Patents Assigned to Agency for Science, Technology and Research
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Patent number: 11930818Abstract: Techniques regarding star polymers with enhanced antimicrobial functionality are provided. For example, a polymer is provided that can comprise a core that can have a singlet oxygen generator and that can generate a singlet oxygen species upon irradiation with light. The polymer can also comprise a plurality of polycarbonate arms covalently bonded to the core. The plurality of polycarbonate arms can be degradable and can comprise a cation. Further, the plurality of polycarbonate arms can have antimicrobial functionality.Type: GrantFiled: January 9, 2020Date of Patent: March 19, 2024Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Victoria A. Piunova, Noah Frederick Fine Nathel, James L. Hedrick, Yi Yan Yang, Willy Chin, Zhi Xiang Voo
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Patent number: 11920137Abstract: A method for producing a carotenoid or apocarotenoid is disclosed. The method comprises the step of expressing in a host cell an expression module comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter. A host cell comprising an expression vector having a coding region encoding at least one optimised carotenoid or apocarotenoid generating enzyme, the coding region being operably linked to a promoter is also provided together with a kit.Type: GrantFiled: February 26, 2018Date of Patent: March 5, 2024Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Congqiang Zhang, Xixian Chen, Heng-Phon Too
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Patent number: 11912761Abstract: The present invention is directed to antigen binding proteins and in particular to IL-1? antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.Type: GrantFiled: January 15, 2021Date of Patent: February 27, 2024Assignee: Agency for Science, Technology and ResearchInventors: Cheng-I Wang, Angeline Goh, Siok Ping Yeo, Alessandra Rosa Mortellaro, Subhra Kumar Biswas, Florent Ginhoux, Pingyu Zhong
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Patent number: 11906946Abstract: This document describes a system and method for selectively switching the fast-wet-etching direction of crystalline silicon, c-Si, nanostructures between the (100) and the (110) crystallographic planes of c-Si by a simple method of sample agitation. This method effectively allows the invention to achieve anisotropic and isotropic wet-etching of c-Si.Type: GrantFiled: October 7, 2021Date of Patent: February 20, 2024Assignees: NATIONAL UNIVERSITY OF SINGAPORE, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Utkur Mirsaidov, Michel Bosman, Tanmay Ghosh, Zainul Aabdin, Frank Holsteyns, Antoine Pacco
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Publication number: 20240052046Abstract: Antigen binding molecules capable of binding to CDI22 and/or common y? chain (CDI32) are disclosed herein. Also disclosed are compositions comprising such antigen binding molecules, and uses and methods using the same.Type: ApplicationFiled: June 29, 2023Publication date: February 15, 2024Applicants: Agency for Science, Technology and Research, Euchloe Bio Pte. Ltd.Inventors: Peter Brauer, John Edward Connolly, Richard Hopkins, Junyun Lai, Jianrong Lionel Low, Kar Wai Tan, Cheng-I Wang, Siok Ping Yeo
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Publication number: 20240052023Abstract: We describe a Cnx/ERp57 inhibitor for use in the treatment or prevention of cancer.Type: ApplicationFiled: August 14, 2023Publication date: February 15, 2024Applicant: Agency for Science, Technology and ResearchInventors: Frederic Bard, Anh Tuan Nguyen, Ros Manon
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Patent number: 11898803Abstract: The present disclosure may provide a cooling plant system, a method of operating a cooling plant system and an energy storage and scheduling control system, the cooling plant system comprising one or more cooling towers; one or more thermal energy storage systems coupled to the one or more cooling towers; one or more electrical energy storage systems, the one or more electrical energy storage systems being coupled to the one or more thermal energy storage systems for selectively providing electrical energy to the one or more thermal energy storage systems; and an energy storage and scheduling control system coupled to the one or more thermal energy storage systems and the one or more electrical energy storage systems.Type: GrantFiled: October 17, 2018Date of Patent: February 13, 2024Assignee: Agency for Science, Technology and Research Singapore District Cooling Pte LtdInventors: Wuhua Hu, Chin Choy Chai, Wenxian Yang, Rongshan Yu
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Patent number: 11891432Abstract: The disclosure provides anti-DENV antibodies having a cross-reactivity to ZIKV and methods of making and using the same. The anti-DENV antibodies have uses that include treating or preventing ZIKV infection.Type: GrantFiled: March 15, 2019Date of Patent: February 6, 2024Assignees: Chugai Seiyaku Kabushiki Kaisha, Agency for Science, Technology & ResearchInventors: Katja Fink, Cheng-I Wang, Lisa Fong Poh Ng, Laurent Renia, Zenjiro Sampei, Xing'er Christine Xoo
