Patents Assigned to Agency for Science, Technology and Research
  • Patent number: 10693626
    Abstract: There is provided a method of generating a ciphertext. The method includes encrypting an input data to produce an encrypted data, and randomizing the encrypted data to produce the ciphertext. In particular, the randomizing process includes performing an exclusive-or (xor) operation on the encrypted data with a cipher pad, whereby the cipher pad is generated based on an xor-homomorphic function of a first key using a second key generated based on the encrypted data. There is also provided a corresponding system for generating a ciphertext, a corresponding method and system for decrypting a ciphertext, and a corresponding method and system for searching ciphertexts in a database, such as at an untrusted server.
    Type: Grant
    Filed: April 23, 2015
    Date of Patent: June 23, 2020
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Shuqin Ren, Benjamin Hong Meng Tan, Khin Mi Mi Aung, Sivaraman Sundaram
  • Patent number: 10690595
    Abstract: Various embodiments may provide an optical sensing device based on surface plasmon resonance (SPR). The optical sensing device may include an optical arrangement configured to provide a first polarization light beam and a second polarization light beam, and a first optical member including a sensing surface, the first optical member configured to receive the first and second polarization light beams and reflect the first and second polarization light beams at the sensing surface. The optical sensing device may further include a second optical member arranged to receive the reflected first and second polarization light beams from the first optical member and configured to separate the reflected first and second polarization light beams in a first direction and a second direction, respectively. The optical device may additionally include a detector arrangement configured to detect the reflected first and second polarization light beams from the second optical member.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: June 23, 2020
    Assignee: Agency for Science, Technology and Research
    Inventors: Chi Lok Wong, Malini Olivo
  • Patent number: 10687528
    Abstract: Techniques regarding ionene and/or polyionene compositions with antimicrobial functionalities are provided. For example, one or more embodiments can comprise a chemical compound, which can comprise an ionene unit. The ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a norspermidine structure having a carbonyl group. Also, the ionene unit can have antimicrobial functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 23, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • Patent number: 10687530
    Abstract: Techniques regarding ionene and/or polyionene compositions with antimicrobial functionality and enhanced hydrophilicity are provided. For example, one or more embodiments can regard a chemical compound that can comprise an ionene unit, which can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. The ionene unit can have antimicrobial functionality. Further, the chemical compound can comprise a hydrophilic functional group covalently bonded to the ionene unit. Also, the chemical compound can have carbohydrate mimetic functionality.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 23, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Yi Yan Yang, Mu San Zhang
  • Patent number: 10687896
    Abstract: A method for surgical resection planning of a mass includes the steps of, modelling the mass based on a plurality of physical dimensions, determining a plurality of safety margins around a plurality of features within the mass, simulating a resection surface on the mass that includes a plurality of triangles, optimizing local area and position of a first of the plurality of triangles on the resection surface based on a triangle-based algorithm, updating the simulation of the resection surface, and repeating the steps of optimizing and updating for each of the plurality of triangles on the resection surface.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: June 23, 2020
    Assignees: Agency for Science, Technology and Research, National University Hospital (Singapore) Pte Ltd.
