Patents Assigned to Allegheny-Singer Research Institute
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Patent number: 7268225Abstract: A DNA sequence of Haemophilus influenzae clone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence of Haemophilus influenzae clone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence of Haemophilus influenzae clone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence of Haemophilus influenzae clone 167_A16 shown in SEQ. ID. NO. 4.Type: GrantFiled: September 15, 2006Date of Patent: September 11, 2007Assignee: Allegheny-Singer Research InstituteInventors: Garth D. Ehrlich, Patricia Antalis, John Gladitz, Geza Erdos, Fen Z. Hu
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Patent number: 7232891Abstract: The subject invention provides a method for detecting the presence of human malignant cells in a sample of tumor cells, which comprises contacting the sample with an antibody directed to an epitope present on the ? subunit of human luteinizing hormone or on intact human luteinizing hormone under conditions such that the antibody forms a complex with cells present in the sample if the epitope is present on the surface of the cells, and determining whether the antibody forms such a complex. The subject invention also provides a method for determining whether a tumor present in a human subject is malignant which comprises obtaining a sample of cells from the tumor and detecting the presence of malignant cells in the sample according to the method of the subject invention.Type: GrantFiled: June 6, 2002Date of Patent: June 19, 2007Assignees: The Trustees of Columbia University in the city of New York, Allegheny-Singer Research InstituteInventors: Hernan Acevedo, Alexander Krichevsky
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Patent number: 7192922Abstract: A method of treating a patient having heart failure due to LV systolic dysfunction with an LV ejection fraction less than 40%. The method includes the steps of administering to a patient in need thereof, a compound selected from the group consisting of GIP, GIP analogs, GIP derivatives and pharmaceutically-acceptable salts thereof, GLP-1, GLP-1 analogs, GLP-1 derivatives and pharmaceutically-acceptable salts thereof, at a therapeutically effective amount to improve LV function.Type: GrantFiled: November 19, 2002Date of Patent: March 20, 2007Assignee: Allegheny-Singer Research InstituteInventors: Richard P. Shannon, Dariush Elahi
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Patent number: 7152471Abstract: An apparatus for assessing a person's hand strength including means for engaging the hand. The apparatus including means for determining the strength of the hand based on a twisting action with the hand of the engaging means relative to the determining means. The engaging means is connected to the determining means. A method for assessing a person's hand strength including the steps of gripping a first object having a first diameter with the hand by the person. There is the step of twisting the first object with the hand. There is the step of measuring torque with a torque sensor, connected to the first object, of the object as it is being twisted by the hand.Type: GrantFiled: October 31, 2003Date of Patent: December 26, 2006Assignee: Allegheny-Singer Research InstituteInventors: Mark E. Baratz, Mark Carl Miller, Patrick D. Devanny, Jufang He
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Patent number: 7115732Abstract: A DNA sequence of Haemophilus influenzae clone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence of Haemophilus influenzae clone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence of Haemophilus influenzae clone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence of Haemophilus influenzae clone 167_A16 shown in SEQ. ID. NO. 4.Type: GrantFiled: May 20, 2005Date of Patent: October 3, 2006Assignee: Allegheny-Singer Research InstituteInventors: Garth D. Ehrlich, Patricia Antalis, John Gladitz, Geza Erdos, Fen Z. Hu
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Patent number: 6969762Abstract: A DNA sequence of Haemophilus influenzae clone 151_04 shown in SEQ. ID. NO. 1. A DNA sequence of Haemophilus influenzae clone 125_L2 shown in SEQ. ID. NO. 2. A DNA sequence of Haemophilus influenzae clone 179_D14 shown in SEQ. ID. NO. 3. A DNA sequence of Haemophilus influenzae clone 167_A16 shown in SEQ. ID. NO. 4.Type: GrantFiled: October 31, 2003Date of Patent: November 29, 2005Assignee: Allegheny-Singer Research InstituteInventors: Garth D. Ehrlich, Patricia Antalis, John Gladitz, Geza Erdos, Fen Z. Hu
