Patents Assigned to Ajinomoto Co., Inc.
  • Patent number: 10662411
    Abstract: Cultivating a pluripotent stem cell in a medium comprising at least one member selected from the group consisting of ethanolamine, an ethanolamine analog, and a pharmaceutically acceptable salt thereof, and which is substantially free of ?-mercaptoethanol or contains ?-mercaptoethanol at a concentration of not more than 9 ?M, and the like, is effective for the proliferation of a pluripotent stem cell while maintaining an undifferentiated state.
    Type: Grant
    Filed: January 8, 2019
    Date of Patent: May 26, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Sho Senda, Tomomi Yoshida, Satoru Okamoto, Yoko Kuriyama, Manabu Kitazawa, Ikue Harata, Nao Sugimoto
  • Patent number: 10653655
    Abstract: Compositions which contain an amino acid containing serine and a lipid containing a n-3 fatty acid are useful for the prophylaxis or improvement of peripheral neuropathy.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: May 19, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Tomoyuki Mine, Ryo Uchida, Naoki Hayashi
  • Publication number: 20200129458
    Abstract: Compounds represented by formula (I): wherein each symbol is as defined in the present specification, or a salt thereof are useful for the prophylaxis or treatment of diabetes and obesity, and diseases related thereto.
    Type: Application
    Filed: December 27, 2019
    Publication date: April 30, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventors: Tomohiro FUJII, Koji Ohsumi, Seiji Kitajima, Yoshiro Kitahara
  • Publication number: 20200113799
    Abstract: The present invention relates to a powder modifying agent containing N?-octanoyl-L-lysine, a composite powder modified using same, and a makeup cosmetic containing the composite powder. According to the present invention, a powder modifying agent that can impart a powder for cosmetics with the properties appropriate as a powder for makeup cosmetics, namely, superior dispersibility and superior caking property when blended with makeup cosmetics, superior texture (e.g., smoothness, moist feeling etc.) when applied to the skin, and water-repellency, adhesiveness and transparency, can be provided, and further, a composite powder capable of exhibiting the above-mentioned properties in good balance, and a makeup cosmetic superior in sense of use, water-repellency, adhesiveness and transparency can be provided.
    Type: Application
    Filed: December 6, 2019
    Publication date: April 16, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventor: Takahiro SUZUKI
  • Patent number: 10617122
    Abstract: A virus infection inhibitor containing a fermentation by-product such as an amino acid fermentation by-product and a nucleic acid fermentation by-product is sprinkled onto a plant body of a plant, such as tobacco, tomato, bell pepper, and chili pepper to control a disease induced by infection of a virus such as Tobamovirus viruses and Cucumovirus viruses.
    Type: Grant
    Filed: April 11, 2014
    Date of Patent: April 14, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Reiko Tomita, Naoki Kadotani, Kentaro Sekine
  • Patent number: 10612006
    Abstract: A method is provided for producing an objective substance, for example, an aromatic aldehyde such as vanillin. The objective substance is produced from a carbon source or a precursor of the objective substance by using a coryneform bacterium that is able to produce the objective substance, wherein bacterium has been modified so that the activity of alcohol dehydrogenase is reduced.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: April 7, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Keita Fukui, Keiko Danjo, Junko Ito, Miku Toyazaki
  • Patent number: 10611804
    Abstract: A method for producing heparosan is provided. Heparosan is produced by culturing an Escherichia bacterium having a heparosan-producing ability and modified so that expression of one or more genes, such as rbsR, rbsK, rbsB, hsrA, glgB, glgX, micF, rcsD, rcsB, ybiX, ybil, ybiJ, ybiC, ybiB, rfaH, nusG, pcoR, pcoS, pcoE, yhcN, yhcO, aaeB, aaeA, aaeX, g1455, alpA, g1453, yrbA, mlaB, mlaC, mlaD, mlaE, mlaF, yrbG, norW, ybjI, ybjJ, ybjK, rybB, yjjY, yjtD, thrL, thrA, thrB, fruA, psuK, ytfT, yjfF, fbp, yagU, paoA, paoB, gsiC, gsiD, yliE, irp2, irp1, bhsA, ycfS, lepB, rnc, era, dapA, gcvR, bcp, hyfA, rpoE, nadB, yfiC, srmB, g1414, g1413, nuoE, nuoF, nuoG, glmZ, hemY, hemX, hemD, rlmL, artQ, artM, artJ, rlmC, ybjO, yejO, yejM, yejL, rpoS, ygbN, ygbM, ygbL, g3798, g3797, g3796, g3795, g3794, g3793, g3792, ryjA, soxR, soxS, yjcC, yjcB, efeU, and efeO, is/are increased in a medium, and collecting heparosan from the medium.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: April 7, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Shunsuke Yamazaki, Tomoko Shimizu, Kenichi Mori, Naoto Tonouchi
