Patents Assigned to Alchemia
-
Patent number: 8114970Abstract: Preparation of synthetic monosaccharides, for use in the preparation of synthetic heparinoids.Type: GrantFiled: January 15, 2009Date of Patent: February 14, 2012Assignee: Alchemia LimitedInventors: Joachim Seifert, Latika Singh, Tracie E. Ramsdale, Michael L. West, Nicholas B. Drinnan
-
Publication number: 20120009193Abstract: The present invention relates generally to the modulation of hyaluronan (HA) synthesis and degradation. More particularly, the present invention provides compositions and methods for modulating the expression of genetic material encoding HA synthase (HAS) and other enzymes or receptors primarily involved in hyaluronan metabolism; or modulating the proteins that synthesise or degrade hyaluronan including HAS function or activity. The compositions include or comprise nucleic acid molecules and interactive molecules such as antibodies and small molecule inhibitors and HAS substrate analogs. The present invention further contemplates modulation of cellular proliferation, useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis.Type: ApplicationFiled: June 13, 2011Publication date: January 12, 2012Applicant: Alchemia Oncology Pty LimitedInventors: Tracey J. Brown, Gary R. Brownlee
-
Patent number: 8093227Abstract: A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I.Type: GrantFiled: August 1, 2008Date of Patent: January 10, 2012Assignee: Alchemia Pty LtdInventors: Michael Leo West, Wim Meutermans, George Adamson, Karl Schafer, Darren Schliebs
-
Publication number: 20110201794Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: ApplicationFiled: December 17, 2010Publication date: August 18, 2011Applicant: Alchemia LimitedInventors: Wim Meutermans, Michael L. West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovani Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
-
Patent number: 7994140Abstract: The present invention relates to a method of identifying a candidate therapeutic agent. The method comprises contacting a G-Protein Coupled Receptor (GPCR) with a compound of General Formula (I), or a pharmaceutically acceptable salt thereof determining whether the compound inhibits or effects signal transduction activity of the GPCR, wherein a compound that inhibits or effects the activity of the GPCR is a candidate therapeutic agent.Type: GrantFiled: October 10, 2003Date of Patent: August 9, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Glang Le Thanh, Giovanni Abbenante, Gerald Tometzki, Judy Halliday, Johannes Zuegg
-
Patent number: 7989422Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:Type: GrantFiled: December 20, 2006Date of Patent: August 2, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Declan McKeveney, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Giang Thanh Le
-
Patent number: 7985844Abstract: Modulation of Hyaluronan (HA) synthesis and degradation is disclosed by compounds and compositions that are capable of reducing the level of hyaluronan synthase (HAS) or hyaluronidase (HYAL) or the function or activity of HAS or HYAL. The compounds and compositions can also inhibit the expression of genetic material encoding these enzymes. The compounds and compositions comprise nucleic acid molecules and interactive molecules such as antibodies, small molecule inhibitors and substrate analogs of HAS and HYAL. The compounds and compositions are useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis.Type: GrantFiled: December 15, 2009Date of Patent: July 26, 2011Assignee: Alchemia Oncology Pty LimitedInventors: Tracey J. Brown, Gary R. Brownlee
-
Publication number: 20110165700Abstract: A method of inhibiting or effecting the activity of an integrin receptor comprises contacting an integrin with a pyranose of formula I, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: March 14, 2011Publication date: July 7, 2011Applicant: Alchemia LimitedInventors: Wim MEUTERMANS, Michael L. West, Giang Thanh Le, Judy Halliday, Christopher Clark
-
Patent number: 7875707Abstract: Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres.Type: GrantFiled: April 24, 2003Date of Patent: January 25, 2011Assignee: Alchemia LimitedInventors: Wim Meutermans, Michael West, George Adamson, Giang Thanh Le, Nicholas B. Drinnan, Giovanni Abbenante, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam, Gerald Tometzki
-
Publication number: 20100184607Abstract: A monosaccharide compound of formula I as shown in the specification. Processes for the preparation of the compound of formula I and methods of screening for antibacterial or antibiotic compounds involving the compound of formula I.Type: ApplicationFiled: August 1, 2008Publication date: July 22, 2010Applicant: Alchemia Pty Ltd.Inventors: Michael Leo West, Wim Meutermans, George Adamson, Karl Schafer, Darren Schliers
-
Patent number: 7737287Abstract: This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.Type: GrantFiled: March 28, 2003Date of Patent: June 15, 2010Assignee: Alchemia LimitedInventors: Wim Meutermans, Michael Leo West, Thanh Le Giang, George Adamson, Karl Schafer, Giovanni Abbenante
-
