues in length and having the sequence X.sub.3 X.sub.4 X.sub.5 GPX.sub.6 TWX.sub.7 X.sub.8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X.sub.3 is C; X.sub.4 is R, H, L, or W; X.sub.5 is M, F, or I; X.sub.6 is independently selected from any one of the 20 genetically coded L-amino acids; X.sub.7 is D, E, I, L, or V; and X.sub.8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.Type: GrantFiled: June 7, 1995Date of Patent: June 30, 1998Assignee: Affymax Technologies N.V.Inventors: Nicholas C. Wrighton, William J. Dower, Ray S. Chang, Arun K. Kashyap, Linda K. Jolliffe, Dana Johnson, Linda Mulcahy
-
Patent number: 5770358Abstract: A general stochastic method for synthesizing random oligomers can be used to synthesize compounds to screen for desired properties. The use of identification tags on the oligomers facilitates identification of oligomers with desired properties.Type: GrantFiled: September 16, 1992Date of Patent: June 23, 1998Assignee: Affymax Technologies N.V.Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop, Michael C. Needels
-
Patent number: 5767234Abstract: Peptides that bind to the interleukin-1 type I receptor (IL-1RtI) can be used to assay the amount of IL-1R, or an IL-1R agonist or antagonist, in a sample and comprise a sequence of amino acids selected from the group consisting of (1) WXXXGZ.sub.1 W (SEQ ID NO: 2) where Z.sub.1 is L, I, A, or Q; (2) XXQZ.sub.5 YZ.sub.6 XX where (SEQ ID NO: 1) Z.sub.5 is P or Aze where Aze is azetidine; and Z.sub.6 is S, A, V, or L; and (3) Z.sub.23 NZ.sub.24 SZ.sub.25 Z.sub.26 Z.sub.27 Z.sub.28 Z.sub.29 Z.sub.30 L (SEQ ID NO: 313) where Z.sub.23 is D or Y; Z.sub.24 is D or S; Z.sub.25 is S or W; Z.sub.26 is S or Y; Z.sub.27 is D or V; Z.sub.28 is S or W; Z.sub.29 is F or L; and Z.sub.30 is D or L; and where each amino acid is indicated by standard one letter abbreviation; and each X can be selected from any one of the 20 genetically coded L-amino acids or the stereoisomeric D-amino acids.Type: GrantFiled: February 1, 1995Date of Patent: June 16, 1998Assignee: Affymax Technologies, N.V.Inventors: Stephen D. Yanofsky, Ronald W. Barrett, David Baldwin, Jeff W. Jacobs
-
Patent number: 5744101Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.Type: GrantFiled: February 14, 1995Date of Patent: April 28, 1998Assignee: Affymax Technologies N.V.Inventors: Stephen P. A. Fodor, Lubert Stryer, James L. Winkler, Christopher P. Holmes, Dennis W. Solas
-
Patent number: 5739386Abstract: Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described.Type: GrantFiled: June 23, 1995Date of Patent: April 14, 1998Assignee: Affymax Technologies N.V.Inventor: Christopher P. Holmes
-
Patent number: 5733731Abstract: A random peptide library constructed by transforming host cells with a collection of recombinant vectors that encode a fusion protein comprised of a DNA binding protein and a random peptide and also encode a binding site for the DNA binding protein can be used to screen for novel ligands. The screening method results in the formation of a complex comprising the fusion protein bound to a receptor through the random peptide ligand and to the recombinant DNA vector through the DNA binding protein.Type: GrantFiled: October 26, 1995Date of Patent: March 31, 1998Assignee: Affymax Technologies N.V.Inventors: Peter J. Schatz, Millard G. Cull, Jeff F. Miller, Willem Peter Christiaan Stemmer, Christian M. Gates
-
Patent number: 5728802Abstract: Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.Type: GrantFiled: May 12, 1995Date of Patent: March 17, 1998Assignee: Affymax Technologies N.V.Inventors: Ronald W. Barrett, Steven E. Cwirla, William J. Dower, Kerry J. Koller, Jung Lee, Christine L. Martens, Beatrice Ruhland
-
Patent number: 5723584Abstract: Biotinylation peptides can be fused to other peptides or proteins of interest using recombinant DNA techniques to provide efficient methods for biotinylating the resulting fusion proteins in vivo or in vitro.Type: GrantFiled: February 3, 1995Date of Patent: March 3, 1998Assignee: Affymax Technologies N.V.Inventor: Peter J. Schatz
-
Patent number: 5723286Abstract: Peptides which bind to selected receptor molecules are identified by screening libraries which encode a random or controlled collection of amino acids. Peptides encoded by the libraries are expressed as fusion proteins of bacteriophage coat proteins, and bacteriophage particles are then screened against the receptors of interest. Peptides having a wide variety of uses, such as therapeutic or diagnostic reagents, may thus be identified without any prior information on the structure of the expected ligand or receptor molecule.Type: GrantFiled: June 20, 1990Date of Patent: March 3, 1998Assignee: Affymax Technologies N.V.Inventors: William J. Dower, Steven E. Cwirla, Ronald W. Barrett
-
Patent number: 5708153Abstract: A general stochastic method for synthesizing random oligomers on particles is disclosed. A further aspect of the invention relates to the use of identification tags on the particles to facilitate identification of the sequence of the monomers in the oligomer.Type: GrantFiled: June 7, 1995Date of Patent: January 13, 1998Assignee: Affymax Technologies N.V.Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop
-
Patent number: 5679773Abstract: Compounds and methods for solid phase synthesis of organic molecules including peptides, oligonucleotides, benzodiazepines, .beta.-turn mimetics, and prostaglandins. The present invention provides new reagents in the form of linking groups and resins and substrates having attached linking groups which are useful in solid phase synthesis of high density arrays of organic molecules. The invention also provides methods which increase yields of various organic synthesis strategies.Type: GrantFiled: January 17, 1995Date of Patent: October 21, 1997Assignee: Affymax Technologies N.VInventor: Christopher P. Holmes