  • Patent number: 10603262
    Abstract: The present invention provides a composition containing component (A): a compound represented by the formula (1) wherein each symbol is as described in the DESCRIPTION, or a salt thereof and component (B): a cationic surfactant, which is superior in the usability during rinsing, which makes the hair surface after treatment smooth and free of dry feeling, provides a uniform touch feeling from the root of the hair to the tip thereof, and can be utilized as an aqueous cosmetic.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: March 31, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Nana Haraya, Shun Kobayashi
  • Patent number: 10597427
    Abstract: The present invention provides a diabetes-inducing bacterium and use thereof, and a reagent and a detection method for detecting the bacterium. According to the present invention, enteric colonization of the diabetes-inducing bacterium can be prevented, and diabetes can be treated and/or prevented.
    Type: Grant
    Filed: September 26, 2014
    Date of Patent: March 24, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Keishi Kameyama, Kikuji Itoh
  • Publication number: 20200085712
    Abstract: Provided is a composition containing the following components (A), (B) and (C) and suppressing formation of scum during cleansing, wherein a weight ratio of (A)/(B) is 0.2-5 and a weight ratio of ((A)+(B))/(C) is 0.01-10: (A) N-lauroyl glycine or a salt thereof (B) N-myristoyl glycine or a salt thereof (C) N-acyl acidic amino acid having an acyl group having 8 to 24 carbon atoms, or a salt thereof.
    Type: Application
    Filed: November 21, 2019
    Publication date: March 19, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventors: Naoaki Ikeda, Naoya Yamato
  • Publication number: 20200061010
    Abstract: Compositions comprising (A) tyrosine, serine, alanine, aspartic acid and glutamic acid as active ingredients are useful for improving brain function and recovering from or suppressing fatigue and are highly safe and permit continuous ingestion or administration.
    Type: Application
    Filed: August 26, 2019
    Publication date: February 27, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventors: Shinobu AKIYOSHI, Ami ITO, Tatsuya HASEGAWA
  • Patent number: 10568324
    Abstract: Coloring of fruits is promoted by applying a one or more the amino acids leucine, isoleucine, and/or phenylalanine, in combination with abscisic acid to a fruit plant, such as those of the genus Vitaceae or Rosaceae. The amino acid(s) and abscisic acid may be present in a solution(s) having concentrations of 0.2 mM to 100 mM and 0.1 ?M to 10 mM, respectively.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: February 25, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Yang Chen, Daisuke Igarashi, Shunji Suzuki
  • Patent number: 10561629
    Abstract: The present invention provides a food of the type based on unit of intake per serving, which contains glycine or a substance that can be hydrolyzed to give glycine in an amount of not less than 0.5 g based on glycine per serving. The food of the present invention can be applied as a food flavoring, a deep sleep disorder improving food, or a bowel movement improving food.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: February 18, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Tohru Kouda, Chika Morishima, Kentaro Inagawa, Shinobu Seki
  • Patent number: 10563234
    Abstract: A method for producing an L-amino acid is provided. An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid-producing ability, wherein the bacterium has been modified so that the activity of aconitase is increased, or the activities of aconitase and acetaldehyde dehydrogenase are increased, in a medium, and collecting the L-amino acid from the medium or cells of the bacterium.
