Abstract: Systems and methods are described for enhancing sensorimotor learning using EEG decoding and closed-loop neuromodulation. A plurality of EEG electrodes and a plurality of stimulation electrodes are coupled to a learning subject. An output device of an adaptive learning system provides a sequence of instructions to the learning subject for performing a sensorimotor task in accordance with a defined learning schedule. The defined learning schedule is adjusted based on a monitored EEG signal while performing the task and, in some implementations, a neuromodulation stimulus signal is applied to the learning subject that is designed to cause the monitored EEG signal of the learning subject to approach at least one target EEG signal parameter.

Abstract: A magnesium-ion battery includes a solid, mechanically flexible polymer-based anode, a solid, mechanically flexible polymer-based cathode, and a polymer gel electrolyte in contact with the anode and the cathode. An electrode can include bismuth nanostructure powder and an electrolyte binder, or tungsten disulfide and an electrolyte binder.

Abstract: A phosphorescent emitter or delayed fluorescent and phosphorescent emitters represented by Formula I or Formula II, where M is platinum or palladium.

Abstract: A layered composite configured to form an interface between a heat exchanger and an integrated circuit includes a first polymer layer, a second polymer layer, a liquid metal in direct contact with the first polymer layer, a solid solute in direct contact with the second polymer layer, and a barrier between the liquid metal and the solid solute. The liquid metal is liquid at normal temperature and pressure. The solid solute includes microparticles, nanoparticles, or both and is solid at normal temperature and pressure. The barrier prevents contact of the liquid metal and the solid solute at normal temperature and pressure, and is configured to rupture under compression of the layered composite, thereby allowing the liquid metal and the solid solute to form a mixture between the first polymer layer and the second polymer layer.

Abstract: A microfluidic device is provided that incorporates a highly organized co-culture of live cells within a microengineered platform, by which the architecture and cellular constituents of an organ or other native tissue environment may be modeled over a long period of culture for biological and/or pharmacological studies. Vertical posts (e.g., microposts) may be used to induce alignment of hydrogel-encapsulated tissues in a cell suspension region of a microfluidic device. Such a device can complement animal studies in recapitulating pathophysiological characteristics of disease. When populated with cardiac cells, such a device provides a three-dimensional (3D) biomimetic human cardiac tissue model that enables the study of pathophysiological events involved in the transition of healthy to diseased cardiac tissue, to better inform therapeutic strategies and functional outcomes in cardiac-based therapies. Other types of cells may be used in certain embodiments.

Abstract: A method to enhance a male erection or female arousal in a mammal includes topically administering a compound of Formula 1 to the mammal.

Abstract: A method for rapid antibiotic susceptibility testing by tracking sub-micron scale motion of single bacterial cells including obtaining a biological sample from a subject including live bacteria. Different doses of antibiotic are added to a multi-well glass slide and adding portions of the biological sample to the wells. Bacterial cells are tethered onto the surface. The tethered bacterial cells are imaged and tracked. Bacterial sub-micron motion of tethered cells is measured at the different doses. A processor performs statistical analysis on a population of cells for each antibiotic dose to generate an antibiotic dose curve proportional to the motion changes, where the antibiotic dose curve plots data including a decrease in movement over time indicating a proportional effectiveness of an antibiotic applied to a well.

Abstract: A method for determining a characteristic of a direct-gap semiconductor comprises measuring at least one optical constant of a first sample of a direct-gap semiconductor with an optical spectrometer, calculating an estimated value of an optical parameter of the first sample of the direct-gap semiconductor based on fitting the model ?g(ln(1+e(h?-Eg)/(pEu))/ln(2))p to an optical absorption curve based on the at least one optical constant, obtaining at least one second value of the optical parameter, and calculating an estimated characteristic of the direct-gap semiconductor from the estimated value of the optical parameter and the obtained second value of the optical parameter. A method for determining a temperature of a direct-gap semiconductor and a system for determining a characteristic of a direct-gap semiconductor are also disclosed.

Abstract: An osseointegratable prosthetic device suitable for implantation via a one-step surgical process includes a threaded insertion end, an externally accessible tool interface end, and an intermediately arranged scaffold portion defining recesses that permit ingrowth of skeletal tissue. Such recesses may include multiple longitudinal fins as well as transverse ribs, which may embody or be coated with porous material to promote bone ingrowth. A split flange portion includes discontinuous portions and may permit pretensioning of the device. The device may be fabricated as a unitary body structure from thermoplastic materials using techniques such as fused filament fabrication (a form of 3D printing). The osseointegratable prosthetic device enables one-step surgical implantation without requiring separately implantable fixture/sleeve and abutment portions according to conventional osseointegratable prosthetics. Methods for fabricating an osseointegratable prosthetic device are further provided.

Abstract: A carbon dioxide adsorbent including a hierarchical zeolite. The hierarchical zeolite defines micropores having a pore width between about 0.4 nm and about 2 nm, and at least one of: mesopores having a pore width between about 2 nm and about 50 nm; and macropores having a pore width greater than about 50 nm.

