Patents Assigned to Ajinomoto Co., Inc.
  • Publication number: 20190136202
    Abstract: Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a s pharmaceutically acceptable salt thereof, and which is substantially free of ?-mercaptoethanol or contains ?-mercaptoethanol at a concentration of not more than 9 ?M, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.
    Type: Application
    Filed: January 8, 2019
    Publication date: May 9, 2019
    Applicant: AJINOMOTO CO., INC.,
    Inventors: Sho SENDA, Tomomi YOSHIDA, Satoru OKAMOTO, Yoko KURIYAMA, Manabu KITAZAWA, Ikue HARATA, Nao SUGIMOTO
  • Publication number: 20190133897
    Abstract: Creamy cleansing compositions and creamy compositions which contain (A) at least one component selected from the group consisting of N-acyl acidic amino acid and a salt thereof, and N-acyl neutral amino acid and a salt thereof, (B) at least one polyhydric alcohol, (C) at least one N-mono middle-chain acyl basic amino acid or a salt thereof, and (D) water have good creamy appearance with high grade pearly gloss, are superior in form stability, and superior in the sense of use such as cream elongation, water miscibility, and the like.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Takahiro SUZUKI, Kazuhiko TOBITA
  • Publication number: 20190137516
    Abstract: An evaluating method includes an evaluating step of evaluating future risk of developing Alzheimer's disease for a subject to be evaluated having mild cognitive impairment using a concentration value of at least one of ?-ABA, Ala, Arg, Asn, Cit, Gln, Glu, Gly, His, Ile, Leu, Lys, Met, Orn, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Cysteine, Taurine, bABA, Ethylglycine, Hypotaurine, 3-Me-His, 5-HydroxyTrp, aAiBA, and N8-Acetylspermidine in blood of the subject.
    Type: Application
    Filed: January 4, 2019
    Publication date: May 9, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Takeshi Ikeuchi, Yuki Yano, Naoko Arashida, Rumi Nishimoto, Kazutaka Shimbo, Nobuhiro Kawai
  • Patent number: 10280267
    Abstract: Polyallylamine derivatives including 10 to 450 structural units represented by Formula (1): are useful for preparing dispersants, treated particles, particle-containing compositions, pigment-containing compositions, paints, ink compositions, liquid developers, and anti-blocking agents.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: May 7, 2019
    Assignee: Ajinomoto Co., Inc.
    Inventors: Yuji Koshima, Naoya Sato
  • Patent number: 10266857
    Abstract: The present invention provides a method for producing N?-dodecanoyl-L-lysine using an enzyme having properties suitable for the industrial production of N?-dodecanoyl-L-lysine. More specifically, the present invention provides a method for producing N?-acyl-L-lysine including reacting a carboxylic acid or a salt thereof and L-lysine or a salt thereof in the presence of a protein having an amino acid sequence of SEQ ID NO: 1; a protein having an amino acid sequence in which one or several amino acid residues are inserted, added, deleted, or substituted in the amino acid sequence of SEQ ID NO: 1 and having N?-acyl-L-lysine-specific aminoacylase activity; and a protein which has 90% or higher homology with the amino acid sequence of SEQ ID NO: 1 and having N?-acyl-L-lysine-specific aminoacylase activity.
    Type: Grant
    Filed: April 17, 2018
    Date of Patent: April 23, 2019
    Assignee: AJINOMOTO CO., INC.
    Inventors: Jun Takakura, Hiroyuki Nozaki
  • Patent number: 10257928
    Abstract: Resin sheets which includes a support and a resin composition layer in contact on the support, and which are characterized in that an extracted water conductivity A of a cured product of the resin composition layer when extracted at 120° C. for 20 hours is 50 ?S/cm or less and an extracted water conductivity B of the cured product of the resin composition layer when extracted at 160° C. for 20 hours is 200 ?S/cm or less, can provide a thin insulating layer having excellent insulating properties.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: April 9, 2019
    Assignee: Ajinomoto Co., Inc.