    Type: Grant
    Filed: November 28, 2016
    Date of Patent: February 18, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Hidetaka Doi, Akiko Matsudaira, Yoshihiro Usuda
  • Publication number: 20200040308
    Abstract: Media which contain 4-tryptophan or an L-tryptophan derivative at a concentration of not less than 176 ?M are useful for culturing pluripotent stem cells.
    Type: Application
    Filed: September 27, 2019
    Publication date: February 6, 2020
    Applicants: AJINOMOTO CO., INC., KEIO UNIVERSITY
    Inventors: Kotoe KOSEKI, Satoru OKAMOTO, Shugo TOHYAMA, Jun FUJITA, Keiichi FUKUDA, Shota SOMEYA
  • Publication number: 20200040331
    Abstract: Morpholino oligonucleotides can be produced efficiently in a high yield by a liquid-phase synthesis method, which includes subjecting a reaction mixture of a condensation reaction to an extraction operation and separating the morpholino oligonucleotide as a resultant product to the organic layer side.
    Type: Application
    Filed: September 25, 2019
    Publication date: February 6, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventors: Daisuke TAKAHASHI, Takayoshi TORII
  • Publication number: 20200030274
    Abstract: Compositions containing at least four kinds of amino acids selected from the group consisting of serine, aspartic acid, glutamic acid, glycine, alanine and proline as active ingredients are useful for improving joint function and skin function and have high safety and permit continued ingestion or administration.
    Type: Application
    Filed: July 24, 2019
    Publication date: January 30, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventors: Shinobu AKIYOSHI, Noriko KAWASAKI, Masako MIMURA
  • Publication number: 20200024629
    Abstract: A method for producing RNA is provided. Objective RNA is produced by culturing a coryneform bacterium having an expression unit for the objective RNA, which has been modified so that the activity of ribonuclease III is reduced, in a medium, to express the objective RNA and accumulate the objective RNA in cells of the bacterium, and collecting the objective RNA from the cells.
    Type: Application
    Filed: September 25, 2019
    Publication date: January 23, 2020
    Applicant: AJINOMOTO CO., INC.
    Inventors: Shuhei Hashiro, Hisashi Yasueda, Mayu Mitsuhashi, Sergei Vladimirovich Mashko, Aleksandr Aleksandrovich Krylov, Yuliya Sergeevna Lobanova
  • Patent number: 10538798
    Abstract: A novel technique for improving secretory production of a heterologous protein by coryneform bacteria is described, as well as a method for secretory production of a heterologous protein. A coryneform bacterium is described that has been modified to have a specific mutation so as to harbor a phoS gene, and when cultured, is able to to produce a heterologous protein by secretory production.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: January 21, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Yoshihiko Matsuda, Yumi Ito, Yukari Kashima, Naoko Yamada, Noriko Tsurui, Hiroshi Itaya
  • Patent number: 10537128
    Abstract: A yeast extract containing 0.2% or more of ?-Glu-Abu based on dry weight of the yeast extract is produced by culturing a yeast, such as Saccharomyces cervisiae or Candida utilis, in a medium containing a compound selected from Abu (L-2-aminobutyric acid) and ?-Glu-Abu (L-?-glutamyl-L-2-aminobutyric acid), and preparing a yeast extract from the obtained cells.
    Type: Grant
    Filed: November 16, 2016
    Date of Patent: January 21, 2020
    Assignee: AJINOMOTO CO., INC.
    Inventors: Hiroaki Nishiuchi, Misato Morita, Wataru Hoshino, Junko Yamazaki, Takayuki Ito, Kazuo Yamagishi