Abstract: The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.

Abstract: Photonic lattice sources drive an optical fiber in an ophthalmic illuminator to illuminate the interior of an eye. To produce white light, an RGB combination of photonic lattice LEDs may be used. Alternatively, a bichromatic combination of photonic lattice LEDs produce white light.

Abstract: The present invention relates to soluble and stable anti-VEGF immunobinders comprising CDRs from rabbit monoclonal antibodies. Said antibodies are designed for the diagnosis and/or treatment of VEGF-mediated disorders. The hybridomas, nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.

Abstract: In various embodiments, a trocar cannula may be configured for insertion into an eye to facilitate insertion and removal of instruments during surgery. The cannula may be affixed to an overcap (to inhibit rotation of the overcap relative to the cannula) that includes a seal. In some embodiments, the seal may be overmolded into the overcap or may include a wafer that is fixed between the cannula and the overcap to inhibit rotation relative to the cannula and the overcap. In some embodiments, the cannula and overcap may snap together through a tab/slot interface in a permanent fashion such that the cannula and overcap may not be separated without damaging the cannula or overcap. In some embodiments, a vent cannula may be receivable in the slit of the seal for allowing fluids to vent from the eye through the cannula (which may include an indentation to frictionally engage the vent).

Abstract: A pellet loading apparatus has a pellet housing configured to receive and hold a plunger so that a cavity is formed by an interior surface of the pellet housing and the plunger. A pellet is located or formed in the cavity. A dispensing chamber housing is located in a disposable drug delivery device. The dispensing chamber housing is configured to couple with the pellet housing so that the plunger and the pellet can be loaded into the dispensing chamber housing.

Abstract: In one embodiment, an illuminator configured to emit light into an optical fiber includes at least one pump light source configured to emit short-wavelength light. The illuminator further includes a white phosphor disposed to receive the short-wavelength light and to emit white light in response. The illuminator also includes a light collector configured to collect the short-wavelength light at the white phosphor such that a brightness of the white light is greater than a brightness of the short-wavelength light.

Abstract: A loudspeaker comprising a housing provided with a magnet unit that generates a magnetic field, and a membrane which is mounted in a frame and which is provided with an electrical conductor arranged in a pattern on the membrane, which membrane is positioned in the magnetic field in such a manner that a force is exerted when current is fed through the conductor pattern on the membrane, which force is capable of setting at least part of the membrane in motion so as to produce sound, wherein a part of the conductor pattern extends beyond the plane of the aforesaid movable part of the membrane near at least one end of the membrane. Preferably, the aforesaid part of the conductor pattern makes an angle of about 90 degrees with the aforesaid movable part of the membrane.

Abstract: The invention provides interfering RNA molecule-ligand conjugates useful as a delivery system for delivering interfering RNA molecules to a cell in vitro or in vivo. The conjugates comprise a ligand that can bind to a low density lipoprotein receptor (LDLR) or LDLR family member. Therapeutic uses for the conjugates are also provided.

Abstract: The present invention is directed to the provision of multi-dose, self-preserved ophthalmic compositions. The compositions possess sufficient antimicrobial activity to satisfy USP preservative efficacy requirements, as well as similar preservative standards (e.g., EP and JP), without requiring the presence of conventional anti-microbial preservative agents, such as benzalkonium chloride. The compositions are effectively preserved by a balanced ionic buffer system containing zinc ions at a concentration of 0.04 to 0.9 mM, preferably 0.04 to 0.4 mM. One aspect of the balanced buffer system is limitation of the amount of buffering anions present to a concentration of 15 mM or less, preferably 5 mM or less. In a preferred embodiment, the compositions also contain borate or, most preferably, one or more borate/polyol complexes. The use of propylene glycol as the polyol in such complexes is strongly preferred.

Abstract: The use of poly(oxyethylene)-poly(oxybutylene) block copolymers in pharmaceutical compositions useful for modifying the surfaces of contact lenses and other medical devices is disclosed. The present invention is based in-part on a discovery that this class of compounds is particularly efficient in wetting hydrophobic surfaces, such as the surfaces of silicone hydrogel contact lenses and other types of ophthalmic lenses. Such compounds are also useful for cleaning purposes. The use of the compounds as surfactants in various types of compositions for treating contact lenses therefore represents a preferred embodiment of the present invention.

