Patents Assigned to Agency for Science, Technology and Research
  • Patent number: 11180608
    Abstract: A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening polymerization; and an optional endcap group. The biodegradable cationic polymers have low cytotoxicity and form complexes with biologically active materials useful in gene therapeutics and drug delivery.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: November 23, 2021
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Kazuki Fukushima, James L. Hedrick, Yi Yan Yang
  • Patent number: 11180733
    Abstract: The present disclosure provides a method of generating mature mesenchymal stem cells and the cell culture medium used in such method. Also disclosed herein include a mesenchymal stem cell culture obtained by the method as disclosed herein, and uses thereof.
    Type: Grant
    Filed: July 4, 2017
    Date of Patent: November 23, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Tong Ming Liu, Bing Lim, Pin Li
  • Patent number: 11179475
    Abstract: Techniques regarding the transportation of molecular cargo across the BBB are provided. For example, one or more embodiments described herein can comprise a chemical compound to facilitate molecular encapsulation of the molecular cargo. The chemical compound can comprise a diblock copolymer having a molecular backbone comprising a polycarbonate structure and a polyethylene glycol structure. Also, the polycarbonate structure can be functionalized with boronic acid.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: November 23, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: James L. Hedrick, Nathaniel H. Park, Yi Yan Yang, Zhi Xiang Voo, Jeremy Tan
  • Patent number: 11174289
    Abstract: De novo, artificial intelligence (AI) designed antimicrobial peptides (AMPs), antibacterial products comprising the AMPs and methods for treating bacterial infections using the products are provided. In one or more embodiments, the AMPs were designed using conditional latent attribute space sampling (CLaSS). The AMPs comprise up to twenty natural amino acids in length, including one with twelve and another with thirteen natural amino acids in length. The AMPs demonstrate low-toxicity and show high antimicrobial potency against diverse pathogens including multi-medication-resistant Gram negative Klebsiella pneumoniae.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: November 16, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Payel Das, Flaviu Cipcigan, James L. Hedrick, Yi Yan Yang, Kahini Wadhawan, Inkit Padhi, Enara C Vijil, Pang Kern Jeremy Tan
  • Patent number: 11174505
    Abstract: The present application discloses an isolated nucleic acid sequence for detecting the presence of a target nucleic acid sequence, a ribozyme for detecting the presence of a target nucleic acid sequence and uses thereof.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: November 16, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Sherry Aw, Yin Nah Teo, Stephen Michael Cohen, Melissa Xue Mei Tang
  • Patent number: 11177318
    Abstract: Various embodiments may provide a semiconductor package. The semiconductor package may include a substrate including a via hole. The semiconductor package may also include a chip attached to the substrate. The semiconductor package may further include a prefabricated ferromagnetic pin having a first portion held by the via hole, a second portion extending from a first end of the first portion, and a third portion extending from a second end of the first portion opposite the first end. The semiconductor package may also include a first magnetic shield structure attached to or extended from the second portion of the prefabricated ferromagnetic pin. The semiconductor package may further include a second magnetic shield structure attached to or extended from the third portion of the prefabricated ferromagnetic pin, such that at least a portion of the chip is between the first magnetic shield structure and the second magnetic shield structure.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: November 16, 2021
    Assignee: Agency for Science, Technology and Research
    Inventors: Teck Guan Lim, Hideaki Fukuzawa, Hang Liu
  • Patent number: 11166857
    Abstract: A liquid sensor for a diaper, and method of manufacturing the same are provided. The liquid sensor includes a plurality of electrochemical cells in series connection. Each of the plurality of electrochemical cells includes an anode, a cathode and a liquid-porous layer including an electrolyte solution. The liquid-porous layer electrically connects the anode to the cathode such that each cell has a respective predetermined potential difference across the cell. Two or more of the plurality of electrochemical cells are operable to be electrically connected by a liquid to form a single electrochemical cell having a potential difference lower than the sum of the predetermined potential differences of the two or more electrochemical cells.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: November 9, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Jackie Y. Ying, Guolin Xu, Rensheng Deng, Min Hu
  • Patent number: 11167036
    Abstract: The subject disclosure is directed to techniques for enhancing the selectivity and efficacy of therapeutic polymers against a broad spectrum of pathogens and cancer cell lines. According to an embodiment, a method is provided that comprises forming a therapeutic polymer based on polymerization of a plurality of therapeutic monomers, wherein the therapeutic polymer provides a therapeutic functionality. The method further comprises attaching biotin to the therapeutic polymer, resulting in a biotin-functionalized therapeutic polymer, wherein the biotin-functionalized therapeutic polymer provides greater therapeutic efficacy relative to the therapeutic polymer.
