Patents Assigned to Arch Development Corporation
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Patent number: 6999899Abstract: A method and system for monitoring at least one of a system, a process and a data source. A method and system have been developed for carrying out surveillance, testing and modification of an ongoing process or other source of data, such as a spectroscopic examination. A signal from the system under surveillance is collected and compared with a reference signal, a frequency domain transformation carried out for the system signal and reference signal, a frequency domain difference function established. The process is then repeated until a full range of data is accumulated over the time domain and a Sequential Probability Ratio Test (“SPRT”) methodology applied to determine a three-dimensional surface plot characteristic of the operating state of the system under surveillance.Type: GrantFiled: February 2, 2004Date of Patent: February 14, 2006Assignee: ARCH Development CorporationInventors: Kenneth C. Gross, Stephan W. Wegerich, Cynthia Criss-Puszkiewicz, Alan D. Wilks
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Patent number: 6984619Abstract: Methods and pharmaceuticals for inhibiting or preventing metastasis formation in animals, including humans, having primary tumors, through the administration of phosphorothioates including their thiol and disulfide metabolites are disclosed. These compounds stimulate angiostatin levels, inhibit matrix metalloproteinases (MMPs), and stimulate manganese superoxidase dismutase (MnSOD). Phosphorothioates, of which amifostine is an example, can be administered as a combination therapy with traditional cancer therapies, including chemotherapy, radiotherapy, surgery, immunotherapy, hormone therapy and gene-therapy. Inhibition or prevention of metastasis by phosphorothioates is independent of tumor type, including adenocarcinomas and sarcomas.Type: GrantFiled: March 13, 2000Date of Patent: January 10, 2006Assignees: Arch Development Corporation, Board of Regents, The University of Texas SystemInventors: David J. Grdina, Luka Milas
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Patent number: 6972196Abstract: Alkanethiols of formula (1) and the enantiomers of the alkanethiol of formula (1): HS-L-Q-T??(1), and disulfides of formula (3) and the enantiomers of the disulfide of formula (3): T-Q-L S-S-J??(3), where -T is a moiety of formula (2) R1 and R2 are each individually selected from the group consisting of H and OH; a is 0 to 3; b is 0 to 3; and indicates that the chirality of the carbon atom to which it is attached is either R or S; may form inert surfaces that prevent the unwanted adsorption of proteins and cells.Type: GrantFiled: October 11, 2000Date of Patent: December 6, 2005Assignee: Arch Development CorporationInventors: Milan Mrksich, Yan-Yeung Luk
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Patent number: 6939604Abstract: A particle, includes a semiconductor nanocrystal. The nanocrystal is doped.Type: GrantFiled: October 19, 2000Date of Patent: September 6, 2005Assignee: Arch Development CorporationInventors: Philippe Guyot-Sionnest, Moonsub Shim, Conjun Wang
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Patent number: 6916610Abstract: Generation of longer cDNA fragments from SAGE tags for gene identification (GLGI) is disclosed. This method converts SAGE tags, which are about 10 base pairs in length, into their corresponding 3? cDNA fragments covering hundred bases. This added information provides for more accurate genome-wide analysis and overcomes the inherent deficiencies of SAGE. The generation of longer cDNA fragments from isolated and purified protein fragments for gene identification is also disclosed. This method converts a short amino acid sequence into extended versions of the DNA sequences encoding the protein/protein fragment and additional 3? end sequences of the gene encoding the protein. This additional sequence information allows gene identification from purified protein sequences. The invention also provides a high-throughput GLGI procedure for identifying genes corresponding to a set of unidentified SAGE tags.Type: GrantFiled: December 22, 2000Date of Patent: July 12, 2005Assignee: Arch Development CorporationInventors: San Ming Wang, Jian-jun Chen, Janet D. Rowley
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Patent number: 6901156Abstract: A method, system and computer readable medium for an intelligent search display into which an automated computerized image analysis has been incorporated. Upon viewing an unknown mammographic case, the display shows both the computer classification output as well as images of lesions with known diagnoses (e.g., malignant vs. benign) and similar computer-extracted features. The similarity index used in the search can be chosen by the radiologist to be based on a single feature, multiple features, or on the computer estimate of the likelihood of malignancy. Specifically the system includes the calculation of features of images in a known database, calculation of features of an unknown case, calculation of a similarity index, display of the known cases along the probability distribution curves at which the unknown case exists.Type: GrantFiled: February 2, 2001Date of Patent: May 31, 2005Assignee: Arch Development CorporationInventors: Maryellen L. Giger, Carl J. Vyborny, Zhimin Huo, Li Lan