-
Patent number: 5677195Abstract: A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are delivered through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.Type: GrantFiled: November 20, 1992Date of Patent: October 14, 1997Assignee: Affymax Technologies N.V.Inventors: James L. Winkler, Stephen P. A. Fodor, Christopher J. Buchko, Debra A. Ross, Lois Aldwin, Douglas N. Modlin
-
Patent number: 5668110Abstract: Described are peptides and peptide mimetics that bind to and the IL-5 receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation of eosinophils, such as asthma, as well as in diagnostic methods employing labeled peptides and peptide mimetics.Type: GrantFiled: June 7, 1995Date of Patent: September 16, 1997Assignee: Affymax Technologies N.V.Inventors: Ronald W. Barrett, Bruce P. England, Peter J. Schatz, Derek Sloan, Min-Jia Chen
-
Patent number: 5665975Abstract: A device and method for efficiently synthesizing diverse molecular products on substrates. A parent vessel 200 contains a suspension of substrates. The suspension is pressurized with argon and transferred to a plurality of reaction vessels 201-209 in one or more reaction vessel banks where monomer addition reactions take place. Optionally, the substrates may be tagged with a tag monomer. A vortexing motor 300 vortexes the contents of reaction vessels 201-209 during monomer addition reactions to enhance synthesis. After the desired monomer and/or tag monomer addition reaction, the suspension is pressurized with argon and transferred back to parent vessel 200 for mixing. Thereafter, the suspension may be pressurized with argon and reallocated among reaction vessels 201-209 for further synthesis.Type: GrantFiled: June 6, 1995Date of Patent: September 9, 1997Assignee: Affymax Technologies N.V.Inventor: Haim Kedar
-
Patent number: 5655560Abstract: In an exemplary aspect, the invention provides a fluid distribution system including a first fluid path, and a second fluid path that is laterally spaced-apart from the first fluid path. A third fluid path connects the first and the second fluid paths. A valve is provided that is axially translatable through a third fluid path between a first position and a second position. In a first position, the valve is removed from the third fluid path, and in the second position, the valve substantially fills the third fluid path.Type: GrantFiled: December 16, 1994Date of Patent: August 12, 1997Assignee: Affymax Technologies N.V.Inventors: Haim Kedar, Donald T. Roth
-
Patent number: 5654276Abstract: Described are peptides and peptide mimetics that bind to and the IL-receptor. Such peptides and peptide mimetics are useful in methods for treating disorders that involve improper production of or response to IL-5 and or the production and accumulation of eosinophils, such as asthma, as well as in diagnostic methods employing labeled peptides and peptide mimetics.Type: GrantFiled: June 7, 1995Date of Patent: August 5, 1997Assignee: Affymax Technologies N.V.Inventors: Ronald W. Barrett, Bruce P. England, Peter J. Schatz, Derek Sloan, Min-Jia Chen
-
Patent number: 5648458Abstract: The peptide HITWDQLWNVMN (SEQ ID NO: 4) and related peptides and peptidomimetics bind to endothelial leukocyte adhesion molecule 1 and block the binding of leukocytes to this important receptor and so can be used to ameliorate the detrimental effects of certain disease conditions.Type: GrantFiled: February 16, 1995Date of Patent: July 15, 1997Assignee: Affymax Technologies N.V.Inventors: Steven E. Cwirla, Ronald W. Barrett, William J. Dower, Christine L. Martens
-
Patent number: 5643873Abstract: Disclosed are peptides and peptide mimetics that bind selectins, including endothelial leukocyte adhesion molecule 1 (ELAM-1). Such peptides and peptide mimetics are useful in methods for blocking adhesion of leukocytes to the selectins for the purpose of inhibiting inflammation as well as in diagnostic methods employing labeled peptides and peptide mimetics that bind selectins for the purpose of determining the site of inflammation in mammals which inflammation is mediated by the presence of one or more selectins.Type: GrantFiled: May 11, 1994Date of Patent: July 1, 1997Assignee: Affymax Technologies N.V.Inventors: Ronald W. Barrett, Steven E. Cwirla, William J. Dower, Kerry J. Koller, Jung Lee, Christine L. Martens, Beatrice Ruhland-Fritsch
-
Patent number: 5639603Abstract: A general stochastic method for synthesizing compounds can be used to generate large collections of tagged compounds that can be screened to identify and isolate compounds with useful properties.Type: GrantFiled: November 2, 1993Date of Patent: June 17, 1997Assignee: Affymax Technologies N.V.Inventors: William J. Dower, Ronald W. Barrett, Mark A. Gallop, Michael C. Needels
-
Patent number: 5635597Abstract: Peptides that bind to the Interleukin-2 (IL-2) receptor subunits IL-2R.alpha., IL-2R.beta. and IL-2R.gamma., and inhibit the binding of IL-2 to these important receptors, are described. The invention also includes methods for treating diseases related to the activation of these receptors, as well as the receptors for IL-4, -7 and -13. In addition, the present invention also includes methods for assaying for the presence of these receptors on cell surfaces.Type: GrantFiled: May 27, 1994Date of Patent: June 3, 1997Assignee: Affymax Technologies, N.V.Inventors: Ronald W. Barrett, Tania Chernov-Rogan, Ann M. Davis