    Inventors: Shigeo Nakamura, Shiro Tatsumi, Ikumi Sawa
  • Patent number: 10226044
    Abstract: A composition for agricultural or horticultural application, which contains isoleucine as an active ingredient, and is sprinkled on a fruit vegetable, fruit tree, or grain plant, or a harvested fruit as a solution having an isoleucine concentration of 0.5 to 75 mM, is sprinkled on a leaf surface and/or a fruit of a plant to provide at least one of promotion of blooming, promotion of the appearance of the fruit, improvement in number of fruit produced, promotion of ripening of fruit, improvement in essential amino acid and/or ?-ABA content, promotion of carotenoid synthesis, and improvement in antioxidant capacity.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: March 12, 2019
    Assignee: AJINOMOTO CO., INC.
    Inventors: Yaqin Lang, Yang Chen, Satoru Kondo, Shunji Suzuki
  • Publication number: 20190070139
    Abstract: Ingestion or administration of cysteine is effective for improving physical capacity for activity and provides a superior improving effect as compared to conventional compositions for the enhancement of improvement of physical capacity for activity relating to physical functions.
    Type: Application
    Filed: September 13, 2018
    Publication date: March 7, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yoshihito NOGUSA, Ami MIZUGAKI
  • Patent number: 10220094
    Abstract: The present invention provides a method of producing an aqueous solution containing an N—C8-22 acyl acidic amino acid and/or a salt thereof and having pH 8.4-9.5, including the first step for reacting an acidic amino acid and/or a salt thereof with a C8-22 fatty acid chloride in a water solvent at pH 10-13 to form an N—C8-22 acyl acidic amino acid salt, and the second step for adjusting the pH of the aqueous solution after the first step to 8.4-9.5.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: March 5, 2019
    Assignee: AJINOMOTO CO., INC.
    Inventors: Gaku Hattori, Hiroji Ishii, Masahiro Ino
  • Publication number: 20190060460
    Abstract: The present invention provides a method of producing an aqueous solution containing an N—C8-22 acyl acidic amino acid and/or a salt thereof and having pH 8.4-9.5, including the first step for reacting an acidic amino acid and/or a salt thereof with a C8-22 fatty acid chloride in a water solvent at pH 10-13 to form an N—C8-22 acyl acidic amino acid salt, and the second step for adjusting the pH of the aqueous solution after the first step to 8.4-9.5.
    Type: Application
    Filed: November 1, 2018
    Publication date: February 28, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Gaku HATTORI, Hiroji ISHII, Masahiro INO
  • Publication number: 20190060199
    Abstract: Compositions for cosmetics containing (A) one or more kinds of N-mono long-chain acyl basic amino acids, and (B) one or more kinds of N-mono middle-chain acyl basic amino acids, and compositions for cosmetics further containing (C) an inorganic powder, provide cosmetics that give, on application, a comfortable silky feeling and, to the skin after application, a natural translucency, good luminous finish and a uniform feeling of the skin surface, and have adhesiveness to the skin and high covering power.
    Type: Application
    Filed: October 25, 2018
    Publication date: February 28, 2019
    Applicant: AJINOMOTO CO., INC
    Inventors: Takahiro SUZUKI, Kazuhiko TOBITA
  • Publication number: 20190055300
    Abstract: The present invention provides a means capable of efficiently manufacturing a fused substance of an Fc protein and a substance of interest (for example, a peptide). Specifically, the present invention provides an azide group-containing Fc protein represented by formula (1): N3-La-Phe-Lb-Fc??(1) wherein N3 represents an azide group; La represents a bond or a divalent group; Phe represents a residue of phenylalanine or a derivative thereof; Lb represents a lysine residue or an arginine residue, or a peptide linker containing two or more amino acid residues having a lysine residue or an arginine residue at/on the N-terminus; and Fc represents an Fc protein; and the like.
    Type: Application
    Filed: November 1, 2018
    Publication date: February 21, 2019
    Applicant: Ajinomoto Co., Inc.
    Inventors: Shigeo HIRASAWA, Masumi Taki
  • Publication number: 20190045825
    Abstract: A bitter taste of a bitter taste ingredient such as a branched chain amino acid may be suppressed (reduced) by forming a granulated product by mixing a raw material core particle containing a bitter taste ingredient and a coating material by stirring at a temperature not lower than the melting point of the coating material.