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Patent number: 6898303Abstract: A method, system and computer readable medium for automated detection of lung nodules in computed tomography (CT) image scans, including generating two-dimensional segmented lung images by segmenting a plurality of two-dimensional CT image sections derived from the CT image scans; generating three-dimensional segmented lung volume images by combining the two-dimensional segmented lung images; determining three-dimensional lung nodule candidates from the three-dimensional segmented lung volume images, including, identifying structures within the three-dimensional segmented lung volume images that meet a volume criterion; deriving features from the lung nodule candidates; and detecting lung nodules by analyzing the features to eliminate false-positive nodule candidates from the nodule candidates.Type: GrantFiled: January 16, 2001Date of Patent: May 24, 2005Assignee: Arch Development CorporationInventors: Samuel G. Armato, III, Maryellen L. Giger, Heber Macmahon
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Patent number: 6870037Abstract: Disclosed are novel nucleic acid and peptide compositions comprising methythlioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and idenification tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.Type: GrantFiled: July 1, 1996Date of Patent: March 22, 2005Assignee: Arch Development CorporationInventor: Olufunmilayo I. Olopade
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Patent number: 6836558Abstract: A method, system and computer readable medium for a computer-automated method for identifying given image data, including obtaining template image data corresponding to said given image data; calculating correlation values between the given image data and said template image data; and identifying said image data based on the correlation values calculated in the calculating step.Type: GrantFiled: March 26, 2001Date of Patent: December 28, 2004Assignee: Arch Development CorporationInventors: Kunio Doi, Hidetaka Arimura, Shigehiko Katsuragawa, Junji Morishita
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Publication number: 20040247166Abstract: A method, system and computer readable medium for an intelligent search display into which an automated computerized image analysis has been incorporated. Upon viewing an unknown mammographic case, the display shows both the computer classification output as well as images of lesions with known diagnoses (e.g., malignant vs. benign) and similar computer-extracted features. The similarity index used in the search can be chosen by the radiologist to be based on a single feature, multiple features, or on the computer estimate of the likelihood of malignancy. Specifically the system includes the calculation of features of images in a known database, calculation of features of an unknown case, calculation of a similarity index, display of the known cases along the probability distribution curves at which the unknown case exists.Type: ApplicationFiled: March 8, 2004Publication date: December 9, 2004Applicant: ARCH DEVELOPMENT CORPORATIONInventors: Maryellen L. Giger, Carl J. Vyborny, Zhimin Huo, Li Lan
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Patent number: 6804628Abstract: A method and system for monitoring at least one of a system, a process and a data source. A method and system have been developed for carrying out surveillance, testing and modification of an ongoing process or other source of data, such as a spectroscopic examination. A signal from the system under surveillance is collected and compared with a reference signal, a frequency domain transformation carried out for the system signal and reference signal, a frequency domain difference function established. The process is then repeated until a full range of data is accumulated over the time domain and a Sequential Probability Ratio Test (“SPRT”) methodology applied to determine a three-dimensional surface plot characteristic of the operating state of the system under surveillance.Type: GrantFiled: May 28, 2002Date of Patent: October 12, 2004Assignee: ARCH Development CorporationInventors: Kenneth C. Gross, Stephan W. Wegerich, Cynthia Criss-Puszkiewicz, Alan D. Wilks
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Publication number: 20040162685Abstract: A method and system for monitoring at least one of a system, a process and a data source. A method and system have been developed for carrying out surveillance, testing and modification of an ongoing process or other source of data, such as a spectroscopic examination. A signal from the system under surveillance is collected and compared with a reference signal, a frequency domain transformation carried out for the system signal and reference signal, a frequency domain difference function established. The process is then repeated until a full range of data is accumulated over the time domain and a Sequential Probability Ratio Test (“SPRT”) methodology applied to determine a three-dimensional surface plot characteristic of the operating state of the system under surveillance.Type: ApplicationFiled: February 2, 2004Publication date: August 19, 2004Applicant: ARCH Development CorporationInventors: Kenneth C. Gross, Stephan W. Wegerich, Cynthia Criss-Puszkiewicz, Alan D. Wilks
