Patents Assigned to Ares Trading S.A.
  • Method of stabilizing proteins
    Patent number: 7858082
    Abstract: A method of preparing a stabilized bulk solution of a monomeric protein is described, which consists in providing a bulk of monomeric protein in a buffer solution and adding an excipient to the bulk, wherein the excipient is selected from the group consisting of bacteriostatic agents, surfactants, isotonicity agents, amino acids, antioxidants and combinations thereof. Prefereably the monomeric protein is IFN-beta.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: December 28, 2010
    Assignee: Ares Trading S.A.
    Inventor: Amer Jaber
  • Aromatase inhibition to enhance assisted reproduction
    Patent number: 7846957
    Abstract: The use of at least one aromatase inhibitor in the production of a medicament for improving the implantation and pregnancy rates for a female undergoing assisted reproduction treatment, which comprises one or more daily doses of an aromatase inhibitor (AI) for administration during assisted reproduction cycles or ovarian stimulation cycles, wherein the doses of AI are selected from amounts effective to reduce serum estradiol levels. Also disclosed are related pharmaceutical preparations and packages.
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: December 7, 2010
    Assignee: Ares Trading S.A.
    Inventors: Robert F. Casper, Mohamed F. M. Mitwally
  • Stabilized interferon liquid formulations
    Patent number: 7846427
    Abstract: Stabilized liquid pharmaceutical composition comprising an interferon (IFN) or an isoform, mutein, fused protein, functional derivative, active fraction or salt thereof, wherein said formulation is a solution that comprises a buffer, a cyclodextrin, an isotonicity agent and an anti-oxidant are described here. Preferably the interferon is interferon beta-1a and the cyclodextrin is HPBCD. These formulations are stable at room temperature, thus bringing the advantage of lower costs for formulation storage and increased safety for the patient with respect to possible “errors” during handling. As a matter of fact, having such formulations stable at room temperature reduces the risk of formation of degradation products potentially responsible for adverse events (e.g. immunogenicity).
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: December 7, 2010
    Assignee: Ares Trading S.A.
    Inventor: Maria Dorly Del Curto
  • Methods for treating B-cell malignancies using a TACI-Ig fusion molecule
    Patent number: 7842292
    Abstract: The present invention provides methods and compositions for treatment of B-cell malignancies, including non-Hodgkin's lymphoma, comprising administering to a patient in need of the treatment a TACI-Ig fusion molecule in amount sufficient to suppress proliferation-inducing functions of BlyS and APRIL.
    Type: Grant
    Filed: August 9, 2006
    Date of Patent: November 30, 2010
    Assignees: Ares Trading S.A., Zymogenetics, Inc., Mayo Foundation for Medical Education and Research
    Inventors: Herve Broly, Arnaud Ythier, Eric Sievers, Sharon J. Busby, Jan Öhrström, Ivan Nestorov, Stephen M. Ansell
  • Benzothiazole formulations and use thereof
    Patent number: 7838522
    Abstract: The present invention is related to macrogol glyceride pharmaceutical formulations containing benzothiazole derivatives. In particular, the invention is related to benzothiazole stearoyl macrogol pharmaceutical formulations, method of preparation and use thereof.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: November 23, 2010
    Assignee: Ares Trading S.A.
    Inventors: Pierandrea Esposito, Daniela Chicco, Luca Donati, Andrea Leonardi, Stefania Bertero, Jean-Pierre Gotteland, Pascale Gaillard, Isabelle Jeanclaude-Etter, Simone Grandolini, Mario Maio
  • Multiple dose aromatase inhibitor for treating infertility
    Patent number: 7820706
    Abstract: A method of inducing ovulation in a female suffering from anovulatory infertility which comprises administering to said female two or more daily doses of at least one aromatase inhibitor. A method for augmenting ovulation in an ovulating female suffering from unexplained infertility or another type of ovulatory infertility which comprises administering to said female two or more daily doses of at least one aromatase inhibitor early in one or more menstrual cycles. A method of substantially reducing dosage levels of follicle stimulating hormone (FSH) for administration to a female undergoing infertility treatment which comprises administering a combination of two or more daily doses of at least one aromatase inhibitor (AI) with a plurality of daily doses of follicle stimulating hormone (FSH).