    Type: Application
    Filed: October 18, 2018
    Publication date: February 14, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Hiroto MUKOUYAMA, Susumu Yamaguchi
  • Patent number: 10202333
    Abstract: The present invention provides a method of producing an aqueous solution containing bis(N?-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, and having a pH of 9-11, which includes a first step of reacting N?-lauroyl lysine and/or a salt thereof with dicarboxylic acid dichloride in a water solvent having a pH of 12-14 to form bis(N?-lauroyl lysine)dicarboxylic acid diamide and/or a salt thereof, a second step of adjusting the aqueous solution obtained in the first step to pH 7.5-8.5, a third step of adding N?-lauroyl lysine to the aqueous solution obtained in the second step and filtering the mixture, and a fourth step of adjusting the aqueous solution obtained in the third step to pH 9-11.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: February 12, 2019
    Assignee: AJINOMOTO CO., INC.
    Inventor: Shun Kobayashi
  • Publication number: 20190040429
    Abstract: A method for producing a basic acid such as L-lysine is provided. A basic amino acid or a fermentation product containing the same is produced by a method including the following steps (A) and (B): (A) a step of culturing a microorganism able to produce a basic amino acid in a culture medium so that bicarbonate ions and/or carbonate ions serve as counter ions for the basic amino acid, to obtain a fermentation broth containing the basic amino acid; (B) a step of subjecting the fermentation broth to a heat treatment under a pressure sufficient for preventing generation of carbon dioxide gas from the fermentation broth.
    Type: Application
    Filed: August 24, 2018
    Publication date: February 7, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Kisho Suzuki, Masayuki Mori, Takehiro Hiura, Nobuaki Matsuoka, Takehiko Chikamori
  • Publication number: 20190037883
    Abstract: Provided is a vegetable protein-containing food having an excellent texture, preferably also having good flavor/taste. The vegetable protein-containing food can be produced by adding transglutaminase and glucose oxidase or adding transglutaminase, glucose oxidase and phospholipase to a food raw material containing a vegetable protein.
    Type: Application
    Filed: September 7, 2018
    Publication date: February 7, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yuki TOHO, Nao OSANAI, Hiroaki SATO
  • Patent number: 10195127
    Abstract: The present invention provides a cosmetic composition containing (A) a powder composed of one or more kinds of the N-medium-chain-acyl basic amino acid powder represented by the following formula (I), (B) an inorganic powder, and (C) an oil material: wherein R is a saturated or unsaturated straight hydrocarbon group having 5-9 carbon atoms, and m is an integer of 1-4.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: February 5, 2019
    Assignee: AJINOMOTO CO., INC.
    Inventors: Masayuki Kuramoto, Eiko Oshimura
  • Publication number: 20190022039
    Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the present specification, or a salt thereof are useful for the prophylaxis or treatment of diabetes and obesity, and diseases related thereto.
    Type: Application
    Filed: September 27, 2018
    Publication date: January 24, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Tomohiro FUJII, Koji OHSUMI, Seiji KITAJIMA, Yoshiro KITAHARA
  • Publication number: 20190024047
    Abstract: Media which are substantially free of one or more amino acids selected from the group consisting of L-glutamine, L-asparagine, and L-aspartic acid are useful for producing a neural stem cell and/or a neural progenitor cell with promoted neuronal differentiation potency.
    Type: Application
    Filed: September 27, 2018
    Publication date: January 24, 2019
    Applicant: AJINOMOTO CO., INC.
    Inventors: Takuya MATSUMOTO, Ikue HARATA, Sho SENDA
  • Publication number: 20190021353
    Abstract: The present invention aims to provide a production method of low-fat and low-protein yogurt with smooth taste, suppressed syneresis and superior shape retainability, including adding protein glutaminase and starch to raw milk.
    Type: Application
    Filed: September 27, 2018
    Publication date: January 24, 2019
    Applicants: AJINOMOTO CO., INC., AMANO ENZYME INC.
    Inventor: Hiroaki SATO