Patent number: 7700577Abstract: A method of inhibiting bacterial growth by contacting a bacteria with at least one disaccharide compound of General Formula I,Type: GrantFiled: October 16, 2003Date of Patent: April 20, 2010Assignee: Alchemia LimitedInventors: Wim Meutermans, Giang Le Thanh, Giovani Abbenante, Gerald Tometzki, George Adamson, Bernd Becker, Matthias Grathwohl, Premraj Rajaratnam
-
Patent number: 7662929Abstract: Modulation of Hyaluronan (HA) synthesis and degradation is disclosed by compounds and compositions that are capable of reducing the level of hyaluronan synthase (HAS) or hyaluronidase (HYAL) or the function or activity of HAS or HYAL. The compounds and compositions can also inhibit the expression of genetic material encoding these enzymes. The compounds and compositions comprise nucleic acid molecules and interactive molecules such as antibodies, small molecule inhibitors and substrate analogs of HAS and HYAL. The compounds and compositions are useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis.Type: GrantFiled: October 11, 2004Date of Patent: February 16, 2010Assignee: Alchemia Oncology Pty LimitedInventors: Tracey J. Brown, Gary R. Brownlee
-
Publication number: 20090306012Abstract: The present invention relates to the field of chemotherapy of diseases such as cell proliferation disorders including cancer. In particular, the present invention relates to the use of hyaluronan (HA) as a protective agent in the treatment of subjects. HA is administered in conjunction with a chemotherapeutic agent to facilitate the prolonged administration of a dose of the chemotherapeutic agent to be administered to a subject. Owing to the protective effects of the HA, the dose of chemotherapeutic agent may be substantially higher than a generally accepted effective dose, which would otherwise be expected to cause unacceptable side effects in the subject.Type: ApplicationFiled: June 11, 2009Publication date: December 10, 2009Applicant: Alchemia Oncology Pty LimitedInventors: Tracey Jean BROWN, Richard Mark FOX
-
Publication number: 20090187013Abstract: Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.Type: ApplicationFiled: January 15, 2009Publication date: July 23, 2009Applicant: Alchemia LimitedInventors: Joachim SEIFERT, Latika Singh, Tracie Elizabeth Ramsdale, Michael Leo West, Nicholas Barry Drinnan
-
Publication number: 20090163373Abstract: The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula (1) to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the library has same number of pharmacophoric groups; (b) assaying the first library of compounds in one or more biological assay(s); and (c) designing a second library wherein each compound of the second library contains one or more additional pharmacophoric group with respect to the first library; such that the/each component of the first and second library is a compound of formula (1).Type: ApplicationFiled: October 3, 2006Publication date: June 25, 2009Applicant: Alchemia LimitedInventors: Gerald B. Tometzki, Michael L. West, Wim Meutermans, Johannes Zuegg
-
Patent number: 7541445Abstract: Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.Type: GrantFiled: September 6, 2002Date of Patent: June 2, 2009Assignee: Alchemia LimitedInventors: Joachim Seifert, Latika Singh, Tracie E. Ramsdale, Michael L. West, Nicholas B. Drinnan
-
Publication number: 20090068183Abstract: The present invention is directed to compounds, agents, pharmaceutically active agents, medicaments, therapeutics, actives, drugs and the like which specifically target a portion of the HAS molecule which is accessible to the extracellular environment in a first form of a cell but which is not accessible to the extracellular environment in another form of or in a transformed cell form the same or related cell. In particular, the present invention provides compounds which target a portion of HAS which is accessible to the extracellular environment in malignant or inflammatory or proliferative cells but which portion is not accessible to the external environment in “normal” cells. A “normal” cell in this instance is a non-malignant, inflammatory or proliferative cell.Type: ApplicationFiled: March 23, 2007Publication date: March 12, 2009Applicant: Alchemia Oncology LimitedInventors: Tracey J. Brown, Gary Brownlee
-
Publication number: 20090054537Abstract: The present invention relates generally to the field of therapeutics and in particular, chemotherapy. Even more particularly, the present invention provides therapeutic strategies which reduce the toxicity or enhance the efficacy of chemotherapeutic agents. Compositions and methods of treatment and prophylaxis are also contemplated by the present invention.Type: ApplicationFiled: July 27, 2006Publication date: February 26, 2009Applicant: Alchemia Oncoloogy Pty LimitedInventor: Tracey J. Brown
-
Publication number: 20090023669Abstract: The present invention, in one aspect, provides a method of inhibiting bacterial growth by contacting bacteria with an effective amount of at least one monosaccharide compound of formula (1) as described herein:Type: ApplicationFiled: December 20, 2006Publication date: January 22, 2009Applicant: Alchemia LimitedInventors: Wim Meutermans, Declan McKeveney, Johannes Zuegg, Rajaratnam Premraj, Craig Muldoon, Giang Thanh Le