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: October 26, 2010
    Assignee: Ares Trading S.A.
    Inventors: Robert F. Casper, Mohamed F. M. Mitwally
  • Process for the purification of IL-18 binding protein
    Patent number: 7820800
    Abstract: The invention relates to a process for the purification of IL-18 binding protein (IL-18BP) from a fluid comprising hydrophobic charge-induction chromatography.
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: October 26, 2010
    Assignee: Ares Trading S.A.
    Inventors: Mara Rossi, Thierry Ziegler, Laure Valognes
  • Method of treatment using a cytokine able to bind IL-18BP to inhibit the activity of a second cytokine
    Patent number: 7820156
    Abstract: The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof capable of binding to IL-18BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: October 26, 2010
    Assignee: Ares Trading S.A.
    Inventors: Charles A Dinarello, Soo-Hyun Kim, Philip Bufler
  • Method of controlled ovarian hyperstimulation and pharmaceutical kit for use in such method
    Patent number: 7815912
    Abstract: One aspect of the present invention is concerned with a method of controlled ovarian hyperstimulation in a mammalian female, said method comprising the co-administration to said female of —a substance having follicle stimulating hormone activity (FSH substance) in an amount effective to stimulate multiple follicular development; —gonadotropin releasing hormone (GnRH) antagonist in an amount equivalent to a daily subcutaneous dose of at least 0.5 mg ganirelix to prevent a premature LH-surge; and —a LH substance in an amount effective to prevent or suppress symptoms of luteinising hormone (LH) deficiency resulting from the administration of the GnRH antagonist; followed by administering a meiosis and luteinisation inducing substance (ML substance) in an amount effective to stimulate resumption of meiosis and luteinisation, and wherein the LH substance is not obtained from the urine of human females.
    Type: Grant
    Filed: June 6, 2003
    Date of Patent: October 19, 2010
    Assignee: Ares Trading, S.A.
    Inventors: Evert Johannes Bunschoten, Herman Jan Tijmen Coelingh Bennink
  • TACI-IMMUNOGLOBULIN FUSION PROTEINS FOR TREATMENT OF RELAPSING MULTIPLE SCLEROSIS
    Publication number: 20100261887
    Abstract: The invention relates to TACI-Immunoglobulin fusion proteins for the treatment of relapsing multiple sclerosis.
    Type: Application
    Filed: November 11, 2008
    Publication date: October 14, 2010
    Applicant: Ares Trading S.A.
    Inventors: Alessandra Del Rio, Rinaldi Gianluca, Joel Richard, Thomas Plitz
  • Method of treatment comprising administration of a cytokine antagonist molecule
    Patent number: 7803383
    Abstract: This invention relates to novel uses of a protein sequence (INSP052EC), herein identified as an immunoglobulin domain-containing cell surface recognition, in the diagnosis, prevention and treatment of diseases, in particular those related to the excessive expression and/or secretion of cytokines.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: September 28, 2010
    Assignee: Ares Trading S.A.
    Inventors: Richard Joseph Fagan, Andrew Robert Davids, Christopher Benjamin Phelps, Christine Power, Ursula Boschert, Yolande Chvatchko
  • Serum-Free Cell Culture Medium for Mammalian Cells
    Publication number: 20100227819
    Abstract: The invention relates to a process for the manufacturing of a protein in mammalian cells cultured in a serum-free medium.
    Type: Application
    Filed: April 16, 2010
    Publication date: September 9, 2010
    Applicant: ARES TRADING S.A.
    Inventors: Jose Casatorres Hernandez, Carlos Martin Piera
  • REELER DOMAIN CONTAINING PROTEIN
    Publication number: 20100196349
    Abstract: This invention relates to protein INSP 171, herein identified as containing a Reeler domain, and to the use of this protein and the nucleic acid sequence from the encoding gene in the diagnosis, prevention and treatment of disease.