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Patent number: 11883460Abstract: The present disclosure provides dry powder antibiotic compositions that are effective in the treatment of bacterial infections and associated conditions. Moreover, the present disclosure provides dry powder antibiotic compositions for the treatment of bacterial infections, by multi-drug resistant bacteria, resulting in the subsequent reduction in the prevalent rates of drug resistance.Type: GrantFiled: February 12, 2021Date of Patent: January 30, 2024Assignees: Agency for Science, Technology and Research, National University Hospital (Singapore) PTE LtdInventors: Desmond Heng, Sie Huey Lee, Jeanette Teo, Wai Kiong Ng, Reginald Tan
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Patent number: 11880215Abstract: This disclosure relates to a digital comparator coupled to a pair of pull-up resistors and a pair of pull-down resistors whereby both pairs of resistors are coupled to an output terminal of a low dropout (LDO) regulator. In particular, the digital comparator comprises an edge detector module, a consecutive two-edge detector module and a consecutive three-edge detector module whereby the edge detector module is configured to receive two clock signals as inputs and after being processed by these three modules, to pull-up or pull-down the resistors at the output terminal of the LDO regulator based on the rising and falling edges of the received clock signals.Type: GrantFiled: March 27, 2020Date of Patent: January 23, 2024Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Jianming Zhao, Yuan Gao
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Publication number: 20240018221Abstract: The invention relates generally to antigen-binding molecules that specifically bind to Myosin Heavy Chain 9 (MYH9) and uses thereof for the treatment of specific cancers, such as mast cell tumors. In one embodiment, the MYH9 is canine MYH9 and the antigen-binding molecule is an antibody. In another embodiment, the antigen-binding molecule is conjugated to a toxin, for the treatment of canine mast cell tumors.Type: ApplicationFiled: October 26, 2021Publication date: January 18, 2024Applicant: Agency for Science, Technology and ResearchInventors: Wey Jia FONG, Boon Hwa CHOO, Mei Yee Vanessa DING, Chui Ping CHIN
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Publication number: 20240023446Abstract: Various embodiments may relate to an acoustic resonator. The acoustic resonator may include a piezoelectric layer. The acoustic resonator may also include a first electrode in contact with a first surface of the piezoelectric layer. The acoustic resonator may further include a plurality of dielectric structures in contact with the first surface of the piezoelectric layer. The acoustic resonator may additionally include a second electrode in contact with a second surface of the piezoelectric layer opposite the first surface. The first electrode may include a plurality of electrode structures. A dielectric structure of the plurality of dielectric structures may be in contact with a pair of neighboring electrode structures of the plurality of electrode structures.Type: ApplicationFiled: February 3, 2021Publication date: January 18, 2024Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Yao ZHU, Chen LIU, Nan WANG
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Patent number: 11872230Abstract: The present invention relates generally to a therapeutic protocol for treating a subject having cancer. Taught herein is a method of treating cancer or reducing the risk of recurrence of cancer in a subject following an anti-cancer therapy.Type: GrantFiled: May 16, 2022Date of Patent: January 16, 2024Assignee: Agency for Science, Technology and ResearchInventors: Zhenxun Wang, Wai Leong Tam, Lian Yee Yip, Ying Swan Ho, Zhengwei Wu, Bing Lim
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Patent number: 11873508Abstract: There is provided a polymeric microsphere comprising a thermally responsive monomer crosslinked with a functional group monomer, wherein the functional group monomer comprises at least one of a carboxylic acid functional group or an amine functional group. The thermally responsive monomer is preferably N-isopropylacrylamide (NIPAM), and the microspheres preferably comprise a coating of polymerized catecholamines (e.g. DOPA). There is also provided a method of preparing the polymeric microsphere and uses of the polymeric microsphere in culturing, harvesting, or expanding stem cells or stromal cells. Preferably, the cells, e.g. hMSCs (human mesenchymal stem/stromal cells), are expanded or harvested in serum-free and xeno-free medium.Type: GrantFiled: January 22, 2018Date of Patent: January 16, 2024Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Jackie Y. Ying, Leng Leng Chng, Daniele Zink, Aysha Farwin
