Patents Assigned to Allegheny-Singer Research Institute
  • Patent number: 10481151
    Abstract: The present disclosure provides methods of obtaining, recovering and culturing pulmonary arterial endothelial cells from an individual patient subjected to a right heart catheterization in regard to diagnosis of pulmonary hypertension. These isolated pulmonary arterial endothelial cells from an individual patient may be utilized to generate cellular phenotyping profile for the cell population, allowing generation of a personalized pharmacotherapy regime to assist the clinician in treatment and prognosis of the disorder for an individual patient.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: November 19, 2019
    Assignee: Allegheny-Singer Research Institute
    Inventors: Michael J. Passineau, Srinivas Murali, Raymond L. Benza, Jonathan B. Pollett
  • Patent number: 10067128
    Abstract: Methods, systems, and kits useful for determining whether a subject is likely to benefit from therapy with an antibody are provided. In particular aspects, cell-bound complement activation products (CB-CAPs) associated with B lymphocytes may serve as diagnostic biomarkers.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: September 4, 2018
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • Patent number: 9863946
    Abstract: Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus. This document also describes methods for determining whether a patient who has been determined to exhibit pre-Lupus has progressed to exhibiting definite Lupus.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: January 9, 2018
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • Patent number: 9835617
    Abstract: The present disclosure provides methods of obtaining, recovering and culturing pulmonary arterial endothelial cells from an individual patient, subjected to a right heart catheterization in regard to diagnosis of pulmonary hypertension. These isolated pulmonary arterial endothelial cells from an individual patient may be utilized to generate cellular phenotyping profile for the cell population, allowing generation of a personalized pharmacotherapy regime to assist the clinician in treatment and prognosis of the disorder for an individual patient.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: December 5, 2017
    Assignee: Allegheny-Singer Research Institute
    Inventors: Michael J. Passineau, Srinivas Murali, Raymond L. Benza, Jonathan B. Pollett
  • Patent number: 9709564
    Abstract: Provided are methods, systems, and kits for diagnosing or monitoring systemic lupus erythematosus in an individual. In particular aspects, in a blood sample containing white blood cells from the individual, autoantibodies deposited on or contacting with the surface of a T lymphocyte in the sample are quantitated.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: July 18, 2017
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • Patent number: 9611491
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Grant
    Filed: August 25, 2014
    Date of Patent: April 4, 2017
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ALLEGHENY-SINGER RESEARCH INSTITUTE, COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Patent number: 9495517
    Abstract: Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: November 15, 2016
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • Patent number: 9364503
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: December 15, 2014
    Date of Patent: June 14, 2016
    Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 9162910
    Abstract: A fluid treatment system includes a fluid source, at least one anaerobic reactor vessel, and at least one aerobic reactor vessel. The anaerobic reactor vessel contains retaining a set of retaining structures that are at least partially coated with an anaerobic biofilm. The aerobic reactor vessel contains an aerobic biofilm. When fluid from the fluid source is exposed to the anaerobic biofilm, the anaerobic biofilm removes one or more metal substances from the fluid. When the fluid is exposed to the aerobic biofilm, the aerobic biofilm may cause organic materials in the fluid to metabolize. The system also may include a precipitation reactor that separates divalent metals from the fluid, a settling facility that forms a slurry comprising separated metals, and a neutralization reactor that modifies the fluid to a substantially neutral pH.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: October 20, 2015
    Assignee: ALLEGHENY-SINGER RESEARCH INSTITUTE
    Inventors: James Christopher Post, Randy Hiebert, Robert Hyatt
  • Patent number: 8911789
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: December 16, 2014
    Assignees: Carnegie Mellon University, Allegheny-Singer Research Institute, Carmell Therapeutics Corporation
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8880457
    Abstract: A method for improved, automated analysis of a data set improves the reliability of the data set by comparing the data set with a model of similar data. The method may be used in applications such as medical imaging, clinical trial participant selection, marketing, security, traffic control, and other applications.
    Type: Grant
    Filed: November 4, 2011
    Date of Patent: November 4, 2014
    Assignee: Allegheny-Singer Research Institute
    Inventor: Mark Doyle
  • Patent number: 8815562
    Abstract: The present invention is directed to the biosynthetic pathway for a nonribosomal peptide synthetase (NRPS) derived drug and analogs thereof. The invention also discloses polynucleotide sequences useful for heterologous expression in a convenient microbial host for the synthesis of the NRPS derived drug.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: August 26, 2014
    Assignees: The Regenys of the University of Michigan, Allegheny-Singer Research Institute, Colorado State University Research Foundation
    Inventors: David H. Sherman, Garth D. Ehrlich, Benjamin Janto, Robert M. Williams, Christopher M. Rath
  • Patent number: 8688193
    Abstract: A magnetic resonance imager for forming images of a moving portion of a patient includes imaging coils. The imager includes a computer that causes the imaging coils to apply continuously steady-state free precession to k-space of a magnetic resonance image series of the patient and acquire the image series, and generates images from the image series. A method for forming images of a moving portion of a patient includes the steps of applying continuously steady-state free precession to k-space of a magnetic resonance image series of a patient. There is the step of acquiring the image series. There is the step of generating images from the image series. A method for forming images of a patient includes the steps of triggering a steady-state free precision imaging sequence to an ECG r wave of cardiac cycles of the patient.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: April 1, 2014
    Assignee: Allegheny-Singer Research Institute
    Inventors: Mark Doyle, Robert Biederman
  • Patent number: 8529959
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529958
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529960
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Carnell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529956
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: September 10, 2013
    Assignees: Carnell Therapeutics Corporation, Carnegie Mellon University, Allegheny-Singer Research Institute
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Patent number: 8529961
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: September 10, 2013
    Assignees: Carmell Therapeutics Corporation, Allegheny-Singer Research Institute, Carnegie Mellon University
    Inventors: Phil G. Campbell, James E. Burgess, Lee E. Weiss, Jason Smith
  • Publication number: 20130189370
    Abstract: Blood-derived plastic articles prepared from compositions including blood and, in some embodiments, at least one crosslinking agent and/or at least one biological response modifier, that can be useful for biological applications such as wound repair and tissue grafts; methods of making and using the same; methods for assessing the concentration of a biological response modifier in an article; and systems for preparing blood-derived plastic articles are provided.
    Type: Application
    Filed: March 11, 2013
    Publication date: July 25, 2013
    Applicants: CARNEGIE MELLON UNIVERSITY, CARMELL THERAPEUTICS CORPORATION, ALLEGHENY-SINGER RESEARCH INSTITUTE
    Inventors: CARNEGIE MELLON UNIVERSITY, ALLEGHENY-SINGER RESEARCH INSTITUTE, CARMELL THERAPEUTICS CORPORATION
  • Patent number: 8480902
    Abstract: A method of prevention of acid rock drainage excludes oxygen from waste rocks that contain ferrous sulfides by building an oxygen bio-barrier over exposed surfaces of the waste rock. The bio-barrier may be formed by applying a slurry to the rock. The slurry may contain several components such as microbial material, one or more nutrients, water or another fluid, and optionally water-absorbent material. The microbial material may include bacteria, algae, fungi or a combination thereof. Additionally, the slurry may contain one or more acid-neutralizing compounds, one or more cellulose-containing substances, and one or more UV protecting agents.
    Type: Grant
    Filed: July 2, 2010
    Date of Patent: July 9, 2013
    Assignee: Allegheny-Singer Research Institute
    Inventors: James Christopher Post, Garth David Ehrlich, John William Costerton