    Inventors: Wenyu Chen, Sudhakar K. Venkatesh, Qi Tian, Jianyin Zhou, Weimin Huang, Wei Xiong, Oo Thiha
  • Patent number: 10689428
    Abstract: We describe an ELABELA polypeptide comprising a sequence CXXXRCXXXHSRVPFP (SEQ ID NO: 1), in which X signifies an amino acid residue, such as a sequence selected from the group consisting of: SEQ ID NO: 2 to SEQ ID NO: 18, preferably CLQRRCMPLHSRVPFP (SEQ ID NO: 2), or a fragment, homologue, variant or derivative thereof, which polypeptide is capable of maintaining self-renewal and/or pluripotency of a stem cell.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: June 23, 2020
    Assignee: Agency For Science, Technology And Research
    Inventor: Bruno Reversade
  • Patent number: 10689497
    Abstract: This invention relates to a a one-step process for making a polymer composite suspension for coating plastic films characterized in that a first polymer is synthesized in-situ optionally in the presence of other polymers and in the presence of clay. Preferably the polymer composite suspension comprises a) 1.0 to 11.0 wt % of clay or silane modified clay, b) 0.1 to 10.0 wt % of poly (acrylic acid), which is a copolymer of acrylic acid (AA) with at least one other monomer selected from 2-ethylhexyl acrylate (EHA), ?-carboxyethyl acrylate (?-CEA), methacrylamidoethyl ethylene urea (WAM II) and ethoxylated behenyl methacrylate (?-EM), c) 1.0 to 15.0 wt % of other polymers, preferably poly (vinyl alcohol) and d) 70 to 97 wt % of water or mixture of water with 2-propanol. The coating films made from the suspensions show good barrier capabilities against water vapor and oxygen can be used to make barrier layers on or within plastic films for packaging applications.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: June 23, 2020
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Xu Li, Yu Yuan Chieng, Siew Yee Wong, Xikui Zhang
  • Publication number: 20200190086
    Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
    Type: Application
    Filed: December 16, 2019
    Publication date: June 18, 2020
    Applicant: Agency for Science, Technology and Research
    Inventors: Soo Yei HO, Stephanie Eliane BLANCHARD, Athisayamani Jeyaraj DURAISWAMY, Jenefer ALAM, Vikrant Arun ADSOOL
  • Patent number: 10683382
    Abstract: A copolymer comprising an oxygenated polyaromatic alcohol and a poly (alkylene oxide) alkyl ether (meth)acrylate is disclosed, wherein the oxygenated polyaromatic alcohol is preferably lignin or lignin derivative. A hydrogel comprising the copolymer and a cyclic oligosaccharide such as ?-cyclodextrin is also disclosed, which can be used in biomedical or personal care industries, for example as a carrier for an active agent.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: June 16, 2020
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Dan Kai, Xian Jun Loh
  • Patent number: 10683484
    Abstract: This application describes liver stem cells (LSC), and differentiated hepatocytes, cholangiocytes, and 3D cellular structures derived therefrom. Methods for producing LSC and mature, differentiated hepatocytes and cholangiocytes in culture are provided. Also provided are cell culture systems and cell culture media for producing a homogenous population of liver stem cells that remain in an undifferentiated state over multiple passages in culture. The LSC and methods are useful for producing homogenous populations of hepatocytes and cholangiocytes for downstream applications. The LSC can be transplanted into subjects to treat liver diseases.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: June 16, 2020
    Assignees: NATIONAL UNIVERSITY OF SINGAPORE, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Yuanyu Hu, Huck Hui Ng, Yock Young Dan
  • Patent number: 10684272
    Abstract: Presently disclosed is a method of modulating Hepatitis B virus (HBV) replication, by contacting the cell with at least one agent that modulates at least one factor from a specified group consisting of SNAI2, SOX7 and other factors, the screening of said agent and use thereof in a medicament for treating HBV infection or disease or condition associated with a HBV infection in a subject. In one preferred embodiment, the agent is one peptide derived from SOX7 or SNAI2 or stapled peptides thereof. As a separate invention, a method of identifying at least one factor that modulates replication of a virus is also disclosed.
    Type: Grant
    Filed: July 15, 2016
    Date of Patent: June 16, 2020
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Ee Chee Ren, Hul Ling Ko
  • Publication number: 20200181283
    Abstract: The present invention relates to humanised antibodies that bind PRL3.
    Type: Application
    Filed: June 14, 2017
    Publication date: June 11, 2020
    Applicant: Agency for Science, Technology and Research
    Inventor: Qi ZENG
  • Publication number: 20200179487
    Abstract: The invention relates to an ELABELA polypeptide or nucleic acid for use in the treatment, alleviation or prophylaxis of pre-eclampsia in an individual. In another aspect of the invention, there is provided a method of diagnosing or detecting the susceptibility of an individual to pre-eclampsia, wherein the method comprises detecting modulation, preferably down-regulation of expression, amount or activity of ELABELA.
    Type: Application
    Filed: June 28, 2017
    Publication date: June 11, 2020
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Bruno REVERSADE, Lena Wai Mun HO
  • Publication number: 20200181612
    Abstract: The present invention relates to antisense oligonucleotides for modulating the activity of PRDM15 and use thereof in the treatment of cancer. In particular, said antisense oligonucleotides are capable of inducing the skipping of an exon of a PRDM15 mRNA. The present invention also relates to a method for determining prognosis in a patient with cancer, or selecting a therapeutic strategy for a patient with cancer, by assessing the level of PRDM15 nucleic acid, protein or activity in a sample.