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Patent number: 11876188Abstract: The present disclosure relates to an electrolyte comprising: a) a sodium salt; b) an additive comprising at least one additional metallic/metalloid cation having a standard reduction potential which is at least 2.5V more positive than that of sodium cation; wherein said sodium salt and said additive are dispersed in a solvent comprising at least one alkyl carbonate, and wherein the concentration of said metallic/metalloid cation in the electrolyte is 15 mM to 250 mM. The present disclosure also relates to a sodium-sulfur cell comprising a sodium anode, a microporous sulfur cathode, and the electrolyte as described herein. The present disclosure further provides a method of improving cycling life of a sodium-sulfur cell, wherein the sodium-sulfur cell comprising a sodium anode, a sulfur cathode, and an electrolyte containing a sodium salt dispersed in an alkyl carbonate solvent.Type: GrantFiled: October 26, 2020Date of Patent: January 16, 2024Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Vipin Kumar, Zhi Wei Seh
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Patent number: 11865787Abstract: There is provided a method of additive manufacturing using at least one processor, the method includes: determining a first slicing layer of a three-dimensional (3D) model of a 3D object; determining a second slicing layer of the 3D model based on the first slicing layer, the second slicing layer being immediately subsequent to the first slicing layer; and determining a thickness of the second slicing layer and an orientation for a third slicing layer of the 3D model based on a difference between the second slicing layer and the first slicing layer, the third slicing layer being immediately subsequent to the second slicing layer. There is also provided a corresponding system and computer program product for additive manufacturing.Type: GrantFiled: February 14, 2019Date of Patent: January 9, 2024Assignees: Agency for Science, Technology and Research, Nanyang Technological UniversityInventors: Xiling Yao, Youxiang Chew, Guijun Bi, Seung Ki Moon
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Patent number: 11859171Abstract: The present invention provides an approach to increase the effective read length of commercially available sequencing platforms to several kilobases and be broadly applied to obtain long sequence reads from mixed template populations. A method for generating extended sequence reads of long DNA molecules in a sample, comprising the steps of: assigning a specific barcode sequence to each template DNA molecule in a sample to obtain barcode-tagged molecules; amplifying the barcode-tagged molecules to obtain barcode-containing fragments; juxtaposing the barcode-containing fragments to random short segments of the original DNA template molecule during the process of generating a sequencing library to obtain demultiplexed reads; and assembling the demultiplexed reads to obtain extended sequence reads for each DNA template molecule, is disclosed.Type: GrantFiled: April 17, 2014Date of Patent: January 2, 2024Assignee: Agency for Science, Technology and ResearchInventors: Stephen R. Quake, William F. Burkholder, Lewis Z. Hong
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Patent number: 11840694Abstract: The present invention relates to a polypeptide comprising at least one at least one deletion selected from the group consisting of ?HNH (?775-909), ARuvCIII-b (?1002-1074), AREC1-a (?510-655), AREC1-b (?525-587), AREC1-c (?662-710), AREC2 (?180-308), AREC2-a (?212-244), AREC2-b (?244-276), AREC2-c (?276-308), AREC2-d (?199-283), AREC2-e (?198-257), AREC2-f (?235-286), AREC2-g (?217-266), AREC3 (?498-712) and combinations thereof, wherein the position numbering is in accordance with SEQ ID NO: 1 encoding for S. pyogenes Cas9, and wherein the polypeptide has CRISPR-Cas DNA-binding activity. The polypeptide may further comprises a missense mutations selected from G12R, T13K, T13R, N14K, N497K, T657K, T657R, N767K, T770K, T770R, Q920K, Q920R, S1109R, D1135K, D1135R, S1338R and combinations thereof. Also claimed are nucleic acid molecules encoding for said polypeptides, compositions and method of site-directed engineering of a target DNA thereof.Type: GrantFiled: October 17, 2017Date of Patent: December 12, 2023Assignees: NANYANG TECHNOLOGICAL UNIVERSITY, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHInventors: Meng How Tan, Kean Hean Ooi
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Publication number: 20230391789Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.Type: ApplicationFiled: May 8, 2023Publication date: December 7, 2023Applicant: Agency for Science, Technology and ResearchInventor: Vikrant Arun ADSOOL
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Patent number: 11834475Abstract: Provided herein are polypeptides, polynucleotides, expression vectors, infectious clones, virus particles and immunogenic compositions of recombinant alphaviruses which can be used as vaccines. Also provided are methods for eliciting an immune response against alphavirus infection using the immunogenic composition comprising the alphavirus mutants described herein.Type: GrantFiled: August 19, 2021Date of Patent: December 5, 2023Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, University of TartuInventors: Lisa Fong Poh Ng, Yi Hao Chan, Andres Merits, Age Utt