    Type: Application
    Filed: December 4, 2006
    Publication date: August 5, 2010
    Applicant: ARES TRADING S.A.
    Inventors: Christine Power, Melanie Yorke-Smith, Richard Fagan, Tania Rodrigues, Dave Michalovich
  • Method for purifying FSH
    Patent number: 7754860
    Abstract: The invention provides a method for purifying recombinant FSH.
    Type: Grant
    Filed: December 16, 2004
    Date of Patent: July 13, 2010
    Assignee: Ares Trading S.A.
    Inventor: Mara Rossi
  • USE OF IL-6/IL-6 CHIMERA IN HUNTINGTON'S DISEASE
    Publication number: 20100166703
    Abstract: The invention relates to the use of an IL-6R/IL-6 chimera, a mutein, isoform, fused protein, functional derivative, active fraction or circularly permutated derivative or a salt thereof, for the manufacture of a medicament for the treatment and/or prevention of Huntington's disease.
    Type: Application
    Filed: March 4, 2010
    Publication date: July 1, 2010
    Applicant: ARES TRADING S.A.
    Inventors: NICOLE DEGLON, PATRICK AEBISCHER, JEAN-CHARLES BENSADOUN
  • Hand-Held Electronically Controlled Injection Device For Injecting Liquid Medications
    Publication number: 20100160857
    Abstract: A medication delivery device includes a housing, a door coupled to the housing and moveable between a closed position and an open position. The door permits insertion of a medication container, containing liquid medication, into the housing in the open position. A door opening mechanism is coupled to the door. A push member is axially moveable between a retracted position and a non-retracted position and located external to the medication container. The push member enters the medication container and pushes the liquid medication out of the medication container. A lock mechanism is coupled to the door opening mechanism and prevents opening of the door when the push member is in the non-retracted position inside the medication container, wherein the lock mechanism automatically unlocks the door opening mechanism when the push member is in the retracted position.
    Type: Application
    Filed: March 4, 2010
    Publication date: June 24, 2010
    Applicant: ARES TRADING S.A.
    Inventors: Vincent Pongpairochana, Timothy John MacLean, Robert Prasser, Gerhard Lauchard, Werner Wurmbauer, Gerhard Kogler
  • Freeze-dried FSH/LH formulations
    Patent number: 7740884
    Abstract: The invention relates to the field of pharmaceutical formulations of a mixture of follicle stimulating hormone (FSH) and luteinising hormone (LH), and to methods of producing such formulations.
    Type: Grant
    Filed: June 16, 2004
    Date of Patent: June 22, 2010
    Assignee: Ares Trading S.A.
    Inventors: Fabrizio Samaritani, Piergiorgio Donati
  • Use of interleukin-18 inhibitors to inhibit tumor metastasis
    Patent number: 7741276
    Abstract: Use of IL-18 inhibitors in tumor metastasis is disclosed.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: June 22, 2010
    Assignee: Ares Trading S.A.
    Inventor: Charles Dinarello
  • Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant
    Patent number: 7741268
    Abstract: The invention relates to the field of pharmaceutical formulations of follicle-stimulating hormone (FSH), luteinising hormone (LH), and mixtures of FSH and luteinising hormone (LH), and to methods of producing such formulations. The invention provides a liquid or freeze-dried formulation of FSH, or LH, or FSH and LH comprising a surfactant selected from Pluronic® F77, Pluronic F87, Pluronic F88 and Pluronic F68.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: June 22, 2010
    Assignee: Ares Trading S.A.
    Inventors: Fabrizio Samaritani, Piergiorgio Donati
  • Stabilized interferon liquid formulations
    Patent number: 7731948
    Abstract: A stabilized HSA-free liquid pharmaceutical composition is described, which comprises an interferon (IFN), wherein said formulation is a solution that comprises a buffer, an amino acid and an antioxidant. Preferably, the interferon is human recombinant IFN-beta.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: June 8, 2010
    Assignee: Ares Trading S.A.
    Inventors: Fabrizio Samaritani, Alessandra Del Rio