Patents Assigned to Agency for Science, Technology and Research
  • Patent number: 10316079
    Abstract: Disclosed is an isolated antibody or an antigen-binding fragment thereof The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: June 11, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Yue Wang, Xiaoli Xu
  • Patent number: 10316078
    Abstract: Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: June 11, 2019
    Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Cheng-I Wang, Katja Fink, Paul Macary, Roland Zuest, Meihui Xu
  • Patent number: 10311744
    Abstract: A cognitive training method has a step of obtaining sensor data of a subject during a memory exercise which in turn determines whether the sensor data includes predetermined information indicative of cognitive functions used for remembering. The step of advancing the memory exercise is carried out when it is determined that the sensor data includes predetermined information indicative of cognitive functions used for remembering. The step of calculating an objective cognitive assessment of the subject is carried out when the memory exercise is completed and cognitive training is measured at least partially in response to the advancing of the memory exercise. The fact that an objective cognitive assessment is calculated provides a method of using an autodidactic cognitive training device.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: June 4, 2019
    Assignees: Agency for Science, Technology and Research, National University of Singapore
    Inventors: Hai Hong Zhang, Cuntai Guan, Ranga Krishnan, Tih Shih Lee, Zheng Yang Chin, Chuan Chu Wang
  • Patent number: 10302555
    Abstract: The invention relates to a sensor for sensing an analyte.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: May 28, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Zi En Ooi, Jie Zhang, Kok Leong Chang
  • Patent number: 10293083
    Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: May 21, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Charlotte Hauser, Wei Yang Seow
  • Publication number: 20190144535
    Abstract: The present invention is directed to antigen binding proteins and in particular to IL-1? antigen binding proteins. The present invention further provides compositions comprising the antigen binding proteins, use of the antigen binding proteins and methods for production.
    Type: Application
    Filed: November 15, 2018
    Publication date: May 16, 2019
    Applicant: Agency for Science, Technology and Research
    Inventors: Cheng-l Wang, Angeline Goh, Siok Ping Yeo, Alessandra Mortellaro, Subhra Kumar Biswas, Florent Ginhoux, Pingyu Zhong
  • Patent number: 10286110
    Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: May 14, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Charlotte Hauser, Wei Yang Seow
  • Patent number: 10287547
    Abstract: This invention refers to an antibody or an antigen binding portion thereof, that binds specifically to human corneal endothelial cells (hCENCs), wherein the target of the monoclonal antibody, or antigen binding portion thereof, is essentially cell surface-expressed Peroxiredoxin-6 (Prdx6), as well as to methods for determining suitability of a cell sample for corneal transplantation, for quantitative enrichment of human corneal endothelial cells from a mixture of cells, and for isolating human corneal endothelial cells from a mixture of cell.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: May 14, 2019
    Assignees: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Mei Yee Vanessa Ding, Boon Hwa Andre Choo, Chui Ping Angela Chin, Jodhbir Singh Mehta, Gary Peh
  • Patent number: 10286111
    Abstract: The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: May 14, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Charlotte Hauser, Wei Yang Seow
  • Patent number: 10287553
    Abstract: There is provided a method for culturing a stem cell in vitro. The method comprises providing a substrate surface coated with a coating comprising a molecule having a catechol moiety or a polymer thereof; and growing a stem cell on said coated substrate surface in a growth medium.
