Abstract: A hand-held manually operated pipette having an adjustable plunger stroke and calibrated electronic digital volumetric display draws-up and dispenses viscous, dense or high vapor pressure liquids by means of an easily replaced, disposable, integral, positive displacement type plunger tip and capillary assembly. The pipette in another form utilizes a disposable air displacement capillary. The plunger adjustably strokes to a first stop in a first mode for calibration or sample draw-up and dispensing with the volume of pipette liquid contents continuously displayed. In a second mode an over-travel arrangement enables the plunger shaft to stroke beyond the first stop to permit collet type attachment and ejection of the integral plunger tip and capillary for positive displacement service or to eject an air displacement capillary.

Abstract: A nebulizer for converting liquid into aerosol which includes a housing having a sidewall defining a liquid reservoir and an outlet opening through which aerosol passes. A gas nozzle having a gas orifice is included in the nebulizer, which gas nozzle has a gas inlet for introducing gas to the nozzle. A liquid inlet is provided on the nebulizer which is spaced from the gas nozzle for introducing liquid to the gas nozzle as gas flows through the gas orifice. A liquid passage in communication with the reservoir and the liquid inlet is provided, which liquid passage extends along and spaced from the sidewall of the housing which defines the liquid reservoir.

Abstract: A container closure includes a cover portion and a rim portion at the edge of, and upstanding from the cover portion; the rim includes a flat, solid, annular ring member surrounding a raised, solid, round-shouldered, circular center area; the rim portion surrounds the cover portion and includes an upstanding, annular wall with an outwardly-projecting annular flange for engaging the inner surface of a container at its opening and, at the top edge of the annular wall, a planar flange parallel to the cover portion for seating on the rim of a container opening.

Abstract: The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S-- where R.sub.1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y).sub.A is --CH.sub.2 NR.sub.2 R.sub.3 where R.sub.2 and R.sub.3 may be hydrogen, substituted alkyls, aryls, or together with N form a 5 to 7 membered heterocyclic group; and Ar is a substituted or unsubstituted aryl. These compounds are useful in the treatment of various cardiac arrhythmias.

Abstract: A method for the treatment of glaucoma or lowering intraocular pressure in a mammal, involving topically administering to the eye of such mammal a selectively metabolized beta-blocking compound of the formula: ##STR1## wherein Ar may be substituted or unsubstituted aromatic, Y may be a straight or branched carbon chain or aralkyl, R may be lower alkyl, lower alkenyl, lower alkynyl, aryl, or aralkyl, and x is an integer from 1 to about 3; or a pharmaceutically acceptable salt thereof. Because of a relatively long duration of action of such compounds in ocular fluids and a relatively short duration of action in the systemic circulation, such compounds are useful for the treatment of excessive intraocular pressure without substantial systemic effects.

Abstract: A cardiac pacer has separate digital filter circuits for sensing atrial and ventricular activity. Parameter data stored in memory is used by the digital filters for identifying the various components of cardiac activity, such as the P, R and T waves, as well as for identifying Premature Ventricular Contractions (PVC). A Ventricular Rate Time Out period is established from the last natural beat or stimulating pulse; and if a P wave or natural R wave is not sensed during that period, the system generates a stimulating pulse and, using T wave parameters in the ventricular filter, tests to verify capture.

Abstract: Described herein are compounds of the formula ##STR1## wherein R.sub.1 is alkyl of from 1 to about 5 carbon atoms, alkenyl of from 2 to about 5 carbon atoms, alkynyl of from 3 to about 5 carbon atoms, cycloalkyl of from 3 to about 7 carbon atoms, alkylcarboxymethyl wherein the alkyl portion is from 1 to about 5 carbon atoms, arylcarboxymethyl wherein the aryl portion is from 6 to about 10 carbon atoms, aryl of from 6 to about 10 carbon atoms, or aralkyl wherein the alkyl portion is from 1 to about 5 carbon atoms and the aryl portion is from about 6 to about 10 carbon atoms; R.sub.2 and R.sub.

Abstract: Described are compounds of the formula ##STR1## wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, --CH.sub.2 NH.sub.2, CH.sub.2 OH or COOR"; R' is hydrogen, lower cycloalkyl or lower alkyl; R" is lower alkyl or --CH.sub.2 Ar wherein Ar is phenyl, substituted phenyl, furan or thiophene; R'" is COOR", ##STR2## and x is oxygen or nitrogen; or a pharmaceutically acceptable salt thereof and their use in the treatment of impaired ventricular myocardial contractility.The compounds exhibit cardiotonic activity.