Abstract: An ophthalmic illuminator is disclosed, one embodiment comprising: an illumination source and an optical fiber for transmitting a combined light beam from the illumination source to a site, such as a surgical site within an eye, wherein the illumination source comprises a plurality of light emitting diode (LED) chips optically coupled to a corresponding plurality of light pipes, the LED chips and light pipes arranged in a configuration such that the light pipes converge together at their distal ends to form a cubic box having five sides formed by the distal ends of the light guides and an open side from which the combined light beam, composed of light from a plurality of light beams generated by the LED chips and transmitted to the cubic box by the light guides, is emitted. The luminance of the combined light beam has a luminance greater than the luminance of any one of the plurality of LED chips.

Abstract: The invention provides methods for identifying immunobinders, such as scFv antibodies, capable of specifically binding to cell surface antigens, and compositions identified according to said methods.

Abstract: An intraocular lens injection device comprises a tubular housing with a plunger longitudinally disposed within the tubular housing. An electric drive system longitudinally translates the plunger so that its tip engages an insertion cartridge to fold and displace an intraocular lens disposed within and to inject the folded lens into the lens capsule of an eye. A control circuit is configured to start translation of the plunger, responsive to user input, to detect at least one fault condition based on a counter-electromotive force produced by the electric motor, and to stop translation of the plunger assembly responsive to the detected fault condition, which may comprise excessive resistance to forward or rearward translation of the plunger or insufficient resistance to forward translation of the plunger.

Abstract: An intraocular lens (IOL) injection device is modularized to enable cleaning of internal components after surgery. The device includes first and second housing modules. These modules collectively define a passageway along which an injector rod moves between a retracted position and an extended position. The first module is further configured to accommodate a lens cartridge module. The cartridge module has disposed therein an IOL, in alignment with the passageway. Thus as the rod moves from the retracted position to the extended position, a front portion of the rod that is substantially surrounded by the first module in the retracted position moves into the cartridge module and displaces the IOL. This causes the front portion of the rod to accumulate on it viscoelastic substances. The first module, though, is configured to detach from the second module, to thereby expose the front portion of the rod in the retracted position for cleaning.

Abstract: The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists.

Abstract: A vitrectomy probe having a variable duty cycle cutting mechanism is disclosed. The probe includes a motor and a cam driver rotationally driven by the motor. The cam driver has a non-planar driver surface having surface features that vary at different radii. A follower mechanism is arranged to selectively interface with the driver surface at different radii on the driver surface in a manner to selectively interface with the varied surface features at the different radii. The follower is arranged to transfer rotational movement of the cam driver into linear movement of the follower mechanism.

Abstract: The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework. Antibodies generated by the methods of the invention are useful in a variety of diagnostic and therapeutic applications.

Abstract: An ophthalmic endoilluminator is provided. The ophthalmic endoilluminator includes one or more white light emitting diodes (LEDs), an additional light source, a first optical assembly, an optical coupling element, and an optical fiber optically coupled to the optical coupling element. The white LED is capped with a phosphor layer. The additional light source illuminates at least a portion of an exterior surface of the phosphor layer within an absorption band of phosphor material of the phosphor layer in order to excite the phosphor layer and produce additional white light. The first optical assembly receives and substantially collimates the white light. The optical coupling element receives the substantially collimated white light from the first optical assembly and directs the light to an optical fiber. The optical fiber is then used to conduct the white light into an eye.

Abstract: RNA interference is provided for inhibition of histamine receptor H1 mRNA expression, in particular, for treating patients having an HRH1-related condition or at risk of developing an HRH1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy.

Abstract: An infusion pressure monitoring system for a phacoemulsification or vitrectomy machine to be operated by a health care provider includes an irrigation path configured to carry an irrigation solution to a surgical site and a fluid sensor configured to detect a fluid parameter in the irrigation path. An input device receives a variable fluid flow command from the health care provider commanding an irrigation fluid flow through the irrigation path at a flow rate corresponding to the command. A controller communicates with both the fluid sensor and the input device. The controller determines an expected fluid pressure value and a dynamically variable threshold pressure value based upon the variable fluid flow command.