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Publication number: 20040152681Abstract: Steroid derivatives of this invention interact with nuclear liver X receptor (LXR) and ubiquitous receptor (UR) and can be used to treat a variety of LXR- or UR-mediated disorders.Type: ApplicationFiled: November 10, 2003Publication date: August 5, 2004Applicant: Arch Development Corporation, an Illinois corporationInventors: Shutsung Liao, Ching Song
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Patent number: 6764768Abstract: An alkanethiol of formula (1): HS—L—Q1—T—Q2—M—G—Z (1), may for a SAM. Under application of a potential to the surface, the leaving group —Z is released.Type: GrantFiled: February 28, 2001Date of Patent: July 20, 2004Assignee: Arch Development CorporationInventors: Milan Mrksich, Christian Hodneland
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Publication number: 20040105158Abstract: An apparatus and method for manipulating small dielectric particles. The apparatus and method involves use of a diffractive optical element which receives a laser beam and forms a plurality of light beams. These light beams are operated on by a telescope lens system and then an objective lens element to create an array of optical traps for manipulating small dielectric particles.Type: ApplicationFiled: September 22, 2003Publication date: June 3, 2004Applicant: ARCH DEVELOPMENT CORPORATIONInventors: David G. GRIER, Eric R. DUFRESNE
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Patent number: 6738499Abstract: A method, computer program product, and system (100) for computerized analysis of the likelihood of malignancy in a pulmonary nodule using artificial neural networks (ANNs) (S4). The method, on which the computer program product and the system is based on, includes obtaining a digital outline of a nodule; generating objective measures corresponding to physical features of the outline of the nodule; applying the generated objective measures to an ANN; and determining a likelihood of malignancy of the nodule based on an output of the ANN. Techniques include novel developments and implementations of artificial neural networks and feature extraction for digital images. Output from the inventive method yields an estimate of the likelihood of malignancy (S7) for a pulmonary nodule.Type: GrantFiled: July 2, 2001Date of Patent: May 18, 2004Assignee: Arch Development CorporationInventors: Kunio Doi, Katsumi Nakamura
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Publication number: 20040077087Abstract: The present invention relates to the signalling pathways connecting DNA damage, such as that induced by ionizing radiation or alkylating agents, and phosphorylation by tyrosine kinases.Type: ApplicationFiled: February 24, 2003Publication date: April 22, 2004Applicants: ARCH Development Corporation, Dana-Farber Cancer InstituteInventors: Donald Kufe, Ralph R. Weichselbaum
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Patent number: 6724925Abstract: A method, system, and computer product for the automated segmentation of the lung fields and costophrenic angle (CP) regions in posteroanterior (PA) chest radiographs, wherein image segmentation based on gray-level threshold analysis is performed by applying an iterative global gray-level thresholding method to a chest image based on the features of a global gray-level histogram. Features of the regions in a binary image constructed at each iteration are identified and analyzed to exclude regions external to the lung fields. The initial lung contours that result from this global process are used to facilitate a local gray-level thresholding method. Individual regions-of-interest (ROIs) are placed along the initial contour. A procedure is implemented to determine the gray-level thresholds to be applied to the pixels within the individual ROIs. The result is a binary image, from which final contours are constructed. Smoothing processes are applied, including a unique adaptation of a rolling ball method.Type: GrantFiled: October 30, 2002Date of Patent: April 20, 2004Assignee: Arch Development CorporationInventors: Samuel G. Armato, III, Maryellen L. Giger, Heber MacMahon
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Patent number: 6723511Abstract: The ICP4 protein of herpes simplex virus plays an important role in the transactivation of viral genes. The present invention discloses that ICP4 also has the ability to inhibit apoptosis. This function appears to reside in functional domain distinct from the transactivating function, as indicated by studies using temperature sensitive mutants of ICP4 that transactivating function at elevated temperatures. Also disclosed are methods for inhibition of apoptosis using ICP4 or an ICP4 encoding gene, such as an &agr;4 gene, methods of inhibiting ICP4's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections.Type: GrantFiled: April 2, 2001Date of Patent: April 20, 2004Assignee: Arch Development CorporationInventors: Rosario Leopardi, Bernard Roizman
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Patent number: 6716422Abstract: The invention provides methods of inducing the production of cytolytic T lymphocytes directed against malignancy or infectious agent by a mammal and treating such disease such that deleterious side effects are minimized and treatment of metastatic melanomas are surprisingly and dramatically improved.Type: GrantFiled: October 8, 1998Date of Patent: April 6, 2004Assignees: ARCH Development Corporation, Genetics Institute IncorporatedInventors: Thomas F. Gajewski, Francesca Fallarino