Abstract: Methods for screening of affinity reagents for many target proteins of interest simultaneously. Arrayed targets (e.g., peptide, protein, RNA, cell, etc.) are used in affinity selection experiments to reduce the amount of target needed and to improve the throughput of discovering recombinant affinity reagents to a large collection of targets.

Abstract: A computer-implemented framework and/or system for cyberbullying detection is disclosed. The system includes two main components: (1) A representation learning network that encodes the social media session by exploiting multi-modal features, e.g., text, network, and time; and (2) a multi-task learning network that simultaneously fits the comment inter-arrival times and estimates the bullying likelihood based on a Gaussian Mixture Model. The system jointly optimizes the parameters of both components to overcome the shortcomings of decoupled training. The system includes an unsupervised cyberbullying detection model that not only experimentally outperforms the state-of-the-art unsupervised models, but also achieves competitive performance compared to supervised models.

Abstract: Described herein are means for training a deep model to learn contrastive representations embedded within part-whole semantics via a self-supervised learning framework, in which the trained deep models are then utilized for the processing of medical imaging. For instance, an exemplary system is specifically configured for performing a random cropping operation to crop a 3D cube from each of a plurality of medical images received at the system as input; performing a resize operation of the cropped 3D cubes; performing an image reconstruction operation of the resized and cropped 3D cubes to predict the resized whole image represented by the original medical images received; and generating a reconstructed image which is analyzed for reconstruction loss against the original image representing a known ground truth image to the reconstruction loss function. Other related embodiments are disclosed.

Abstract: Various embodiments of a system and associated method for anonymization of text without losing semantic utility of text by extracting a latent embedding representation of content with respect to a given task and by learning an optimal strategy for text embedding manipulation to satisfy both privacy and utility requirements are disclosed herein. In particular, the system balances private attribute obfuscation with retained semantic utility.

Abstract: A method for imaging of an object includes, for each of a plurality of surface-regions of the object, determining a corresponding image-sensor pixel group of a camera illuminated by light propagating from the surface-region via a lens of the camera. The method also includes, after the step of determining and for each surface-region: (i) changing a distance between the object and the lens such that the surface region intersects an in-focus object-plane of the camera and the lens forms an in-focus surface-region image on the corresponding image-sensor pixel group; (ii) capturing, with the corresponding image-sensor pixel group, the in-focus surface-region image of the surface-region; and (iii) combining the in-focus surface-region images, obtained by performing said capturing for each surface-region, to yield an all-in-focus image of the object.

Abstract: Provided herein are compositions and methods for treating respiratory and pulmonary vascular disease. In particular, provided herein are spray dried simvastatin for delivery to the lung.

Abstract: A system includes a Bayesian Spatiotemporal Graph Transformer (B-STAR) architecture that models spatial and temporal relationship of multiple agents under uncertainties. The system enables Multi-Agent Trajectory Prediction for safety-critical engineering applications, (e.g., autonomous driving and flight systems) and considers the impact of various sources, such as environmental conditions, pilot/controller behaviors, and potential conflicts with nearby aircraft. It is shown that B-STAR achieves state-of-the-art performance on the ETH/UCY pedestrian dataset with UQ competence.

Abstract: Methods and systems are described that enable three-dimensional (3D) imaging of objects. One example system includes a light source that produces multiple light beams having specific spectral content and polarization states. The system also includes phase masks that modify the intensity or phase of the light, and projection optics that allow simultaneously projection of at least three fringe patterns onto an object having particular phase, polarization and spectral characteristics. The detection system includes a camera that simultaneously receives light associated with the at the fringe patterns upon reflection from the object, and a processing unit coupled to the camera unit that determines one or both of a phase or a depth information associated with the object. The system and associated methods can efficiency produce 2D images of the object and allow determination of characteristics such as surface profile. The disclosed systems and methods can be effectively implemented with moving objects.

Abstract: Provided herein are synthetic nucleic acid molecules and methods of using such synthetic nucleic acid molecules for strong repression of target gene expression. In particular, provided herein are methods for altering expression of a protein in a cell, where the method comprises introducing into a cell a protein coding sequence operably linked to a near-threshold translational repressor having first and second trigger recognition sequences that are fully or partially complementary to a repressing trigger RNA; and introducing into a cell the repressing trigger RNA.

Abstract: Compositions and methods for genetically modifying at least one nucleic acid sequence of interest in a polyploid organism.

Abstract: A wound dressing includes: a structural material formed into a dressing; at least one immunomodulatory agent associated with the dressing; and a growth factor associated with the dressing. A wound dressing kit includes: a structural material formed into a wound dressing; an immunomodulatory agent; and a growth factor composition, wherein the structural material contains the immunomodulatory agent and/or the immunomodulatory agent in a separate composition. A method of treating a wound in a tissue includes: applying an immunomodulatory agent to the wound; applying a wound dressing to the wound; and allowing the wound to heal with the immunomodulatory agent and wound dressing. The application of a growth factor can be before, during and/or after applying the wound dressing to the wound.

