Patents Assigned to Applied Medical Research
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Patent number: 10391335Abstract: A method of monitoring a state of a Linac beam in an MRI-Linac system for real-time in vivo patient dosimetry is provided that includes disposing a Linac beam proximal to a PIN diode of an imaging RF coil to induce RF noise in an MRI image from an MRI imager, and using the MRI imager to monitor the induced RF noise in the MRI image, where a change in a percentage of RF noise in the MRI image is used to determine a state of the Linac beam in the presence of a magnetic field of the MRI imager, where the state of the Linac beam includes an ON state, an Off state, or a relative intensity of the Linac beam.Type: GrantFiled: February 26, 2018Date of Patent: August 27, 2019Assignee: Ingham Institute for Applied Medical ResearchInventors: Gary Liney, Bin Dong
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Patent number: 8048056Abstract: A gastrostomy device includes a tubular portion and an internal bolster having a radial wing secured to the tubular portion. The internal bolster is flexible and permits elastic deformation between a first orientation with the wing wrapped into a generally cylindrical configuration and a second orientation with the wing unfurled. A constraining member encases the internal bolster to retain the internal bolster in the first orientation and to cover at least a major portion of the wrapped wing. Removal of the casing permits the internal bolster to move from the first orientation to the second orientation. The internal bolster may be deployed by a ripcord, freeing the internal bolster into the patient' stomach and deploying the internal bolster to the second orientation. Alternatively, the internal bolster may be deployed by the constraining member being dissolved by the patient's bodily fluids located inside the patient's stomach.Type: GrantFiled: February 17, 2005Date of Patent: November 1, 2011Assignee: Applied Medical ResearchInventors: George J. Picha, Davor G. Mandic
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Patent number: 7833204Abstract: Intramedullary access or infusion devices that includes a tubular conduit having a distal end and a proximal end with a length sufficient to pass through the cortical region to the cancellous region of a bone; a flange circling the outside of the proximal end of the conduit; and a penetrable diaphragm positioned within the tubular conduit, are described. The devices may be placed in bone and later used, for example, as a site for administering a pharmacologically active agent.Type: GrantFiled: May 13, 2008Date of Patent: November 16, 2010Assignee: Applied Medical ResearchInventor: George J. Picha
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Publication number: 20090069904Abstract: A biomaterial including a designed pattern of micropores one at least one surface of the biomaterial is described. The micropores can be provided in a regular or irregular pattern, and can be either continuous or discontinuous. The biomaterial may be formed from a variety of materials, such as a biocompatible polymer or biocompatible tissue. The biomaterial including micropores on a surface may be used for a variety of medical applications such as tissue scaffolding, drug delivery, or tissue fixation.Type: ApplicationFiled: September 12, 2008Publication date: March 12, 2009Applicant: Applied Medical ResearchInventor: George J. Picha
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Patent number: 7041140Abstract: A method of using a neuro decompression device is disclosed that significantly reduces fibroplasia proximate to nerve tissue. The device used in the method utilizes particular surface topographies to disrupt scar tissue formation around nerves, and may include one or more drugs to influence tissue growth.Type: GrantFiled: September 24, 2002Date of Patent: May 9, 2006Assignee: Applied Medical Research, Inc.Inventor: George J. Picha
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Patent number: 6896665Abstract: A gastrostomy device includes a tubular portion and an internal bolster having a radial wing secured to the tubular portion. The internal bolster is flexible and permits elastic deformation between a first orientation with the wing wrapped into a generally cylindrical configuration and a second orientation with the wing unfuried. A constraining member encases the internal bolster to retain the internal bolster in the first orientation and to cover at least a major portion of the wrapped wing. Removal of the casing permits the internal bolster to move from the first orientation to the second orientation. The internal bolster may be deployed by a ripcord, freeing the internal bolster into the patient' stomach and deploying the internal bolster to the second orientation. Alternatively, the internal bolster may be deployed by the constraining member being dissolved by the patient's bodily fluids located inside the patient's stomach.Type: GrantFiled: December 10, 2001Date of Patent: May 24, 2005Assignee: Applied Medical ResearchInventors: George J. Picha, Davor G. Mandic
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Patent number: 6364858Abstract: A gastrostomy device including a tubular portion having an outer end and an inner end, and an internal bolster integrally attached to the tubular portion inner end and resiliently movable between an installation configuration and a deployed configuration. The internal bolster has an inner surface and an outer surface. The inner surface surrounds the tubular portion inner end and is generally convex in shape. The outer surface includes a planar portion and a concave portion that extends from the planar portion. The bolster is placed in an installation configuration by the cooperative action of a rod member and a suture member. The rod member is inserted into a pocket provided on the outer surface of the bolster, and the suture member is wrapped around internal bolster to keep the internal bolster generally aligned with the tubular portion axis.Type: GrantFiled: March 31, 1998Date of Patent: April 2, 2002Assignee: Applied Medical Research, Inc.Inventor: George J. Picha
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Patent number: 6106558Abstract: A neuro decompression device is disclosed that significantly reduces fibroplasia proximate to nerve tissue. The device utilizes particular surface topographies to disrupt scar tissue formation around nerves, and which may include one or more drugs to influence tissue growth.Type: GrantFiled: September 15, 1997Date of Patent: August 22, 2000Assignee: Applied Medical Research, Inc.Inventor: George J. Picha
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Patent number: 5706807Abstract: An implant is provided with an open-celled silicone elastomer foam outer layer. The implant may be formed by compressively deforming beads mixed with liquid elastomer in a mold containing a preformed support structure. The elastomer is cured and the beads dissolved out. Infusion and sensor catheters covered with the foam provide improved transport rates and faster response.Type: GrantFiled: October 11, 1996Date of Patent: January 13, 1998Assignee: Applied Medical ResearchInventor: George J. Picha