    Type: Grant
    Filed: November 27, 2018
    Date of Patent: November 9, 2021
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: James L. Hedrick, Nathaniel H. Park, Yi Yan Yang, Zhi Xiang Voo
  • Publication number: 20210341427
    Abstract: A transducer for monitoring integrity of an adhesive bond between a first element and a second element, the transducer comprising: a transducing adhesive, the transducing adhesive provided to act as at least one of: an actuator to convert an electrical signal to an acoustic signal and a sensor to convert an acoustic signal to an electrical signal; and an electrode provided on the transducing adhesive, the electrode provided to perform at least one of: providing an electrical signal to the transducing adhesive and receiving an electrical signal from the transducing adhesive; wherein, in use, the transducer is provided at least partially in the adhesive bond between the first element and the second element, and the acoustic signal is passed through the adhesive bond.
    Type: Application
    Filed: October 25, 2019
    Publication date: November 4, 2021
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Zheng Zheng WONG, Kui YAO, Shuting CHEN, Lei ZHANG
  • Patent number: 11161125
    Abstract: A fluid jet dispenser using at least two multilayer piezoelectric actuators is provided. The fluid jet dispenser includes a dispensing head and an electrical driver. The dispensing head includes at least two d31-mode multilayer piezoelectric actuators, a displacement magnifying element mechanically coupled to the d31-mode multilayer piezoelectric actuators, a piston, and a nozzle. More preferably, the two d31-mode multilayer piezoelectric actuators operate in an anti-phase condition. The electrical driver is electrically coupled to the d31-mode multilayer piezoelectric actuators for displacing the actuators in directions substantially perpendicular to polarization of piezoelectric layers in the d31-mode multilayer piezoelectric actuators in response to charging and discharging of the actuators by the electrical driver, to generate a fast movement of the piston to jet a pressurized fluid out of the nozzle of the dispensing head.
    Type: Grant
    Filed: June 22, 2016
    Date of Patent: November 2, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Meysam Sharifzadeh Mirshekarloo, Kui Yao, Szu Cheng Lai, Chee Kiang Ivan Tan, Lei Zhang
  • Patent number: 11154054
    Abstract: The present disclosure relates to an antimicrobial coating on a surface, a method for preparing and uses of the same. In particular it relates to a process for preparing an antimicrobial coating on a surface, the process comprising the steps of: a) providing a surface; b) coating a metal oxide or a metal hydroxide on the surface in the presence of a solvent in a hydrothermal synthesis step to form a coated surface having a plurality of nanostructures; c) optionally drying the coated surface, wherein said nanostructure is preferably in nanopillar structure. The coating of the present application exhibits excellent antimicrobial activity against different types of microorganism, such as bacteria and yeast. The nanostructures are able to exert stress to the microorganism, and therefore controlling or killing them.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: October 26, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Yugen Zhang, Guangshun Yi
  • Patent number: 11156616
    Abstract: We describe a method of detecting a therapeutic exosome, the method comprising detecting an activity of an exosome. The activity may be selected from the group consisting of: (a) immunodulatory activity; (b) complement inhibition activity; (c) proteasome activity; (d) glycolytic enzyme activity; (e) anti-oxidative activity; (f) extracellular matrix (ECM) modifying activity; (g) NT5E (CD73) ecto-5?-ectonucleotidase activity; (h) ion homeostasis activity; and (i) chaperone activity. If the exosome is detected as having one or more such activities, the exosome is likely to comprise a therapeutic exosome having therapeutic activity.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: October 26, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventor: Sai Kiang Lim
  • Patent number: 11155636
    Abstract: The present invention relates to humanised antibodies that bind PRL3.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: October 26, 2021
    Assignee: Agency for Science, Technology and Research
    Inventor: Qi Zeng
  • Patent number: 11155113