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Patent number: 6945926Abstract: A muscle energy converter for a patient. The converter includes a casing having a fluid port. The converter includes a bellows mechanism disposed in the casing adapted to contain fluid. The converter includes an actuator arm mechanism adapted to be attached to a tendon of a muscle of the patient which moves against the bellows mechanism when the muscle pulls the actuator arm mechanism and forces fluid out the fluid port. The actuator arm mechanism is engaged with the casing. A method for moving fluid in a patient with a muscle of a patient. The method includes the steps of rotating an actuator arm mechanism against a bellows mechanism in a casing when the muscle pulls the actuator arm mechanism. There is the step of forcing fluid out a fluid port of the casing as the actuator arm mechanism moves against the bellows mechanism.Type: GrantFiled: October 18, 2001Date of Patent: September 20, 2005Assignee: Allegheny-Singer Research InstituteInventor: Dennis R. Trumble
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Publication number: 20040253738Abstract: An apparatus for correcting for cell aggregates in a cell suspension from patients. The apparatus includes a laser cytometry scanning mechanism for scanning cells of a sample of a cell suspension to obtain data about the samples patients. The apparatus includes a memory for storing the data, the memory in communication with the scanning mechanism patients. The apparatus includes a computer for identifying in the data cell aggregates in the samples from the samples that have been scanned with an APT function, the computer in communication with the memory. A method for correcting for cell aggregates in a cell suspension from patients with an APT function. A method for correcting for cell aggregates in a cell suspension from patients with up to 98.6% accuracy. A computer readable medium.Type: ApplicationFiled: June 13, 2003Publication date: December 16, 2004Applicant: Allegheny-Singer Research InstituteInventors: Stanley E. Shackney, Charles Smith, Agnese Pollice, Kathryn Brown, Deborah Kociban
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Patent number: 6808482Abstract: A blood pump device comprises a blood pump having blood transport ports, cannulae connected to the ports, and a coating material covering the junction between the inner surfaces of the ports and cannulae. This forms a smooth transition so blood can flow unimpeded therefrom and collection cavities for the blood are eliminated. Also included is a method for producing a smooth coating. The blood pump device comprises a second portion including a stator mechanism, a rotor mechanism, an impeller, a journal, and a seat member. The second portion is constructed to pump blood through the cannulae when power is provided. The blood pump device is also equipped with a safety occluder device, a sensor for detecting back emf in the stator mechanism, and a controller having the capability of indicating stator current and rotor speed.Type: GrantFiled: September 22, 2000Date of Patent: October 26, 2004Assignee: Allegheny-Singer Research InstituteInventors: John J. Pacella, Andrew H. Goldstein, Dennis R. Trumble, Richard E. Clark, Fred W. Moeller, George J. Magovern
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Patent number: 6786902Abstract: The present invention pertains to an apparatus for cryosurgery. The apparatus comprises a cryoneedle having a diameter less than 3.2 mm. The apparatus is also comprised of a thermal insulation shell disposed about a portion of the cryoneedle for reduction of heat transfer from surrounding tissues or freezing prevention of surrounding tissues during application of the cryoneedle with the shell. The cryoneedle and shell are configured for insertion into a body of a patient. The present invention pertains to a method for freezing tissues. The method comprises the steps of bringing into contact a cryoneedle having a diameter of less than 3.2 mm with a patient's body. Next, there is the step of flowing the cryofluid through the cryoneedle.Type: GrantFiled: March 16, 2000Date of Patent: September 7, 2004Assignee: Allegheny-Singer Research InstituteInventors: Yoed Rabin, Thomas Benjamin Julian, Norman Wolmark
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Publication number: 20040097411Abstract: A method of treating a patient having heart failure due to LV systolic dysfunction with an LV ejection fraction less than 40%. The method includes the steps of administering to a patient in need thereof, a compound selected from the group consisting of GIP, GIP analogs, GIP derivatives and pharmaceutically-acceptable salts thereof, GLP-1, GLP-1 analogs, GLP-1 derivatives and pharmaceutically-acceptable salts there of, at a therapeutically effective amount to improve LV function.Type: ApplicationFiled: November 19, 2002Publication date: May 20, 2004Applicant: Allegheny-Singer Research InstituteInventors: Richard P. Shannon, Dariush Elahi
