Abstract: A strain of Bifidobacterium longum APC 1472 is described. The strain has weight lowering effects in-vivo, achieved through inducing satiety via decreased internalisation of the Ghrelin receptor, and therefore, decreased constitutive activity. Moreover, the strain also showed a trend towards decreased ghrelin receptor hypothalamic expression in HFD-fed mice when compared with vehicle control group. The strain also improves glucose tolerance and decreased insulin plasma levels in mice, indicating the strain in the prevention and/or treatment of Type II diabetes, especially in obese individuals.
Type:
Grant
Filed:
August 27, 2018
Date of Patent:
December 5, 2023
Assignees:
UNIVERSITY COLLEGE CORK—NATIONAL UNIVERSITY OF IRELAND, CORK, AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC)
Inventors:
John Cryan, Ted Dinan, Catherine Stanton, Harriet Schellekens, Cristina Torres, Bernard Roy
Abstract: A method of sequential isoelectric solubilisation of animal by-product comprising the steps of isoelectric solubilisation of the animal by-product in one of an acid or alkali solution to provide a first solubilised protein fraction, separating the first solubilised protein fraction from unsolubilised animal by-product, isoelectric solubilisation of the unsolubilised animal by-product to provide a second solubilised protein fraction, and separation of the second solubilised protein fraction from unsolubilised animal by-product. The protein from the first and/or second solubilised protein fractions is recovered by drying or precipitation. In one embodiment, the acid and alkali soluble protein fractions are proportionally combined to neutralise the composite fraction and precipitate protein.
Type:
Grant
Filed:
July 15, 2016
Date of Patent:
May 10, 2022
Assignee:
AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC)
Inventors:
Brijesh K. Tiwari, Carlos Alvarez Garcia, Declan Troy
Abstract: An isolated Lactobacillus mucosae (DPC6426) strain deposited with the National Collection of Industrial and Marine Bacteria Limited (NCIMB) on 27 Jul. 2012 under NCIMB Deposit Accession No. 42015.
Type:
Grant
Filed:
September 2, 2013
Date of Patent:
November 7, 2017
Assignees:
University College Cork—National University of Ireland, Cork, Agriculture and Food Development Authority (TEAGASC)
Inventors:
Catherine Stanton, Paul Ross, Gerald F. Fitzgerald, Noel Caplice, Fergus Shanahan
Abstract: An antimicrobial peptide having potent antibacterial activity against Listeria monocytogenes and Staphylococcus aureus is described. Also described is an isolated Lactobacillus salivarius DPC6502 strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 41840, and variants thereof, wherein the isolated bacteria and variants thereof express an antimicrobial peptide of the invention.
Type:
Application
Filed:
April 3, 2017
Publication date:
September 7, 2017
Applicants:
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK, AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC)
Abstract: Provided herein are methods and kits directed to a method of assaying a sample to determine the presence of a source of pink discoloration defect of a dairy product, such as cheese. In some embodiments, the method comprises the steps of assaying the sample to detect the presence of a Thermus species of bacteria, such as Thermus thermophilus bacteria, wherein detection of Thermus thermophilus bacteria in the sample indicates that the sample contains a source of pink discoloration of a dairy product.
Type:
Application
Filed:
June 19, 2015
Publication date:
June 1, 2017
Applicant:
AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC)
Inventors:
Paul Cotter, Diarmuid Sheehan, Lisa Quigley
Abstract: An antimicrobial peptide having potent antibacterial activity against Listeria monocytogenes and Staphylococcus aureus is described. Also described is an isolated Lactobacillus salivarius DPC6502 strain as deposited with the National Collection of Industrial and Marine Bacteria under the Accession No. NCIMB 41840, and variants thereof, wherein the isolated bacteria and variants thereof express an antimicrobial peptide of the invention.
Type:
Application
Filed:
July 27, 2012
Publication date:
September 25, 2014
Applicants:
AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC), UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Abstract: An isolated bacteriophage MR299-2 or NH-4 deposited under NCIMB Deposit Accession Nos. 41729 and 41730, respectively, is described. The phages have lytic activity against P. aeruginosa strains, including mucoid and CF clinical isolate strains. Variant hages are also described, wherein said variants retain the phenotypic characteristics of said phage and wherein said phage and variants thereof have lytic activity against P. aeruginosa strains.
Type:
Application
Filed:
December 20, 2011
Publication date:
July 12, 2012
Applicants:
AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC), UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
Inventors:
Paul Ross, Debebe Alemayehu, Colin Hill, James Gerard Martin