    Abstract: There is provided a holographic security element including a substrate; and an array of nano-reflectors configured to form a pattern on the substrate and to generate a holographic image corresponding to the pattern at a predetermined distance from the substrate when irradiated with a predetermined light source. In particular, the array of nano-reflectors is configured to generate the holographic image at the predetermined distance to have a size that is larger than a size of the pattern. There is also provided a method of forming the holographic security element, and an article having one or more holographic security elements incorporated therein.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: October 26, 2021
    Assignee: Agency for Science, Technology and Research
    Inventors: Kun Huang, Jinghua Teng, Xiao Ming Goh, Junhao Shawn Tan
  • Patent number: 11149114
    Abstract: A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening polymerization; and an optional endcap group. The biodegradable cationic polymers have low cytotoxicity and form complexes with biologically active materials useful in gene therapeutics and drug delivery.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: October 19, 2021
    Assignees: International Business Machines Corporation, Agency For Science, Technology And Research
    Inventors: Kazuki Fukushima, James L. Hedrick, Yi Yan Yang
  • Patent number: 11143637
    Abstract: The present invention generally relates to a method for analyzing and identification of the plurality of lipids in a sample that is profiled using a combined Liquid Chromatography-Mass Spectrometry (LC-MS) technique, comprising the steps of: a) providing a list of Liquid Chromatography-Mass Spectrometry (LC-MS)-based mass features; b) deconvoluting said list of LC-MS-based mass features; c) inferring daughter ions from the deconvoluted list of LC-MS-based mass features; d) identifying one or more parental exact masses from the inferred daughter ions; e) scoring each of the one more parental exact masses based on the inferred daughter ions; f) determining characteristic mass features in response to the scoring of each of the one or more parental exact masses; and g) determining each of the plurality of lipids based on the characteristic mass features thereof. In particular, the present invention also relates to identification of the plurality of lipids undergoing in-source fragmentation.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: October 12, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Dong-Yup Lee, Hock Chuan Yeo, Ying Swan Ho, Shuwen Chen
  • Patent number: 11142585
    Abstract: The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof. In particular, the present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to ERBB2. Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: October 12, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Heng Liang Tan, Andre Boon Hwa Choo
  • Patent number: 11142574
    Abstract: Anti-TIM-3 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: October 12, 2021
    Assignee: Agency for Science, Technology and Research
    Inventors: Cheng-I Wang, Hsueh Ling Janice Oh, Siok Ping Yeo, Yun Pei Sharon Goh
  • Patent number: 11142790
    Abstract: There is provided a microfluidic device comprising: a plurality of wells, each well comprising one opening to function as an inlet and an outlet for the well, wherein each opening is in fluid communication with a common fluidic channel, and wherein each opening is connected to the common fluidic channel via an isolation channel, and wherein the plurality of wells is arranged on the device in a radially symmetrical pattern. There is also provided a system and method comprising the device.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: October 12, 2021
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Jackie Y. Ying, Guolin Xu, Rensheng Deng
  • Publication number: 20210309668
    Abstract: The present disclosure relates to derivatives of bicyclic compounds and their uses in therapy. In particular, the present disclosure relates to derivatives of bicyclic compounds for use in modulating kinase enzymatic activity and accordingly modulating kinase-dependent diseases and conditions such as cancer and in specific embodiments, hepatocellular carcinoma (HCC). The present disclosure also relates to methods of synthesizing these compounds.
    Type: Application
    Filed: July 23, 2019
    Publication date: October 7, 2021
    Applicant: Agency for Science, Technology and Research
    Inventor: Vikrant Arun ADSOOL