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Publication number: 20030078464Abstract: A muscle energy converter for a patient. The converter includes a casing having a fluid port. The converter includes a bellows mechanism disposed in the casing adapted to contain fluid. The converter includes an actuator arm mechanism adapted to be attached to a tendon of a muscle of the patient which moves against the bellows mechanism when the muscle pulls the actuator arm mechanism and forces fluid out the fluid port. The actuator arm mechanism is engaged with the casing. A method for moving fluid in a patient with a muscle of a patient. The method includes the steps of rotating an actuator arm mechanism against a bellows mechanism in a casing when the muscle pulls the actuator arm mechanism. There is the step of forcing fluid out a fluid port of the casing as the actuator arm mechanism moves against the bellows mechanism.Type: ApplicationFiled: October 18, 2001Publication date: April 24, 2003Applicant: Allegheny-Singer Research InstituteInventor: Dennis R. Trumble
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Patent number: 6398715Abstract: The present invention pertains to an apparatus for assisting a patient's heart operation. The apparatus comprises a mechanism for expanding and collapsing a right ventricle free wall of a heart of a patient. The apparatus also comprises a mechanism for powering the expanding and collapsing mechanism. The powering mechanism is in communication with the expanding and collapsing mechanism. The present invention pertains to a method for assisting operation of a patient's heart. The method comprises the steps of expanding a balloon placed between a right ventricle free wall and a septum of a patient such that right ventricular compression is achieved during cardiac systole. Then there is the step of collapsing the balloon during cardiac diastole.Type: GrantFiled: September 18, 2000Date of Patent: June 4, 2002Assignee: Allegheny-Singer Research InstituteInventors: James A. Magovern, Dennis R. Trumble
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Patent number: 6186149Abstract: The present invention pertains to a circulatory system, such as a circulatory assist system for a patient. The system comprises a blood pump having tubing fluidically communicating with a person's blood vessel. The blood pump can be, for instance, a centrifugal blood pump but is not limited thereto. The system also comprises an occluder device for controlling flow of the blood pump. The occluder device is in contact with the tubing of the blood pump. The occluder device can be incorporated into an anti-kink sheath over the outlet graft tubing of the blood pump. Preferably, the system comprises control means for actuating the occluder device when the blood pump malfunctions. In this manner, potentially fatal retrograde blood due to pump failure is automatically prevented. In a preferred embodiment, the occluder device comprises a cylindrical tube and a bladder mechanism connected to the inside surface of the tube. Type bladder mechanism preferably comprises a bladder and means for inflating the bladder.Type: GrantFiled: March 13, 2000Date of Patent: February 13, 2001Assignee: Allegheny-Singer Research InstituteInventors: John J. Pacella, Richard E. Clark
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Patent number: 6162167Abstract: A blood pump device which includes a blood pump having blood transport ports and cannulae connected to the ports. The blood pump device also includes a coating material covering the junction between the inner surfaces of the ports and cannulae. A method of producing a smooth coating. A blood pump device including a second portion having a stator mechanism and a rotor mechanism disposed adjacent to and driven by the stator mechanism. The second portion has a journal disposed about the rotor mechanism to provide support therewith. The second portion has an impeller disposed in the chamber and a seal member for sealing about a shaft of the impeller. The seal member is fixedly attached to the journal so that the seal member is supported by the journal. A mechanism for providing power to the blood pump so that blood can be pumped through a cannula.Type: GrantFiled: July 21, 1997Date of Patent: December 19, 2000Assignee: Allegheny-Singer Research InstituteInventors: Andrew H. Goldstein, John J. Pacella, Dennis R. Trumble, Richard E. Clark, Fred W. Moeller, George J. Magovern
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Patent number: 6120431Abstract: The present invention pertains to an apparatus for assisting a patient's heart operation. The apparatus comprises a mechanism for expanding and collapsing a right ventricle free wall of a heart of a patient. The apparatus also comprises a mechanism for powering the expanding and collapsing mechanism. The powering mechanism is in communication with the expanding and collapsing mechanism. The present invention pertains to a method for assisting operation of a patient's heart. The method comprises the steps of expanding a balloon placed between a right ventricle free wall and a septum of a patient such that right ventricular compression is achieved during cardiac systole. Then there is the step of collapsing the balloon during cardiac diastole.Type: GrantFiled: March 14, 1997Date of Patent: September 19, 2000Assignee: Allegheny-Singer Research InstituteInventors: James A. Magovern, Dennis R. Trumble
