Patents Assigned to American Cyanamid Company
  • Patent number: 6340464
    Abstract: Vaccine adjuvants comprising a liquid medium contain polymers with anionic constitutive repeating units and hydrophobic constitutive repeating units. Advantageously, the adjuvants are aqueous solutions of partially esterified polyacrylic acids. The novel adjuvants are highly stable, effective and have a relatively low level of local toxicity. Further, vaccines comprising such adjuvants and a process for producing them are described.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: January 22, 2002
    Assignee: American Cyanamid Company
    Inventors: Luuk Hilgers, Michel Strebelle
  • Publication number: 20020006922
    Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states.
    Type: Application
    Filed: July 5, 2001
    Publication date: January 17, 2002
    Applicant: American Cyanamid Company
    Inventors: Aranapakam Mudumbai Venkatesan, George Theodore Grosu, Jamie Marie Davis, Jannie Lea Baker, Jeremy Ian Levin
  • Publication number: 20020004600
    Abstract: The invention relates to a process for the preparation of substituted pyrimidines of formula I, 1
    Type: Application
    Filed: June 29, 2001
    Publication date: January 10, 2002
    Applicant: American Cyanamid Company
    Inventors: Oliver Meyer, Dieter Gutheil
  • Publication number: 20020004486
    Abstract: Sustained-release compositions comprising a macrolide compound, a surfactant, a co-solvent, and a solvent. The sustained-release compositions of this invention may be parenterally administered to animals, and are useful for preventing or treating helminth, acarid or arthropod endo- or ectoparasitic infection or infestation in warm-blooded animals for prolonged periods of time.
    Type: Application
    Filed: March 15, 2001
    Publication date: January 10, 2002
    Applicant: American Cyanamid Company
    Inventors: William David Steber, Sivaja Ranjan
  • Publication number: 20010056088
    Abstract: Hydroxamic acids having the formula 1
    Type: Application
    Filed: June 14, 2001
    Publication date: December 27, 2001
    Applicant: American Cyanamid Company
    Inventors: Jeremy I. Levin, James M. Chen
  • Patent number: 6328965
    Abstract: Vaccine adjuvants comprising a sulpholipid polysaccharide in combination with an interface-forming constituent. The invention also provides a method for preparing a vaccine by emulsifying an aqueous solution of an antigen and a sulpholipid polysaccharide. The adjuvants are stable at high temperatures, and are at least as effective as conventional adjuvants. Their local toxicity, i.e. their reactogenicity, is generally lower than that of conventional adjuvants.
    Type: Grant
    Filed: September 15, 1997
    Date of Patent: December 11, 2001
    Assignee: American Cyanamid Company
    Inventor: Luuk Hilgers
  • Patent number: 6326165
    Abstract: Promising groups of environmentally-safe insecticides consist of analogues of insect hormones, such as juvenile hormone, and antagonists of such hormones. The traditional bioassay approach for screening potential juvenile hormone analogs and antagonists is slow, expensive and inefficient. A recombinant bHLH-PAS-juvenile hormone receptor, isolated from methoprene-tolerant locus on Drosophila, provides the basis of in vitro and in vivo binding assays that can be used to discover new juvenile hormone-type targeted insecticides. Moreover, the nucleotide sequence of the Drosophila bHLH-PAS/JHR polypeptide provides tools for isolating juvenile hormone receptor genes from other insect species.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: December 4, 2001
    Assignees: Colorado State University Research Foundation, American Cyanamid Company
    Inventors: Thomas G. Wilson, Julia N. Heinrich
  • Patent number: 6326516
    Abstract: The invention discloses hydroxamide acids of the formula: which are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: December 4, 2001
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, James M. Chen, Arie Zask
  • Patent number: 6323209
    Abstract: This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having the formula wherein: X is phenyl which is optionally substituted; R and R1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl; Y is a radical selected from the group consisting of R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n=2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.
    Type: Grant
    Filed: November 3, 1998
    Date of Patent: November 27, 2001
    Assignee: American Cyanamid Company
    Inventor: Philip Frost
  • Patent number: 6320053
    Abstract: The invention relates to a process for the preparation of hetero)aryloxyheteroarylcarboxylic amide or ester of formula VI wherein A1, A2, A3, A4, A5 Hal, X, R1, and R4 are defined within, which process comprises preparing the heteroarylcarboxylic amide or ester of formula I or a salt thereof,  from a trichoromethyl-heteroaromatic compound of formula II and reacting the compound of formula I with an aromatic or heteroaromatic hydroxyl compound of formula VII, R4—OH  VII optionally in the presence of a base.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: November 20, 2001
    Assignee: American Cyanamid Company
    Inventors: Marcus Knell, Monika Brink, Jan Hendrik Wevers, Willi Heinz
  • Patent number: 6320059
    Abstract: There is provided a process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-[1-chloro-1-(perfluoroalkyl)methyl]arylimidoyl chloride compounds. The 2-aryl-5-(perfluoroalkyl)pyrrole compounds are useful for the control of insect and acrid pests, and may also be used to prepare other pesticidal arylpyrrole compounds. In addition, the present invention provides compounds which are useful as intermediates in the preparation of arylpyrrole compounds.
