Abstract: The invention provides compounds of formulae I, II, III, and IV: and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.

Abstract: Systems, methods, and media for detecting an anatomical object in a medical device image are provided. In some embodiments, system for detecting an anatomical object in a medical device image are provided, the systems comprising: at least one hardware processor that: applies the medical device image to a classifier having a plurality of stages, wherein a first stage of the plurality of stages and a second stage of the plurality of stages each includes a strong learner formed from a plurality of weak learners, and the weak learners in the second stage include a plurality of the weak learners included in the first stage; and identifies the medical device image as being positive or negative of showing the anatomical object based on the application the medical device image to be classifier.

Abstract: A liquid electrolyte formed by reacting phosphoric acid (H3PO4) in the liquid state with silicon tetrachloride (SiCl4), thereby forming a fluid suspension. The fluid suspension is heated to yield a liquid electrolyte including phosphoric acid (H3PO4), pyrophosphoric acid (H4P2O7), and a particulate solid comprising a silicophosphoric acid, wherein the silicophosphoric acid is an acidic molecular compound including silicon and phosphorus. A concentrated silicophosphoric acid composition prepared by removing most of the liquid from the liquid electrolyte is dissolved in water to yield a homogeneous solution. The homogeneous solution is dried to yield a solid electrolyte. In some cases, the homogenous solution is dried on a substrate to coat at least a portion of the substrate with a proton conductive solid electrolyte. A fuel cell may include the liquid electrolyte, the solid electrolyte, or the coated substrate.

Abstract: Forming a ferrite thin film laminate includes heating a layered assembly to form a laminate. The layered assembly includes a first coated substrate having a first ferrite layer opposite a first thermoplastic surface and a second coated substrate having a second ferrite layer opposite a second thermoplastic surface to form a laminate. Each coated substrate is formed by forming a ferrite layer on a surface of a thermoplastic substrate. The coated substrates are arranged such that the first ferrite layer contacts the second thermoplastic surface. Heating the layered assembly includes bonding the first coated substrate to the second coated substrate such that the first ferrite layer is sandwiched between a first thermoplastic substrate and a second thermoplastic substrate. The ferrite thin film laminate may include a multiplicity of coated substrates.

Abstract: The present invention relates to therapeutic agents comprising bispecific recombinant antibody fragments to selectively clear a protein associated with a neurological disease and methods of use of these therapeutic agents to treat neurological diseases.

Abstract: A transition metal hydroxy-anion electrode material for lithium-ion battery cathodes includes the charge-neutral structure Mx(OH)n(XO4)m, where M is one or more transition metals, x is the total number of transition metal atoms, X is sulfur or phosphorus, and x, n, and m are integers. (OH)n(XO4)m is a hydroxysulfate or hydroxyphosphate, and M can be one or more (e.g., a solid solution of) transition metals selected from the group consisting of copper, iron, manganese, nickel, vanadium, cobalt, zinc, chromium, and molybdenum. A lithium-ion battery may have a cathode including Mx(OH)n(XO4)m as a cathode material, and an electronic device may include a lithium-ion battery having a cathode including Mx(OH)n(XO4)m as a cathode material.

Abstract: Some embodiments include a method. The method can comprise: providing a carrier substrate; providing an adhesion modification layer over the carrier substrate; providing a device substrate; and coupling the device substrate and the carrier substrate together, the adhesion modification layer being located between the device substrate and the carrier substrate when the device substrate and the carrier substrate are coupled together. In these embodiments, the adhesion modification layer can be configured so that the device substrate couples indirectly with the carrier substrate by way of the adhesion modification layer with a first bonding force that is greater than a second bonding force by which the device substrate couples with the carrier substrate absent the adhesion modification layer. Other embodiments of related methods and devices are also disclosed.

Abstract: The invention provides compounds of formulae (I), (II), (III), and (IV): and salts thereof, as well as pharmaceutical compositions comprising such compounds. The compounds are useful for treating cancers and Alzheimer's disease.

Abstract: Some embodiments include an imaging system. The image sensor array includes multiple image sensor sheets configured in an array grid. Each image sensor sheet of the multiple image sensor sheets can include a flexible substrate layer, and the flexible substrate layer can include a first flexible substrate side and a second flexible substrate side opposite the first flexible substrate side. Meanwhile, each image sensor sheet of the multiple sensor sheets can include multiple image sensors over the first flexible substrate side, the multiple image sensors can include multiple flat panel image detectors configured in a sheet grid, and the image sensor array can include an approximately constant pixel pitch. Other embodiments of related systems and methods are also disclosed.

Abstract: The present invention provides methods for tumor treatment by administering an inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1), compositions comprising such inhibitors, and methods for identifying such inhibitors.

Abstract: The present invention relates to new auristatin compounds and prodrugs thereof, compositions comprising them and uses thereof.

Abstract: A system for non-invasively monitoring a stress level of a subject is presented. A sensor is configured to monitor an attribute of the subject. A housing is configured to removably attach to the subject, the housing includes a processor in communication with the sensor, the processor is configured to retrieve data from the sensor, and use the data retrieved from the sensor to determine a stress level of the subject.

Abstract: A method and related microfluidic chip and kit for high throughput detection of proteins of interest contained in a sample is disclosed. The method comprises of specifically labeling fusion proteins in a complex sample with fusion tag specific fluorophores that specifically bind the fusion tags coupled to the proteins of interest, and subjecting the sample to automated capillary electrophoresis, wherein the presence of the proteins of interest in the sample is detected by fluorescence signals associated with the fusion tag specific fluorophores.

Abstract: The present invention relates to therapeutic agents comprising bispecific recombinant antibody fragments to selectively clear a protein associated with a neurological disease and methods of use of these therapeutic agents to treat neurological diseases.

Abstract: Some embodiments include a wireless sensor network system. Other embodiments of related systems and methods are also disclosed.

Abstract: The plant-based production of a therapeutic antibody against West Nile Virus is disclosed.

Abstract: Systems, methods, and media for optical recognition are provided. In some embodiments, systems for optical recognition are provided, the systems comprising: at least one hardware processor that: identifies a plurality of fixation points in optically detected data; identifies features of the plurality of fixation points; and identifies one or more characteristics of an object represented in the optically detected data. In some embodiments, methods for optical recognition are provided, the methods comprising: identifying a plurality of fixation points in optically detected data using a hardware processor; identifying features of the plurality of fixation points using the hardware processor; and identifying one or more characteristics of an object represented in the optically detected data using the hardware processor.

Abstract: Some embodiments include a method. The method can include providing a carrier substrate, providing a release layer over the carrier substrate, and providing a device substrate over the carrier substrate and the release layer. Providing the device substrate can include bonding the device substrate to the carrier substrate, and bonding the device substrate to the release layer. Further, providing the release layer can include bonding the release layer to the carrier substrate. Meanwhile, the release layer can include polymethylmethacrylate, and the device substrate can be bonded to the carrier substrate with a first adhesion strength, the device substrate can be bonded to the release layer with a second adhesion strength less than the first adhesion strength, and the release layer can be bonded to the carrier substrate with a third adhesion strength greater than the second adhesion strength. Other embodiments of related methods and devices are also disclosed.

Abstract: The invention provides methods for identifying cell binding and/or lytic polypeptides that permit production of specific polypeptide therapeutics in a high throughput manner.

Abstract: Some embodiments include a distributed estimation system. Other embodiments of related systems and methods are also disclosed.