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Patent number: 6045496Abstract: The present invention pertains to a circulatory system, such as a circulatory assist system for a patient. The system comprises a blood pump having tubing fluidically communicating with a person's blood vessel. The blood pump can be, for instance, a centrifugal blood pump but is not limited thereto. The system also comprises an occluder device for controlling flow of the blood pump. The occluder device is in contact with the tubing of the blood pump. The occluder device can be incorporated into an anti-kink sheath over the outlet graft tubing of the blood pump. Preferably, the system comprises control means for actuating the occluder device when the blood pump malfunctions. In this manner, potentially fatal retrograde blood due to pump failure is automatically prevented. In a preferred embodiment, the occluder device comprises a cylindrical tube and a bladder mechanism connected to the inside surface of the tube. The bladder mechanism preferably comprises a bladder and means for inflating the bladder.Type: GrantFiled: April 15, 1994Date of Patent: April 4, 2000Assignee: Allegheny-Singer Research InstituteInventors: John J. Pacella, Richard E. Clark
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Patent number: 6042567Abstract: An apparatus for the introduction or removal of fluid based material from a body of a patient by a clinician. The apparatus comprises a mechanism for connecting into a blood vessel of the patient's blood vessel to continuously introduce fluid based material into or remove the fluid based material from the patient's body. The connecting mechanism is fluidically sealed and self-sealing such that fluid based material cannot escape therefrom and contact the clinician at all times during installation and operation of the apparatus. The apparatus is also comprised of a device for controlling whether the fluid based material is introduced into or removed from the blood vessel while the connecting means is in contact with the blood vessel without the escape of the fluid based material therefrom. The controlling device is in fluidic communication with the connecting mechanism.Type: GrantFiled: November 23, 1993Date of Patent: March 28, 2000Assignee: Allegheny-Singer Research InstituteInventor: Robert M. McNamara
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Patent number: 6039730Abstract: The present invention pertains to an apparatus for cryosurgery. The apparatus comprises a cryoneedle having a diameter less than 3.2 mm. The apparatus is also comprised of a thermal insulation shell disposed about a portion of the cryoneedle for reduction of heat transfer from surrounding tissues or freezing prevention of surrounding tissues during application of the cryoneedle with the shell. The cryoneedle and shell are configured for insertion into a body of a patient. The present invention pertains to a method for freezing tissues. The method comprises the steps of bringing into contact a cryoneedle having a diameter of less than 3.2 mm with a patient's body. Next, there is the step of flowing the cryofluid through the cryoneedle.Type: GrantFiled: June 24, 1996Date of Patent: March 21, 2000Assignee: Allegheny-Singer Research InstituteInventors: Yoed Rabin, Thomas Benjamin Julian, Norman Wolmark
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Patent number: 5899897Abstract: The system includes a mechanism for freezing tissue in a patient. Additionally, the system includes a mechanism for heating other tissue near the tissue being frozen by the freezing mechanism such that essentially only desired region is frozen by the freezing mechanism and heat from the heating mechanism prevents the other tissue from being frozen. The heating mechanism is disposed adjacent to but separate and apart from the freezing mechanism. Alternatively, the mechanism for heating can be used with tissue already frozen by the freezing mechanism. A method for performing cryosurgery on a patient. The method includes the steps of inserting a cryoprobe into a patient. Next, there is the step of placing a cryoheater in contact with the patient adjacent the cryoprobe. Then, there is the step of activating the cryoprobe and the cryoheater so the cryoprobe freezes desired tissue in the patient and the cryoheater heats other tissue around the desired tissue so the other tissue is not frozen by the cryoprobe.Type: GrantFiled: September 25, 1997Date of Patent: May 4, 1999Assignee: Allegheny-Singer Research InstituteInventors: Yoed Rabin, Thomas Benjamin Julian, Norman Wolmark