Abstract: Vaccine adjuvants comprising a liquid medium contain polymers with anionic constitutive repeating units and hydrophobic constitutive repeating units. Advantageously, the adjuvants are aqueous solutions of partially esterified polyacrylic acids. The novel adjuvants are highly stable, effective and have a relatively low level of local toxicity. Further, vaccines comprising such adjuvants and a process for producing them are described.
Abstract: Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-&agr; from membrane bound TNF-&agr; precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states.
Type:
Application
Filed:
July 5, 2001
Publication date:
January 17, 2002
Applicant:
American Cyanamid Company
Inventors:
Aranapakam Mudumbai Venkatesan, George Theodore Grosu, Jamie Marie Davis, Jannie Lea Baker, Jeremy Ian Levin
Abstract: Sustained-release compositions comprising a macrolide compound, a surfactant, a co-solvent, and a solvent. The sustained-release compositions of this invention may be parenterally administered to animals, and are useful for preventing or treating helminth, acarid or arthropod endo- or ectoparasitic infection or infestation in warm-blooded animals for prolonged periods of time.
Abstract: Vaccine adjuvants comprising a sulpholipid polysaccharide in combination with an interface-forming constituent. The invention also provides a method for preparing a vaccine by emulsifying an aqueous solution of an antigen and a sulpholipid polysaccharide. The adjuvants are stable at high temperatures, and are at least as effective as conventional adjuvants. Their local toxicity, i.e. their reactogenicity, is generally lower than that of conventional adjuvants.
Abstract: Promising groups of environmentally-safe insecticides consist of analogues of insect hormones, such as juvenile hormone, and antagonists of such hormones. The traditional bioassay approach for screening potential juvenile hormone analogs and antagonists is slow, expensive and inefficient. A recombinant bHLH-PAS-juvenile hormone receptor, isolated from methoprene-tolerant locus on Drosophila, provides the basis of in vitro and in vivo binding assays that can be used to discover new juvenile hormone-type targeted insecticides. Moreover, the nucleotide sequence of the Drosophila bHLH-PAS/JHR polypeptide provides tools for isolating juvenile hormone receptor genes from other insect species.
Type:
Grant
Filed:
November 17, 1997
Date of Patent:
December 4, 2001
Assignees:
Colorado State University Research Foundation, American Cyanamid Company
Abstract: The invention discloses hydroxamide acids of the formula:
which are useful in treating disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss.
Type:
Grant
Filed:
January 27, 2000
Date of Patent:
December 4, 2001
Assignee:
American Cyanamid Company
Inventors:
Jeremy I. Levin, James M. Chen, Arie Zask
Abstract: This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having the formula
wherein:
X is phenyl which is optionally substituted;
R and R1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl;
R2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl;
Y is a radical selected from the group consisting of
R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl;
n=2-4;
or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.
Abstract: The invention relates to a process for the preparation of hetero)aryloxyheteroarylcarboxylic amide or ester of formula VI
wherein A1, A2, A3, A4, A5 Hal, X, R1, and R4 are defined within, which process comprises preparing the heteroarylcarboxylic amide or ester of formula I or a salt thereof,
from a trichoromethyl-heteroaromatic compound of formula II
and reacting the compound of formula I with an aromatic or heteroaromatic hydroxyl compound of formula VII,
R4—OH VII
optionally in the presence of a base.
Type:
Grant
Filed:
May 4, 2000
Date of Patent:
November 20, 2001
Assignee:
American Cyanamid Company
Inventors:
Marcus Knell, Monika Brink, Jan Hendrik Wevers, Willi Heinz
Abstract: There is provided a process for the preparation of 2-aryl-5-(perfluoroalkyl)pyrrole compounds from N-[1-chloro-1-(perfluoroalkyl)methyl]arylimidoyl chloride compounds. The 2-aryl-5-(perfluoroalkyl)pyrrole compounds are useful for the control of insect and acrid pests, and may also be used to prepare other pesticidal arylpyrrole compounds.
In addition, the present invention provides compounds which are useful as intermediates in the preparation of arylpyrrole compounds.