    Type: Grant
    Filed: March 7, 2000
    Date of Patent: November 20, 2001
    Assignee: American Cyanamid Company
    Inventor: Venkataraman Kameswaran
  • Patent number: 6313072
    Abstract: The novel compounds of formula I: (A, B, R1, R2, R3, X and m are defined in the specification) show selective herbicidal activity. The new compounds can be prepared according to known methods and can be used as herbicides in agriculture and related fields.
    Type: Grant
    Filed: February 18, 1999
    Date of Patent: November 6, 2001
    Assignee: American Cyanamid Company
    Inventors: Stephen Scheiblich, Thomas Maier, Axel Kleemann, Helmut Siegfried Baltruschat
  • Patent number: 6313123
    Abstract: The compounds of formula B: which are useful in disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: November 6, 2001
    Assignee: American Cyanamid Company
    Inventors: Jeremy I. Levin, James M. Chen
  • Patent number: 6310006
    Abstract: The invention relates to novel compounds of formula I: wherein R, A, B and X have the meaning given in claim 1; and the agronomically acceptable salts or N-oxides thereof, and to herbicidal compositions containing such compounds as active ingredients.
    Type: Grant
    Filed: May 13, 1998
    Date of Patent: October 30, 2001
    Assignee: American Cyanamid Company
    Inventors: Thomas Maier, Stefan Scheiblich, Helmut S. Baltruschat
  • Patent number: 6305444
    Abstract: A container for use in a closed application system includes a valve mounted to a discharge opening of the container and rotatable with the container for controlling the discharge of material from the container. The valve includes an element for engaging corresponding structure in a receptacle for receiving the contents of the container. The element engages and locks the valve in the receptacle when the valve is opened and the contents are being discharged from the container into the receptacle. The valve element and the corresponding structure on the receptacle cooperate so that the container can only be received in and removed from the receptacle when the valve is closed. In this manner, the contents in the container can be discharged only when the container is received within the receptacle and the container is rotated in a direction to open the valve.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventor: Keith F. Woodruff
  • Patent number: 6307103
    Abstract: An improved process for the preparation of a 1,1,1-trifluoro-2-aminoalkane of formula I wherein R1 represents an optionally substituted alkyl group; which comprises hydrogenating the corresponding oxime of formula II wherein R1 has the meaning given above and the winding line indicates that the hydroxy group may be in the (E)- or (Z)-position with respect to the trifluoromethyl group, in the presence of Raney nickel and a diluent; the improvement wherein is, that said reaction is carried out in a diluent selected from an alkanol, a cyclic ether and an aromatic hydrocarbon.
    Type: Grant
    Filed: March 28, 2000
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventors: Hans-Peter Niedermann, Dieter Gutheil
  • Patent number: 6306404
    Abstract: The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission of greater than or equal to 88% as measured spectrophotometrically.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventors: Vincent James LaPosta, John Hayward Eldridge
  • Patent number: 6306866
    Abstract: There are provided compositions and methods comprising compounds of formula I: wherein R1, A, B, X, Y and Z have the meaning given in claim 1, for the control of insect and acarid pests.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: October 23, 2001
    Assignee: American Cyanamid Company
    Inventors: William Wakefield Wood, Linda Fleming, Salvatore John Cuccia
  • Publication number: 20010031879
    Abstract: The present invention relates to arylpyrrole particles which are prepared by a process in which the particles are aged and milled, and pesticidal suspension concentrate compositions comprising them. The size of the particles of this invention remains surprisingly stable during storage.
    Type: Application
    Filed: April 2, 2001
    Publication date: October 18, 2001
    Applicant: Intellectual Property Department American Cyanamid Company
    Inventors: Mimi Yih-Pei Chou Schaaf, Steven Brunt, Jian James Xu, Andrew Evelyn Goldsmith, Anthony Francis Walker, Patrick C. Mowery, Edward S. Donoghue, Srinivasan Rajan
  • Patent number: 6297258
    Abstract: This invention provides compounds of formula I having the structure wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: October 2, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Philip Frost