Abstract: Systems and methods for digital reflex quantization and signature analysis. Movement of a stimulating device invoking a reflex response in an organism is captured as stimuli data. Electromyographic (EMG) of the reflex response is captured as EMG data. Movement resulting from the reflex response of a limb/appendage of the organism is captured as motion data. One or more of the stimuli data, the EMG data, and the motion data are analyzed to determine one or both of a motion signature and an EMG signature defining quantitative evaluation of the reflex response.

Abstract: Fabricating a nanopore sensor includes depositing a first and second oxide layers on first and second sides of a sapphire substrate. The second oxide layer is patterned to form an etch mask having a mask opening in the second oxide layer. A crystalline orientation dependent wet anisotropic etch is performed on the second side of the sapphire substrate using the etch mask to form a cavity having sloped side walls through the sapphire substrate to yield an exposed portion of the first oxide layer, each of the sloped side walls being a crystalline facet aligned with a respective crystalline plane of the sapphire substrate. A silicon nitride layer is deposited on the first oxide layer. The exposed portion of the first oxide layer in the cavity is removed, thereby defining a silicon nitride membrane in the cavity. An opening is formed through the silicon nitride membrane.

Abstract: Various embodiments for predicting which software vulnerabilities will be exploited by malicious hackers and hence prioritized by patching are disclosed.

Abstract: The disclosure provides mutant Brassica plants that have increased locules and seed production relative to native wild-type plants. Such plants include a point mutation in the clavata 1 gene (CLV1), such as a G->A substitution at position 1745 of the Brassica rapa coding sequence, which leads to an S582N substitution in the protein sequence. Equivalent substitutions can be made in any Brassicaceae coding/protein sequence. Also provided are methods of using such plants in breeding programs, as well as parts of such plants (such as seeds), and methods of making commodity products from such plants (e.g., oil). Also provided are mutant CLV1 sequences. Brassica plants harboring the disclosed CLV1 mutation can include other desirable traits, such as herbicide tolerance.

Abstract: A neural network accelerator architecture for multiple task adaptation comprises a volatile memory comprising a plurality of subarrays, each subarray comprising M rows and N columns of volatile memory cells; a source line driver connected to a plurality of N source lines, each source line corresponding to a column in the subarray; a binary mask buffer memory having size at least N bits, each bit corresponding to a column in the subarray, where a 0 corresponds to turning off the column for a convolution operation and a 1 corresponds to turning on the column for the convolution operation; and a controller configured to selectively drive each of the N source lines with a corresponding value from the mask buffer; wherein each column in the subarray is configured to store a convolution kernel.

Abstract: Described herein are polyhedral, three-dimensional tunable nanocages assembled with a multimeric protein covalently linked to a polynucleotide handle and a DNA origami base assembly including sequences complementary to the polynucleotide handles, wherein the polynucleotide handle and the complementary sequences hybridize to for double-stranded DNA helices.

Abstract: Compact occlusion-capable optical see-through head mounted displays (OCOST-HMDs) are described having a double-wrapped path and capable of rendering per-pixel mutual occlusion, and correct see-through viewing perspective or a pupil-matched viewing between the virtual and real views. An example device includes a polarizer, a polarizing beam splitter, an objective lens, a spatial light modulator (SLM), an eyepiece lens, a quarter wave plate, and a reflective optical element configured to reflect the light that is incident thereupon in a first direction, and to transit the light received from a microdisplay that is incident thereupon from a second direction. The components form a first double-pass configurations that allow the light that passes through the objective to reflect from the SLM and propagate again through the objective, and a second double-pass configuration that allows the light that passes through the eyepiece to reflect from the reflective optical element and propagate again through the eyepiece.

Abstract: Provided herein are CRISPR-based synthetic repression systems as well as methods and compositions using the synthetic repression systems to treat septicemia, an adverse immune response in a subject and Waldenström macroglobulinemia.

Abstract: The present disclosure provides an implantable optogenetic stimulation device. In one embodiment the device includes a housing and an optoelectronic stimulation circuit for light delivery for optogenetic stimulation. The stimulation circuit includes energy harvesting circuitry to receive radio frequency (RF) energy; one or more capacitor storage elements to store energy associated with the RF energy; a light emitting diode (LED) to generate a light source for optogenetic stimulation at a selected frequency and duty cycle; and controller circuitry to discharge the one or more capacitor storage elements at a selected duty cycle to cause the LED to generate pulsed light at the selected duty cycle with energy requirement above the peak power capability of the RF harvesting circuit.