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Patent number: 5555898Abstract: A gastric access device having an external bolster and a tubular body. The tubular body has an integral bolster portion at one end and an integral dilator portion at an opposite end. An incision extending from an external body surface to an internal body cavity is formed and the gastric access device is inserted through the incision such that the bolster portion is in contact with an inner body surface surrounding the internal body cavity, the tubular body lies within and projects outwardly from the incision, and the dilator portion is on the outside or exterior of the body. The external bolster is slid or pushed down over the dilator portion and the projecting portion of the tubular body and into contact with the external surface of the body. The projecting portion of the tubular body is clamped and subsequently severed to disconnect the dilator portion from the tubular body.Type: GrantFiled: September 26, 1994Date of Patent: September 17, 1996Assignee: Applied Medical Research, Inc.Inventors: Yutaka Suzuki, Hideyuki Kashiwagi, Teruaki Aoki, Fumiichi Koshino, George J. Picha, Anthony J. Szpak
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Patent number: 5356382Abstract: A surgical tool for use in initial placement of a gastrostomy device in a patient includes an obturator, a cannula and an outer flexible tubular member. A pointed end of the obturator and an adjacent dilator cooperate to incise a tract through the abdominal and stomach walls of the patient. The obturator is removed, leaving the cannula and outer tubular member in place. A deformable section of the flexible tubular member is expanded by movement of the cannula. The outwardly deformed section is then pulled up against the inner wall of the stomach wherein the thickness of the stomach and abdominal walls can be measured by use of visible scale indicia carried on the external surface of the flexible tubular member. Subsequent to the noted measurement, a guidewire or pull wire is passed through a lumen provided by the cannula. The guidewire is used for placing a gastrostomy device of suitable size in the incised tract.Type: GrantFiled: October 23, 1992Date of Patent: October 18, 1994Assignee: Applied Medical Research, Inc.Inventors: George J. Picha, Angela P. Nguyen, Jim Gelbke
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Patent number: 5342628Abstract: A drug diffusion polymer system for the sustained release of drugs includes a composition comprising a polymeric matrix containing a uniform dispersion of a matrix expander and a drug. The matrix expander and drug are each present in the form of solid particulate. Upon exposure to body fluid or water, the matrix expander swells to cause the ingress of fluid into the polymeric matrix for solubilizing and diffusing the drug. Devices may incorporate such drug diffusion compositions as a coating or as a primary material of construction. Such devices may be formed by molding the compositions at room or elevated temperatures depending on the polymer used.Type: GrantFiled: October 11, 1990Date of Patent: August 30, 1994Assignee: Applied Medical Research, Inc.Inventor: George J. Picha
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Patent number: 5271736Abstract: An implant is provided with an open-celled silicone elastomer foam outer layer. The implant may be formed by compressively deforming beads mixed with liquid elastomer in a mold containing a preformed support structure. The elastomer is cured and the beads dissolved out. Infusion and sensor catheters covered with the foam provide improved transport rates and faster response.Type: GrantFiled: September 25, 1992Date of Patent: December 21, 1993Assignee: Applied Medical ResearchInventor: George J. Picha
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Patent number: 4855305Abstract: A method of effecting contraception in human females comprises administering an ovulation-inhibiting amount of melatonin. Optionally, the melatonin is administered in combination with a progestogen and/or an estrogen. The administration of melatonin also provides a method of preventing breast cancer in women.Type: GrantFiled: March 23, 1987Date of Patent: August 8, 1989Assignee: Applied Medical ResearchInventor: Michael Cohen
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Patent number: 4127110Abstract: A wireless, surgically implantable pressure transducer for measuring pressure of fluid or tissue in a body chamber such as a brain ventricle of a patient suffering hydrocephalus or a head injury. The transducer includes an inductor and a capacitor connected in parallel to form a resonant L-C circuit. One of these reactive components is variable, and a bellows (or similar pressure-sensitive force-summing device) is mechanically connected to the variable component to vary the value of capacitance or inductance and hence the resonant frequency of the L-C circuit in response to pressure changes of the fluid in which the bellows is immersed. The transducer is electromagnetically coupled to an external source of variable-frequency energy such as a grid-dip oscillator, enabling external detection of the transducer resonant frequency which is a measure of the fluid pressure being sensed.Type: GrantFiled: May 24, 1976Date of Patent: November 28, 1978Assignee: Huntington Institute of Applied Medical ResearchInventor: Leo A. Bullara
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Patent number: 3958558Abstract: A wireless, surgically implantable pressure transducer for measuring pressure of fluid or tissue in a body chamber such as brain ventricle of a patient suffering hydrocephalus or a severe head injury. The transducer includes a coaxial variable capacitor electrically connected across an inductor to form a parallel resonant L-C circuit. Alternatively, a coaxially variable inductor may be connected across a capacitor to form the L-C circuit. A bellows is mechanically connected to the variable component to vary the value of capacitance or inductance and hence the resonant frequency of the L-C circuit in response to pressure changes of the fluid in which the bellows is immersed. The transducer is electromagnetically coupled to an external source of variable-frequency oscillatory energy such as a grid-dip oscillator which enables external detection of the transducer resonant frequency which is in turn indicative of the level of fluid pressure being sensed.Type: GrantFiled: September 16, 1974Date of Patent: May 25, 1976Assignee: Huntington Institute of Applied Medical ResearchInventors: Roderick R. Dunphy, Leo A. Bullara, Robert H. Pudenz
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Patent number: D406335Type: GrantFiled: October 3, 1997Date of Patent: March 2, 1999Assignee: Applied Medical Research, Inc.Inventors: George J. Picha, Gary Austin, Shawn Heipp, Steven Bobinski