Abstract: Preparing a porous hybrid media includes contacting porous media (e.g., strong base ion-exchange media) with an aqueous solution including aluminum ions to yield a aluminum-ion-containing porous media, contacting the aluminum-ion containing porous media with a reducing agent to impregnate elemental aluminum in the porous media, and oxidizing the elemental aluminum to yield a porous hybrid media including aluminum hydr(oxide) impregnated in the porous media. In some cases, a pH of an aqueous mixture including the aluminum-ion-containing porous media may be adjusted to form a floc including aluminum hydroxide, and the aluminum hydroxide-containing porous media may be contacted with a reducing agent to yield a porous hybrid media including aluminum hydr(oxide) impregnated in the porous media. The porous hybrid media may advantageously be prepared at low temperature (e.g., room temperature).

Abstract: The complexes disclosed herein are cyclometalated metal complexes of Formula (I) that are useful for full color displays and lighting applications.

Abstract: Embodiments of systems and methods for gray-box adversarial testing for control systems with machine learning components are disclosed.

Abstract: An integrated method for assessing metabolic rate and maintaining indoor air quality and efficient ventilation energy use. A physical sensor assesses room occupancy. An actuated ventilation system is set to a constant CO2 level in a predetermined healthy range, where the actuated ventilation system includes a CO2 sensor. The actuated ventilation system sets a first air ventilation rate and the sensor measures a first CO2 level. The system determines whether CO2 level is in a healthy range, if not then the CO2 level is adjusted by setting a subsequent air ventilation rate. A subsequent CO2 level is measured. If the CO2 level is determined to meet a predetermined healthy range, then an assessment of change of air ventilation rate (? ACH) is determined. The determination of air change rate can be further augmented by a physical pressure based measurement. The overall metabolic rate is generated.

Abstract: A real time end-to-end learning system for a high frame rate video compressive sensing network is described. The slow reconstruction speed of conventional compressive sensing approaches is overcome by directly modeling an inverse mapping from compressed domain to original domain in a single forward propagation. Through processing massive unlabeled video data such a mapping is learned by a neural network using data-driven methods. Systems and methods according to this disclosure incorporate a multi-rate convolutional neural network (CNN) and a synthesizing recurrent neural network (RNN) to achieve real time compression and reconstruction of video data.

Abstract: A microreactor array platform and method for sealing a reagent in microreactors of an array of microreactors are provided. The microreactor array platform includes an array of microreactors, and a sealing film having a first surface and an opposite second surface, the sealing film configured to movably seal the array of microreactors. The microreactor array platform also includes an injector for delivering a reagent into the array of microreactors via a fluid path between the array and the second surface of the sealing film, and an applicator for directing a sealing liquid against the first surface of the sealing film. The microreactor array platform further includes a system for creating a pressure differential between the reagent in the injector and a space between the array of microreactors and the second surface of the sealing film.

Abstract: An autozeroed comparator controls a frequency fsw of the input voltage inputted to a DC/DC converter. A digital frequency synchronization circuit is connected to the autozeroed comparator so as to form a phase locked loop, wherein the DES circuit controls the hysteretic window of the autozeroed comparator so as to lock fsw to a clock reference frequency. A plurality of slave phase circuits may be connected to the master phase circuit including the DFS circuit and the autozeroed comparator. Duty cycle calibration circuits adjust a duty cycle signal applied to each of the slave phase circuits, in response to average current measured in the slave phase circuits, so that each slave phase circuit is synchronized with the master phase circuit. A 6 A 90.5% peak efficiency 4-phase hysteretic quasi-current-mode buck converter is provided with constant frequency and maximum ±1.5% current mismatch between the slave phases and the master phase.

Abstract: The present invention provides detection reagents and method for determining risk of traumatic brain injury (TBI) and/or susceptibility to neurodegenerative disease in a subject.

Abstract: The disclosed technology relates generally to apparatus comprising conductive polymers and more particularly to tag and tag devices comprising a redox-active polymer film, and method of using and manufacturing the same. In one aspect, an apparatus includes a substrate and a conductive structure formed on the substrate which includes a layer of redox-active polymer film having mobile ions and electrons. The conductive structure further includes a first terminal and a second terminal configured to receive an electrical signal therebetween, where the layer of redox-active polymer is configured to conduct an electrical current generated by the mobile ions and the electrons in response to the electrical signal. The apparatus additionally includes a detection circuit operatively coupled to the conductive structure and configured to detect the electrical current flowing through the conductive structure.

Abstract: A system and method for characterizing tissues of a subject using multi-parametric imaging are provided. In some aspects, the method includes receiving a set of multi-parametric magnetic resonance (“MR”) images acquired from a subject using an MR imaging system, and selecting at least one region of interest (“ROI”) in the subject using one or more images in the set of multi-parametric MR images. The method also includes performing a texture analysis on corresponding ROIs in the set of multi-parametric MR images to generate a set of texture features, and applying a classification scheme, using the set of texture features, to characterize tissues in the ROI. The method further includes generating a report indicative of characterized tissues in the ROI.