Abstract: The novel compounds of formula I:
(A, B, R1, R2, R3, X and m are defined in the specification) show selective herbicidal activity.
The new compounds can be prepared according to known methods and can be used as herbicides in agriculture and related fields.
Type:
Grant
Filed:
February 18, 1999
Date of Patent:
November 6, 2001
Assignee:
American Cyanamid Company
Inventors:
Stephen Scheiblich, Thomas Maier, Axel Kleemann, Helmut Siegfried Baltruschat
Abstract: The compounds of formula B:
which are useful in disease conditions mediated by TNF-&agr;, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis, Crohn's disease and degenerative cartilage loss
Abstract: The invention relates to novel compounds of formula I:
wherein R, A, B and X have the meaning given in claim 1;
and the agronomically acceptable salts or N-oxides thereof,
and to herbicidal compositions containing such compounds as active ingredients.
Type:
Grant
Filed:
May 13, 1998
Date of Patent:
October 30, 2001
Assignee:
American Cyanamid Company
Inventors:
Thomas Maier, Stefan Scheiblich, Helmut S. Baltruschat
Abstract: The invention pertains to adjuvant and vaccine compositions of monophosphoryl lipid A, sugar and optionally an amine based surfactant, which when frozen and thawed or lyophilized and reconstituted reform a colloidal suspension having a light transmission of greater than or equal to 88% as measured spectrophotometrically.
Type:
Grant
Filed:
July 13, 1999
Date of Patent:
October 23, 2001
Assignee:
American Cyanamid Company
Inventors:
Vincent James LaPosta, John Hayward Eldridge
Abstract: There are provided compositions and methods comprising compounds of formula I:
wherein R1, A, B, X, Y and Z have the meaning given in claim 1,
for the control of insect and acarid pests.
Type:
Grant
Filed:
March 6, 1998
Date of Patent:
October 23, 2001
Assignee:
American Cyanamid Company
Inventors:
William Wakefield Wood, Linda Fleming, Salvatore John Cuccia
Abstract: An improved process for the preparation of a 1,1,1-trifluoro-2-aminoalkane of formula I
wherein
R1 represents an optionally substituted alkyl group;
which comprises hydrogenating the corresponding oxime of formula II
wherein R1 has the meaning given above and the winding line indicates that the hydroxy group may be in the (E)- or (Z)-position with respect to the trifluoromethyl group, in the presence of Raney nickel and a diluent;
the improvement wherein is, that said reaction is carried out in a diluent selected from an alkanol, a cyclic ether and an aromatic hydrocarbon.
Abstract: A container for use in a closed application system includes a valve mounted to a discharge opening of the container and rotatable with the container for controlling the discharge of material from the container. The valve includes an element for engaging corresponding structure in a receptacle for receiving the contents of the container. The element engages and locks the valve in the receptacle when the valve is opened and the contents are being discharged from the container into the receptacle. The valve element and the corresponding structure on the receptacle cooperate so that the container can only be received in and removed from the receptacle when the valve is closed. In this manner, the contents in the container can be discharged only when the container is received within the receptacle and the container is rotated in a direction to open the valve.
Abstract: The present invention relates to arylpyrrole particles which are prepared by a process in which the particles are aged and milled, and pesticidal suspension concentrate compositions comprising them. The size of the particles of this invention remains surprisingly stable during storage.
Type:
Application
Filed:
April 2, 2001
Publication date:
October 18, 2001
Applicant:
Intellectual Property Department American Cyanamid Company
Inventors:
Mimi Yih-Pei Chou Schaaf, Steven Brunt, Jian James Xu, Andrew Evelyn Goldsmith, Anthony Francis Walker, Patrick C. Mowery, Edward S. Donoghue, Srinivasan Rajan
Abstract: This invention provides compounds of formula I having the structure
wherein G1, G2, R1, R4, Z, n, and X are defined in the specification or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
Type:
Grant
Filed:
August 1, 2000
Date of Patent:
October 2, 2001
Assignee:
American Cyanamid Company
Inventors:
Allan Wissner, Hwei-Ru Tsou, Dan M. Berger, Middleton B. Floyd, Jr., Philip R. Hamann, Nan Zhang, Philip Frost