    Type: Grant
    Filed: April 22, 2013
    Date of Patent: May 14, 2019
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Daniele Zink, Ming Ni, Karthikeyan Narayanan, Karthikeyan Kandasamy, Andrew C. A. Wan, Jackie Y. Ying
  • Patent number: 10280224
    Abstract: Anti-PD-1 antibodies are disclosed. Also disclosed are pharmaceutical compositions comprising such antibodies, and uses and methods using the same.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: May 7, 2019
    Assignee: Agency For Science, Technology and Research
    Inventors: Cheng-i Wang, Hsueh Ling Janice Oh, Siok Ping Yeo, Jianrong Lionel Low, Hwee Ching Tan
  • Patent number: 10280168
    Abstract: The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazopyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), neurodegenerative diseases (e.g., Alzheimer's disease), metabolic diseases (e.g. diabetes), neurodevelopmental disorders (e.g. autism), or psychiatric disorders (e.g. schizophrenia or anxiety)) as well as methods of treating these diseases.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: May 7, 2019
    Assignee: Agency for Science, Technology and Research
    Inventor: Kassoum Nacro
  • Patent number: 10280195
    Abstract: Methods are provided for enhancing reduction of virus and viral DNA levels in protein preparations.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: May 7, 2019
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventor: Peter Stanley Gagnon
  • Patent number: 10278701
    Abstract: An implant having an adhesive structure comprising a planar surface having two sides and rectangular cuboid-based protrusions having pyramidal tips extending from at least one of said sides, optionally having a porous basic supporting structure, and methods of making and using such implants.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: May 7, 2019
    Assignees: ETHICON, INC., AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH
    Inventors: Sriram Natarajan, Joseph J. Hammer, Kevin Cooper, Murty Vyakarnam, Hong Yee Low, Isabel Rodriguez, Chee Tiong Lim, Audrey Yoke Yee Ho
  • Patent number: 10276236
    Abstract: A memory device includes a metal oxide material disposed between and in electrical contact with first and second conductive electrodes, and an electrical current source configured to apply one or more electrical current pulses through the metal oxide material. For each of the one or more electrical current pulses, an amplitude of the electrical current increases over time during the electrical current pulse to form a conductive filament in metal oxide material.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: April 30, 2019
    Assignees: Silicon Storage Technology, Inc., Agency For Science, Technology, And Research
    Inventors: Santosh Hariharan, Hieu Van Tran, Feng Zhou, Xian Liu, Steven Lemke, Nhan Do, Zhixian Chen, Xinpeng Wang
  • Publication number: 20190120770
    Abstract: A system and a method for imaging a surface defect on an object are provided. The system includes an actuator, a sensor assembly connected to the actuator, and a processor configured to control the actuator and the sensor assembly. The sensor assembly includes at least one sensor configured to capture at least one image of the object. The processor is configured to control the actuator and the sensor assembly to identify the actuator and the sensor assembly, a region of a region of interest associated with the surface defect using an using an image of the object and to repeatedly identify at least one subsequent region of interest associated with the surface defect using at least a preceding region of interest such that the surface defect is identified according to a predetermined criterion.
    Type: Application
    Filed: March 30, 2017
    Publication date: April 25, 2019
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Wenyu CHEN, Wei XIONG, Jia DU, Jierong CHENG, Teck Sun Marcus WAN
  • Publication number: 20190122445
    Abstract: The present disclosure generally relates to an automated method and system for generating a panoramic visualization of a coronary arterial tree of a subject. The method comprises: acquiring an image volume of a thoracic cavity of the subject, the image volume providing a three-dimensional (3D) representation of the thoracic cavity; isolating a coronary structure in the 3D representation by abating one or more other anatomical structures in the thoracic cavity; abating one or more portions of the coronary structure in the 3D representation that attenuate visualization of the coronary arterial tree; generating, by maximum intensity projection (MIP), a plurality of MIP images of the coronary structure from the 3D representation; and compositing the MIP images to generate the panoramic visualization of the coronary arterial tree.
    Type: Application
    Filed: March 31, 2017
    Publication date: April 25, 2019
    Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, SINGAPORE HEALTH SERVICES PTE LTD
    Inventors: Yanling CHI, Liang ZHONG, Ru San TAN, Weimin HUANG, Jiayin ZHOU, Kyaw Kyar TOE
  • Publication number: 20190120760
    Abstract: In a first aspect, a system for analysing a fluid sample is provided, comprises: a container configured to receive the fluid sample; a first light source optically coupled to the container and configured to project a first light having a first wavelength; a second light source optically coupled to the container and configured to project a second light having a second wavelength different from the first wavelength; one or more photo-sensors optically coupled to the container and configured to analyse the fluid sample in response to a first scattered light generated in response to projecting the fluid sample with the first light source and a second scattered light generated in response to projecting the fluid sample with the second light source. In a preferred embodiment, the nutritious compositions (such as the concentration of fats and protein) of milk samples are identified based on the scattering of the first and second light source by the milk sample.
    Type: Application
    Filed: March 30, 2017
    Publication date: April 25, 2019
    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Szu Cheng LAI, Lin KE, Nan ZHANG
  • Patent number: 10266612
    Abstract: A novel class of structurally and functionally related isolated Heparan sulphate is disclosed. The novel class of Heparan sulphates has been found to bind FGF2 and enhance the proliferation of stem cells while maintaining their pluripotency/multipotency.
    Type: Grant
    Filed: May 16, 2013
    Date of Patent: April 23, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Victor Nurcombe, Simon Cool
  • Patent number: 10259851
    Abstract: Methods are provided for extracting DNA-compaction proteins from biological samples.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: April 16, 2019
    Assignee: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
    Inventors: Peter Stanley Gagnon, Hui Theng Gan