    Type: Application
    Filed: September 4, 2017
    Publication date: June 11, 2020
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Ernesto GUCCIONE, Keng Boon Dave WEE
  • Patent number: 10677682
    Abstract: Systems and methods for monitoring plastic deformation of a structural material are provided. An acoustic wave actuator is configured to generate acoustic wave signals to be propagated within the structural material and is in-situ fabricated on the structural material at a first location. An alternating current (AC) electric signal source drives the acoustic wave actuator to generate the acoustic wave signals at a predetermined frequency. One or more acoustic wave sensors detect the acoustic wave signals generated by the acoustic wave actuator and propagated within the structural material. More particularly, the acoustic wave detectors are configured to detect both fundamental and second harmonic acoustic signals at the predetermined frequency. The acoustic wave sensors are in-situ fabricated on the structural material at one or more second locations.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: June 9, 2020
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Kui Yao, Shifeng Guo, Shuting Chen, Lei Zhang
  • Patent number: 10679860
    Abstract: A method for fabrication of high electron mobility transistor (HEMT) semiconductor devices is presented. The method includes providing a substrate, growing a HEMT layer structure on the substrate; and self-aligned common metal stack formation of source, drain and gate electrodes on the HEMT layer structure using a single lithographic mask.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: June 9, 2020
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Lakshmi Kanta Bera, Yee Chong Loke, Surani Bin Dolmanan, Sudhiranjan Tripathy, Wai Hoe Tham
  • Patent number: 10667514
    Abstract: Techniques regarding amine monomers that can form ionene compositions with antimicrobial functionality are provided. For example, one or more embodiments described herein can comprise a monomer, which can comprise a molecular backbone. The molecular backbone can comprise a norspermidine structure. The norspermidine structure can comprise a tertiary amino group. Also, the tertiary amino group can comprise a functional group, and an amino group of the norspermidine structure can be capable of being ionized.
    Type: Grant
    Filed: December 12, 2017
    Date of Patent: June 2, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Mareva B. Fevre, James L. Hedrick, Nathaniel H. Park, Victoria A. Piunova, Pang Kern Jeremy Tan, Chuan Yang, Yi Yan Yang
  • Patent number: 10668500
    Abstract: A method for preparing an amorphous metal oxide film is provided. The method comprises providing an aqueous composition comprising a metal fluorine compound; and contacting a substrate with the aqueous composition at a temperature of less than about 100° C. to obtain said amorphous metal oxide film on the substrate. An amorphous metal oxide film, and use of the amorphous metal oxide film in various applications are also provided.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: June 2, 2020
    Assignee: Agency for Science, Technology and Research
    Inventors: Kia Liang Gregory Goh, Hong Quang Le, Ajay Kumar Kushwaha
  • Patent number: 10669152
    Abstract: Various embodiments may provide a device arrangement. The device arrangement may include a substrate including a conductive layer. The device arrangement may further include a microelectromechanical systems (MEMS) device monolithically integrated with the substrate, wherein the MEMS device may be electrically coupled to the conductive layer. A cavity may be defined through the conductive layer for acoustically isolating the MEMS device MEMS device from the substrate. At least one anchor structure may be defined by the conductive layer to support the MEMS device.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: June 2, 2020
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Navab Singh, Jae Wung Lee, Srinivas Merugu
  • Publication number: 20200168996
    Abstract: A circularly polarized (CP) antenna for Radio Frequency energy harvesting comprising: a top substrate; a bottom substrate disposed on a ground plane; a middle substrate disposed between the top substrate and the bottom substrate; a slotted patch comprising more than one slots, the slotted patch being disposed on the top substrate; a slitted patch comprising a plurality of slits, the slitted patch being disposed between the top substrate and the middle substrate; a microstrip feed line disposed between the middle substrate and the bottom substrate; and a via connecting the slotted-circular-patch and the microstrip feed line to enable the slotted-circular-patch to be fed by the microstrip feed line, wherein the more than one slots and the slits are arranged so as to generate more than one orthogonal modes with equal magnitude for receiving RF signals.
    Type: Application
    Filed: August 6, 2018
    Publication date: May 28, 2020
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Nasimuddin NASIMUDDIN, Muhammad Faeyz KARIM, Karthik Thothathri CHANDRASEKARAN