Abstract: A container for use in sterilization of medical items is made entirely of resin-treated, fluid repellent, semi-rigid nonwoven material. The container includes a bottom or receptacle having extending side wall or side walls and a cover having depending side wall or side walls. The material is readily permeable to gas or steam, yet is resistant to the transmission of bacteria. The container and its contents may be retrieved from a sterilizing vessel almost immediately after sterilization without special procedures or devices and without fear of being burned. Because of its low cost, the container is disposable and may be molded to a particular shape for use in shipping prosthetic devices, implants or delicate instruments in sterilized condition.

Abstract: Disclosed is a process for preparing optically active alpha-aminonitriles of the formula ##STR1## by the reaction of alpha-trimethylsilyloxynitriles with optically active alpha-methylbenzylamine in the presence of a loweralkyl alcohol.In the above formula, R denotes C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.12 cycloalkyl, C.sub.7 -C.sub.15 aralkyl or unsubstituted or substituted aryl or heteroaryl.In general, R-alpha-methylbenzylamine gave I and III as the major and the minor products, respectively. Whereas, S-alpha-methylbenzylamine gave II and IV as the major and the minor products, respectively.The compounds so prepared are intermediates in the preparation of optically active aminoacids.

Abstract: A medication infusion system which includes an infusion line for introducing medication to a peripheral vein of a patient. The infusion system includes a pump for delivering the medication and a pressure transducer within the infusion line for converting sensed fluid pressure waves to electrical signals. An amplifier is provided within the system for increasing the strength of the electrical signal. A gain control amplifier is electrically connected within the system for maintaining the electrical signal at a predetermined amplitude regardless of input variations. A tracking filter is provided within the system to provide an electrical signal representative of the patient's respiration rate over a preselected full clinical respiration rate range. A microprocessor is provided within the system for deriving from the electrical signal a control signal for controlling the operation of the pump.

Abstract: Described is a process for preparing alpha-aminonitriles having the formula ##STR1## where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.3 -C.sub.12 cycloalkyl, C.sub.7 -C.sub.15 aralkyl, unsubstituted or substituted aryl or heteroaryl or alternatively, R.sub.1 and R.sub.2 together with the carbon atom form a 3 to 12 member cycloalkyl group, or with a heteroatom form a 3 to 12 member heterocyclic group and R.sub.3 and R.sub.4 together with the nitrogen atom form a 3 to 12 member heterocyclic group and R.sub.3 and R.sub.

Abstract: An adjustable stop for gripping a rod at selected locations intermittent the length of the rod, including a base member with a pair of longitudinally spaced openings for receiving a rod having a longitudinal axis. A clamp member is provided with an opening located between the base member openings for receiving the same rod. A cam surface is provided on the clamp member for engaging the base member to misalign the clamp member opening between the two base member openings for gripping the rod with the three openings as the clamp member is rotated about the rod's longitudinal axis when the rod extends through the adjustable stop.

Abstract: A system for applying relatively large adhesive backed bandages to a patient for a wound dressing, burn dressing, surgical incise drape, etc. The system includes an applicator handle that is substantially less flexible than the bandage, which is joinable to the bandage during application, but which is removed from the bandage so as not to interfere with the flexible functioning of such bandage on a patient's anatomy.

Abstract: An implantable metered dose drug delivery system is disclosed which comprises implantable components including an injection site, reservoir, metering valve and delivery catheter, all of which are interconnected through suitable tubing. The metering valve has a domed body constructed of a resilient elastomeric material with a fluid-flow passageway extending therethrough and opening into a chamber within the domed body. A valve is positioned within an outlet leading from the chamber, which valve is opened by exerting an external pressure on the domed body to first collapse and occlude the fluid-flow passageway and then open the valve to permit medication within the chamber to flow through the outlet. Upon release of the external pressure, the fluid-flow passageway opens and reduced pressure in the chamber draws additional fluid through the passageway to fill the chamber.

Abstract: A self-sealing subcutaneous injection site for implantation in the body includes a housing having a bottom wall and a generally resilient dome-shaped wall which defines an interior chamber within the housing. The interior chamber has a durometer and shape for providing compressive forces within the dome-shaped wall for sealing punctures extending through the dome-shaped wall upon fluid pressurization of the interior chamber. A conduit extends through the dome-shaped wall into the interior chamber to provide a fluid-flow passageway to the chamber.

Abstract: An antiserum for immunohematologic agglutination reactions involving IgG antibodies wherein reduced IgG antibodies are suspended in a low ionic strength medium.